DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Burns D002056 34 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Qu L et al. Enhancement of docosahexaenoic acid production by Schizochytrium sp. using a two-stage oxygen supply control strategy based on oxygen transfer coefficient. 2011 Lett. Appl. Microbiol. pmid:21070268
Kim HW et al. Dietary n-6 PUFA deprivation downregulates arachidonate but upregulates docosahexaenoate metabolizing enzymes in rat brain. 2011 Biochim. Biophys. Acta pmid:21070866
Hashimoto M and Hossain S Neuroprotective and ameliorative actions of polyunsaturated fatty acids against neuronal diseases: beneficial effect of docosahexaenoic acid on cognitive decline in Alzheimer's disease. 2011 J. Pharmacol. Sci. pmid:21606627
Madden J et al. The impact of common gene variants on the response of biomarkers of cardiovascular disease (CVD) risk to increased fish oil fatty acids intakes. 2011 Annu. Rev. Nutr. pmid:21568708
Solakivi T et al. Serum fatty acid profile in subjects with irritable bowel syndrome. 2011 Scand. J. Gastroenterol. pmid:21073373
Musto AE et al. The omega-3 fatty acid-derived neuroprotectin D1 limits hippocampal hyperexcitability and seizure susceptibility in kindling epileptogenesis. 2011 Epilepsia pmid:21569016
Eckert GP et al. Liposome-incorporated DHA increases neuronal survival by enhancing non-amyloidogenic APP processing. 2011 Biochim. Biophys. Acta pmid:21036142
Wang RX et al. [Mechanism related to docosahexaenoic acid induced large conductance calcium-activated potassium channel currents increase in coronary smooth muscle cells]. 2011 Zhonghua Xin Xue Guan Bing Za Zhi pmid:21624312
Amano T et al. Impact of omega-3 polyunsaturated fatty acids on coronary plaque instability: an integrated backscatter intravascular ultrasound study. 2011 Atherosclerosis pmid:21684546
Granot E et al. DHA supplementation during pregnancy and lactation affects infants' cellular but not humoral immune response. 2011 Mediators Inflamm. pmid:21941411
Westphal C et al. CYP-eicosanoids--a new link between omega-3 fatty acids and cardiac disease? 2011 Prostaglandins Other Lipid Mediat. pmid:21945326
Kohlboeck G et al. Effect of fatty acid status in cord blood serum on children's behavioral difficulties at 10 y of age: results from the LISAplus Study. 2011 Am. J. Clin. Nutr. pmid:22071708
James S et al. Omega-3 fatty acids supplementation for autism spectrum disorders (ASD). 2011 Cochrane Database Syst Rev pmid:22071839
Chang WK et al. The comparison of protein-entrapped liposomes and lipoparticles: preparation, characterization, and efficacy of cellular uptake. 2011 Int J Nanomedicine pmid:22072876
Vinayavekhin N and Saghatelian A Discovery of a protein-metabolite interaction between unsaturated fatty acids and the nuclear receptor Nur77 using a metabolomics approach. 2011 J. Am. Chem. Soc. pmid:21973308
Hull MA Omega-3 polyunsaturated fatty acids. 2011 Best Pract Res Clin Gastroenterol pmid:22122770
Turgut S et al. The effects of docosahexaenoic acid supplementation and exercise on growth hormone and insulin-like growth factor I serum levels during chronic hypoxia in rats. 2011 J Basic Clin Physiol Pharmacol pmid:22865430
Kumosani TA and Moselhy SS Modulatory effect of cod-liver oil on Na(+)-K(+) ATPase in rats' brain. 2011 Hum Exp Toxicol pmid:20488854
Hung ND et al. Oral administration of 2-docosahexaenoyl lysophosphatidylcholine displayed anti-inflammatory effects on zymosan A-induced peritonitis. 2011 Inflammation pmid:20490641
Zeng Y et al. Development of a temperature shift strategy for efficient docosahexaenoic acid production by a marine fungoid protist, Schizochytrium sp. HX-308. 2011 Appl. Biochem. Biotechnol. pmid:21120635
Itakura H et al. Relationships between plasma fatty acid composition and coronary artery disease. 2011 J. Atheroscler. Thromb. pmid:21099130
Sullivan JC et al. Modeling the primary oxidation in commercial fish oil preparations. 2011 Lipids pmid:21104333
Shulse CN and Allen EE Diversity and distribution of microbial long-chain fatty acid biosynthetic genes in the marine environment. 2011 Environ. Microbiol. pmid:21105981
