Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Titos E et al. | Resolvin D1 and its precursor docosahexaenoic acid promote resolution of adipose tissue inflammation by eliciting macrophage polarization toward an M2-like phenotype. | 2011 | J. Immunol. | pmid:22013115 |
Wang RX et al. | [Mechanism related to docosahexaenoic acid induced large conductance calcium-activated potassium channel currents increase in coronary smooth muscle cells]. | 2011 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:21624312 |
van de Lagemaat M et al. | Post term dietary-induced changes in DHA and AA status relate to gains in weight, length, and head circumference in preterm infants. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21995887 |
Yi SH et al. | A randomized, placebo-controlled, double-blind trial of supplemental docosahexaenoic acid on cognitive processing speed and executive function in females of reproductive age with phenylketonuria: A pilot study. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22000478 |
Sidhu VK et al. | Effects of docosahexaenoic acid on mouse brain synaptic plasma membrane proteome analyzed by mass spectrometry and (16)O/(18)O labeling. | 2011 | J. Proteome Res. | pmid:22003853 |
Labayen I et al. | Associations of birth weight with serum long chain polyunsaturated fatty acids in adolescents; the HELENA study. | 2011 | Atherosclerosis | pmid:21550607 |
Granot E et al. | DHA supplementation during pregnancy and lactation affects infants' cellular but not humoral immune response. | 2011 | Mediators Inflamm. | pmid:21941411 |
Rahman M et al. | Docosahexaenoic acid inhibits UVB-induced activation of NF-κB and expression of COX-2 and NOX-4 in HR-1 hairless mouse skin by blocking MSK1 signaling. | 2011 | PLoS ONE | pmid:22140508 |
Johnson B | Consciousness reinstated using the certainty principle--a better mental health strategy. | 2011 | Nutr Health | pmid:22141192 |
Wood PL et al. | Oral bioavailability of the ether lipid plasmalogen precursor, PPI-1011, in the rabbit: a new therapeutic strategy for Alzheimer's disease. | 2011 | Lipids Health Dis | pmid:22142382 |
Decsi T et al. | Inverse association between trans isomeric and long-chain polyunsaturated fatty acids in pregnant women and their newborns: data from three European countries. | 2011 | Ann. Nutr. Metab. | pmid:22142767 |
Park CK et al. | Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1. | 2011 | J. Neurosci. | pmid:22016541 |
Czerner M et al. | Ripening of salted anchovy (Engraulis anchoita): development of lipid oxidation, colour and other sensorial characteristics. | 2011 | J. Sci. Food Agric. | pmid:21302314 |
McNamara RK et al. | Chronic risperidone normalizes elevated pro-inflammatory cytokine and C-reactive protein production in omega-3 fatty acid deficient rats. | 2011 | Eur. J. Pharmacol. | pmid:21118685 |
Kim HY et al. | N-Docosahexaenoylethanolamide promotes development of hippocampal neurons. | 2011 | Biochem. J. | pmid:21281269 |
Ulven SM et al. | Metabolic effects of krill oil are essentially similar to those of fish oil but at lower dose of EPA and DHA, in healthy volunteers. | 2011 | Lipids | pmid:21042875 |
Morin C et al. | Docosahexaenoic acid derivative prevents inflammation and hyperreactivity in lung: implication of PKC-Potentiated inhibitory protein for heterotrimeric myosin light chain phosphatase of 17 kD in asthma. | 2011 | Am. J. Respir. Cell Mol. Biol. | pmid:21057106 |
Mischoulon D | The impact of omega-3 fatty acids on depressive disorders and suicidality: can we reconcile 2 studies with seemingly contradictory results? | 2011 | J Clin Psychiatry | pmid:22244020 |
