DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

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Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

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What functions are associated with DHA?


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What lipids are associated with DHA?

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What genes are associated with DHA?

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What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with DHA

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Authors Title Published Journal PubMed Link
Nasiri AH et al. Combined effect of DHA and α-tocopherol supplementation during bull semen cryopreservation on sperm characteristics and fatty acid composition. 2012 Andrologia pmid:21951061
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Lin DC et al. Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor. 2012 Mol. Pharmacol. pmid:22859723
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Mitchell DC et al. Quantifying the differential effects of DHA and DPA on the early events in visual signal transduction. 2012 Chem. Phys. Lipids pmid:22405878
Stough C et al. The effects of 90-day supplementation with the omega-3 essential fatty acid docosahexaenoic acid (DHA) on cognitive function and visual acuity in a healthy aging population. 2012 Neurobiol. Aging pmid:21531481
Hughes BH et al. Oxidative stability and consumer acceptance of fish oil fortified nutrition bars. 2012 J. Food Sci. pmid:22957916
Gruber JF et al. Associations between toenail arsenic concentration and dietary factors in a New Hampshire population. 2012 Nutr J pmid:22747713
Sirot V et al. A restricted cubic spline approach to assess the association between high fat fish intake and red blood cell EPA + DHA content. 2012 Nutr Metab Cardiovasc Dis pmid:20875947
Moon HJ et al. Positive correlation between erythrocyte levels of n-3 polyunsaturated fatty acids and bone mass in postmenopausal Korean women with osteoporosis. 2012 Ann. Nutr. Metab. pmid:22507833
Meldrum SJ et al. Determinants of DHA levels in early infancy: differential effects of breast milk and direct fish oil supplementation. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22572105
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Jacobson TA et al. Effects of eicosapentaenoic acid and docosahexaenoic acid on low-density lipoprotein cholesterol and other lipids: a review. 2012 Jan-Feb J Clin Lipidol pmid:22264569
Widgerow AD Cellular resolution of inflammation--catabasis. 2012 Jan-Feb Wound Repair Regen pmid:22276585
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Brenna T Tissue-specific LCPUFA accretion in fetal humans. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22078006
Helmersson-Karlqvist J et al. Enhanced prostaglandin F2α formation in human pregnancy and the effect of increased oily fish intake: results from the Salmon in Pregnancy Study. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22047909
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Ma L et al. Arginyl-glutamine dipeptide or docosahexaenoic acid attenuate hyperoxia-induced lung injury in neonatal mice. 2012 Nov-Dec Nutrition pmid:23044165
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Block RC et al. The combination of EPA+DHA and low-dose aspirin ingestion reduces platelet function acutely whereas each alone may not in healthy humans. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:23017325
Kartikasari LR et al. Dietary alpha-linolenic acid enhances omega-3 long chain polyunsaturated fatty acid levels in chicken tissues. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:22925778
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Mustafa M et al. Resolvin D1 protects periodontal ligament. 2013 Am. J. Physiol., Cell Physiol. pmid:23864609
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Milic I et al. Simultaneous detection of low and high molecular weight carbonylated compounds derived from lipid peroxidation by electrospray ionization-tandem mass spectrometry. 2013 Anal. Chem. pmid:23186270
Mizwicki MT et al. 1α,25-dihydroxyvitamin D3 and resolvin D1 retune the balance between amyloid-β phagocytosis and inflammation in Alzheimer's disease patients. 2013 J. Alzheimers Dis. pmid:23186989
Carlson SJ et al. The role of the ω-3 fatty acid DHA in the human life cycle. 2013 JPEN J Parenter Enteral Nutr pmid:23192455
Fiol-deRoque MA et al. Cognitive recovery and restoration of cell proliferation in the dentate gyrus in the 5XFAD transgenic mice model of Alzheimer's disease following 2-hydroxy-DHA treatment. 2013 Biogerontology pmid:24114505