Koletzko B et al. Genetic variants of the fatty acid desaturase gene cluster predict amounts of red blood cell docosahexaenoic and other polyunsaturated fatty acids in pregnant women: findings from the Avon Longitudinal Study of Parents and Children. 2011 Am. J. Clin. Nutr. pmid:21106917
Sun H et al. Omega-3 fatty acids induce apoptosis in human breast cancer cells and mouse mammary tissue through syndecan-1 inhibition of the MEK-Erk pathway. 2011 Carcinogenesis pmid:21771724
Opreanu M et al. The unconventional role of acid sphingomyelinase in regulation of retinal microangiopathy in diabetic human and animal models. 2011 Diabetes pmid:21771974
Kalupahana NS et al. (n-3) Fatty acids alleviate adipose tissue inflammation and insulin resistance: mechanistic insights. 2011 Adv Nutr pmid:22332072
Wiese DM et al. The effects of an oral supplement enriched with fish oil, prebiotics, and antioxidants on nutrition status in Crohn's disease patients. 2011 Nutr Clin Pract pmid:21775642
Madec S et al. CYP4F3B expression is associated with differentiation of HepaRG human hepatocytes and unaffected by fatty acid overload. 2011 Drug Metab. Dispos. pmid:21778351
Flachs P et al. Synergistic induction of lipid catabolism and anti-inflammatory lipids in white fat of dietary obese mice in response to calorie restriction and n-3 fatty acids. 2011 Diabetologia pmid:21779874
Molinari R et al. The n3-polyunsaturated fatty acid docosahexaenoic acid induces immunogenic cell death in human cancer cell lines via pre-apoptotic calreticulin exposure. 2011 Cancer Immunol. Immunother. pmid:21779875
Friedrichs W et al. Omega-3 fatty acid inhibition of prostate cancer progression to hormone independence is associated with suppression of mTOR signaling and androgen receptor expression. 2011 Nutr Cancer pmid:21667400
Sakayori N et al. Distinctive effects of arachidonic acid and docosahexaenoic acid on neural stem /progenitor cells. 2011 Genes Cells pmid:21668588
Shulse CN and Allen EE Widespread occurrence of secondary lipid biosynthesis potential in microbial lineages. 2011 PLoS ONE pmid:21629834
Okpala I et al. Pilot study of omega-3 fatty acid supplements in sickle cell disease. 2011 APMIS pmid:21635551
Hajjaji N et al. Determinants of DHA incorporation into tumor tissue during dietary DHA supplementation. 2011 Lipids pmid:21638063
Kuang YL et al. Docosahexaenoic acid suppresses apolipoprotein A-I gene expression through hepatocyte nuclear factor-3β. 2011 Am. J. Clin. Nutr. pmid:21653803
Roqueta-Rivera M et al. Deficiency in the omega-3 fatty acid pathway results in failure of acrosome biogenesis in mice. 2011 Biol. Reprod. pmid:21653892
Nakamoto K et al. Possible involvement of β-endorphin in docosahexaenoic acid-induced antinociception. 2011 Eur. J. Pharmacol. pmid:21658380
O'Sullivan TA et al. Dietary intake and food sources of fatty acids in Australian adolescents. 2011 Nutrition pmid:20338727
Beck G et al. Neuroaxonal dystrophy in calcium-independent phospholipase A2β deficiency results from insufficient remodeling and degeneration of mitochondrial and presynaptic membranes. 2011 J. Neurosci. pmid:21813701
Konrad M et al. The acute effect of ingesting a quercetin-based supplement on exercise-induced inflammation and immune changes in runners. 2011 Int J Sport Nutr Exerc Metab pmid:21813917
Morin C et al. 19,20-EpDPE, a bioactive CYP450 metabolite of DHA monoacyglyceride, decreases Ca²⁺ sensitivity in human pulmonary arteries. 2011 Am. J. Physiol. Heart Circ. Physiol. pmid:21821782
McLaren JE et al. Eicosapentaenoic acid and docosahexaenoic acid regulate modified LDL uptake and macropinocytosis in human macrophages. 2011 Lipids pmid:21822944
Kawabata T et al. Associations between dietary n-6 and n-3 fatty acids and arachidonic acid compositions in plasma and erythrocytes in young and elderly Japanese volunteers. 2011 Lipids Health Dis pmid:21838914
Tian H et al. Autacoid 14S,21R-dihydroxy-docosahexaenoic acid counteracts diabetic impairment of macrophage prohealing functions. 2011 Am. J. Pathol. pmid:21839062
Kimura F et al. Supplementation of DHA-rich microalgal oil or fish oil during the suckling period in mildly n-3 fatty acid-deficient rat pups. 2011 Lipids pmid:21901511
Lewis MD et al. Suicide deaths of active-duty US military and omega-3 fatty-acid status: a case-control comparison. 2011 J Clin Psychiatry pmid:21903029
