DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Pneumonia, Bacterial D018410 16 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Premature Birth D047928 6 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Long QT Syndrome D008133 10 associated lipids
Short Bowel Syndrome D012778 3 associated lipids
Retinoblastoma D012175 12 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Vibrio Infections D014735 5 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Vyncke KE et al. Intake and serum profile of fatty acids are weakly correlated with global dietary quality in European adolescents. 2013 Nutrition pmid:23312763
Yu Y et al. DHA prevents altered 5-HT1A, 5-HT2A, CB1 and GABAA receptor binding densities in the brain of male rats fed a high-saturated-fat diet. 2013 J. Nutr. Biochem. pmid:23337348
Cederholm T et al. ω-3 fatty acids in the prevention of cognitive decline in humans. 2013 Adv Nutr pmid:24228198
Chen F et al. Fish oil attenuates liver injury caused by LPS in weaned pigs associated with inhibition of TLR4 and nucleotide-binding oligomerization domain protein signaling pathways. 2013 Innate Immun pmid:23339927
Amminger GP et al. Omega-3 fatty acid supplementation in adolescents with borderline personality disorder and ultra-high risk criteria for psychosis: a post hoc subgroup analysis of a double-blind, randomized controlled trial. 2013 Can J Psychiatry pmid:23870722
Lotrich FE et al. Anger induced by interferon-alpha is moderated by ratio of arachidonic acid to omega-3 fatty acids. 2013 J Psychosom Res pmid:24182638
Pande G et al. Enzymatic synthesis of extra virgin olive oil based infant formula fat analogues containing ARA and DHA: one-stage and two-stage syntheses. 2013 J. Agric. Food Chem. pmid:24117100
Murphy EJ A lipid neurochemist's siren: docosahexaenoic acid and its elusive function in the central nervous system. 2013 J. Neurochem. pmid:24117623
Flock MR et al. Long-chain omega-3 fatty acids: time to establish a dietary reference intake. 2013 Nutr. Rev. pmid:24117792
Lee HJ et al. Resolvin D1 inhibits TGF-β1-induced epithelial mesenchymal transition of A549 lung cancer cells via lipoxin A4 receptor/formyl peptide receptor 2 and GPR32. 2013 Int. J. Biochem. Cell Biol. pmid:24120851
Kautharapu KB et al. Growth condition optimization for docosahexaenoic acid (DHA) production by Moritella marina MP-1. 2013 Appl. Microbiol. Biotechnol. pmid:23111600
Nozue T et al. Effects of statins on serum n-3 to n-6 polyunsaturated fatty acid ratios in patients with coronary artery disease. 2013 J. Cardiovasc. Pharmacol. Ther. pmid:23324995
Méndez L et al. Reduced protein oxidation in Wistar rats supplemented with marine ω3 PUFAs. 2013 Free Radic. Biol. Med. pmid:23159545
Cooke M et al. Expression and function of OXE receptor, an eicosanoid receptor, in steroidogenic cells. 2013 Mol. Cell. Endocrinol. pmid:23159987
Al-Hilal M et al. Genetic variation at the FADS1-FADS2 gene locus influences delta-5 desaturase activity and LC-PUFA proportions after fish oil supplement. 2013 J. Lipid Res. pmid:23160180
Larson MK et al. Exogenous modification of platelet membranes with the omega-3 fatty acids EPA and DHA reduces platelet procoagulant activity and thrombus formation. 2013 Am. J. Physiol., Cell Physiol. pmid:23174566
Mussi SV et al. New approach to improve encapsulation and antitumor activity of doxorubicin loaded in solid lipid nanoparticles. 2013 Eur J Pharm Sci pmid:23178339
Cao AH et al. Composition of long chain polyunsaturated fatty acids (LC-PUFAs) in different encephalic regions and its association with behavior in spontaneous hypertensive rat (SHR). 2013 Brain Res. pmid:23811335
Klingler M et al. Comparison of the incorporation of orally administered DHA into plasma, erythrocyte and cheek cell glycerophospholipids. 2013 Br. J. Nutr. pmid:22874641
Tu WC et al. Dietary alpha-linolenic acid does not enhance accumulation of omega-3 long-chain polyunsaturated fatty acids in barramundi (Lates calcarifer). 2013 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:23085323
Paschoal VA et al. Eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid differentially modulate rat neutrophil function in vitro. 2013 Lipids pmid:23086551
Cedernaes J et al. Adipose tissue stearoyl-CoA desaturase 1 index is increased and linoleic acid is decreased in obesity-prone rats fed a high-fat diet. 2013 Lipids Health Dis pmid:23298201
