Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kain V et al. | Resolvin D1 activates the inflammation resolving response at splenic and ventricular site following myocardial infarction leading to improved ventricular function. | 2015 | J. Mol. Cell. Cardiol. | pmid:25870158 |
Valenzuela R et al. | Modification of Docosahexaenoic Acid Composition of Milk from Nursing Women Who Received Alpha Linolenic Acid from Chia Oil during Gestation and Nursing. | 2015 | Nutrients | pmid:26247968 |
Wang H et al. | 4-Hydroxy-7-oxo-5-heptenoic Acid (HOHA) Lactone is a Biologically Active Precursor for the Generation of 2-(ω-Carboxyethyl)pyrrole (CEP) Derivatives of Proteins and Ethanolamine Phospholipids. | 2015 | Chem. Res. Toxicol. | pmid:25793308 |
Aursnes M et al. | Synthesis of the 16S,17S-Epoxyprotectin Intermediate in the Biosynthesis of Protectins by Human Macrophages. | 2015 | J. Nat. Prod. | pmid:26580578 |
Domenichiello AF et al. | Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain? | 2015 | Prog. Lipid Res. | pmid:25920364 |
Gu Z et al. | Resolvin D1, resolvin D2 and maresin 1 activate the GSK3β anti-inflammatory axis in TLR4-engaged human monocytes. | 2016 | Innate Immun | pmid:26878867 |
Xie W et al. | ResolvinD1 reduces apoptosis and inflammation in primary human alveolar epithelial type 2 cells. | 2016 | Lab. Invest. | pmid:26878131 |
Liu Y et al. | Resolvin D1 protects against inflammation in experimental acute pancreatitis and associated lung injury. | 2016 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:26702138 |
Crandell JR et al. | Lipid effects of switching from prescription EPA+DHA (omega-3-acid ethyl esters) to prescription EPA only (icosapent ethyl) in dyslipidemic patients. | 2016 | Postgrad Med | pmid:27684412 |
Visentin S et al. | Red blood cell membrane fatty acid composition in infants fed formulas with different lipid profiles. | 2016 | Early Hum. Dev. | pmid:27391868 |
Viola JR et al. | Resolving Lipid Mediators Maresin 1 and Resolvin D2 Prevent Atheroprogression in Mice. | 2016 | Circ. Res. | pmid:27531933 |
Zhang MJ et al. | Resolvin D2 Enhances Postischemic Revascularization While Resolving Inflammation. | 2016 | Circulation | pmid:27507404 |
Stein K et al. | A role for 12/15-lipoxygenase-derived proresolving mediators in postoperative ileus: protectin DX-regulated neutrophil extravasation. | 2016 | J. Leukoc. Biol. | pmid:26292977 |
McManus S et al. | Differential effects of EPA versus DHA on postprandial vascular function and the plasma oxylipin profile in men. | 2016 | J. Lipid Res. | pmid:27170732 |
Graciano MF et al. | Omega-3 fatty acids control productions of superoxide and nitrogen oxide and insulin content in INS-1E cells. | 2016 | J. Physiol. Biochem. | pmid:27474043 |
Li R et al. | Maresin 1, a Proresolving Lipid Mediator, Mitigates Carbon Tetrachloride-Induced Liver Injury in Mice. | 2016 | Oxid Med Cell Longev | pmid:26881046 |
Hanssens L et al. | The clinical benefits of long-term supplementation with omega-3 fatty acids in cystic fibrosis patients - A pilot study. | 2016 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:27154364 |
Lu Y et al. | Impedance spectroscopy analysis of human odorant binding proteins immobilized on nanopore arrays for biochemical detection. | 2016 | Biosens Bioelectron | pmid:26710343 |
Ghosh S et al. | Epigenomic maintenance through dietary intervention can facilitate DNA repair process to slow down the progress of premature aging. | 2016 | IUBMB Life | pmid:27364681 |
Subbaiah PV et al. | Enhanced incorporation of dietary DHA into lymph phospholipids by altering its molecular carrier. | 2016 | Biochim. Biophys. Acta | pmid:27178174 |
Gold DR et al. | Lung VITAL: Rationale, design, and baseline characteristics of an ancillary study evaluating the effects of vitamin D and/or marine omega-3 fatty acid supplements on acute exacerbations of chronic respiratory disease, asthma control, pneumonia and lung function in adults. | 2016 | Contemp Clin Trials | pmid:26784651 |
Bassuk SS et al. | Baseline characteristics of participants in the VITamin D and OmegA-3 TriaL (VITAL). | 2016 | Contemp Clin Trials | pmid:26767629 |
Allaire J et al. | A randomized, crossover, head-to-head comparison of eicosapentaenoic acid and docosahexaenoic acid supplementation to reduce inflammation markers in men and women: the Comparing EPA to DHA (ComparED) Study. | 2016 | Am. J. Clin. Nutr. | pmid:27281302 |
Gramer G et al. | Long-chain polyunsaturated fatty acid status in children, adolescents and adults with phenylketonuria. | 2016 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:27269713 |