Kuipers RS et al. Differences in preterm and term milk fatty acid compositions may be caused by the different hormonal milieu of early parturition. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21903369
Sala-Vila A et al. Determinants of the omega-3 index in a Mediterranean population at increased risk for CHD. 2011 Br. J. Nutr. pmid:21450116
Vincentini O et al. Docosahexaenoic acid modulates in vitro the inflammation of celiac disease in intestinal epithelial cells via the inhibition of cPLA2. 2011 Clin Nutr pmid:21421277
Weylandt KH et al. Suppressed liver tumorigenesis in fat-1 mice with elevated omega-3 fatty acids is associated with increased omega-3 derived lipid mediators and reduced TNF-α. 2011 Carcinogenesis pmid:21421544
Stapleton RD et al. A phase II randomized placebo-controlled trial of omega-3 fatty acids for the treatment of acute lung injury. 2011 Crit. Care Med. pmid:21423000
Kulkarni A et al. Effects of altered maternal folic acid, vitamin B12 and docosahexaenoic acid on placental global DNA methylation patterns in Wistar rats. 2011 PLoS ONE pmid:21423696
Hong WK et al. Production of lipids containing high levels of docosahexaenoic acid by a newly isolated microalga, Aurantiochytrium sp. KRS101. 2011 Appl. Biochem. Biotechnol. pmid:21424706
Farias SE et al. Lipid mediators in cerebral spinal fluid of traumatic brain injured patients. 2011 J Trauma pmid:21427623
Bhatia HS et al. Omega-3 fatty acid deficiency during brain maturation reduces neuronal and behavioral plasticity in adulthood. 2011 PLoS ONE pmid:22163304
Wiedemann HP Fish oil is not the fix for acute lung injury. 2011 Crit. Care Med. pmid:21685749
Park CK et al. Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1. 2011 J. Neurosci. pmid:22171045
Zúñiga J et al. N-3 PUFA supplementation triggers PPAR-α activation and PPAR-α/NF-κB interaction: anti-inflammatory implications in liver ischemia-reperfusion injury. 2011 PLoS ONE pmid:22174823
Dewell A et al. Low- and high-dose plant and marine (n-3) fatty acids do not affect plasma inflammatory markers in adults with metabolic syndrome. 2011 J. Nutr. pmid:22031659
Meldrum SJ et al. The Infant Fish Oil Supplementation Study (IFOS): design and research protocol of a double-blind, randomised controlled n--3 LCPUFA intervention trial in term infants. 2011 Contemp Clin Trials pmid:21718804
Rapoport SI et al. Docosahexaenoic acid (DHA) incorporation into the brain from plasma, as an in vivo biomarker of brain DHA metabolism and neurotransmission. 2011 Prostaglandins Other Lipid Mediat. pmid:21704722
Escolano-Margarit MV et al. Prenatal DHA status and neurological outcome in children at age 5.5 years are positively associated. 2011 J. Nutr. pmid:21525247
Rockett BD et al. Membrane raft organization is more sensitive to disruption by (n-3) PUFA than nonraft organization in EL4 and B cells. 2011 J. Nutr. pmid:21525263
De Franceschi G et al. Structural and morphological characterization of aggregated species of α-synuclein induced by docosahexaenoic acid. 2011 J. Biol. Chem. pmid:21527634
Schnebelen C et al. Dietary polyunsaturated fatty acids reduce retinal stress induced by an elevation of intraocular pressure in rats. 2011 Nutr Res pmid:21530802
Glew RH et al. Low docosahexaenoic acid in the diet and milk of American Indian women in New Mexico. 2011 J Am Diet Assoc pmid:21515123
Courville AB et al. Consumption of a DHA-containing functional food during pregnancy is associated with lower infant ponderal index and cord plasma insulin concentration. 2011 Br. J. Nutr. pmid:21521543
Decsi T and Kennedy K Sex-specific differences in essential fatty acid metabolism. 2011 Am. J. Clin. Nutr. pmid:22089435
Sengupta A and Ghosh M Integrity of erythrocytes of hypercholesterolemic and normocholesterolemic rats during ingestion of different structured lipids. 2011 Eur J Nutr pmid:21127890
Lin YH et al. Altered essential fatty acid metabolism and composition in rat liver, plasma, heart and brain after microalgal DHA addition to the diet. 2011 J. Nutr. Biochem. pmid:21111595
Sun C et al. DHA regulates lipogenesis and lipolysis genes in mice adipose and liver. 2011 Mol. Biol. Rep. pmid:20383747