Lagarde M et al. Dose-effect and metabolism of docosahexaenoic acid: pathophysiological relevance in blood platelets. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22520055
Hong WK et al. Production of lipids containing high levels of docosahexaenoic acid from empty palm fruit bunches by Aurantiochytrium sp. KRS101. 2013 Bioprocess Biosyst Eng pmid:23053417
Hjorth E et al. Omega-3 fatty acids enhance phagocytosis of Alzheimer's disease-related amyloid-β42 by human microglia and decrease inflammatory markers. 2013 J. Alzheimers Dis. pmid:23481688
Gustafson KM et al. Effects of docosahexaenoic acid supplementation during pregnancy on fetal heart rate and variability: a randomized clinical trial. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23433688
Lohner S et al. Gender differences in the long-chain polyunsaturated fatty acid status: systematic review of 51 publications. 2013 Ann. Nutr. Metab. pmid:23327902
Kondo T et al. Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness. 2013 Cell Stem Cell pmid:23434393
MacIntosh BA et al. Low-n-6 and low-n-6 plus high-n-3 diets for use in clinical research. 2013 Br. J. Nutr. pmid:23328113
García-Layana A et al. Effects of lutein and docosahexaenoic Acid supplementation on macular pigment optical density in a randomized controlled trial. 2013 Nutrients pmid:23434908
Williams JJ et al. N-3 fatty acid rich triglyceride emulsions are neuroprotective after cerebral hypoxic-ischemic injury in neonatal mice. 2013 PLoS ONE pmid:23437099
Kamolrat T and Gray SR The effect of eicosapentaenoic and docosahexaenoic acid on protein synthesis and breakdown in murine C2C12 myotubes. 2013 Biochem. Biophys. Res. Commun. pmid:23438435
Cieslik M et al. Docosahexaenoic acid and tetracyclines as promising neuroprotective compounds with poly(ADP-ribose) polymerase inhibitory activities for oxidative/genotoxic stress treatment. 2013 Neurochem. Int. pmid:23439385
Carey AN et al. The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells. 2013 Nutr Neurosci pmid:23321679
Usami M et al. Analysis of fecal microbiota, organic acids and plasma lipids in hepatic cancer patients with or without liver cirrhosis. 2013 Clin Nutr pmid:23068014
Kimura AK and Kim HY Phosphatidylserine synthase 2: high efficiency for synthesizing phosphatidylserine containing docosahexaenoic acid. 2013 J. Lipid Res. pmid:23071296
Kang JX and Gleason ED Omega-3 Fatty acids and hippocampal neurogenesis in depression. 2013 CNS Neurol Disord Drug Targets pmid:23574158
Khaled M et al. Effects of resolvin D1 on cell survival and cytokine expression of human gingival fibroblasts. 2013 J. Periodontol. pmid:23398023
Wu A et al. Exercise facilitates the action of dietary DHA on functional recovery after brain trauma. 2013 Neuroscience pmid:23811071
Pettit LK et al. Modulating the inflammatory properties of activated microglia with Docosahexaenoic acid and Aspirin. 2013 Lipids Health Dis pmid:23398903
Sugasini D and Lokesh BR Enhanced incorporation of docosahexaenoic acid in serum, heart, and brain of rats given microemulsions of fish oil. 2013 Mol. Cell. Biochem. pmid:23812902
Montes R et al. Fatty-acid composition of maternal and umbilical cord plasma and early childhood atopic eczema in a Spanish cohort. 2013 Eur J Clin Nutr pmid:23549201
Fukui M et al. EPA, an omega-3 fatty acid, induces apoptosis in human pancreatic cancer cells: role of ROS accumulation, caspase-8 activation, and autophagy induction. 2013 J. Cell. Biochem. pmid:22903547
Stark MJ et al. Differential effects of docosahexaenoic acid on preterm and term placental pro-oxidant/antioxidant balance. 2013 Reproduction pmid:23813449
Rupp TP et al. Replacement of reduced highly unsaturated fatty acids (HUFA deficiency) in dilative heart failure: dosage of EPA/DHA and variability of adverse peroxides and aldehydes in dietary supplement fish oils. 2013 Cardiology pmid:23816637
Tu WC et al. Correlations between blood and tissue omega-3 LCPUFA status following dietary ALA intervention in rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22521090
Wu Z et al. Reduction of histamine H1 receptor binding induced by high-fat diet can be prevented by DHA and dietary fiber in specific brain areas of male rats. 2013 Brain Res. Bull. pmid:23817050
Berman DR et al. Docosahexaenoic acid augments hypothermic neuroprotection in a neonatal rat asphyxia model. 2013 Neonatology pmid:23817197
Friedman AN et al. Fatty acids and other risk factors for sudden cardiac death in patients starting hemodialysis. 2013 Am. J. Nephrol. pmid:23816975
