DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma D054218 5 associated lipids
Acute Lung Injury D055371 33 associated lipids
Geographic Atrophy D057092 1 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Plaque, Amyloid D058225 19 associated lipids
Plaque, Atherosclerotic D058226 7 associated lipids
Peripheral Arterial Disease D058729 7 associated lipids
Peripheral Nerve Injuries D059348 6 associated lipids
Chronic Pain D059350 5 associated lipids
Dysbiosis D064806 2 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Danthiir V et al. The older people, omega-3, and cognitive health (EPOCH) trial design and methodology: a randomised, double-blind, controlled trial investigating the effect of long-chain omega-3 fatty acids on cognitive ageing and wellbeing in cognitively healthy older adults. 2011 Nutr J pmid:22011460
Titos E et al. Resolvin D1 and its precursor docosahexaenoic acid promote resolution of adipose tissue inflammation by eliciting macrophage polarization toward an M2-like phenotype. 2011 J. Immunol. pmid:22013115
van de Lagemaat M et al. Post term dietary-induced changes in DHA and AA status relate to gains in weight, length, and head circumference in preterm infants. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21995887
Yi SH et al. A randomized, placebo-controlled, double-blind trial of supplemental docosahexaenoic acid on cognitive processing speed and executive function in females of reproductive age with phenylketonuria: A pilot study. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:22000478
Uddin MS et al. Isolation and characterization of lecithin from squid (Todarodes pacificus) viscera deoiled by supercritical carbon dioxide extraction. 2011 J. Food Sci. pmid:21535756
Sidhu VK et al. Effects of docosahexaenoic acid on mouse brain synaptic plasma membrane proteome analyzed by mass spectrometry and (16)O/(18)O labeling. 2011 J. Proteome Res. pmid:22003853
Labayen I et al. Associations of birth weight with serum long chain polyunsaturated fatty acids in adolescents; the HELENA study. 2011 Atherosclerosis pmid:21550607
Rahman M et al. Docosahexaenoic acid inhibits UVB-induced activation of NF-κB and expression of COX-2 and NOX-4 in HR-1 hairless mouse skin by blocking MSK1 signaling. 2011 PLoS ONE pmid:22140508
Johnson B Consciousness reinstated using the certainty principle--a better mental health strategy. 2011 Nutr Health pmid:22141192
Wood PL et al. Oral bioavailability of the ether lipid plasmalogen precursor, PPI-1011, in the rabbit: a new therapeutic strategy for Alzheimer's disease. 2011 Lipids Health Dis pmid:22142382
Decsi T et al. Inverse association between trans isomeric and long-chain polyunsaturated fatty acids in pregnant women and their newborns: data from three European countries. 2011 Ann. Nutr. Metab. pmid:22142767
Morin C et al. Docosahexaenoic acid derivative prevents inflammation and hyperreactivity in lung: implication of PKC-Potentiated inhibitory protein for heterotrimeric myosin light chain phosphatase of 17 kD in asthma. 2011 Am. J. Respir. Cell Mol. Biol. pmid:21057106
Andreo U et al. Role of superoxide radical anion in the mechanism of apoB100 degradation induced by DHA in hepatic cells. 2011 FASEB J. pmid:21757500
Mischoulon D The impact of omega-3 fatty acids on depressive disorders and suicidality: can we reconcile 2 studies with seemingly contradictory results? 2011 J Clin Psychiatry pmid:22244020
Le-Niculescu H et al. Convergent functional genomic studies of ω-3 fatty acids in stress reactivity, bipolar disorder and alcoholism. 2011 Transl Psychiatry pmid:22832392
Sekikawa A et al. Differential association of docosahexaenoic and eicosapentaenoic acids with carotid intima-media thickness. 2011 Stroke pmid:21757663