Le-Niculescu H et al. | Convergent functional genomic studies of ω-3 fatty acids in stress reactivity, bipolar disorder and alcoholism. | 2011 | Transl Psychiatry | pmid:22832392 |
Yang R et al. | Decoding functional metabolomics with docosahexaenoyl ethanolamide (DHEA) identifies novel bioactive signals. | 2011 | J. Biol. Chem. | pmid:21757729 |
Gajos G | The fish oil story--back to Greenland? | 2011 | Cardiology | pmid:21757896 |
Ozsoy O et al. | The influence and the mechanism of docosahexaenoic acid on a mouse model of Parkinson's disease. | 2011 | Neurochem. Int. | pmid:21736911 |
Haraguchi T et al. | Fish oil feeding up-regulates the expression of 5-aminolevulinate synthase 2 mRNA in rat brain. | 2011 | Biosci. Biotechnol. Biochem. | pmid:21737922 |
Johnsen GM et al. | Docosahexaenoic acid stimulates tube formation in first trimester trophoblast cells, HTR8/SVneo. | 2011 | Placenta | pmid:21741084 |
Lespérance F et al. | The efficacy of omega-3 supplementation for major depression: a randomized controlled trial. | 2011 | J Clin Psychiatry | pmid:20584525 |
Keithly JI et al. | Thermogenesis, blood metabolites and hormones, and growth of lambs born to ewes supplemented with algae-derived docosahexaenoic acid. | 2011 | J. Anim. Sci. | pmid:21742943 |
Sun H et al. | Omega-3 fatty acids induce apoptosis in human breast cancer cells and mouse mammary tissue through syndecan-1 inhibition of the MEK-Erk pathway. | 2011 | Carcinogenesis | pmid:21771724 |
Caputo M et al. | Selective regulation of UGT1A1 and SREBP-1c mRNA expression by docosahexaenoic, eicosapentaenoic, and arachidonic acids. | 2011 | J. Cell. Physiol. | pmid:20648548 |
Alves SP et al. | Acetonitrile covalent adduct chemical ionization tandem mass spectrometry of non-methylene-interrupted pentaene fatty acid methyl esters. | 2011 | Rapid Commun. Mass Spectrom. | pmid:21698676 |
Szajewska H and Makrides M | Is early nutrition related to short-term health and long-term outcome? | 2011 | Ann. Nutr. Metab. | pmid:21701166 |
Serebruany VL et al. | Early impact of prescription Omega-3 fatty acids on platelet biomarkers in patients with coronary artery disease and hypertriglyceridemia. | 2011 | Cardiology | pmid:21701167 |
Frisardi V et al. | Glycerophospholipids and glycerophospholipid-derived lipid mediators: a complex meshwork in Alzheimer's disease pathology. | 2011 | Prog. Lipid Res. | pmid:21703303 |
Walczewska A et al. | [The role of docosahexaenoic acid in neuronal function]. | 2011 | Postepy Hig Med Dosw (Online) | pmid:21677356 |
Davis-Bruno K and Tassinari MS | Essential fatty acid supplementation of DHA and ARA and effects on neurodevelopment across animal species: a review of the literature. | 2011 | Birth Defects Res. B Dev. Reprod. Toxicol. | pmid:21678548 |
Klingler M et al. | Fatty acid status determination by cheek cell sampling combined with methanol-based ultrasound extraction of glycerophospholipids. | 2011 | Lipids | pmid:21681560 |
Liu SJ et al. | Effect of ruminal pulse dose of polyunsaturated fatty acids on ruminal microbial populations and duodenal flow and milk profiles of fatty acids. | 2011 | J. Dairy Sci. | pmid:21605768 |
Rice TW et al. | Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury. | 2011 | JAMA | pmid:21976613 |
Miles EA et al. | The Salmon in Pregnancy Study: study design, subject characteristics, maternal fish and marine n-3 fatty acid intake, and marine n-3 fatty acid status in maternal and umbilical cord blood. | 2011 | Am. J. Clin. Nutr. | pmid:21849598 |
