DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Polycystic Kidney Diseases D007690 12 associated lipids
Intracranial Hemorrhages D020300 2 associated lipids
Intermittent Claudication D007383 6 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Depression, Postpartum D019052 3 associated lipids
Dyskinesias D020820 3 associated lipids
Dysbiosis D064806 2 associated lipids
Glaucoma, Open-Angle D005902 3 associated lipids
Milk Hypersensitivity D016269 4 associated lipids
Dementia, Vascular D015140 7 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Mori TA Dietary n-3 PUFA and CVD: a review of the evidence. 2014 Proc Nutr Soc pmid:24119287
Hua J et al. The resolvin D1 analogue controls maturation of dendritic cells and suppresses alloimmunity in corneal transplantation. 2014 Invest. Ophthalmol. Vis. Sci. pmid:25146982
Navarro-Guillén C et al. Effect of varying dietary levels of LC-PUFA and vegetable oil sources on performance and fatty acids of Senegalese sole post larvae: puzzling results suggest complete biosynthesis pathway from C18 PUFA to DHA. 2014 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:24120522
Fedorova-Dahms I et al. A 3-week dietary bioequivalence study in preweaning farm piglets of two sources of docosahexaenoic acid produced from two different organisms. 2014 Food Chem. Toxicol. pmid:24333867
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Amiano P et al. Intake of total omega-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid and risk of coronary heart disease in the Spanish EPIC cohort study. 2014 Nutr Metab Cardiovasc Dis pmid:24360762
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Currais A et al. Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice. 2014 Aging Cell pmid:24341874
Jilkova ZM et al. Adipose tissue-related proteins locally associated with resolution of inflammation in obese mice. 2014 Int J Obes (Lond) pmid:23756677
De Mel D and Suphioglu C Fishy business: effect of omega-3 fatty acids on zinc transporters and free zinc availability in human neuronal cells. 2014 Nutrients pmid:25195602
Keelan JA Letter to the editor: "fatty acids and placental transport: insight or in vitro artifact?". 2014 Am. J. Physiol., Cell Physiol. pmid:25452382
Hiram R et al. Resolvin D1 reverses reactivity and Ca2+ sensitivity induced by ET-1, TNF-α, and IL-6 in the human pulmonary artery. 2014 Am. J. Physiol. Heart Circ. Physiol. pmid:25281570
Zhu G et al. Enhanced production of docosahexaenoic acid in mammalian cells. 2014 PLoS ONE pmid:24788769
Martin CR et al. Resolvin D1 and lipoxin A4 improve alveolarization and normalize septal wall thickness in a neonatal murine model of hyperoxia-induced lung injury. 2014 PLoS ONE pmid:24892762
Makrides M et al. Four-year follow-up of children born to women in a randomized trial of prenatal DHA supplementation. 2014 JAMA pmid:24794375
Jung JY et al. Effect of dietary supplementation with omega-3 fatty acid and gamma-linolenic acid on acne vulgaris: a randomised, double-blind, controlled trial. 2014 Acta Derm. Venereol. pmid:24553997
Mirakaj V et al. Vagus nerve controls resolution and pro-resolving mediators of inflammation. 2014 J. Exp. Med. pmid:24863066
Chen R et al. [Effects of docosahexaenoic acid on hypoxia-induced pulmonary arterial hypertension]. 2014 Zhonghua Jie He He Hu Xi Za Zhi pmid:24796591
Ooi SY and Andrews JM Commentary: The association between high dietary intake of docosahexaenoic acid and reduced risk of Crohn's disease. 2014 Aliment. Pharmacol. Ther. pmid:24803245
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Betsholtz C Physiology: Double function at the blood-brain barrier. 2014 Nature pmid:24828036
Nguyen LN et al. Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. 2014 Nature pmid:24828044
Chua A et al. Effect of docosahexaenoic acid and furan fatty acids on cytokinesis block micronucleus cytome assay biomarkers in astrocytoma cell lines under conditions of oxidative stress. 2014 Environ. Mol. Mutagen. pmid:24828973
Hong S et al. Neuroprotectin/protectin D1: endogenous biosynthesis and actions on diabetic macrophages in promoting wound healing and innervation impaired by diabetes. 2014 Am. J. Physiol., Cell Physiol. pmid:25273880
Ma QL et al. Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging. 2014 J. Neurosci. pmid:24849348
