Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Peterson LD et al. | Eicosapentaenoic and docosahexaenoic acids alter rat spleen leukocyte fatty acid composition and prostaglandin E2 production but have different effects on lymphocyte functions and cell-mediated immunity. | 1998 | Lipids | pmid:9507239 |
Conquer JA and Holub BJ | Effect of supplementation with different doses of DHA on the levels of circulating DHA as non-esterified fatty acid in subjects of Asian Indian background. | 1998 | J. Lipid Res. | pmid:9507989 |
Osmundsen H et al. | Effects of dietary treatment of rats with eicosapentaenoic acid or docosahexaenoic acid on hepatic lipid metabolism. | 1998 | Biochem. J. | pmid:9512474 |
Larsen LN et al. | Alpha- and beta- alkyl-substituted eicosapentaenoic acids: incorporation into phospholipids and effects on prostaglandin H synthase and 5-lipoxygenase. | 1998 | Biochem. Pharmacol. | pmid:9514074 |
Ward PE et al. | Niacin skin flush in schizophrenia: a preliminary report. | 1998 | Schizophr. Res. | pmid:9516668 |
Ramanadham S et al. | Electrospray ionization mass spectrometric analyses of phospholipids from rat and human pancreatic islets and subcellular membranes: comparison to other tissues and implications for membrane fusion in insulin exocytosis. | 1998 | Biochemistry | pmid:9521776 |
Urano S et al. | Aging and oxidative stress in neurodegeneration. | 1998 | Biofactors | pmid:9523034 |
Paulsen JE et al. | A fish oil-derived concentrate enriched in eicosapentaenoic and docosahexaenoic acid as ethyl esters inhibits the formation and growth of aberrant crypt foci in rat colon. | 1998 | Pharmacol. Toxicol. | pmid:9527643 |
Rhodes LE and White SI | Dietary fish oil as a photoprotective agent in hydroa vacciniforme. | 1998 | Br. J. Dermatol. | pmid:9536243 |
Wolk A et al. | Effect of additional questions about fat on the validity of fat estimates from a food frequency questionnaire. Study Group of MRS SWEA. | 1998 | Eur J Clin Nutr | pmid:9537304 |
Starkopf J et al. | Lipid peroxidation, arachidonic acid and products of the lipoxygenase pathway in ischaemic preconditioning of rat heart. | 1998 | Cardiovasc. Res. | pmid:9539859 |
Voskuyl RA et al. | Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model. | 1998 | Eur. J. Pharmacol. | pmid:9543232 |
Rousseau D et al. | Is a dietary n-3 fatty acid supplement able to influence the cardiac effect of the psychological stress? | 1998 | Mol. Cell. Biochem. | pmid:9546620 |
Sebaldt RJ and Marignani P | Diradylglycerol formation is altered by n-3 highly unsaturated fatty acids, with differences between eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids. | 1997 | Adv. Exp. Med. Biol. | pmid:9547650 |
Madsen L et al. | Docosahexaenoic and eicosapentaenoic acids are differently metabolized in rat liver during mitochondria and peroxisome proliferation. | 1998 | J. Lipid Res. | pmid:9548590 |
Hørby Jørgensen M et al. | Effect of formula supplemented with docosahexaenoic acid and gamma-linolenic acid on fatty acid status and visual acuity in term infants. | 1998 | J. Pediatr. Gastroenterol. Nutr. | pmid:9552137 |
Timmer-Bosscha H et al. | Differential effects of all-trans-retinoic acid, docosahexaenoic acid, and hexadecylphosphocholine on cisplatin-induced cytotoxicity and apoptosis in a cisplantin-sensitive and resistant human embryonal carcinoma cell line. | 1998 | Cancer Chemother. Pharmacol. | pmid:9554591 |
Kishida E et al. | Distinctive inhibitory activity of docosahexaenoic acid against sphingosine-induced apoptosis. | 1998 | Biochim. Biophys. Acta | pmid:9555103 |
Bechoua S et al. | Docosahexaenoic acid lowers phosphatidate level in human activated lymphocytes despite phospholipase D activation. | 1998 | J. Lipid Res. | pmid:9555950 |
Nabekura J et al. | Functional modulation of human recombinant gamma-aminobutyric acid type A receptor by docosahexaenoic acid. | 1998 | J. Biol. Chem. | pmid:9556589 |
Nøding R et al. | Effects of polyunsaturated fatty acids and their n-6 hydroperoxides on growth of five malignant cell lines and the significance of culture media. | 1998 | Lipids | pmid:9560803 |
Horie T et al. | Docosahexaenoic acid exhibits a potent protection of small intestine from methotrexate-induced damage in mice. | 1998 | Life Sci. | pmid:9566775 |
Zerouga M et al. | Can docosahexaenoic acid inhibit metastasis by decreasing deformability of the tumor cell plasma membrane? | 1997 | Cancer Lett. | pmid:9570367 |
Green P and Yavin E | Mechanisms of docosahexaenoic acid accretion in the fetal brain. | 1998 | J. Neurosci. Res. | pmid:9579403 |
