| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Li L et al. | Resolvin D1 promotes the interleukin-4-induced alternative activation in BV-2 microglial cells. | 2014 | J Neuroinflammation | pmid:24708771 |
| Chatterjee A et al. | The pro-resolving lipid mediator maresin 1 (MaR1) attenuates inflammatory signaling pathways in vascular smooth muscle and endothelial cells. | 2014 | PLoS ONE | pmid:25409514 |
| Abe E et al. | Novel lysophospholipid acyltransferase PLAT1 of Aurantiochytrium limacinum F26-b responsible for generation of palmitate-docosahexaenoate-phosphatidylcholine and phosphatidylethanolamine. | 2014 | PLoS ONE | pmid:25090090 |
| Lane K et al. | Bioavailability and potential uses of vegetarian sources of omega-3 fatty acids: a review of the literature. | 2014 | Crit Rev Food Sci Nutr | pmid:24261532 |
| Steffens JP et al. | Testosterone regulates bone response to inflammation. | 2014 | Horm. Metab. Res. | pmid:24526374 |
| Maffei S et al. | Effects of ω-3 PUFAs supplementation on myocardial function and oxidative stress markers in typical Rett syndrome. | 2014 | Mediators Inflamm. | pmid:24526821 |
| Saito H and Ishikawa S | Lipid classes and fatty acid profile of cultured and wild black rockfish, Sebastes schlegeli. | 2014 | J Oleo Sci | pmid:24829130 |
| Leigh NJ et al. | Expression of resolvin D1 biosynthetic pathways in salivary epithelium. | 2014 | J. Dent. Res. | pmid:24389810 |
| Nakagawa F et al. | 4-Hydroxy hexenal derived from dietary n-3 polyunsaturated fatty acids induces anti-oxidative enzyme heme oxygenase-1 in multiple organs. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24361890 |
| Saito H | Lipid characteristics of five epinephelinae fishes, Epinephelus fasciatus, Epinephelus retouti, Cephalopholis aurantia, Cephalopholis miniatus, and Variola louti, in the Coral Reef. | 2014 | J Oleo Sci | pmid:24717545 |
| Russell CD and Schwarze J | The role of pro-resolution lipid mediators in infectious disease. | 2014 | Immunology | pmid:24400794 |
| AlSaleh A et al. | Interaction between a CSK gene variant and fish oil intake influences blood pressure in healthy adults. | 2014 | J. Nutr. | pmid:24401815 |
| Paterniti I et al. | Docosahexaenoic acid attenuates the early inflammatory response following spinal cord injury in mice: in-vivo and in-vitro studies. | 2014 | J Neuroinflammation | pmid:24405628 |
| Wang JL et al. | Preparation and characterization of novel lipid carriers containing microalgae oil for food applications. | 2014 | J. Food Sci. | pmid:24446860 |
| Wu A et al. | Dietary strategy to repair plasma membrane after brain trauma: implications for plasticity and cognition. | 2014 | Neurorehabil Neural Repair | pmid:23911971 |
| Ganesan B et al. | Fortification of foods with omega-3 polyunsaturated fatty acids. | 2014 | Crit Rev Food Sci Nutr | pmid:24188235 |
| Chang G et al. | The relationship of oxygen uptake rate and k(L)a with rheological properties in high cell density cultivation of docosahexaenoic acid by Schizochytrium sp. S31. | 2014 | Bioresour. Technol. | pmid:24292203 |
| Ponnampalam EN et al. | Sources of variation of health claimable long chain omega-3 fatty acids in meat from Australian lamb slaughtered at similar weights. | 2014 | Meat Sci. | pmid:23265412 |
| Liu L et al. | Higher efficacy of dietary DHA provided as a phospholipid than as a triglyceride for brain DHA accretion in neonatal piglets. | 2014 | J. Lipid Res. | pmid:24470588 |
| de Waal H et al. | The effect of souvenaid on functional brain network organisation in patients with mild Alzheimer's disease: a randomised controlled study. | 2014 | PLoS ONE | pmid:24475144 |
| Desai A et al. | Depletion of brain docosahexaenoic acid impairs recovery from traumatic brain injury. | 2014 | PLoS ONE | pmid:24475126 |
| Hernández E et al. | Prenatal determinants of cord blood total immunoglobulin E levels in Mexican newborns. | 2013 Sep-Oct | Allergy Asthma Proc | pmid:23998234 |
| Harris WS et al. | Comparative effects of an acute dose of fish oil on omega-3 fatty acid levels in red blood cells versus plasma: implications for clinical utility. | 2013 Sep-Oct | J Clin Lipidol | pmid:24079284 |
| Tatsuno I et al. | Long-term safety and efficacy of TAK-085 in Japanese subjects with hypertriglyceridemia undergoing lifestyle modification: the omega-3 fatty acids randomized long-term (ORL) study. | 2013 Nov-Dec | J Clin Lipidol | pmid:24314359 |
