DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Burns D002056 34 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Hua J et al. The resolvin D1 analogue controls maturation of dendritic cells and suppresses alloimmunity in corneal transplantation. 2014 Invest. Ophthalmol. Vis. Sci. pmid:25146982
Navarro-Guillén C et al. Effect of varying dietary levels of LC-PUFA and vegetable oil sources on performance and fatty acids of Senegalese sole post larvae: puzzling results suggest complete biosynthesis pathway from C18 PUFA to DHA. 2014 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:24120522
Fedorova-Dahms I et al. A 3-week dietary bioequivalence study in preweaning farm piglets of two sources of docosahexaenoic acid produced from two different organisms. 2014 Food Chem. Toxicol. pmid:24333867
Lee EJ et al. Down-regulation of lipid raft-associated onco-proteins via cholesterol-dependent lipid raft internalization in docosahexaenoic acid-induced apoptosis. 2014 Biochim. Biophys. Acta pmid:24120917
Fernández-González R et al. Decontamination solutions for polychlorinated biphenyls (PCBs) in raw fish oils from environmentally contaminated sea fishes. 2014 Sci. Total Environ. pmid:24095964
Amiano P et al. Intake of total omega-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid and risk of coronary heart disease in the Spanish EPIC cohort study. 2014 Nutr Metab Cardiovasc Dis pmid:24360762
Huang X et al. Serum and adipose tissue fatty acid composition as biomarkers of habitual dietary fat intake in elderly men with chronic kidney disease. 2014 Nephrol. Dial. Transplant. pmid:23229929
Currais A et al. Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice. 2014 Aging Cell pmid:24341874
Ponnampalam EN et al. Health beneficial long chain omega-3 fatty acid levels in Australian lamb managed under extensive finishing systems. 2014 Meat Sci. pmid:23643471
Hennebelle M et al. Ageing and apoE change DHA homeostasis: relevance to age-related cognitive decline. 2014 Proc Nutr Soc pmid:24103099
Jilkova ZM et al. Adipose tissue-related proteins locally associated with resolution of inflammation in obese mice. 2014 Int J Obes (Lond) pmid:23756677
Schuster GU et al. Dietary long-chain omega-3 fatty acids do not diminish eosinophilic pulmonary inflammation in mice. 2014 Am. J. Respir. Cell Mol. Biol. pmid:24134486
Maitin V et al. Docosahexaenoic acid impairs the maturation of very low density lipoproteins in rat hepatic cells. 2014 J. Lipid Res. pmid:24136824
Wang S et al. Lipid content in hepatic and gonadal adipose tissue parallel aortic cholesterol accumulation in mice fed diets with different omega-6 PUFA to EPA plus DHA ratios. 2014 Clin Nutr pmid:23672804
De Mel D and Suphioglu C Fishy business: effect of omega-3 fatty acids on zinc transporters and free zinc availability in human neuronal cells. 2014 Nutrients pmid:25195602
Katakura M et al. Omega-3 fatty acids protect renal functions by increasing docosahexaenoic acid-derived metabolite levels in SHR.Cg-Lepr(cp)/NDmcr rats, a metabolic syndrome model. 2014 Molecules pmid:24642910
Browning LM et al. Compared with daily, weekly n-3 PUFA intake affects the incorporation of eicosapentaenoic acid and docosahexaenoic acid into platelets and mononuclear cells in humans. 2014 J. Nutr. pmid:24647395
Hiram R et al. Resolvin D1 reverses reactivity and Ca2+ sensitivity induced by ET-1, TNF-α, and IL-6 in the human pulmonary artery. 2014 Am. J. Physiol. Heart Circ. Physiol. pmid:25281570
Jung JY et al. Effect of dietary supplementation with omega-3 fatty acid and gamma-linolenic acid on acne vulgaris: a randomised, double-blind, controlled trial. 2014 Acta Derm. Venereol. pmid:24553997
Chan SS and Hart AR Commentary: The association between high dietary intake of docosahexaenoic acid and reduced risk of Crohn's disease--authors' reply. 2014 Aliment. Pharmacol. Ther. pmid:24803246
Betsholtz C Physiology: Double function at the blood-brain barrier. 2014 Nature pmid:24828036
Nguyen LN et al. Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. 2014 Nature pmid:24828044
Chua A et al. Effect of docosahexaenoic acid and furan fatty acids on cytokinesis block micronucleus cytome assay biomarkers in astrocytoma cell lines under conditions of oxidative stress. 2014 Environ. Mol. Mutagen. pmid:24828973