Olson MV et al. Docosahexaenoic acid reduces inflammation and joint destruction in mice with collagen-induced arthritis. 2013 Inflamm. Res. pmid:24008816
Sato SB et al. Inhibition of constitutive Akt (PKB) phosphorylation by docosahexaenoic acid in the human breast cancer cell line MDA-MB-453. 2013 Biochim. Biophys. Acta pmid:23085420
Marze S et al. In vitro digestion of fish oils rich in n-3 polyunsaturated fatty acids studied in emulsion and at the oil-water interface. 2013 Food Funct pmid:23086175
Metherel AH et al. Butylated hydroxytoluene can protect polyunsaturated fatty acids in dried blood spots from degradation for up to 8 weeks at room temperature. 2013 Lipids Health Dis pmid:23425563
Isosapent ethyl (Vascepa) for severe hypertriglyceridemia. 2013 Med Lett Drugs Ther pmid:23836343
Carlson SE et al. DHA supplementation and pregnancy outcomes. 2013 Am. J. Clin. Nutr. pmid:23426033
Cartiff SE et al. Eicosapentaenoic and docosahexaenoic acids increase insulin sensitivity in growing steers. 2013 J. Anim. Sci. pmid:23463554
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Raatz SK et al. Dose-dependent consumption of farmed Atlantic salmon (Salmo salar) increases plasma phospholipid n-3 fatty acids differentially. 2013 J Acad Nutr Diet pmid:23351633
Goustard-Langelier B et al. Rat neural stem cell proliferation and differentiation are durably altered by the in utero polyunsaturated fatty acid supply. 2013 J. Nutr. Biochem. pmid:23036607
Usami M et al. Analysis of fecal microbiota, organic acids and plasma lipids in hepatic cancer patients with or without liver cirrhosis. 2013 Clin Nutr pmid:23068014
Harris WS et al. Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: observations from 160,000 patients. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23375840
Cardenia V et al. Health-related lipids components of sardine muscle as affected by photooxidation. 2013 Food Chem. Toxicol. pmid:23500769
Dalli J et al. The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype. 2013 FASEB J. pmid:23504711
Arem H et al. Omega-3 and omega-6 fatty acid intakes and endometrial cancer risk in a population-based case-control study. 2013 Eur J Nutr pmid:22915050
Mickleborough TD Omega-3 polyunsaturated fatty acids in physical performance optimization. 2013 Int J Sport Nutr Exerc Metab pmid:23400626
Minihane AM Fish oil omega-3 fatty acids and cardio-metabolic health, alone or with statins. 2013 Eur J Clin Nutr pmid:23403872
Saha SS and Ghosh M Protective effect of conjugated linolenic acid isomers present in vegetable oils against arsenite-induced renal toxicity in rat model. 2013 Nutrition pmid:23422533
Rahman MM et al. DHA is a more potent inhibitor of breast cancer metastasis to bone and related osteolysis than EPA. 2013 Breast Cancer Res. Treat. pmid:24062211
Wijendran V et al. Dietary arachidonic acid and docosahexaenoic acid regulate liver fatty acid desaturase (FADS) alternative transcript expression in suckling piglets. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:24075244
Liu X et al. Oxidized fatty acid analysis by charge-switch derivatization, selected reaction monitoring, and accurate mass quantitation. 2013 Anal. Biochem. pmid:23850559
Khaled M et al. Effects of resolvin D1 on cell survival and cytokine expression of human gingival fibroblasts. 2013 J. Periodontol. pmid:23398023
Faxén-Irving G et al. Effects on transthyretin in plasma and cerebrospinal fluid by DHA-rich n - 3 fatty acid supplementation in patients with Alzheimer's disease: the OmegAD study. 2013 J. Alzheimers Dis. pmid:23563245
Gao F et al. Aging decreases rate of docosahexaenoic acid synthesis-secretion from circulating unesterified α-linolenic acid by rat liver. 2013 Age (Dordr) pmid:22388930
Arnold C et al. Macular xanthophylls and ω-3 long-chain polyunsaturated fatty acids in age-related macular degeneration: a randomized trial. 2013 JAMA Ophthalmol pmid:23519529
Xu MX et al. Resolvin D1, an endogenous lipid mediator for inactivation of inflammation-related signaling pathways in microglial cells, prevents lipopolysaccharide-induced inflammatory responses. 2013 CNS Neurosci Ther pmid:23521911
Guo B et al. Identification and heterologous expression of a Δ4-fatty acid desaturase gene from Isochrysis sphaerica. 2013 J. Microbiol. Biotechnol. pmid:23851273
Zulyniak MA et al. Fish oil supplementation alters circulating eicosanoid concentrations in young healthy men. 2013 Metab. Clin. Exp. pmid:23522836
Muldoon MF et al. Concurrent physical activity modifies the association between n3 long-chain fatty acids and cardiometabolic risk in midlife adults. 2013 J. Nutr. pmid:23884386
