| MeSH term | MeSH ID | Detail |
|---|---|---|
| Keratitis, Herpetic | D016849 | 5 associated lipids |
| Phenylketonuria, Maternal | D017042 | 1 associated lipids |
| Glucose Intolerance | D018149 | 13 associated lipids |
| Carcinoma, Embryonal | D018236 | 8 associated lipids |
| Trophoblastic Tumor, Placental Site | D018245 | 1 associated lipids |
| Pneumonia, Bacterial | D018410 | 16 associated lipids |
| Ventricular Dysfunction, Left | D018487 | 33 associated lipids |
| Sepsis | D018805 | 11 associated lipids |
| Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
| Peroxisomal Disorders | D018901 | 5 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Infante JP and Huszagh VA | Secondary carnitine deficiency and impaired docosahexaenoic (22:6n-3) acid synthesis: a common denominator in the pathophysiology of diseases of oxidative phosphorylation and beta-oxidation. | 2000 | FEBS Lett. | pmid:10683429 |
| Bonin A and Khan NA | Regulation of calcium signalling by docosahexaenoic acid in human T-cells. Implication of CRAC channels. | 2000 | J. Lipid Res. | pmid:10681412 |
| Calviello G et al. | n-3 PUFA dietary supplementation inhibits proliferation and store-operated calcium influx in thymoma cells growing in Balb/c mice. | 2000 | J. Lipid Res. | pmid:10681400 |
| Larqué E et al. | Dietary trans fatty acids affect docosahexaenoic acid concentrations in plasma and liver but not brain of pregnant and fetal rats. | 2000 | Pediatr. Res. | pmid:10674359 |
| Engler MM et al. | The effects of a diet rich in docosahexaenoic acid on organ and vascular fatty acid composition in spontaneously hypertensive rats. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10670690 |
| Stillwell W et al. | Detection of lipid domains in docasahexaenoic acid-rich bilayers by acyl chain-specific FRET probes. | 2000 | Chem. Phys. Lipids | pmid:10669305 |
| Morrow JD et al. | Formation of novel isoprostane-like compounds from docosahexaenoic acid. | 1999 | Adv. Exp. Med. Biol. | pmid:10667351 |
| Moore SA et al. | Regulation of cerebrovascular cyclooxygenase-2 by pro- and anti-inflammatory cytokines. | 1999 | Adv. Exp. Med. Biol. | pmid:10667320 |
| Shikano M et al. | Inhibition of protein tyrosine kinase activity by 1a-docosahexaenoyl mitomycin C. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10667236 |
| Calabresi L et al. | Omacor in familial combined hyperlipidemia: effects on lipids and low density lipoprotein subclasses. | 2000 | Atherosclerosis | pmid:10657575 |
| Ollero M et al. | Variation of docosahexaenoic acid content in subsets of human spermatozoa at different stages of maturation: implications for sperm lipoperoxidative damage. | 2000 | Mol. Reprod. Dev. | pmid:10657052 |
| Cunnane SC and Francescutti V | Fatty acid profiles of maternal adipose tissue in relation to infant development. | 1999 | Br. J. Nutr. | pmid:10655972 |
| Wensing AG et al. | Effects of dietary n-3 polyunsaturated fatty acids from plant and marine origin on platelet aggregation in healthy elderly subjects. | 1999 | Br. J. Nutr. | pmid:10655965 |
| Cunnane S | Modelling human infant requirements for long-chain polyunsaturated fatty acids. | 1999 | Br. J. Nutr. | pmid:10655962 |
| Lapillonne A et al. | Erythrocyte fatty acid composition in term infants fed human milk or a formula enriched with a low eicosapentanoic acid fish oil for 4 months. | 2000 Jan-Feb | Eur. J. Pediatr. | pmid:10653329 |
| Janssen A et al. | Docosahexaenoic acid deficit is not a major pathogenic factor in peroxisome-deficient mice. | 2000 | Lab. Invest. | pmid:10653000 |
| Polette A et al. | Synthesis of acetyl,docosahexaenoyl-glycerophosphocholine and its characterization using nuclear magnetic resonance. | 1999 | Lipids | pmid:10652994 |
| Devlin AM and Innis SM | Dietary phospholipid alters biliary lipid composition in formula-fed piglets. | 1999 | Lipids | pmid:10652991 |
| Hashimoto M et al. | Effects of eicosapentaenoic acid and docosahexaenoic acid on plasma membrane fluidity of aortic endothelial cells. | 1999 | Lipids | pmid:10652989 |
| Greener M | Fatty acid imbalance might lead to novel treatments for CF. | 2000 | Mol Med Today | pmid:10652475 |
| Diep QN et al. | Endothelin-1 attenuates omega3 fatty acid-induced apoptosis by inhibition of caspase 3. | 2000 | Hypertension | pmid:10642312 |
| Connolly JM et al. | Effects of reduced dietary linoleic acid intake, alone or combined with an algal source of docosahexaenoic acid, on MDA-MB-231 breast cancer cell growth and apoptosis in nude mice. | 1999 | Nutr Cancer | pmid:10624705 |
| Lucas A et al. | Efficacy and safety of long-chain polyunsaturated fatty acid supplementation of infant-formula milk: a randomised trial. | 1999 | Lancet | pmid:10622297 |