Hirafuji M et al. | Effect of docosahexaenoic acid on smooth muscle cell functions. | 1998 | Life Sci. | pmid:9585158 |
Habán P et al. | [The effect of n-3 fatty acid administration on selected indicators of cardiovascular disease risk in patients with type 2 diabetes mellitus]. | 1998 | Bratisl Lek Listy | pmid:9588078 |
Tashiro T et al. | Effects of a newly developed fat emulsion containing eicosapentaenoic acid and docosahexaenoic acid on fatty acid profiles in rats. | 1998 | Nutrition | pmid:9591310 |
Hossain MS et al. | Influence of docosahexaenoic acid on cerebral lipid peroxide level in aged rats with and without hypercholesterolemia. | 1998 | Neurosci. Lett. | pmid:9593513 |
Roberts LJ et al. | Formation of isoprostane-like compounds (neuroprostanes) in vivo from docosahexaenoic acid. | 1998 | J. Biol. Chem. | pmid:9593698 |
Glozman S et al. | Intraamniotic ethyl docosahexaenoate administration protects fetal rat brain from ischemic stress. | 1998 | J. Neurochem. | pmid:9603213 |
Kikuchi S et al. | Modulation of eosinophil chemotactic activities to leukotriene B4 by n-3 polyunsaturated fatty acids. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9610849 |
Christensen MM et al. | Dietary structured triacylglycerols containing docosahexaenoic acid given from birth affect visual and auditory performance and tissue fatty acid profiles of rats. | 1998 | J. Nutr. | pmid:9614162 |
Ikeda I et al. | Effects of dietary alpha-linolenic, eicosapentaenoic and docosahexaenoic acids on hepatic lipogenesis and beta-oxidation in rats. | 1998 | Biosci. Biotechnol. Biochem. | pmid:9614698 |
Lu CY et al. | Docosahexaenoic acid, a constituent of fetal and neonatal serum, inhibits nitric oxide production by murine macrophages stimulated by IFN gamma plus LPS, or by IFN gamma plus Listeria monocytogenes. | 1998 | J. Reprod. Immunol. | pmid:9616876 |
Almallah YZ et al. | Distal procto-colitis, natural cytotoxicity, and essential fatty acids. | 1998 | Am. J. Gastroenterol. | pmid:9625132 |
Yeh YY et al. | Modification of milk formula to enhance accretion of long-chain n-6 and n-3 polyunsaturated fatty acids in artificially reared infant rats. | 1998 | Lipids | pmid:9625599 |
Bojesen IN and Bojesen E | Nature of the elements transporting long-chain fatty acids through the red cell membrane. | 1998 | J. Membr. Biol. | pmid:9625774 |
Peterson LD et al. | Low levels of eicosapentaenoic and docosahexaenoic acids mimic the effects of fish oil upon rat lymphocytes. | 1998 | Life Sci. | pmid:9627080 |
Henderson RJ et al. | Effects of docosahexaenoic (22:6n-3), tetracosapentaenoic (24:5n-3) and tetracosahexaenoic (24:6n-3) acids on the desaturation and elongation of n-3 polyunsaturated fatty acids in trout liver microsomes. | 1998 | Biochim. Biophys. Acta | pmid:9630696 |
Williams EE et al. | Docosahexaenoic acid (DHA) alters the structure and composition of membranous vesicles exfoliated from the surface of a murine leukemia cell line. | 1998 | Biochim. Biophys. Acta | pmid:9630720 |
Cadroy Y et al. | Arachidonic acid enhances the tissue factor expression of mononuclear cells by the cyclo-oxygenase-1 pathway: beneficial effect of n-3 fatty acids. | 1998 | J. Immunol. | pmid:9637532 |
Hibbeln JR | Fish consumption and major depression. | 1998 | Lancet | pmid:9643729 |
Kimura S et al. | Ameliorative effects of docosahexaenoic acid on serum lipid changes in stroke-prone spontaneously hypertensive rats. | 1998 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:9644719 |
He Q et al. | Reduction of 4-hydroxynonenal and 4-hydroxyhexenal by retinal aldose reductase. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9647760 |
Leaf A and Kang JX | Omega 3 fatty acids and cardiovascular disease. | 1998 | World Rev Nutr Diet | pmid:9648502 |
Hoffman DR and Birch DG | Omega 3 fatty acid status in patients with retinitis pigmentosa. | 1998 | World Rev Nutr Diet | pmid:9648504 |
Barclay W et al. | Production of docosahexaenoic acid from microalgae and its benefits for use in animal feeds. | 1998 | World Rev Nutr Diet | pmid:9648505 |
Abril R and Barclay W | Production of docosahexaenoic acid-enriched poultry eggs and meat using an algae-based feed ingredient. | 1998 | World Rev Nutr Diet | pmid:9648506 |
Kyle DJ and Arterburn LM | Single cell oil sources of docosahexaenoic acid: clinical studies. | 1998 | World Rev Nutr Diet | pmid:9648509 |
Wright T et al. | Docosahexaenoic acid-enriched milk. | 1998 | World Rev Nutr Diet | pmid:9648512 |