Hong S et al. Neuroprotectin/protectin D1: endogenous biosynthesis and actions on diabetic macrophages in promoting wound healing and innervation impaired by diabetes. 2014 Am. J. Physiol., Cell Physiol. pmid:25273880
Ma QL et al. Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging. 2014 J. Neurosci. pmid:24849348
Tungen JE et al. Synthesis and anti-inflammatory and pro-resolving activities of 22-OH-PD1, a monohydroxylated metabolite of protectin D1. 2014 J. Nat. Prod. pmid:25247845
McCauley LK et al. Cutting edge: Parathyroid hormone facilitates macrophage efferocytosis in bone marrow via proresolving mediators resolvin D1 and resolvin D2. 2014 J. Immunol. pmid:24890726
Serhan CN Pro-resolving lipid mediators are leads for resolution physiology. 2014 Nature pmid:24899309
[Recommendations of the Polish Gynecological Society concerning docosahexaenoic acid supplementation in the prevention of preterm birth]. 2014 Ginekol. Pol. pmid:24834713
[Recommendations of the Polish Gynecological Society concerning docosahexaenoic acid supplementation in the prevention of preterm birth]. 2014 Ginekol. Pol. pmid:25011224
Skender B et al. DHA-mediated enhancement of TRAIL-induced apoptosis in colon cancer cells is associated with engagement of mitochondria and specific alterations in sphingolipid metabolism. 2014 Biochim. Biophys. Acta pmid:24953781
Zhao Z and Zlokovic BV Blood-brain barrier: a dual life of MFSD2A? 2014 Neuron pmid:24853933
Abdulnour RE et al. Maresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25369934
Chan SS et al. Association between high dietary intake of the n-3 polyunsaturated fatty acid docosahexaenoic acid and reduced risk of Crohn's disease. 2014 Aliment. Pharmacol. Ther. pmid:24611981
Aursnes M et al. Stereoselective synthesis of protectin D1: a potent anti-inflammatory and proresolving lipid mediator. 2014 Org. Biomol. Chem. pmid:24253202
Shimamoto C et al. Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies. 2014 Hum. Mol. Genet. pmid:25027319
White PJ et al. Protectin DX alleviates insulin resistance by activating a myokine-liver glucoregulatory axis. 2014 Nat. Med. pmid:24813250
Balas L et al. Confusion between protectin D1 (PD1) and its isomer protectin DX (PDX). An overview on the dihydroxy-docosatrienes described to date. 2014 Biochimie pmid:24262603
Evans SJ et al. Dietary intake and plasma metabolomic analysis of polyunsaturated fatty acids in bipolar subjects reveal dysregulation of linoleic acid metabolism. 2014 J Psychiatr Res pmid:24953860
Siddesha JM et al. Docosahexaenoic acid reverses angiotensin II-induced RECK suppression and cardiac fibroblast migration. 2014 Cell. Signal. pmid:24447911
Mussi SV et al. Novel nanostructured lipid carrier co-loaded with doxorubicin and docosahexaenoic acid demonstrates enhanced in vitro activity and overcomes drug resistance in MCF-7/Adr cells. 2014 Pharm. Res. pmid:24522814
Santos S et al. Fatty acids derived from a food frequency questionnaire and measured in the erythrocyte membrane in relation to adiponectin and leptin concentrations. 2014 Eur J Clin Nutr pmid:24642786
Torres M et al. Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease. 2014 Biochim. Biophys. Acta pmid:24374316
Liu X et al. Amide-type adduct of dopamine - plausible cause of Parkinson diseases. 2014 Subcell. Biochem. pmid:24374917
Vandal M et al. Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2. 2014 J. Neurochem. pmid:24345162
De Felice C et al. Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome. 2014 Neurobiol. Dis. pmid:24769161
Berasategi I et al. Healthy reduced-fat Bologna sausages enriched in ALA and DHA and stabilized with Melissa officinalis extract. 2014 Meat Sci. pmid:24334039
Sengupta A and Ghosh M Effect of sterol esters on lipid composition and antioxidant status of erythrocyte membrane of hypercholesterolemic rats. 2014 J Oleo Sci pmid:24770475
Koppenol A et al. Effect of the ratio of dietary n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid on broiler breeder performance, egg quality, and yolk fatty acid composition at different breeder ages. 2014 Poult. Sci. pmid:24604849
