Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Visentin S et al. | Red blood cell membrane fatty acid composition in infants fed formulas with different lipid profiles. | 2016 | Early Hum. Dev. | pmid:27391868 |
Zhang MJ et al. | Resolvin D2 Enhances Postischemic Revascularization While Resolving Inflammation. | 2016 | Circulation | pmid:27507404 |
Lu Y et al. | Impedance spectroscopy analysis of human odorant binding proteins immobilized on nanopore arrays for biochemical detection. | 2016 | Biosens Bioelectron | pmid:26710343 |
Lam SM et al. | Biological relevance of fatty acyl heterogeneity to the neural membrane dynamics of rhesus macaques during normative aging. | 2016 | Oncotarget | pmid:27517158 |
Bassuk SS et al. | Baseline characteristics of participants in the VITamin D and OmegA-3 TriaL (VITAL). | 2016 | Contemp Clin Trials | pmid:26767629 |
Gao J et al. | Neuroprotective effects of docosahexaenoic acid on hippocampal cell death and learning and memory impairments in a valproic acid-induced rat autism model. | 2016 | Int. J. Dev. Neurosci. | pmid:26639559 |
Moeinzadeh F et al. | Effects of Omega-3 Fatty Acid Supplementation on Serum Biomarkers, Inflammatory Agents, and Quality of Life of Patients on Hemodialysis. | 2016 | Iran J Kidney Dis | pmid:27903997 |
Zhao Z et al. | The Association of Fatty Acid Levels and Gleason Grade among Men Undergoing Radical Prostatectomy. | 2016 | PLoS ONE | pmid:27880795 |
Revuelta M et al. | Antioxidant Treatments Recover the Alteration of Auditory-Evoked Potentials and Reduce Morphological Damage in the Inferior Colliculus after Perinatal Asphyxia in Rat. | 2016 | Brain Pathol. | pmid:25990815 |
Kuda O et al. | Docosahexaenoic Acid-Derived Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) With Anti-inflammatory Properties. | 2016 | Diabetes | pmid:27313314 |
Zhao YL et al. | Resolvin D1 Protects Lipopolysaccharide-induced Acute Kidney Injury by Down-regulating Nuclear Factor-kappa B Signal and Inhibiting Apoptosis. | 2016 | Chin. Med. J. | pmid:27098797 |
Qin Y et al. | Fish Oil Supplements Lower Serum Lipids and Glucose in Correlation with a Reduction in Plasma Fibroblast Growth Factor 21 and Prostaglandin E2 in Nonalcoholic Fatty Liver Disease Associated with Hyperlipidemia: A Randomized Clinical Trial. | 2015 | PLoS ONE | pmid:26226139 |
Rossi S et al. | Protection from endotoxic uveitis by intravitreal Resolvin D1: involvement of lymphocytes, miRNAs, ubiquitin-proteasome, and M1/M2 macrophages. | 2015 | Mediators Inflamm. | pmid:25684860 |
Nury T et al. | Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7β-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of α-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3). | 2015 | Steroids | pmid:25683890 |
Filipcikova R et al. | Lycopene improves the distorted ratio between AA/DHA in the seminal plasma of infertile males and increases the likelihood of successful pregnancy. | 2015 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub | pmid:23446211 |
Li R et al. | Enzymatic Synthesis of Refined Olive Oil-Based Structured Lipid Containing Omega -3 and -6 Fatty Acids for Potential Application in Infant Formula. | 2015 | J. Food Sci. | pmid:26408984 |
Linhartova P and Sampels S | Combined incubation of cadmium, docosahexaenoic and eicosapentaenoic acid results in increased uptake of cadmium and elevated docosapentaenoic acid content in hepatocytes in vitro. | 2015 | Lipids Health Dis | pmid:26627047 |
Schwager J et al. | ω-3 PUFAs and Resveratrol Differently Modulate Acute and Chronic Inflammatory Processes. | 2015 | Biomed Res Int | pmid:26301248 |
Katakura M et al. | Chronic Arachidonic Acid Administration Decreases Docosahexaenoic Acid- and Eicosapentaenoic Acid-Derived Metabolites in Kidneys of Aged Rats. | 2015 | PLoS ONE | pmid:26485038 |
Cotogni P et al. | The Omega-3 Fatty Acid Docosahexaenoic Acid Modulates Inflammatory Mediator Release in Human Alveolar Cells Exposed to Bronchoalveolar Lavage Fluid of ARDS Patients. | 2015 | Biomed Res Int | pmid:26301250 |