Watson AM et al. Taurine supplementation of plant derived protein and n-3 fatty acids are critical for optimal growth and development of cobia, Rachycentron canadum. 2013 Lipids pmid:23884630
Mocellin MC et al. Fish oil decreases C-reactive protein/albumin ratio improving nutritional prognosis and plasma fatty acid profile in colorectal cancer patients. 2013 Lipids pmid:23888317
Aslan M et al. LC-MS/MS analysis of plasma polyunsaturated fatty acids in type 2 diabetic patients after insulin analog initiation therapy. 2013 Lipids Health Dis pmid:24195588
Leino O et al. Effects of docosahexaenoic acid and methylmercury on child's brain development due to consumption of fish by Finnish mother during pregnancy: a probabilistic modeling approach. 2013 Food Chem. Toxicol. pmid:21723361
Morel PC et al. Effect of lipid type on growth performance, meat quality and the content of long chain n-3 fatty acids in pork meat. 2013 Meat Sci. pmid:23739265
Liu Y et al. Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge. 2013 J. Nutr. pmid:23739309
Parletta N et al. Effects of fish oil supplementation on learning and behaviour of children from Australian Indigenous remote community schools: a randomised controlled trial. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23756346
Sala-Vila A et al. Eicosapentaenoic acid in serum phospholipids relates to a less atherogenic lipoprotein profile in subjects with familial hypercholesterolemia. 2013 J. Nutr. Biochem. pmid:23618530
Shida T et al. Colonic delivery of docosahexaenoic acid improves impaired glucose tolerance via GLP-1 secretion and suppresses pancreatic islet hyperplasia in diabetic KK-A(y) mice. 2013 Int J Pharm pmid:23618969
Berger H et al. SOCS3 transactivation by PPARγ prevents IL-17-driven cancer growth. 2013 Cancer Res. pmid:23619236
Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. 2013 JAMA pmid:23644932
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Ravacci GR et al. Lipid raft disruption by docosahexaenoic acid induces apoptosis in transformed human mammary luminal epithelial cells harboring HER-2 overexpression. 2013 J. Nutr. Biochem. pmid:22749134
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Hashimoto M et al. Prescription n-3 fatty acids, but not eicosapentaenoic acid alone, improve reference memory-related learning ability by increasing brain-derived neurotrophic factor levels in SHR.Cg-Lepr(cp)/NDmcr rats, a metabolic syndrome model. 2013 Neurochem. Res. pmid:23963508
Tabbaa M et al. Docosahexaenoic acid, inflammation, and bacterial dysbiosis in relation to periodontal disease, inflammatory bowel disease, and the metabolic syndrome. 2013 Nutrients pmid:23966110
Szklenar M et al. Eicosanoids and docosanoids in plasma and aorta of healthy and atherosclerotic rabbits. 2013 J. Vasc. Res. pmid:23969947
O'Sullivan BP et al. Evolution of pancreatic function during the first year in infants with cystic fibrosis. 2013 J. Pediatr. pmid:23245194
Rincón Cervera MÁ et al. Acyl migration evaluation in monoacylglycerols from Echium plantagineum seed oil and Marinol. 2013 J. Biosci. Bioeng. pmid:23287502
Köhnke T et al. Acetylsalicylic Acid reduces the severity of dextran sodium sulfate-induced colitis and increases the formation of anti-inflammatory lipid mediators. 2013 Biomed Res Int pmid:24083240
Lluís L et al. Protective effect of the omega-3 polyunsaturated fatty acids: Eicosapentaenoic acid/Docosahexaenoic acid 1:1 ratio on cardiovascular disease risk markers in rats. 2013 Lipids Health Dis pmid:24083393
Nikolakopoulou Z et al. Omega-3 polyunsaturated fatty acids selectively inhibit growth in neoplastic oral keratinocytes by differentially activating ERK1/2. 2013 Carcinogenesis pmid:23892603
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Kenchegowda S et al. Involvement of pigment epithelium-derived factor, docosahexaenoic acid and neuroprotectin D1 in corneal inflammation and nerve integrity after refractive surgery. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22579364
Delplanque B et al. A dairy fat matrix providing alpha-linolenic acid (ALA) is better than a vegetable fat mixture to increase brain DHA accretion in young rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22884780
Gupta A et al. Pollen baiting facilitates the isolation of marine thraustochytrids with potential in omega-3 and biodiesel production. 2013 J. Ind. Microbiol. Biotechnol. pmid:23990167
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Li Y et al. Plasticity of leukocytic exudates in resolving acute inflammation is regulated by MicroRNA and proresolving mediators. 2013 Immunity pmid:24238341