Gil-Zamorano J et al. Docosahexaenoic acid modulates the enterocyte Caco-2 cell expression of microRNAs involved in lipid metabolism. 2014 J. Nutr. pmid:24623846
Buckley CD et al. Proresolving lipid mediators and mechanisms in the resolution of acute inflammation. 2014 Immunity pmid:24656045
Cui ZG et al. Molecular mechanisms of hyperthermia-induced apoptosis enhanced by docosahexaenoic acid: implication for cancer therapy. 2014 Chem. Biol. Interact. pmid:24661947
Adarme-Vega TC et al. Towards sustainable sources for omega-3 fatty acids production. 2014 Curr. Opin. Biotechnol. pmid:24607804
Aronow ME and Chew EY Age-related Eye Disease Study 2: perspectives, recommendations, and unanswered questions. 2014 Curr Opin Ophthalmol pmid:24614146
Wang Q et al. Resolvin D1 stimulates alveolar fluid clearance through alveolar epithelial sodium channel, Na,K-ATPase via ALX/cAMP/PI3K pathway in lipopolysaccharide-induced acute lung injury. 2014 J. Immunol. pmid:24646745
Pottala JV et al. Higher RBC EPA + DHA corresponds with larger total brain and hippocampal volumes: WHIMS-MRI study. 2014 Neurology pmid:24453077
Zhao JP et al. Circulating docosahexaenoic acid levels are associated with fetal insulin sensitivity. 2014 PLoS ONE pmid:24454790
Harden CJ et al. Long-chain polyunsaturated fatty acid supplementation had no effect on body weight but reduced energy intake in overweight and obese women. 2014 Nutr Res pmid:24418242
Asai M et al. [Cellular models for individualized medicine in Alzheimer's disease using patient-derived induced pluripotent stem cells]. 2014 Nippon Yakurigaku Zasshi pmid:24420133
Jin M et al. Eicosapentaenoic acid and docosahexaenoic acid suppress Th2 cytokine expression in RBL-2H3 basophilic leukemia cells. 2014 J Med Food pmid:24460246
O'Callaghan N et al. Telomere shortening in elderly individuals with mild cognitive impairment may be attenuated with ω-3 fatty acid supplementation: a randomized controlled pilot study. 2014 Nutrition pmid:24342530
Patterson AC et al. The percentage of DHA in erythrocytes can detect non-adherence to advice to increase EPA and DHA intakes. 2014 Br. J. Nutr. pmid:23920312
Martorell M et al. Effect of DHA on plasma fatty acid availability and oxidative stress during training season and football exercise. 2014 Food Funct pmid:24955731
Fredman G et al. Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25246560
Kitessa SM et al. DHA-containing oilseed: a timely solution for the sustainability issues surrounding fish oil sources of the health-benefitting long-chain omega-3 oils. 2014 Nutrients pmid:24858407
Dendelé B et al. Protective action of n-3 fatty acids on benzo[a]pyrene-induced apoptosis through the plasma membrane remodeling-dependent NHE1 pathway. 2014 Chem. Biol. Interact. pmid:24246761
Murali G et al. Differential effects of eicosapentaenoic acid and docosahexaenoic acid in promoting the differentiation of 3T3-L1 preadipocytes. 2014 Prostaglandins Leukot. Essent. Fatty Acids pmid:24332315
Walhovd KB et al. Blood markers of fatty acids and vitamin D, cardiovascular measures, body mass index, and physical activity relate to longitudinal cortical thinning in normal aging. 2014 Neurobiol. Aging pmid:24332985
Eto M et al. A novel lysophosphatidic acid acyltransferase enzyme (LPAAT4) with a possible role for incorporating docosahexaenoic acid into brain glycerophospholipids. 2014 Biochem. Biophys. Res. Commun. pmid:24333445
Nelson JW et al. ALX/FPR2 receptor for RvD1 is expressed and functional in salivary glands. 2014 Am. J. Physiol., Cell Physiol. pmid:24259417
O'Sullivan A et al. Habitual diets rich in dark-green vegetables are associated with an increased response to ω-3 fatty acid supplementation in Americans of African ancestry. 2014 J. Nutr. pmid:24259553
Cipollina C et al. Dual anti-oxidant and anti-inflammatory actions of the electrophilic cyclooxygenase-2-derived 17-oxo-DHA in lipopolysaccharide- and cigarette smoke-induced inflammation. 2014 Biochim. Biophys. Acta pmid:24594225
Siddiqui RA et al. Characterization of lovastatin-docosahexaenoate anticancer properties against breast cancer cells. 2014 Bioorg. Med. Chem. pmid:24556504
Hashimoto M et al. Possibility of polyunsaturated fatty acids for the prevention and treatment of neuropsychiatric illnesses. 2014 J. Pharmacol. Sci. pmid:24561447