Zulyniak MA et al. Fish oil supplementation alters circulating eicosanoid concentrations in young healthy men. 2013 Metab. Clin. Exp. pmid:23522836
Qadhi R et al. Differential responses to docosahexaenoic acid in primary and immortalized cardiac cells. 2013 Toxicol. Lett. pmid:23523905
Gódor-Kacsándi A et al. Developmental docosahexaenoic and arachidonic acid supplementation improves adult learning and increases resistance against excitotoxicity in the brain. 2013 Acta Physiol Hung pmid:23524180
Meijerink J et al. N-Acyl amines of docosahexaenoic acid and other n-3 polyunsatured fatty acids - from fishy endocannabinoids to potential leads. 2013 Br. J. Pharmacol. pmid:23088259
Simões T et al. Seasonal variation in proximate composition and fatty acid profile of grey triggerfish (Balistes capriscus) captured along the coast of Portugal. 2013 J. Food Sci. pmid:23551246
Guihéneuf F et al. Use of radiolabeled substrates to determine the desaturase and elongase activities involved in eicosapentaenoic acid and docosahexaenoic acid biosynthesis in the marine microalga Pavlova lutheri. 2013 Phytochemistry pmid:23528573
Devaraj S et al. Modulation of endothelial progenitor cell number and function with n-3 polyunsaturated fatty acids. 2013 Atherosclerosis pmid:23528830
Finlin BS et al. Regulation of thrombospondin-1 expression in alternatively activated macrophages and adipocytes: role of cellular cross talk and omega-3 fatty acids. 2013 J. Nutr. Biochem. pmid:23528972
Davidson MH Omega-3 fatty acids: new insights into the pharmacology and biology of docosahexaenoic acid, docosapentaenoic acid, and eicosapentaenoic acid. 2013 Curr. Opin. Lipidol. pmid:24184945
Wu JH et al. Plasma phospholipid omega-3 fatty acids and incidence of postoperative atrial fibrillation in the OPERA trial. 2013 J Am Heart Assoc pmid:24145742
Martins DA et al. Alternative sources of n-3 long-chain polyunsaturated fatty acids in marine microalgae. 2013 Mar Drugs pmid:23807546
Kagan ML et al. Acute appearance of fatty acids in human plasma--a comparative study between polar-lipid rich oil from the microalgae Nannochloropsis oculata and krill oil in healthy young males. 2013 Lipids Health Dis pmid:23855409
Lee HN and Surh YJ Resolvin D1-mediated NOX2 inactivation rescues macrophages undertaking efferocytosis from oxidative stress-induced apoptosis. 2013 Biochem. Pharmacol. pmid:23856291
Xie W et al. Resolvin D1 reduces deterioration of tight junction proteins by upregulating HO-1 in LPS-induced mice. 2013 Lab. Invest. pmid:23857007
Li Q et al. A comparative study: In vitro effects of EPA and DHA on immune functions of head-kidney macrophages isolated from large yellow croaker (Larmichthys crocea). 2013 Fish Shellfish Immunol. pmid:23859878
Mizia-Stec K et al. N-3 polyunsaturated fatty acids do not influence the efficacy of dual antiplatelet therapy in stable angina pectoris patients after percutaneous coronary intervention. 2013 Cardiol J pmid:24469870
Eickmeier O et al. Aspirin-triggered resolvin D1 reduces mucosal inflammation and promotes resolution in a murine model of acute lung injury. 2013 Mucosal Immunol pmid:22785226
Titova OE et al. Dietary intake of eicosapentaenoic and docosahexaenoic acids is linked to gray matter volume and cognitive function in elderly. 2013 Age (Dordr) pmid:22791395
Juman S et al. Effects of long-term oral administration of arachidonic acid and docosahexaenoic acid on the immune functions of young rats. 2013 Nutrients pmid:23760060
Klek S et al. Four-week parenteral nutrition using a third generation lipid emulsion (SMOFlipid)--a double-blind, randomised, multicentre study in adults. 2013 Clin Nutr pmid:22796064
Merendino N et al. Dietary ω -3 polyunsaturated fatty acid DHA: a potential adjuvant in the treatment of cancer. 2013 Biomed Res Int pmid:23762838
Hunina LM et al. [Effectiveness of use of omega-3 polyunsaturated fatty acids at physical loads]. 2013 Fiziol Zh pmid:23713352
Dangour AD et al. N-3 fatty acids and retinal function. 2013 Ophthalmology pmid:23714605
Qu L et al. Batch, fed-batch and repeated fed-batch fermentation processes of the marine thraustochytrid Schizochytrium sp. for producing docosahexaenoic acid. 2013 Bioprocess Biosyst Eng pmid:23673897
Schuchardt JP and Hahn A Bioavailability of long-chain omega-3 fatty acids. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23676322
