DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Burns D002056 34 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Mairesse G et al. Effects of geographic source, rearing system, and season on the nutritional quality of wild and farmed Perca fluviatilis. 2006 Lipids pmid:16711596
Thomson AB et al. Influence of dietary fat composition on intestinal absorption in the rat. 1989 Lipids pmid:2549323
Stamey Lanier J et al. Mammary uptake of fatty acids supplied by intravenous triacylglycerol infusion to lactating dairy cows. 2013 Lipids pmid:23504269
Hashimoto M et al. Effects of eicosapentaenoic acid and docosahexaenoic acid on plasma membrane fluidity of aortic endothelial cells. 1999 Lipids pmid:10652989
Devlin AM and Innis SM Dietary phospholipid alters biliary lipid composition in formula-fed piglets. 1999 Lipids pmid:10652991
Polette A et al. Synthesis of acetyl,docosahexaenoyl-glycerophosphocholine and its characterization using nuclear magnetic resonance. 1999 Lipids pmid:10652994
Sullivan JC et al. Modeling the primary oxidation in commercial fish oil preparations. 2011 Lipids pmid:21104333
Lu FS et al. Oxidative stability of marine phospholipids in the liposomal form and their applications. 2011 Lipids pmid:21088919
Sajiki J and Takahashi K Free fatty acids inducing mouse lethal toxicity in lipid extracts of Engraulis japonica, the Japanese anchovy. 1992 Lipids pmid:1487961
Paschoal VA et al. Eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid differentially modulate rat neutrophil function in vitro. 2013 Lipids pmid:23086551
Ackman RG The absorption of fish oils and concentrates. 1992 Lipids pmid:1491603
Betancor MB et al. Vitamin C enhances vitamin E status and reduces oxidative stress indicators in sea bass larvae fed high DHA microdiets. 2012 Lipids pmid:23086553
Innis SM n-3 fatty acid requirements of the newborn. 1992 Lipids pmid:1491606
Birbes H et al. Inhibition of Ca2+-independent phospholipase A2 affects arachidonate-, not docosahexaenoate-, phospholipid remodeling in U(III) cells. 1999 Lipids pmid:10419092
Aukema HM et al. Abnormal lipid and fatty acid compositions of kidneys from mice with polycystic kidney disease. 1992 Lipids pmid:1385849
McLennan PL and Raederstorff D Diabetes puts myocardial n-3 fatty acid status at risk in the absence of supplementation in the rat. 1999 Lipids pmid:10419102
Takahata K et al. Protection from chemotherapy-induced alopecia by docosahexaenoic acid. 1999 Lipids pmid:10419109
Finstad HS et al. Proliferation and types of killing of leukemia cell lines by very long chain polyunsaturated fatty acids. 1999 Lipids pmid:10419110
Bougnoux P et al. Cytotoxic drug efficacy correlates with adipose tissue docosahexaenoic acid level in locally advanced breast carcinoma. 1999 Lipids pmid:10419111
Calviello G et al. Effects of eicosapentaenoic and docosahexaenoic acids dietary supplementation on cell proliferation and apoptosis in rat colonic mucosa. 1999 Lipids pmid:10419112
Rotstein NP et al. Essentiality of docosahexaenoic acid in retina photoreceptor cell development. 1999 Lipids pmid:10419114
Gilbert M et al. Opposite regulation of prostaglandin H synthase isoforms by eicosapentaenoic and docosahexaenoic acids. 1999 Lipids pmid:10419156
Løchsen T et al. Effects of fish oil and n-3 fatty acids on the regulation of delta9-fatty acid desaturase mRNA and -activity in rat liver. 1999 Lipids pmid:10419157
Jensen CL et al. Effects of maternal docosahexaenoic acid supplementation on visual function and growth of breast-fed term infants. 1999 Lipids pmid:10419159
Otto SJ et al. The postpartum docosahexaenoic acid status of lactating and nonlactating mothers. 1999 Lipids pmid:10419160
van Houwelingen AC et al. The female docosahexaenoic acid status related to the number of completed pregnancies. 1999 Lipids pmid:10419161