Ciaccio CE and Girdhar M Effect of maternal ω3 fatty acid supplementation on infant allergy. 2014 Ann. Allergy Asthma Immunol. pmid:24565593
Zanfini A et al. GC-EI-MS analysis of fatty acid composition in brain and serum of twitcher mouse. 2014 Lipids pmid:25208498
von Schacky C Omega-3 index and cardiovascular health. 2014 Nutrients pmid:24566438
Bauer I et al. Does omega-3 fatty acid supplementation enhance neural efficiency? A review of the literature. 2014 Hum Psychopharmacol pmid:24285504
Nehra D et al. Docosahexaenoic acid, G protein-coupled receptors, and melanoma: is G protein-coupled receptor 40 a potential therapeutic target? 2014 J. Surg. Res. pmid:24576779
Abdel-Dayem MA et al. Valproate-induced liver injury: modulation by the omega-3 fatty acid DHA proposes a novel anticonvulsant regimen. 2014 Drugs R D pmid:24733439
Höper AC et al. Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice. 2014 J. Nutr. pmid:24285691
Boca SM et al. Testing multiple biological mediators simultaneously. 2014 Bioinformatics pmid:24202540
Sublimi Saponetti M et al. Aggregation of Aß(25-35) on DOPC and DOPC/DHA bilayers: an atomic force microscopy study. 2014 PLoS ONE pmid:25551704
Hong S et al. Maresin-like lipid mediators are produced by leukocytes and platelets and rescue reparative function of diabetes-impaired macrophages. 2014 Chem. Biol. pmid:25200603
Cho Y et al. Colon cancer cell apoptosis is induced by combined exposure to the n-3 fatty acid docosahexaenoic acid and butyrate through promoter methylation. 2014 Exp. Biol. Med. (Maywood) pmid:24495951
Ponnampalam EN et al. Sources of variation of health claimable long chain omega-3 fatty acids in meat from Australian lamb slaughtered at similar weights. 2014 Meat Sci. pmid:23265412
Chen F et al. Resolvin D1 improves survival in experimental sepsis through reducing bacterial load and preventing excessive activation of inflammatory response. 2014 Eur. J. Clin. Microbiol. Infect. Dis. pmid:24072678
Park J et al. Reciprocal modulation of surface expression of annexin A2 in a human umbilical vein endothelial cell-derived cell line by eicosapentaenoic acid and docosahexaenoic acid. 2014 PLoS ONE pmid:24465474
Eady TN et al. Docosahexaenoic acid complexed to albumin provides neuroprotection after experimental stroke in aged rats. 2014 Neurobiol. Dis. pmid:24063996
Tang H et al. Protective actions of aspirin-triggered (17R) resolvin D1 and its analogue, 17R-hydroxy-19-para-fluorophenoxy-resolvin D1 methyl ester, in C5a-dependent IgG immune complex-induced inflammation and lung injury. 2014 J. Immunol. pmid:25172497
Montgomery P et al. Fatty acids and sleep in UK children: subjective and pilot objective sleep results from the DOLAB study--a randomized controlled trial. 2014 J Sleep Res pmid:24605819
Walker CG et al. Age and sex differences in the incorporation of EPA and DHA into plasma fractions, cells and adipose tissue in humans. 2014 Br. J. Nutr. pmid:24063767
Zheng MG et al. Cloning, expression and stress-respondent transcription of long-chain acyl-coenzyme A synthetase cDNA gene of Nannochloropsis gaditana and its involvement in the biosynthesis of eicosapentaenoic and decosahexaenoic acids. 2014 Biotechnol. Lett. pmid:24068506
Bahety P et al. Metabotyping of docosahexaenoic acid - treated Alzheimer's disease cell model. 2014 PLoS ONE pmid:24587236
Kwon B et al. Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells. 2014 Biochim. Biophys. Acta pmid:24732014
Harris WS and Schmitt TL Unexpected similarity in RBC DHA and AA levels between bottlenose dolphins and humans. 2014 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:24393427
Kar S Omacor and omega-3 fatty acids for treatment of coronary artery disease and the pleiotropic effects. 2014 Jan-Feb Am J Ther pmid:21975796
Casanova E et al. Omega-3 polyunsaturated fatty acids and proanthocyanidins improve postprandial metabolic flexibility in rat. 2014 Jan-Feb Biofactors pmid:23983179
Mohajeri S and Newman SA Review of evidence for dietary influences on atopic dermatitis. 2014 Jul-Aug Skin Therapy Lett. pmid:25188523
Akimov MG et al. [The influence of docosahexaenoic acid moiety on cytotoxic activity of 1,2,4-thiadiazole derivatives]. 2014 Jul-Aug Biomed Khim pmid:25249531