Kitson AP et al. Treatment of ovariectomized rats with 17β-estradiol increases hepatic delta-6 desaturase enzyme expression and docosahexaenoic acid levels in hepatic and plasma phospholipids. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23764042
Gow RV et al. Omega-3 fatty acids are inversely related to callous and unemotional traits in adolescent boys with attention deficit hyperactivity disorder. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23664595
Ramprasath VR et al. Enhanced increase of omega-3 index in healthy individuals with response to 4-week n-3 fatty acid supplementation from krill oil versus fish oil. 2013 Lipids Health Dis pmid:24304605
Harris WS et al. Docosahexaenoic acid ethyl esters ineffective? 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23671065
Fecchio C et al. α-Synuclein oligomers induced by docosahexaenoic acid affect membrane integrity. 2013 PLoS ONE pmid:24312431
Trofimiuk E and Braszko JJ Concomitant docosahexaenoic acid administration ameliorates stress-induced cognitive impairment in rats. 2013 Physiol. Behav. pmid:23672853
Cheng R et al. Cloning and functional analysis of putative malonyl-CoA:acyl-carrier protein transacylase gene from the docosahexaenoic acid-producer Schizochytrium sp. TIO1101. 2013 World J. Microbiol. Biotechnol. pmid:23292648
Chen J et al. Docosahexaenoic acid (DHA) attenuated paraquat induced lung damage in mice. 2013 Inhal Toxicol pmid:23293968
Szklenar M et al. Eicosanoids and docosanoids in plasma and aorta of healthy and atherosclerotic rabbits. 2013 J. Vasc. Res. pmid:23969947
Opperman M and Benade S Analysis of the omega-3 fatty acid content of South African fish oil supplements: a follow-up study. 2013 Cardiovasc J Afr pmid:24240381
Dabkowski ER et al. Docosahexaenoic acid supplementation alters key properties of cardiac mitochondria and modestly attenuates development of left ventricular dysfunction in pressure overload-induced heart failure. 2013 Cardiovasc Drugs Ther pmid:24013804
Porta A et al. Biology and chemistry of neuroprostanes. First total synthesis of 17-A4-NeuroP: validation of a convergent strategy to a number of cyclopentenone neuroprostanes. 2013 Chem. Phys. Lipids pmid:23895793
Costa S et al. The emerging farmed fish species meagre (Argyrosomus regius): how culinary treatment affects nutrients and contaminants concentration and associated benefit-risk balance. 2013 Food Chem. Toxicol. pmid:23900006
Akiyama M et al. Impact of docosahexaenoic acid on gene expression during osteoclastogenesis in vitro--a comprehensive analysis. 2013 Nutrients pmid:23945674
Rosa A et al. Potential anti-tumor effects of Mugil cephalus processed roe extracts on colon cancer cells. 2013 Food Chem. Toxicol. pmid:23948356
Gibson RA et al. Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22515943
Yee LD et al. The inhibition of early stages of HER-2/neu-mediated mammary carcinogenesis by dietary n-3 PUFAs. 2013 Mol Nutr Food Res pmid:23213007
Kilpinen L et al. Aging bone marrow mesenchymal stromal cells have altered membrane glycerophospholipid composition and functionality. 2013 J. Lipid Res. pmid:23271708
Takkunen M et al. Dietary fat in relation to erythrocyte fatty acid composition in men. 2013 Lipids pmid:23975575
Storck Lindholm E et al. Different fatty acid pattern in breast milk of obese compared to normal-weight mothers. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23273824
Qu L et al. Biomass composition, lipid characterization, and metabolic profile analysis of the fed-batch fermentation process of two different docosahexanoic acid producing Schizochytrium sp. strains. 2013 Appl. Biochem. Biotechnol. pmid:24061873
Spite M Deciphering the role of n-3 polyunsaturated fatty acid-derived lipid mediators in health and disease. 2013 Proc Nutr Soc pmid:23991833
Becerir C et al. The protective effect of docosahexaenoic acid on the bilirubin neurotoxicity. 2013 J Enzyme Inhib Med Chem pmid:22591320
Siddiqui RA et al. Characterization of synergistic anti-cancer effects of docosahexaenoic acid and curcumin on DMBA-induced mammary tumorigenesis in mice. 2013 BMC Cancer pmid:24034496
Borghetti G et al. Tumor growth reduction is regulated at the gene level in Walker 256 tumor-bearing rats supplemented with fish oil rich in EPA and DHA. 2013 Braz. J. Med. Biol. Res. pmid:24036940
Innis SM et al. Long chain omega-3 fatty acids: micronutrients in disguise. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22709913