Borod E et al. Effects of third trimester consumption of eggs high in docosahexaenoic acid on docosahexaenoic acid status and pregnancy. 1999 Lipids pmid:10419162
Koussoroplis AM et al. From aquatic to terrestrial food webs: decrease of the docosahexaenoic acid/linoleic acid ratio. 2008 Lipids pmid:18335265
Smuts CM et al. High-DHA eggs: feasibility as a means to enhance circulating DHA in mother and infant. 2003 Lipids pmid:12848286
Visioli F et al. Dietary intake of fish vs. formulations leads to higher plasma concentrations of n-3 fatty acids. 2003 Lipids pmid:12848287
Cleland LG et al. A biomarker of n-3 compliance in patients taking fish oil for rheumatoid arthritis. 2003 Lipids pmid:12848288
Hajjaji N et al. Determinants of DHA incorporation into tumor tissue during dietary DHA supplementation. 2011 Lipids pmid:21638063
Mitchell DC et al. Enhancement of G protein-coupled signaling by DHA phospholipids. 2003 Lipids pmid:12848291
Gawrisch K et al. The structure of DHA in phospholipid membranes. 2003 Lipids pmid:12848292
Lagarde M et al. Pathophysiologic role of redox status in blood platelet activation. Influence of docosahexaenoic acid. 2003 Lipids pmid:12848295
Tanaka T et al. Oral supplementation with dihomo-γ-linolenic acid (DGLA)-enriched oil increases serum DGLA content in healthy adults. 2012 Lipids pmid:22411689
Frøyland L et al. Chronic administration of eicosapentaenoic acid and docosahexaenoic acid as ethyl esters reduced plasma cholesterol and changed the fatty acid composition in rat blood and organs. 1996 Lipids pmid:8835405
Yeh YY et al. Dietary supplementation with arachidonic and docosahexaenoic acids has no effect on pulmonary surfactant in artificially reared infant rats. 1999 Lipids pmid:10380120
Calviello G et al. Cell proliferation, differentiation, and apoptosis are modified by n-3 polyunsaturated fatty acids in normal colonic mucosa. 1999 Lipids pmid:10405974
Reicks M et al. Recovery of fish oil-derived fatty acids in lymph of thoracic duct-cannulated Wistar rats. 1990 Lipids pmid:2139156
Boeynaems JM et al. Iodination of docosahexaenoic acid by lactoperoxidase and thyroid gland in vitro: formation of an lodolactone. 1981 Lipids pmid:6153054
Ryan AS et al. The hypolipidemic effect of an ethyl ester of algal-docosahexaenoic acid in rats fed a high-fructose diet. 2009 Lipids pmid:19655188
Bryan DL et al. Modulation of respiratory syncytial virus-induced prostaglandin E2 production by n-3 long-chain polyunsaturated fatty acids in human respiratory epithelium. 2005 Lipids pmid:16382572
McLaren JE et al. Eicosapentaenoic acid and docosahexaenoic acid regulate modified LDL uptake and macropinocytosis in human macrophages. 2011 Lipids pmid:21822944
Sørensen BM et al. Storage lipid accumulation and acyltransferase action in developing flaxseed. 2005 Lipids pmid:16382576
Waldron MK et al. Plasma phospholipid fatty acid and ex vivo neutrophil responses are differentially altered in dogs fed fish- and linseed-oil containing diets at the same n-6:n-3 fatty acid ratio. 2012 Lipids pmid:22252853
Kimura F et al. Supplementation of DHA-rich microalgal oil or fish oil during the suckling period in mildly n-3 fatty acid-deficient rat pups. 2011 Lipids pmid:21901511
Vandal M et al. Plasma omega-3 fatty acid response to a fish oil supplement in the healthy elderly. 2008 Lipids pmid:18795357
Kitson AP et al. Elevated production of docosahexaenoic acid in females: potential molecular mechanisms. 2010 Lipids pmid:20151220
Hawkes JS et al. Transforming growth factor beta in human milk does not change in response to modest intakes of docosahexaenoic acid. 2001 Lipids pmid:11768164
Talahalli RR et al. Lower efficacy in the utilization of dietary ALA as compared to preformed EPA + DHA on long chain n-3 PUFA levels in rats. 2010 Lipids pmid:20734237