Wu A et al. | The salutary effects of DHA dietary supplementation on cognition, neuroplasticity, and membrane homeostasis after brain trauma. | 2011 | J. Neurotrauma | pmid:21851229 |
Weise C et al. | Inhibition of IgE production by docosahexaenoic acid is mediated by direct interference with STAT6 and NFκB pathway in human B cells. | 2011 | J. Nutr. Biochem. | pmid:20576420 |
Lalancette-Hébert M et al. | Accumulation of dietary docosahexaenoic acid in the brain attenuates acute immune response and development of postischemic neuronal damage. | 2011 | Stroke | pmid:21852616 |
Schuchardt JP et al. | Incorporation of EPA and DHA into plasma phospholipids in response to different omega-3 fatty acid formulations--a comparative bioavailability study of fish oil vs. krill oil. | 2011 | Lipids Health Dis | pmid:21854650 |
Murakami M | Lipid mediators in life science. | 2011 | Exp. Anim. | pmid:21325748 |
Beck G et al. | Neuroaxonal dystrophy in calcium-independent phospholipase A2β deficiency results from insufficient remodeling and degeneration of mitochondrial and presynaptic membranes. | 2011 | J. Neurosci. | pmid:21813701 |
Kuipers RS et al. | Postpartum changes in maternal and infant erythrocyte fatty acids are likely to be driven by restoring insulin sensitivity and DHA status. | 2011 | Med. Hypotheses | pmid:21388747 |
Boucher O et al. | Neurophysiologic and neurobehavioral evidence of beneficial effects of prenatal omega-3 fatty acid intake on memory function at school age. | 2011 | Am. J. Clin. Nutr. | pmid:21389181 |
Grant GE et al. | Enhanced formation of 5-oxo-6,8,11,14-eicosatetraenoic acid by cancer cells in response to oxidative stress, docosahexaenoic acid and neutrophil-derived 5-hydroxy-6,8,11,14-eicosatetraenoic acid. | 2011 | Carcinogenesis | pmid:21393477 |
Trofimiuk E and Braszko JJ | Long-term administration of cod liver oil ameliorates cognitive impairment induced by chronic stress in rats. | 2011 | Lipids | pmid:21442272 |
Chauveau F et al. | Brain-targeting form of docosahexaenoic acid for experimental stroke treatment: MRI evaluation and anti-oxidant impact. | 2011 | Curr Neurovasc Res | pmid:21443458 |
Collins CT et al. | Pre- and post-term growth in pre-term infants supplemented with higher-dose DHA: a randomised controlled trial. | 2011 | Br. J. Nutr. | pmid:21443815 |
Sala-Vila A et al. | Determinants of the omega-3 index in a Mediterranean population at increased risk for CHD. | 2011 | Br. J. Nutr. | pmid:21450116 |
Lebold KM et al. | Vitamin E deficiency decreases long-chain PUFA in zebrafish (Danio rerio). | 2011 | J. Nutr. | pmid:22013196 |
Guesnet P and Alessandri JM | Docosahexaenoic acid (DHA) and the developing central nervous system (CNS) - Implications for dietary recommendations. | 2011 | Biochimie | pmid:20478353 |
Amtul Z et al. | DHA supplemented in peptamen diet offers no advantage in pathways to amyloidosis: is it time to evaluate composite lipid diet? | 2011 | PLoS ONE | pmid:21931647 |
Sublette ME et al. | Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression. | 2011 | J Clin Psychiatry | pmid:21939614 |
Serini S et al. | Differential anti-cancer effects of purified EPA and DHA and possible mechanisms involved. | 2011 | Curr. Med. Chem. | pmid:21824086 |
Fagali N and Catalá A | Melatonin and structural analogues do not possess antioxidant properties on Fe(2+)-initiated peroxidation of sonicated liposomes made of retinal lipids. | 2011 | Chem. Phys. Lipids | pmid:21827740 |
Newens KJ et al. | DHA-rich fish oil reverses the detrimental effects of saturated fatty acids on postprandial vascular reactivity. | 2011 | Am. J. Clin. Nutr. | pmid:21831993 |