Yang R et al. Decoding functional metabolomics with docosahexaenoyl ethanolamide (DHEA) identifies novel bioactive signals. 2011 J. Biol. Chem. pmid:21757729
Gajos G The fish oil story--back to Greenland? 2011 Cardiology pmid:21757896
Ozsoy O et al. The influence and the mechanism of docosahexaenoic acid on a mouse model of Parkinson's disease. 2011 Neurochem. Int. pmid:21736911
Haraguchi T et al. Fish oil feeding up-regulates the expression of 5-aminolevulinate synthase 2 mRNA in rat brain. 2011 Biosci. Biotechnol. Biochem. pmid:21737922
Johnsen GM et al. Docosahexaenoic acid stimulates tube formation in first trimester trophoblast cells, HTR8/SVneo. 2011 Placenta pmid:21741084
Lespérance F et al. The efficacy of omega-3 supplementation for major depression: a randomized controlled trial. 2011 J Clin Psychiatry pmid:20584525
Caputo M et al. Selective regulation of UGT1A1 and SREBP-1c mRNA expression by docosahexaenoic, eicosapentaenoic, and arachidonic acids. 2011 J. Cell. Physiol. pmid:20648548
Frisardi V et al. Glycerophospholipids and glycerophospholipid-derived lipid mediators: a complex meshwork in Alzheimer's disease pathology. 2011 Prog. Lipid Res. pmid:21703303
Walczewska A et al. [The role of docosahexaenoic acid in neuronal function]. 2011 Postepy Hig Med Dosw (Online) pmid:21677356
Davis-Bruno K and Tassinari MS Essential fatty acid supplementation of DHA and ARA and effects on neurodevelopment across animal species: a review of the literature. 2011 Birth Defects Res. B Dev. Reprod. Toxicol. pmid:21678548
Klingler M et al. Fatty acid status determination by cheek cell sampling combined with methanol-based ultrasound extraction of glycerophospholipids. 2011 Lipids pmid:21681560
Friedrichs W et al. Omega-3 fatty acid inhibition of prostate cancer progression to hormone independence is associated with suppression of mTOR signaling and androgen receptor expression. 2011 Nutr Cancer pmid:21667400
Sakayori N et al. Distinctive effects of arachidonic acid and docosahexaenoic acid on neural stem /progenitor cells. 2011 Genes Cells pmid:21668588
Liu SJ et al. Effect of ruminal pulse dose of polyunsaturated fatty acids on ruminal microbial populations and duodenal flow and milk profiles of fatty acids. 2011 J. Dairy Sci. pmid:21605768
Cook DJ and Heyland DK Pharmaconutrition in acute lung injury. 2011 JAMA pmid:21976612
Rice TW et al. Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury. 2011 JAMA pmid:21976613
Faragó N et al. MicroRNA profile of polyunsaturated fatty acid treated glioma cells reveal apoptosis-specific expression changes. 2011 Lipids Health Dis pmid:21961478
Wang TM et al. Docosahexaenoic acid attenuates VCAM-1 expression and NF-κB activation in TNF-α-treated human aortic endothelial cells. 2011 J. Nutr. Biochem. pmid:20573493
Campoy C et al. Effects of prenatal fish-oil and 5-methyltetrahydrofolate supplementation on cognitive development of children at 6.5 y of age. 2011 Am. J. Clin. Nutr. pmid:21849596
Miles EA et al. The Salmon in Pregnancy Study: study design, subject characteristics, maternal fish and marine n-3 fatty acid intake, and marine n-3 fatty acid status in maternal and umbilical cord blood. 2011 Am. J. Clin. Nutr. pmid:21849598
Wu A et al. The salutary effects of DHA dietary supplementation on cognition, neuroplasticity, and membrane homeostasis after brain trauma. 2011 J. Neurotrauma pmid:21851229
Weise C et al. Inhibition of IgE production by docosahexaenoic acid is mediated by direct interference with STAT6 and NFκB pathway in human B cells. 2011 J. Nutr. Biochem. pmid:20576420