De Craemer D et al. Dietary docosahexaenoic acid has little effect on peroxisomes in healthy mice. 1996 Lipids pmid:8934448
Rahmawaty S et al. Dietary intake and food sources of EPA, DPA and DHA in Australian children. 2013 Lipids pmid:23881381
Bonatto SJ et al. Fish oil supplementation improves neutrophil function during cancer chemotherapy. 2012 Lipids pmid:22160495
Watson AM et al. Taurine supplementation of plant derived protein and n-3 fatty acids are critical for optimal growth and development of cobia, Rachycentron canadum. 2013 Lipids pmid:23884630
Mocellin MC et al. Fish oil decreases C-reactive protein/albumin ratio improving nutritional prognosis and plasma fatty acid profile in colorectal cancer patients. 2013 Lipids pmid:23888317
Ratledge C et al. Production of docosahexaenoic acid by Crypthecodinium cohnii grown in a pH-auxostat culture with acetic acid as principal carbon source. 2001 Lipids pmid:11795857
Schnebelen C et al. Dietary n-3 and n-6 PUFA enhance DHA incorporation in retinal phospholipids without affecting PGE(1) and PGE (2) levels. 2009 Lipids pmid:19242743
Bharadwaj AS et al. Dietary source of stearidonic acid promotes higher muscle DHA concentrations than linolenic acid in hybrid striped bass. 2010 Lipids pmid:20049582
Meyer BJ et al. Improvement of major depression is associated with increased erythrocyte DHA. 2013 Lipids pmid:23733443
Ghebremeskel K et al. Blood fatty acid composition of pregnant and nonpregnant Korean women: red cells may act as a reservoir of arachidonic acid and docosahexaenoic acid for utilization by the developing fetus. 2000 Lipids pmid:10907792
Ando Y et al. Reinvestigation of positional distribution of fatty acids in docosahexaenoic acid-rich fish oil triacyl-sn-glycerols. 2000 Lipids pmid:10907794
Kao BT et al. Mice raised on milk transgenically enriched with n-3 PUFA have increased brain docosahexaenoic acid. 2006 Lipids pmid:16981432
Park Y and Harris W EPA, but not DHA, decreases mean platelet volume in normal subjects. 2002 Lipids pmid:12530552
Besson N et al. Selective incorporation of docosahexaenoic acid into lysobisphosphatidic acid in cultured THP-1 macrophages. 2006 Lipids pmid:17707985
Xu Y et al. Different ratios of docosahexaenoic and eicosapentaenoic acids do not alter growth, nucleic acid and fatty acids of juvenile cobia (Rachycentron canadum). 2009 Lipids pmid:19760445
Nichols PD et al. Occurrence of high levels of tetracosahexaenoic acid in the jellyfish Aurelia sp. 2003 Lipids pmid:14733367
Tou JS Acylation of docosahexaenoic acid into phospholipids by intact human neutrophils. 1986 Lipids pmid:2941637
Van den Branden C et al. Peroxisomes in mice fed a diet supplemented with low doses of fish oil. 1995 Lipids pmid:7475984
Kanayasu T et al. Eicosapentaenoic acid inhibits tube formation of vascular endothelial cells in vitro. 1991 Lipids pmid:1714032
Wu T et al. Enrichment of LDL with EPA and DHA decreased oxidized LDL-induced apoptosis in U937 cells. 2002 Lipids pmid:12371750
Nelson GJ et al. The effect of dietary docosahexaenoic acid on platelet function, platelet fatty acid composition, and blood coagulation in humans. 1997 Lipids pmid:9397397
Nelson GJ et al. The effect of dietary docosahexaenoic acid on plasma lipoproteins and tissue fatty acid composition in humans. 1997 Lipids pmid:9397398
Zanfini A et al. GC-EI-MS analysis of fatty acid composition in brain and serum of twitcher mouse. 2014 Lipids pmid:25208498
Martin DD et al. The fatty acid composition of human gliomas differs from that found in nonmalignant brain tissue. 1996 Lipids pmid:8972462
Scheja L et al. Liver TAG transiently decreases while PL n-3 and n-6 fatty acids are persistently elevated in insulin resistant mice. 2008 Lipids pmid:18763007