Gao J et al. | Neuroprotective effects of docosahexaenoic acid on hippocampal cell death and learning and memory impairments in a valproic acid-induced rat autism model. | 2016 | Int. J. Dev. Neurosci. | pmid:26639559 |
Wang H et al. | Potential serum biomarkers from a metabolomics study of autism. | 2016 | J Psychiatry Neurosci | pmid:26395811 |
Si TL et al. | Enhanced anti-inflammatory effects of DHA and quercetin in lipopolysaccharide-induced RAW264.7 macrophages by inhibiting NF-κB and MAPK activation. | 2016 | Mol Med Rep | pmid:27176922 |
Primdahl KG et al. | Synthesis of 13(R)-Hydroxy-7Z,10Z,13R,14E,16Z,19Z Docosapentaenoic Acid (13R-HDPA) and Its Biosynthetic Conversion to the 13-Series Resolvins. | 2016 | J. Nat. Prod. | pmid:27704804 |
Jeyanathan J et al. | Biohydrogenation of 22:6n-3 by Butyrivibrio proteoclasticus P18. | 2016 | BMC Microbiol. | pmid:27283157 |
Khaire A et al. | Vitamin B Deficiency Across Three Generations Adversely Influences Long-chain Polyunsaturated Fatty Acid Status and Cardiometabolic Markers in Rats. | 2016 | Arch. Med. Res. | pmid:27986122 |
Meesawatsom P et al. | Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models. | 2016 | J Neuroinflammation | pmid:27589850 |
Kjær MA et al. | Regulation of the Omega-3 Fatty Acid Biosynthetic Pathway in Atlantic Salmon Hepatocytes. | 2016 | PLoS ONE | pmid:27973547 |
Kondreddy VK and Kamatham AN | Celecoxib, a COX-2 inhibitor, synergistically potentiates the anti-inflammatory activity of docosahexaenoic acid in macrophage cell line. | 2016 | Immunopharmacol Immunotoxicol | pmid:26954392 |
Moeinzadeh F et al. | Effects of Omega-3 Fatty Acid Supplementation on Serum Biomarkers, Inflammatory Agents, and Quality of Life of Patients on Hemodialysis. | 2016 | Iran J Kidney Dis | pmid:27903997 |
Arnold WR et al. | Asymmetric Binding and Metabolism of Polyunsaturated Fatty Acids (PUFAs) by CYP2J2 Epoxygenase. | 2016 | Biochemistry | pmid:27992998 |
Zhao Z et al. | The Association of Fatty Acid Levels and Gleason Grade among Men Undergoing Radical Prostatectomy. | 2016 | PLoS ONE | pmid:27880795 |
Heskey CE et al. | Adipose tissue α-linolenic acid is inversely associated with insulin resistance in adults. | 2016 | Am. J. Clin. Nutr. | pmid:26912497 |
Lo Van A et al. | Mechanisms of DHA transport to the brain and potential therapy to neurodegenerative diseases. | 2016 | Biochimie | pmid:27496085 |
Cinelli G et al. | Influence of Maternal Obesity and Gestational Weight Gain on Maternal and Foetal Lipid Profile. | 2016 | Nutrients | pmid:27314385 |
Revuelta M et al. | Antioxidant Treatments Recover the Alteration of Auditory-Evoked Potentials and Reduce Morphological Damage in the Inferior Colliculus after Perinatal Asphyxia in Rat. | 2016 | Brain Pathol. | pmid:25990815 |
Kuda O et al. | Docosahexaenoic Acid-Derived Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) With Anti-inflammatory Properties. | 2016 | Diabetes | pmid:27313314 |
Easley JT et al. | AT-RvD1 combined with DEX is highly effective in treating TNF-α-mediated disruption of the salivary gland epithelium. | 2016 | Physiol Rep | pmid:27694530 |
McNamara RK and Welge JA | Meta-analysis of erythrocyte polyunsaturated fatty acid biostatus in bipolar disorder. | 2016 | Bipolar Disord | pmid:27087497 |
Titos E et al. | Signaling and Immunoresolving Actions of Resolvin D1 in Inflamed Human Visceral Adipose Tissue. | 2016 | J. Immunol. | pmid:27647830 |
Bascoul-Colombo C et al. | Dietary DHA supplementation causes selective changes in phospholipids from different brain regions in both wild type mice and the Tg2576 mouse model of Alzheimer's disease. | 2016 | Biochim. Biophys. Acta | pmid:26968097 |
Kim KH et al. | Resolvin D1 prevents smoking-induced emphysema and promotes lung tissue regeneration. | 2016 | Int J Chron Obstruct Pulmon Dis | pmid:27313451 |
Zhao YL et al. | Resolvin D1 Protects Lipopolysaccharide-induced Acute Kidney Injury by Down-regulating Nuclear Factor-kappa B Signal and Inhibiting Apoptosis. | 2016 | Chin. Med. J. | pmid:27098797 |
Shi H et al. | VIP protects human retinal microvascular endothelial cells against high glucose-induced increases in TNF-α and enhances RvD1. | 2016 | Prostaglandins Other Lipid Mediat. | pmid:27026343 |
Gharekhani A et al. | Potential Effects of Omega-3 Fatty Acids on Insulin Resistance and Lipid Profile in Maintenance Hemodialysis Patients: a Randomized Placebo-Controlled Trial. | 2016 | Iran J Kidney Dis | pmid:27721230 |
Schmid M et al. | Resolvin D1 Polarizes Primary Human Macrophages toward a Proresolution Phenotype through GPR32. | 2016 | J. Immunol. | pmid:26969756 |