von Schacky C | The Omega-3 Index as a risk factor for cardiovascular diseases. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21726658 |
Giltay EJ et al. | Effects of n-3 fatty acids on depressive symptoms and dispositional optimism after myocardial infarction. | 2011 | Am. J. Clin. Nutr. | pmid:22030221 |
Engström KS et al. | Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction: a case-control study. | 2011 | Environ Health | pmid:21504558 |
Dewell A et al. | Low- and high-dose plant and marine (n-3) fatty acids do not affect plasma inflammatory markers in adults with metabolic syndrome. | 2011 | J. Nutr. | pmid:22031659 |
Berry KA et al. | MALDI imaging MS of phospholipids in the mouse lung. | 2011 | J. Lipid Res. | pmid:21508254 |
Klebanoff MA et al. | Fish consumption, erythrocyte fatty acids, and preterm birth. | 2011 | Obstet Gynecol | pmid:21508745 |
Altenburg JD et al. | A synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: unique signaling not explained by the effects of either compound alone. | 2011 | BMC Cancer | pmid:21510869 |
Mancini I et al. | Fatty acid composition of common barbel (Barbus barbus) roe and evaluation of its haemolytic and cytotoxic activities. | 2011 | Toxicon | pmid:21510968 |
Hadders-Algra M | Prenatal and early postnatal supplementation with long-chain polyunsaturated fatty acids: neurodevelopmental considerations. | 2011 | Am. J. Clin. Nutr. | pmid:21525202 |
Nudda A et al. | Documentation of fatty acid profiles in lamb meat and lamb-based infant foods. | 2011 | J. Food Sci. | pmid:21535766 |
Lynch ML et al. | Varying coefficient function models to explore interactions between maternal nutritional status and prenatal methylmercury toxicity in the Seychelles Child Development Nutrition Study. | 2011 | Environ. Res. | pmid:20961536 |
Yu YH et al. | The function of porcine PPARγ and dietary fish oil effect on the expression of lipid and glucose metabolism related genes. | 2011 | J. Nutr. Biochem. | pmid:20970313 |
Pomponi MF et al. | Why docosahexaenoic acid and aspirin supplementation could be useful in women as a primary prevention therapy against Alzheimer's disease? | 2011 | Ageing Res. Rev. | pmid:20920611 |
Wojcicki JM and Heyman MB | Maternal omega-3 fatty acid supplementation and risk for perinatal maternal depression. | 2011 | J. Matern. Fetal. Neonatal. Med. | pmid:20925595 |
Sasaki K et al. | Total synthesis and bioactivities of two proposed structures of maresin. | 2011 | Chem Asian J | pmid:21254430 |
Huang L et al. | Enduring prevention and transient reduction of postoperative pain by intrathecal resolvin D1. | 2011 | Pain | pmid:21255928 |
van der Pols JC et al. | Serum omega-3 and omega-6 fatty acids and cutaneous p53 expression in an Australian population. | 2011 | Cancer Epidemiol. Biomarkers Prev. | pmid:21217086 |
Belin RJ et al. | Fish intake and the risk of incident heart failure: the Women's Health Initiative. | 2011 | Circ Heart Fail | pmid:21610249 |
Poudel-Tandukar K et al. | Long chain n-3 fatty acids intake, fish consumption and suicide in a cohort of Japanese men and women--the Japan Public Health Center-based (JPHC) prospective study. | 2011 | J Affect Disord | pmid:20692041 |
Mariee AD and Abd-Ellah MF | Protective effect of docosahexaenoic acid against cyclosporine A-induced nephrotoxicity in rats: a possible mechanism of action. | 2011 | Ren Fail | pmid:21219208 |
Safarinejad MR | Effect of omega-3 polyunsaturated fatty acid supplementation on semen profile and enzymatic anti-oxidant capacity of seminal plasma in infertile men with idiopathic oligoasthenoteratospermia: a double-blind, placebo-controlled, randomised study. | 2011 | Andrologia | pmid:21219381 |