| Gibson RA | Long-chain polyunsaturated fatty acids and infant development. | 1999 | Lancet | pmid:10622289 |
| MartÃnez M et al. | Therapeutic effects of docosahexaenoic acid ethyl ester in patients with generalized peroxisomal disorders. | 2000 | Am. J. Clin. Nutr. | pmid:10618001 |
| Donadio JV | Use of fish oil to treat patients with immunoglobulin a nephropathy. | 2000 | Am. J. Clin. Nutr. | pmid:10618000 |
| Ziboh VA et al. | Metabolism of polyunsaturated fatty acids by skin epidermal enzymes: generation of antiinflammatory and antiproliferative metabolites. | 2000 | Am. J. Clin. Nutr. | pmid:10617998 |
| Hughes DA and Pinder AC | n-3 polyunsaturated fatty acids inhibit the antigen-presenting function of human monocytes. | 2000 | Am. J. Clin. Nutr. | pmid:10617997 |
| Kremer JM | n-3 fatty acid supplements in rheumatoid arthritis. | 2000 | Am. J. Clin. Nutr. | pmid:10617995 |
| James MJ et al. | Dietary polyunsaturated fatty acids and inflammatory mediator production. | 2000 | Am. J. Clin. Nutr. | pmid:10617994 |
| Burgess JR et al. | Long-chain polyunsaturated fatty acids in children with attention-deficit hyperactivity disorder. | 2000 | Am. J. Clin. Nutr. | pmid:10617991 |
| Stordy BJ | Dark adaptation, motor skills, docosahexaenoic acid, and dyslexia. | 2000 | Am. J. Clin. Nutr. | pmid:10617990 |
| Dutta-Roy AK | Transport mechanisms for long-chain polyunsaturated fatty acids in the human placenta. | 2000 | Am. J. Clin. Nutr. | pmid:10617989 |
| Auestad N and Innis SM | Dietary n-3 fatty acid restriction during gestation in rats: neuronal cell body and growth-cone fatty acids. | 2000 | Am. J. Clin. Nutr. | pmid:10617988 |
| Makrides M and Gibson RA | Long-chain polyunsaturated fatty acid requirements during pregnancy and lactation. | 2000 | Am. J. Clin. Nutr. | pmid:10617987 |
| Jensen CL et al. | Effect of docosahexaenoic acid supplementation of lactating women on the fatty acid composition of breast milk lipids and maternal and infant plasma phospholipids. | 2000 | Am. J. Clin. Nutr. | pmid:10617985 |
| Al MD et al. | Long-chain polyunsaturated fatty acids, pregnancy, and pregnancy outcome. | 2000 | Am. J. Clin. Nutr. | pmid:10617984 |
| Crawford M | Placental delivery of arachidonic and docosahexaenoic acids: implications for the lipid nutrition of preterm infants. | 2000 | Am. J. Clin. Nutr. | pmid:10617983 |
| Carlson SE | Behavioral methods used in the study of long-chain polyunsaturated fatty acid nutrition in primate infants. | 2000 | Am. J. Clin. Nutr. | pmid:10617982 |
| Neuringer M | Infant vision and retinal function in studies of dietary long-chain polyunsaturated fatty acids: methods, results, and implications. | 2000 | Am. J. Clin. Nutr. | pmid:10617981 |
| Innis SM | Essential fatty acids in infant nutrition: lessons and limitations from animal studies in relation to studies on infant fatty acid requirements. | 2000 | Am. J. Clin. Nutr. | pmid:10617978 |
| Connor WE | Importance of n-3 fatty acids in health and disease. | 2000 | Am. J. Clin. Nutr. | pmid:10617967 |
| Connor SL et al. | Cheek cell phospholipids in human infants: a marker of docosahexaenoic and arachidonic acids in the diet, plasma, and red blood cells. | 2000 | Am. J. Clin. Nutr. | pmid:10617942 |
| Tolley EA and Carlson SE | Considerations of statistical power in infant studies of visual acuity development and docosahexaenoic acid status. | 2000 | Am. J. Clin. Nutr. | pmid:10617938 |
| Makrides M et al. | A critical appraisal of the role of dietary long-chain polyunsaturated fatty acids on neural indices of term infants: a randomized, controlled trial. | 2000 | Pediatrics | pmid:10617701 |
| Ghebremeskel K et al. | Maternal diet high in fat reduces docosahexaenoic acid in liver lipids of newborn and sucking rat pups. | 1999 | Br. J. Nutr. | pmid:10615212 |
| McGahon BM et al. | Age-related changes in synaptic function: analysis of the effect of dietary supplementation with omega-3 fatty acids. | 1999 | Neuroscience | pmid:10613520 |
| Nitsan Z et al. | Enrichment of poultry products with omega3 fatty acids by dietary supplementation with the alga Nannochloropsis and mantur oil. | 1999 | J. Agric. Food Chem. | pmid:10606584 |
| Retterstøl K et al. | The pathway from arachidonic to docosapentaenoic acid (20:4n-6 to 22:5n-6) and from eicosapentaenoic to docosahexaenoic acid (20:5n-3 to 22:6n-3) studied in testicular cells from immature rats. | 2000 | Biochim. Biophys. Acta | pmid:10601701 |
| Miyazaki M et al. | Dietary docosahexaenoic acid ameliorates, but rapeseed oil and safflower oil accelerate renal injury in stroke-prone spontaneously hypertensive rats as compared with soybean oil, which is associated with expression for renal transforming growth factor-beta, fibronectin and renin. | 2000 | Biochim. Biophys. Acta | pmid:10601699 |