Lalancette-Hébert M et al. Accumulation of dietary docosahexaenoic acid in the brain attenuates acute immune response and development of postischemic neuronal damage. 2011 Stroke pmid:21852616
Schuchardt JP et al. Incorporation of EPA and DHA into plasma phospholipids in response to different omega-3 fatty acid formulations--a comparative bioavailability study of fish oil vs. krill oil. 2011 Lipids Health Dis pmid:21854650
Boucher O et al. Neurophysiologic and neurobehavioral evidence of beneficial effects of prenatal omega-3 fatty acid intake on memory function at school age. 2011 Am. J. Clin. Nutr. pmid:21389181
Grant GE et al. Enhanced formation of 5-oxo-6,8,11,14-eicosatetraenoic acid by cancer cells in response to oxidative stress, docosahexaenoic acid and neutrophil-derived 5-hydroxy-6,8,11,14-eicosatetraenoic acid. 2011 Carcinogenesis pmid:21393477
Trofimiuk E and Braszko JJ Long-term administration of cod liver oil ameliorates cognitive impairment induced by chronic stress in rats. 2011 Lipids pmid:21442272
Chauveau F et al. Brain-targeting form of docosahexaenoic acid for experimental stroke treatment: MRI evaluation and anti-oxidant impact. 2011 Curr Neurovasc Res pmid:21443458
Collins CT et al. Pre- and post-term growth in pre-term infants supplemented with higher-dose DHA: a randomised controlled trial. 2011 Br. J. Nutr. pmid:21443815
Sala-Vila A et al. Determinants of the omega-3 index in a Mediterranean population at increased risk for CHD. 2011 Br. J. Nutr. pmid:21450116
Mayurasakorn K et al. Docosahexaenoic acid: brain accretion and roles in neuroprotection after brain hypoxia and ischemia. 2011 Curr Opin Clin Nutr Metab Care pmid:21178607
Vincentini O et al. Docosahexaenoic acid modulates in vitro the inflammation of celiac disease in intestinal epithelial cells via the inhibition of cPLA2. 2011 Clin Nutr pmid:21421277
Lebold KM et al. Vitamin E deficiency decreases long-chain PUFA in zebrafish (Danio rerio). 2011 J. Nutr. pmid:22013196
Huffman SL et al. Essential fats: how do they affect growth and development of infants and young children in developing countries? A literature review. 2011 Matern Child Nutr pmid:21929635
Isaacs EB et al. 10-year cognition in preterms after random assignment to fatty acid supplementation in infancy. 2011 Pediatrics pmid:21930549
Amtul Z et al. DHA supplemented in peptamen diet offers no advantage in pathways to amyloidosis: is it time to evaluate composite lipid diet? 2011 PLoS ONE pmid:21931647
Sublette ME et al. Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression. 2011 J Clin Psychiatry pmid:21939614
Serini S et al. Differential anti-cancer effects of purified EPA and DHA and possible mechanisms involved. 2011 Curr. Med. Chem. pmid:21824086
Fagali N and Catalá A Melatonin and structural analogues do not possess antioxidant properties on Fe(2+)-initiated peroxidation of sonicated liposomes made of retinal lipids. 2011 Chem. Phys. Lipids pmid:21827740
Newens KJ et al. DHA-rich fish oil reverses the detrimental effects of saturated fatty acids on postprandial vascular reactivity. 2011 Am. J. Clin. Nutr. pmid:21831993
von Schacky C The Omega-3 Index as a risk factor for cardiovascular diseases. 2011 Prostaglandins Other Lipid Mediat. pmid:21726658
Giltay EJ et al. Effects of n-3 fatty acids on depressive symptoms and dispositional optimism after myocardial infarction. 2011 Am. J. Clin. Nutr. pmid:22030221
Berry KA et al. MALDI imaging MS of phospholipids in the mouse lung. 2011 J. Lipid Res. pmid:21508254
Klebanoff MA et al. Fish consumption, erythrocyte fatty acids, and preterm birth. 2011 Obstet Gynecol pmid:21508745
