| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammation | D007249 | 119 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sanders TA et al. | The influence of a maternal diet rich in linoleic acid on brain and retinal docosahexaenoic acid in the rat. | 1984 | Br. J. Nutr. | pmid:6228249 |
| Onuma Y et al. | Selective incorporation of docosahexaenoic acid in rat brain. | 1984 | Biochim. Biophys. Acta | pmid:6231055 |
| Ishii H et al. | The effect of plasma on platelet function in hypercholesterolemic rabbits and the changes in fatty acid composition of the plasma. | 1984 | Thromb. Res. | pmid:6234679 |
| VanRollins M et al. | Oxidation of docosahexaenoic acid by rat liver microsomes. | 1984 | J. Biol. Chem. | pmid:6232277 |
| VanRollins M and Murphy RC | Autooxidation of docosahexaenoic acid: analysis of ten isomers of hydroxydocosahexaenoate. | 1984 | J. Lipid Res. | pmid:6234372 |
| Harris WS et al. | Will dietary omega-3 fatty acids change the composition of human milk? | 1984 | Am. J. Clin. Nutr. | pmid:6237575 |
| Reddy TS et al. | Long-chain acyl-coenzyme A synthetase from rat brain microsomes. Kinetic studies using [1-14C]docosahexaenoic acid substrate. | 1984 | Eur. J. Biochem. | pmid:6237910 |
| Bazan NG et al. | Docosahexaenoic acid (22:6, n-3) is metabolized to lipoxygenase reaction products in the retina. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6240268 |
| Neuringer M et al. | Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys. | 1984 | J. Clin. Invest. | pmid:6317716 |
| Yorek MA et al. | Comparative utilization of n-3 polyunsaturated fatty acids by cultured human Y-79 retinoblastoma cells. | 1984 | Biochim. Biophys. Acta | pmid:6089899 |
| Fogerty AC et al. | Liver fatty acids and the sudden infant death syndrome. | 1984 | Am. J. Clin. Nutr. | pmid:6230001 |
| Fischer S et al. | Uptake, release and metabolism of docosahexaenoic acid (DHA, c22:6 omega 3) in human platelets and neutrophils. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6329189 |
| Aveldaño MI and Sprecher H | Synthesis of hydroxy fatty acids from 4, 7, 10, 13, 16, 19-[1-14C] docosahexaenoic acid by human platelets. | 1983 | J. Biol. Chem. | pmid:6223928 |
| Rao GH et al. | Effect of docosahexaenoic acid (DHA) on arachidonic acid metabolism and platelet function. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6229254 |
| Sanders TA and Roshanai F | The influence of different types of omega 3 polyunsaturated fatty acids on blood lipids and platelet function in healthy volunteers. | 1983 | Clin. Sci. | pmid:6295686 |
| Corey EJ et al. | Docosahexaenoic acid is a strong inhibitor of prostaglandin but not leukotriene biosynthesis. | 1983 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6304720 |
| Morisaki N et al. | In vivo effects of cis-5,8,11,14,17-20:5 (n-3) and cis-4,7,10,13,16,19-22:6(n-3) on serum lipoproteins, platelet aggregation, and lipid metabolism in the aorta of rats. | 1983 | Tohoku J. Exp. Med. | pmid:6322383 |
| De Schrijver R and Privett OS | Effects of dietary long-chain fatty acids on the rat biosynthesis of unsaturated fatty acids in the rat. | 1982 | J. Nutr. | pmid:6279803 |
| Nagai M et al. | The fatty acid levels of rat alpha-fetoprotein derived from fetuses, pregnancy and hepatoma sera. | 1982 | Oncodev. Biol. Med. | pmid:6183647 |
| Guffy MM et al. | Effect of cellular fatty acid alteration on hyperthermic sensitivity in cultured L1210 murine leukemia cells. | 1982 | Cancer Res. | pmid:6213296 |
| Talesnik J and Hsia JC | Coronary flow reactions to arachidonic acid are inhibited by docosahexaenoic acid. | 1982 | Eur. J. Pharmacol. | pmid:6213418 |
| Mooibroek J et al. | Comparison of the radiosensitivity of unsaturated fatty acids, structured as micelles or liposomes, under different experimental conditions. | 1982 | Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. | pmid:6219072 |
| Bazan NG | Metabolism of phospholipids in the retina. | 1982 | Vision Res. | pmid:6305026 |
| Armstrong D et al. | Studies on experimentally induced retinal degeneration. 1. Effect of lipid peroxides on electroretinographic activity in the albino rabbit. | 1982 | Exp. Eye Res. | pmid:7151884 |
| Bazan NG et al. | High content of 22:6 (docosahexaenoate) and active [2-3H]glycerol metabolism of phosphatidic acid from photoreceptor membranes. | 1982 | Biochim. Biophys. Acta | pmid:6215065 |
| Organisciak DT et al. | Rod outer segment lipid--opsin ratios in the developing normal and retinal dystrophic rat. | 1982 | Exp. Eye Res. | pmid:6461559 |
| Studies of docosahexaenoic and eicosapentaenoic acids in trout and frogs. | 1982 | Nutr. Rev. | pmid:6289203 | |
| Nissen HP et al. | [Significance of bound fatty acids in human sperm in fertility disorders]. | 1981 Sep-Oct | Andrologia | pmid:6459043 |
| Boeynaems JM et al. | Iodination of docosahexaenoic acid by lactoperoxidase and thyroid gland in vitro: formation of an lodolactone. | 1981 | Lipids | pmid:6153054 |
| Sanders TA et al. | Effect on blood lipids and haemostasis of a supplement of cod-liver oil, rich in eicosapentaenoic and docosahexaenoic acids, in healthy young men. | 1981 | Clin. Sci. | pmid:6266735 |
| Mai J et al. | A new prostaglandin, C22-PGF4 alpha, synthesized from docosahexaenoic acid (C22:6n3) by trout gill. | 1981 | Prostaglandins | pmid:6280241 |
| Hsia JC et al. | alpha-fetoprotein binding specificity for arachidonate, bilirubin, docosahexaenoate, and palmitate. A spin label study. | 1980 | J. Biol. Chem. | pmid:6154708 |
| Iritani N et al. | Identification of shellfish fatty acids and their effects on lipogenic enzymes. | 1980 | Biochim. Biophys. Acta | pmid:6104986 |
| Castledine AJ and Buckley JT | Distribution and mobility of omega 3 fatty acids in rainbow trout fed varying levels and types of dietary lipid. | 1980 | J. Nutr. | pmid:6445002 |
| Giesing M and Zilliken F | Lipid metabolism of developing central nervous tissues in organotypic cultures. III. Ganglionic control of glycerolipids and fatty acids in cortex grey matter. | 1980 | Neurochem. Res. | pmid:6445512 |
| Sanders TA and Naismith DJ | The metabolism of alpha-linolenic acid by the foetal rat. | 1980 | Br. J. Nutr. | pmid:6448628 |
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