| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammation | D007249 | 119 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Balestrieri GP et al. | Fish oil supplementation in patients with heterozygous familial hypercholesterolemia. | 1996 | Recenti Prog Med | pmid:8650428 |
| Chen S and Chen R | Docosahexaenoic acid-containing phospholipids and triglycerides based nutritional supplements. | 2010 | Recent Pat Food Nutr Agric | pmid:20863272 |
| Chen S | Highly pure phospholipids based brain docosahexaenoic acid transporters. | 2010 | Recent Pat CNS Drug Discov | pmid:19832689 |
| Alves SP et al. | Acetonitrile covalent adduct chemical ionization tandem mass spectrometry of non-methylene-interrupted pentaene fatty acid methyl esters. | 2011 | Rapid Commun. Mass Spectrom. | pmid:21698676 |
| Pacetti D et al. | High-performance liquid chromatography/electrospray ionization ion-trap tandem mass spectrometric analysis and quantification of phosphatidylcholine molecular species in the serum of cystic fibrosis subjects supplemented with docosahexaenoic acid. | 2004 | Rapid Commun. Mass Spectrom. | pmid:15386630 |
| Wang B et al. | Resolvin D1 protects mice from LPS-induced acute lung injury. | 2011 | Pulm Pharmacol Ther | pmid:21501693 |
| Lucas M et al. | Plasma n-3 fatty acids and psychological distress in aboriginal Cree Indians (Canada). | 2009 | Public Health Nutr | pmid:19243672 |
| Abu-Saad K et al. | Rapid assessment tools for ranking pregnant minority women into multi-nutrient exposure groups. | 2011 | Public Health Nutr | pmid:20519048 |
| Maqbool A et al. | The skinny on tuna fat: health implications. | 2011 | Public Health Nutr | pmid:21324226 |
| Lucas M et al. | n-3 Fatty acid intake from marine food products among Quebecers: comparison to worldwide recommendations. | 2010 | Public Health Nutr | pmid:19433004 |
| Mendez MA et al. | Maternal fish and other seafood intakes during pregnancy and child neurodevelopment at age 4 years. | 2009 | Public Health Nutr | pmid:19026093 |
| Lucas M et al. | Validation of an FFQ for evaluation of EPA and DHA intake. | 2009 | Public Health Nutr | pmid:19102810 |
| Conklin SM et al. | High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism. | 2007 | Psychosom Med | pmid:17991818 |
| Amin AA et al. | Acute coronary syndrome patients with depression have low blood cell membrane omega-3 fatty acid levels. | 2008 | Psychosom Med | pmid:18842751 |
| Kim HW et al. | Effects of chronic clozapine administration on markers of arachidonic acid cascade and synaptic integrity in rat brain. | 2012 | Psychopharmacology (Berl.) | pmid:22414961 |
| Bazinet RP et al. | Valproic acid selectively inhibits conversion of arachidonic acid to arachidonoyl-CoA by brain microsomal long-chain fatty acyl-CoA synthetases: relevance to bipolar disorder. | 2006 | Psychopharmacology (Berl.) | pmid:16344985 |
| Lee LK et al. | Docosahexaenoic acid-concentrated fish oil supplementation in subjects with mild cognitive impairment (MCI): a 12-month randomised, double-blind, placebo-controlled trial. | 2013 | Psychopharmacology (Berl.) | pmid:22932777 |
| Bazinet RP et al. | Chronic valproate does not alter the kinetics of docosahexaenoic acid within brain phospholipids of the unanesthetized rat. | 2005 | Psychopharmacology (Berl.) | pmid:15986187 |
| Levant B et al. | Decreased brain docosahexaenoic acid content produces neurobiological effects associated with depression: Interactions with reproductive status in female rats. | 2008 | Psychoneuroendocrinology | pmid:18707812 |
| McNamara RK et al. | Gender differences in rat erythrocyte and brain docosahexaenoic acid composition: role of ovarian hormones and dietary omega-3 fatty acid composition. | 2009 | Psychoneuroendocrinology | pmid:19046819 |