Cotogni P et al. | Impact of the omega-3 to omega-6 polyunsaturated fatty acid ratio on cytokine release in human alveolar cells. | 2011 | JPEN J Parenter Enteral Nutr | pmid:21224438 |
Burrows T et al. | Omega-3 index, obesity and insulin resistance in children. | 2011 | Int J Pediatr Obes | pmid:21226540 |
Ueda Y et al. | Effect of dietary lipids on longevity and memory in the SAMP8 mice. | 2011 | J. Nutr. Sci. Vitaminol. | pmid:21512289 |
Dartt DA et al. | Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation. | 2011 | J. Immunol. | pmid:21357260 |
Kawabata T et al. | [Comparison of long-chain polyunsaturated fatty acids in plasma and erythrocyte phospholipids for biological monitoring]. | 2011 | Nihon Eiseigaku Zasshi | pmid:21358141 |
Cavazos DA et al. | Docosahexaenoic acid selectively induces human prostate cancer cell sensitivity to oxidative stress through modulation of NF-κB. | 2011 | Prostate | pmid:21360560 |
Murphy RA et al. | Nutritional intervention with fish oil provides a benefit over standard of care for weight and skeletal muscle mass in patients with nonsmall cell lung cancer receiving chemotherapy. | 2011 | Cancer | pmid:21360698 |
Swenne I et al. | Essential fatty acid status in teenage girls with eating disorders and weight loss. | 2011 | Acta Paediatr. | pmid:21362034 |
Van Dyke TE | Proresolving lipid mediators: potential for prevention and treatment of periodontitis. | 2011 | J. Clin. Periodontol. | pmid:21323709 |
Konkel A and Schunck WH | Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids. | 2011 | Biochim. Biophys. Acta | pmid:20869469 |
Tishinsky JM et al. | Eicosapentaenoic acid and rosiglitazone increase adiponectin in an additive and PPARγ-dependent manner in human adipocytes. | 2011 | Obesity (Silver Spring) | pmid:20814411 |
Siener R et al. | Effect of n-3 fatty acid supplementation on urinary risk factors for calcium oxalate stone formation. | 2011 | J. Urol. | pmid:21168878 |
Marc I et al. | Early docosahexaenoic acid supplementation of mothers during lactation leads to high plasma concentrations in very preterm infants. | 2011 | J. Nutr. | pmid:21169226 |
Shimshoni JA et al. | Valproate uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: relevance to valproate's efficacy against bipolar disorder. | 2011 | Biochim. Biophys. Acta | pmid:21184843 |
Serini S et al. | Docosahexaenoic acid reverts resistance to UV-induced apoptosis in human keratinocytes: involvement of COX-2 and HuR. | 2011 | J. Nutr. Biochem. | pmid:21185708 |
Wang RX et al. | Activation of vascular BK channels by docosahexaenoic acid is dependent on cytochrome P450 epoxygenase activity. | 2011 | Cardiovasc. Res. | pmid:21187320 |
Riedel M et al. | Membrane lipid modification by docosahexaenoic acid (DHA) promotes the formation of α-synuclein inclusion bodies immunopositive for SUMO-1 in oligodendroglial cells after oxidative stress. | 2011 | J. Mol. Neurosci. | pmid:20725866 |
Hamazaki K et al. | Docosahexaenoic acid is an independent predictor of all-cause mortality in hemodialysis patients. | 2011 | Am. J. Nephrol. | pmid:21196723 |
Cho JY et al. | Oral administration of docosahexaenoic acid attenuates colitis induced by dextran sulfate sodium in mice. | 2011 | Mol Nutr Food Res | pmid:20824662 |
Pawlik D et al. | Fish-oil fat emulsion supplementation may reduce the risk of severe retinopathy in VLBW infants. | 2011 | Pediatrics | pmid:21199856 |
Turk HF et al. | Linoleic acid and butyrate synergize to increase Bcl-2 levels in colonocytes. | 2011 | Int. J. Cancer | pmid:20232381 |