McCauley LK et al. Cutting edge: Parathyroid hormone facilitates macrophage efferocytosis in bone marrow via proresolving mediators resolvin D1 and resolvin D2. 2014 J. Immunol. pmid:24890726
Serhan CN Pro-resolving lipid mediators are leads for resolution physiology. 2014 Nature pmid:24899309
Ramon S et al. The specialized proresolving mediator 17-HDHA enhances the antibody-mediated immune response against influenza virus: a new class of adjuvant? 2014 J. Immunol. pmid:25392529
Hughbanks-Wheaton DK et al. Safety assessment of docosahexaenoic acid in X-linked retinitis pigmentosa: the 4-year DHAX trial. 2014 Invest. Ophthalmol. Vis. Sci. pmid:25015354
Velten M et al. Maternal dietary docosahexaenoic acid supplementation attenuates fetal growth restriction and enhances pulmonary function in a newborn mouse model of perinatal inflammation. 2014 J. Nutr. pmid:24453131
Mereghetti P et al. A Fourier transform infrared spectroscopy study of cell membrane domain modifications induced by docosahexaenoic acid. 2014 Biochim. Biophys. Acta pmid:25018005
Lager S et al. Differential regulation of placental amino acid transport by saturated and unsaturated fatty acids. 2014 Am. J. Physiol., Cell Physiol. pmid:25143349
Chan SS et al. Association between high dietary intake of the n-3 polyunsaturated fatty acid docosahexaenoic acid and reduced risk of Crohn's disease. 2014 Aliment. Pharmacol. Ther. pmid:24611981
Aursnes M et al. Stereoselective synthesis of protectin D1: a potent anti-inflammatory and proresolving lipid mediator. 2014 Org. Biomol. Chem. pmid:24253202
Mussi SV et al. Novel nanostructured lipid carrier co-loaded with doxorubicin and docosahexaenoic acid demonstrates enhanced in vitro activity and overcomes drug resistance in MCF-7/Adr cells. 2014 Pharm. Res. pmid:24522814
Nishinaka T et al. Involvement of the long-chain fatty acid receptor GPR40 in depression-related behavior. 2014 J. Pharmacol. Sci. pmid:24758921
Torres M et al. Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease. 2014 Biochim. Biophys. Acta pmid:24374316
Liu X et al. Amide-type adduct of dopamine - plausible cause of Parkinson diseases. 2014 Subcell. Biochem. pmid:24374917
Nagao K et al. Comparison of the lipid-lowering effects of four different n-3 highly unsaturated fatty acids in HepG2 cells. 2014 J Oleo Sci pmid:25213447
De Felice C et al. Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome. 2014 Neurobiol. Dis. pmid:24769161
Sengupta A and Ghosh M Effect of sterol esters on lipid composition and antioxidant status of erythrocyte membrane of hypercholesterolemic rats. 2014 J Oleo Sci pmid:24770475
Nanjappa D et al. Oxylipin diversity in the diatom family Leptocylindraceae reveals DHA derivatives in marine diatoms. 2014 Mar Drugs pmid:24445306
Begum G et al. Docosahexaenoic acid reduces ER stress and abnormal protein accumulation and improves neuronal function following traumatic brain injury. 2014 J. Neurosci. pmid:24599472
Koppenol A et al. Effect of the ratio of dietary n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid on broiler breeder performance, egg quality, and yolk fatty acid composition at different breeder ages. 2014 Poult. Sci. pmid:24604849
Gil-Zamorano J et al. Docosahexaenoic acid modulates the enterocyte Caco-2 cell expression of microRNAs involved in lipid metabolism. 2014 J. Nutr. pmid:24623846
Buckley CD et al. Proresolving lipid mediators and mechanisms in the resolution of acute inflammation. 2014 Immunity pmid:24656045
Cui ZG et al. Molecular mechanisms of hyperthermia-induced apoptosis enhanced by docosahexaenoic acid: implication for cancer therapy. 2014 Chem. Biol. Interact. pmid:24661947
Adarme-Vega TC et al. Towards sustainable sources for omega-3 fatty acids production. 2014 Curr. Opin. Biotechnol. pmid:24607804
Aronow ME and Chew EY Age-related Eye Disease Study 2: perspectives, recommendations, and unanswered questions. 2014 Curr Opin Ophthalmol pmid:24614146
Martorell M et al. Effect of DHA on plasma fatty acid availability and oxidative stress during training season and football exercise. 2014 Food Funct pmid:24955731
Kitessa SM et al. DHA-containing oilseed: a timely solution for the sustainability issues surrounding fish oil sources of the health-benefitting long-chain omega-3 oils. 2014 Nutrients pmid:24858407