Kebir MV et al. Fatty acids in liver, muscle and gonad of three tropical rays including non-methylene-interrupted dienoic fatty acids. 2007 Lipids pmid:17404769
Harris WS et al. Stearidonic acid increases the red blood cell and heart eicosapentaenoic acid content in dogs. 2007 Lipids pmid:17406927
Hwang I et al. N-3 polyunsaturated fatty acids and atopy in Korean preschoolers. 2007 Lipids pmid:17406929
Meyer BJ et al. Dose-dependent effects of docosahexaenoic acid supplementation on blood lipids in statin-treated hyperlipidaemic subjects. 2007 Lipids pmid:17393216
Judge MP et al. A docosahexaenoic acid-functional food during pregnancy benefits infant visual acuity at four but not six months of age. 2007 Lipids pmid:17393217
Aarsetoey H et al. Low levels of the omega-3 index are associated with sudden cardiac arrest and remain stable in survivors in the subacute phase. 2011 Lipids pmid:21234696
Liu M et al. Protectin DX, a double lipoxygenase product of DHA, inhibits both ROS production in human neutrophils and cyclooxygenase activities. 2014 Lipids pmid:24254970
Takkunen M et al. Dietary fat in relation to erythrocyte fatty acid composition in men. 2013 Lipids pmid:23975575
Martin LJ et al. Effect of 4,7,10,13,16,19-docosahexaenoic acid on triglyceride accumulation and secretion in rat hepatocytes in culture. 1991 Lipids pmid:1832732
Lyberg AM and Adlercreutz P Monitoring monohydroperoxides in docosahexaenoic acid using high-performance liquid chromatography. 2006 Lipids pmid:16555474
Li D et al. A significant inverse relationship between concentrations of plasma homocysteine and phospholipid docosahexaenoic acid in healthy male subjects. 2006 Lipids pmid:16555476
Hixson SM et al. Changes in tissue lipid and fatty acid composition of farmed rainbow trout in response to dietary camelina oil as a replacement of fish oil. 2014 Lipids pmid:24264359
Otsuka R et al. Higher serum EPA or DHA, and lower ARA compositions with age independent fatty acid intake in Japanese aged 40 to 79. 2013 Lipids pmid:23389403
Zhang ZJ et al. Metabolism of n-3 polyunsaturated fatty acids by the isolated perfused rat liver. 1991 Lipids pmid:1834902
Willumsen N et al. Eicosapentaenoic acid, but not docosahexaenoic acid, increases mitochondrial fatty acid oxidation and upregulates 2,4-dienoyl-CoA reductase gene expression in rats. 1996 Lipids pmid:8784738
Innis SM et al. Blood lipid docosahexaenoic and arachidonic acid in term gestation infants fed formulas with high docosahexaenoic acid, low eicosapentaenoic acid fish oil. 1996 Lipids pmid:8784742
Dembitsky VM and Rezanka T Unusually high levels of eicosatetraenoic, eicosapentaenoic, and docosahexaenoic fatty acids in Palestinian freshwater sponges. 1996 Lipids pmid:8784746
Mitjavila MT et al. Effect of degree of unsaturation in dietary fatty acids on arachidonic acid mobilization by peritoneal macrophages. 1996 Lipids pmid:8784749
Madsen L et al. Eicosapentaenoic and docosahexaenoic acid affect mitochondrial and peroxisomal fatty acid oxidation in relation to substrate preference. 1999 Lipids pmid:10574660
Hodge J et al. Differential utilization of eicosapentaenoic acid and docosahexaenoic acid in human plasma. 1993 Lipids pmid:8355578
Stillwell W et al. Docosahexaenoic acid increases permeability of lipid vesicles and tumor cells. 1993 Lipids pmid:8441334
Uhl O et al. Changes of molecular glycerophospholipid species in plasma and red blood cells during docosahexaenoic acid supplementation. 2013 Lipids pmid:24043586
Bryan DL et al. Polyunsaturated fatty acids regulate cytokine and prostaglandin E2 production by respiratory cells in response to mast cell mediators. 2006 Lipids pmid:17269555
Elvevoll EO et al. Enhanced incorporation of n-3 fatty acids from fish compared with fish oils. 2006 Lipids pmid:17269556