Kim SH et al. Prospective randomized comparison between omega-3 fatty acid supplements plus simvastatin versus simvastatin alone in Korean patients with mixed dyslipidemia: lipoprotein profiles and heart rate variability. 2011 Eur J Clin Nutr pmid:20877395
Hutchins HL et al. Eicosapentaenoic acid decreases expression of anandamide synthesis enzyme and cannabinoid receptor 2 in osteoblast-like cells. 2011 J. Nutr. Biochem. pmid:20951563
Zhao J et al. Deposition of docosahexaenoic acid (DHA) is limited in forebrain of young obese fa/fa Zucker rats fed a diet high in α-linolenic acid but devoid of DHA. 2011 J. Nutr. Biochem. pmid:21129946
Neubronner J et al. Enhanced increase of omega-3 index in response to long-term n-3 fatty acid supplementation from triacylglycerides versus ethyl esters. 2011 Eur J Clin Nutr pmid:21063431
Teichert SA and Akoh CC Modifications of stearidonic acid soybean oil by enzymatic acidolysis for the production of human milk fat analogues. 2011 J. Agric. Food Chem. pmid:22097918
Belin RJ et al. Fish intake and the risk of incident heart failure: the Women's Health Initiative. 2011 Circ Heart Fail pmid:21610249
Burrows T et al. Omega-3 index, obesity and insulin resistance in children. 2011 Int J Pediatr Obes pmid:21226540
Zhao Y et al. Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARγ-mediated mechanisms in Alzheimer's disease models. 2011 PLoS ONE pmid:21246057
Gomez-Pinilla F The combined effects of exercise and foods in preventing neurological and cognitive disorders. 2011 Prev Med pmid:21281667
Feucht C and Patel DR Herbal medicines in pediatric neuropsychiatry. 2011 Pediatr. Clin. North Am. pmid:21281847
Galicia-Connolly EZ et al. Complementary, holistic, and integrative medicine: therapies for learning disabilities. 2011 Pediatr Rev pmid:21285298
Nobili V et al. Docosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease: double-blind randomised controlled clinical trial. 2011 Arch. Dis. Child. pmid:21233083
Aarsetoey H et al. Low levels of the omega-3 index are associated with sudden cardiac arrest and remain stable in survivors in the subacute phase. 2011 Lipids pmid:21234696
Salm P et al. Simultaneous quantification of total eicosapentaenoic acid, docosahexaenoic acid and arachidonic acid in plasma by high-performance liquid chromatography-tandem mass spectrometry. 2011 Biomed. Chromatogr. pmid:20737653
Ozsoy O et al. The effect of docosahexaenoic Acid on visual evoked potentials in a mouse model of Parkinson's disease: the role of cyclooxygenase-2 and nuclear factor kappa-B. 2011 Neurotox Res pmid:21234736
Harper KN et al. Maternal serum docosahexaenoic acid and schizophrenia spectrum disorders in adult offspring. 2011 Schizophr. Res. pmid:21324652
Grimm MO et al. Docosahexaenoic acid reduces amyloid beta production via multiple pleiotropic mechanisms. 2011 J. Biol. Chem. pmid:21324907
Umhau JC Docosahexaenoic acid supplementation and Alzheimer disease. 2011 JAMA pmid:21325181
Nowak M et al. Impact of polyunsaturated fatty acids on oxidized low density lipoprotein-induced U937 cell apoptosis. 2011 J. Atheroscler. Thromb. pmid:21325776
Murphy RA et al. Supplementation with fish oil increases first-line chemotherapy efficacy in patients with advanced nonsmall cell lung cancer. 2011 Cancer pmid:21328326
Valera B et al. Influence of n-3 fatty acids on cardiac autonomic activity among Nunavik Inuit adults. 2011 Int J Circumpolar Health pmid:21329579
Furuhjelm C et al. Allergic disease in infants up to 2 years of age in relation to plasma omega-3 fatty acids and maternal fish oil supplementation in pregnancy and lactation. 2011 Pediatr Allergy Immunol pmid:21332799
Sriram K Confusion between gamma-linolenic acid and gamma-linoleic acid. 2011 Crit. Care Med. pmid:22094528
Turk HF et al. Linoleic acid and butyrate synergize to increase Bcl-2 levels in colonocytes. 2011 Int. J. Cancer pmid:20232381
Lecchi C et al. In vitro modulation of caprine monocyte immune functions by ω-3 polyunsaturated fatty acids. 2011 Vet. J. pmid:20889357
Toufektsian MC et al. Dietary flavonoids increase plasma very long-chain (n-3) fatty acids in rats. 2011 J. Nutr. pmid:21068183
Liu C and Cai WX [Correlation between the eicosapentaenoic acid, docosahexaenoic acid and the aggressive behavior in mice]. 2011 Fa Yi Xue Za Zhi pmid:21604451