Levy BD and Serhan CN Resolution of acute inflammation in the lung. 2014 Annu. Rev. Physiol. pmid:24313723
Dendelé B et al. Protective action of n-3 fatty acids on benzo[a]pyrene-induced apoptosis through the plasma membrane remodeling-dependent NHE1 pathway. 2014 Chem. Biol. Interact. pmid:24246761
Murali G et al. Differential effects of eicosapentaenoic acid and docosahexaenoic acid in promoting the differentiation of 3T3-L1 preadipocytes. 2014 Prostaglandins Leukot. Essent. Fatty Acids pmid:24332315
Walhovd KB et al. Blood markers of fatty acids and vitamin D, cardiovascular measures, body mass index, and physical activity relate to longitudinal cortical thinning in normal aging. 2014 Neurobiol. Aging pmid:24332985
Eto M et al. A novel lysophosphatidic acid acyltransferase enzyme (LPAAT4) with a possible role for incorporating docosahexaenoic acid into brain glycerophospholipids. 2014 Biochem. Biophys. Res. Commun. pmid:24333445
Nelson JW et al. ALX/FPR2 receptor for RvD1 is expressed and functional in salivary glands. 2014 Am. J. Physiol., Cell Physiol. pmid:24259417
O'Sullivan A et al. Habitual diets rich in dark-green vegetables are associated with an increased response to ω-3 fatty acid supplementation in Americans of African ancestry. 2014 J. Nutr. pmid:24259553
Zanfini A et al. GC-EI-MS analysis of fatty acid composition in brain and serum of twitcher mouse. 2014 Lipids pmid:25208498
Sertoglu E et al. Comparison of plasma and erythrocyte membrane fatty acid compositions in patients with end-stage renal disease and type 2 diabetes mellitus. 2014 Chem. Phys. Lipids pmid:24384240
Stoffel W et al. Obesity resistance and deregulation of lipogenesis in Δ6-fatty acid desaturase (FADS2) deficiency. 2014 EMBO Rep. pmid:24378641
Hong S et al. Maresin-like lipid mediators are produced by leukocytes and platelets and rescue reparative function of diabetes-impaired macrophages. 2014 Chem. Biol. pmid:25200603
Jiang M et al. Isolation and characterization of the diatom Phaeodactylum Δ5-elongase gene for transgenic LC-PUFA production in Pichia pastoris. 2014 Mar Drugs pmid:24608969
Luxwolda MF et al. Interrelationships between maternal DHA in erythrocytes, milk and adipose tissue. Is 1 wt% DHA the optimal human milk content? Data from four Tanzanian tribes differing in lifetime stable intakes of fish. 2014 Br. J. Nutr. pmid:24175990
Gladine C et al. Lipid profiling following intake of the omega 3 fatty acid DHA identifies the peroxidized metabolites F4-neuroprostanes as the best predictors of atherosclerosis prevention. 2014 PLoS ONE pmid:24558496
Ponnampalam EN et al. Sources of variation of health claimable long chain omega-3 fatty acids in meat from Australian lamb slaughtered at similar weights. 2014 Meat Sci. pmid:23265412
Hixson SM et al. Changes in tissue lipid and fatty acid composition of farmed rainbow trout in response to dietary camelina oil as a replacement of fish oil. 2014 Lipids pmid:24264359
Chen F et al. Resolvin D1 improves survival in experimental sepsis through reducing bacterial load and preventing excessive activation of inflammatory response. 2014 Eur. J. Clin. Microbiol. Infect. Dis. pmid:24072678
Park J et al. Reciprocal modulation of surface expression of annexin A2 in a human umbilical vein endothelial cell-derived cell line by eicosapentaenoic acid and docosahexaenoic acid. 2014 PLoS ONE pmid:24465474
Eady TN et al. Docosahexaenoic acid complexed to albumin provides neuroprotection after experimental stroke in aged rats. 2014 Neurobiol. Dis. pmid:24063996
Hernández E et al. Prenatal determinants of cord blood total immunoglobulin E levels in Mexican newborns. 2013 Sep-Oct Allergy Asthma Proc pmid:23998234
Harris WS et al. Comparative effects of an acute dose of fish oil on omega-3 fatty acid levels in red blood cells versus plasma: implications for clinical utility. 2013 Sep-Oct J Clin Lipidol pmid:24079284
Tatsuno I et al. Long-term safety and efficacy of TAK-085 in Japanese subjects with hypertriglyceridemia undergoing lifestyle modification: the omega-3 fatty acids randomized long-term (ORL) study. 2013 Nov-Dec J Clin Lipidol pmid:24314359