| Igarashi M et al. | Kinetics of eicosapentaenoic acid in brain, heart and liver of conscious rats fed a high n-3 PUFA containing diet. | 2013 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24209500 |
| Fenton JI et al. | Immunomodulation by dietary long chain omega-3 fatty acids and the potential for adverse health outcomes. | 2013 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24183073 |
| Docosahexaenoic and arachidonic acid levels in ELBW infants with prolonged exposure to intravenous lipids. | 2013 May-Jun | Neonatal Netw | pmid:23807965 | |
| Tatsuno I et al. | Efficacy and safety of TAK-085 compared with eicosapentaenoic acid in Japanese subjects with hypertriglyceridemia undergoing lifestyle modification: the omega-3 fatty acids randomized double-blind (ORD) study. | 2013 May-Jun | J Clin Lipidol | pmid:23725919 |
| Nishimura RY et al. | Breast milk fatty acid composition of women living far from the coastal area in Brazil. | 2013 May-Jun | J Pediatr (Rio J) | pmid:23669215 |
| Zajdel A et al. | Polyunsaturated fatty acids inhibit melanoma cell growth in vitro. | 2013 Mar-Apr | Acta Pol Pharm | pmid:23614295 |
| Bohr S et al. | Resolvin D2 prevents secondary thrombosis and necrosis in a mouse burn wound model. | 2013 Jan-Feb | Wound Repair Regen | pmid:23110665 |
| Piñeiro-Corrales G et al. | [Role of omega-3 fatty acids in cardiovascular disease prevention]. | 2013 Jan-Feb | Nutr Hosp | pmid:23808424 |
| Lee HN et al. | Resolution of inflammation as a novel chemopreventive strategy. | 2013 | Semin Immunopathol | pmid:23370700 |
| Jansen D et al. | Effects of specific multi-nutrient enriched diets on cerebral metabolism, cognition and neuropathology in AβPPswe-PS1dE9 mice. | 2013 | PLoS ONE | pmid:24086523 |
| Stamey Lanier J et al. | Mammary uptake of fatty acids supplied by intravenous triacylglycerol infusion to lactating dairy cows. | 2013 | Lipids | pmid:23504269 |
| Meher AP et al. | Preconceptional omega-3 fatty acid supplementation on a micronutrient-deficient diet improves the reproductive cycle in Wistar rats. | 2013 | Reprod. Fertil. Dev. | pmid:23137932 |
| Betancor MB et al. | Oxidative status and histological changes in sea bass larvae muscle in response to high dietary content of docosahexaenoic acid DHA. | 2013 | J. Fish Dis. | pmid:23167568 |
| Gerstenblith AT et al. | Electroretinographic effects of omega-3 Fatty Acid supplementation on dry age-related macular degeneration. | 2013 | JAMA Ophthalmol | pmid:23494041 |
| Morais S et al. | Effect of Senegalese sole broodstock nutrition on early larval performance and metabolism of long-chain polyunsaturated fatty acids (DHA and EPA). | 2013 | Commun. Agric. Appl. Biol. Sci. | pmid:25141693 |
| Paz-Raymundo B et al. | Effect of DHA on the expression of the delta6-desaturase during larval development of yellow snapper, Lutjanus argentiventris. | 2013 | Commun. Agric. Appl. Biol. Sci. | pmid:25141709 |
| Ruiz-Lopez N et al. | Reconstitution of EPA and DHA biosynthesis in arabidopsis: iterative metabolic engineering for the synthesis of n-3 LC-PUFAs in transgenic plants. | 2013 | Metab. Eng. | pmid:23500000 |
| Aarak KE et al. | Release of EPA and DHA from salmon oil - a comparison of in vitro digestion with human and porcine gastrointestinal enzymes. | 2013 | Br. J. Nutr. | pmid:23510480 |
| Rahmawaty S et al. | Dietary intake and food sources of EPA, DPA and DHA in Australian children. | 2013 | Lipids | pmid:23881381 |
| Willatts P et al. | Effects of long-chain PUFA supplementation in infant formula on cognitive function in later childhood. | 2013 | Am. J. Clin. Nutr. | pmid:23783296 |
| Meyer BJ et al. | Improvement of major depression is associated with increased erythrocyte DHA. | 2013 | Lipids | pmid:23733443 |
| Hara M and Sakata Y | Polyunsaturated fatty acids in heart failure: reply. | 2013 | Circ. J. | pmid:23628916 |
| Gordon WC and Bazan NG | Mediator lipidomics in ophthalmology: targets for modulation in inflammation, neuroprotection and nerve regeneration. | 2013 | Curr. Eye Res. | pmid:23981028 |
| Lovegrove JA and Griffin BA | The acute and long-term effects of dietary fatty acids on vascular function in health and disease. | 2013 | Curr Opin Clin Nutr Metab Care | pmid:23299700 |
| Chaung HC et al. | Docosahexaenoic acid and phosphatidylserine improves the antioxidant activities in vitro and in vivo and cognitive functions of the developing brain. | 2013 | Food Chem | pmid:23265497 |
| Lyons MR et al. | Impact of sex on the heart's metabolic and functional responses to diabetic therapies. | 2013 | Am. J. Physiol. Heart Circ. Physiol. | pmid:24043256 |