Igarashi M et al. Kinetics of eicosapentaenoic acid in brain, heart and liver of conscious rats fed a high n-3 PUFA containing diet. 2013 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:24209500
Fenton JI et al. Immunomodulation by dietary long chain omega-3 fatty acids and the potential for adverse health outcomes. 2013 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:24183073
Docosahexaenoic and arachidonic acid levels in ELBW infants with prolonged exposure to intravenous lipids. 2013 May-Jun Neonatal Netw pmid:23807965
Tatsuno I et al. Efficacy and safety of TAK-085 compared with eicosapentaenoic acid in Japanese subjects with hypertriglyceridemia undergoing lifestyle modification: the omega-3 fatty acids randomized double-blind (ORD) study. 2013 May-Jun J Clin Lipidol pmid:23725919
Nishimura RY et al. Breast milk fatty acid composition of women living far from the coastal area in Brazil. 2013 May-Jun J Pediatr (Rio J) pmid:23669215
Zajdel A et al. Polyunsaturated fatty acids inhibit melanoma cell growth in vitro. 2013 Mar-Apr Acta Pol Pharm pmid:23614295
Bohr S et al. Resolvin D2 prevents secondary thrombosis and necrosis in a mouse burn wound model. 2013 Jan-Feb Wound Repair Regen pmid:23110665
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Teague H et al. Dendritic cell activation, phagocytosis and CD69 expression on cognate T cells are suppressed by n-3 long-chain polyunsaturated fatty acids. 2013 Immunology pmid:23373457
Renganathan K et al. CEP biomarkers as potential tools for monitoring therapeutics. 2013 PLoS ONE pmid:24098476
Herba CM et al. Breastfeeding and early brain development: the Generation R study. 2013 Matern Child Nutr pmid:23167730
Dallaire R et al. Exposure to organochlorines and mercury through fish and marine mammal consumption: associations with growth and duration of gestation among Inuit newborns. 2013 Environ Int pmid:23422685
Nordgren TM et al. Maresin-1 reduces the pro-inflammatory response of bronchial epithelial cells to organic dust. 2013 Respir. Res. pmid:23663457
McNamara RK et al. Lower docosahexaenoic acid concentrations in the postmortem prefrontal cortex of adult depressed suicide victims compared with controls without cardiovascular disease. 2013 J Psychiatr Res pmid:23759469
Gladyshev MI et al. Production of EPA and DHA in aquatic ecosystems and their transfer to the land. 2013 Prostaglandins Other Lipid Mediat. pmid:23500063
Zhuang W et al. Omega-3 polyunsaturated fatty acids reduce vascular endothelial growth factor production and suppress endothelial wound repair. 2013 J Cardiovasc Transl Res pmid:22993129
Romero VC et al. Developmental programming for allergy: a secondary analysis of the Mothers, Omega-3, and Mental Health Study. 2013 Am. J. Obstet. Gynecol. pmid:23531329
Tapsell LC et al. Foods, nutrients or whole diets: effects of targeting fish and LCn3PUFA consumption in a 12mo weight loss trial. 2013 BMC Public Health pmid:24369765
Markhus MW et al. Low omega-3 index in pregnancy is a possible biological risk factor for postpartum depression. 2013 PLoS ONE pmid:23844041
Cortina MS et al. Neuroprotectin D1 restores corneal nerve integrity and function after damage from experimental surgery. 2013 Invest. Ophthalmol. Vis. Sci. pmid:23702780
Li C et al. High efficient treatment of citric acid effluent by Chlorella vulgaris and potential biomass utilization. 2013 Bioresour. Technol. pmid:23131649
Nicholson T et al. The role of marine n-3 fatty acids in improving cardiovascular health: a review. 2013 Food Funct pmid:23325431
Santos VC et al. Effects of DHA-rich fish oil supplementation on lymphocyte function before and after a marathon race. 2013 Int J Sport Nutr Exerc Metab pmid:23239683
Mühlroth A et al. Pathways of lipid metabolism in marine algae, co-expression network, bottlenecks and candidate genes for enhanced production of EPA and DHA in species of Chromista. 2013 Mar Drugs pmid:24284429
Alicandro G et al. A randomized placebo-controlled study on high-dose oral algal docosahexaenoic acid supplementation in children with cystic fibrosis. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23266209
Delplanque B et al. A dairy fat matrix providing alpha-linolenic acid (ALA) is better than a vegetable fat mixture to increase brain DHA accretion in young rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22884780