Altenburg JD et al. A synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: unique signaling not explained by the effects of either compound alone. 2011 BMC Cancer pmid:21510869
Mancini I et al. Fatty acid composition of common barbel (Barbus barbus) roe and evaluation of its haemolytic and cytotoxic activities. 2011 Toxicon pmid:21510968
Hadders-Algra M Prenatal and early postnatal supplementation with long-chain polyunsaturated fatty acids: neurodevelopmental considerations. 2011 Am. J. Clin. Nutr. pmid:21525202
Escolano-Margarit MV et al. Prenatal DHA status and neurological outcome in children at age 5.5 years are positively associated. 2011 J. Nutr. pmid:21525247
Rockett BD et al. Membrane raft organization is more sensitive to disruption by (n-3) PUFA than nonraft organization in EL4 and B cells. 2011 J. Nutr. pmid:21525263
De Franceschi G et al. Structural and morphological characterization of aggregated species of α-synuclein induced by docosahexaenoic acid. 2011 J. Biol. Chem. pmid:21527634
Siddiqui NF et al. Enhanced generation of megakaryocytes from umbilical cord blood-derived CD34(+) cells expanded in the presence of two nutraceuticals, docosahexanoic acid and arachidonic acid, as supplements to the cytokine-containing medium. 2011 Cytotherapy pmid:20230224
Hanada H et al. Induction of apoptosis and lipogenesis in human preadipocyte cell line by n-3 PUFAs. 2011 Cell Biol. Int. pmid:20812919
Milberg P et al. Antiarrhythmic effects of free polyunsaturated fatty acids in an experimental model of LQT2 and LQT3 due to suppression of early afterdepolarizations and reduction of spatial and temporal dispersion of repolarization. 2011 Heart Rhythm pmid:21459164
Nudda A et al. Documentation of fatty acid profiles in lamb meat and lamb-based infant foods. 2011 J. Food Sci. pmid:21535766
Pomponi MF et al. Why docosahexaenoic acid and aspirin supplementation could be useful in women as a primary prevention therapy against Alzheimer's disease? 2011 Ageing Res. Rev. pmid:20920611
Wojcicki JM and Heyman MB Maternal omega-3 fatty acid supplementation and risk for perinatal maternal depression. 2011 J. Matern. Fetal. Neonatal. Med. pmid:20925595
Kim SH et al. Prospective randomized comparison between omega-3 fatty acid supplements plus simvastatin versus simvastatin alone in Korean patients with mixed dyslipidemia: lipoprotein profiles and heart rate variability. 2011 Eur J Clin Nutr pmid:20877395
Blum JL et al. Profiling of fatty acids released during calcium-induced mitochondrial permeability transition in isolated rabbit kidney cortex mitochondria. 2011 Toxicol In Vitro pmid:21443943
Huang L et al. Enduring prevention and transient reduction of postoperative pain by intrathecal resolvin D1. 2011 Pain pmid:21255928
van der Pols JC et al. Serum omega-3 and omega-6 fatty acids and cutaneous p53 expression in an Australian population. 2011 Cancer Epidemiol. Biomarkers Prev. pmid:21217086
Poudel-Tandukar K et al. Long chain n-3 fatty acids intake, fish consumption and suicide in a cohort of Japanese men and women--the Japan Public Health Center-based (JPHC) prospective study. 2011 J Affect Disord pmid:20692041
Mariee AD and Abd-Ellah MF Protective effect of docosahexaenoic acid against cyclosporine A-induced nephrotoxicity in rats: a possible mechanism of action. 2011 Ren Fail pmid:21219208
Safarinejad MR Effect of omega-3 polyunsaturated fatty acid supplementation on semen profile and enzymatic anti-oxidant capacity of seminal plasma in infertile men with idiopathic oligoasthenoteratospermia: a double-blind, placebo-controlled, randomised study. 2011 Andrologia pmid:21219381
Cotogni P et al. Impact of the omega-3 to omega-6 polyunsaturated fatty acid ratio on cytokine release in human alveolar cells. 2011 JPEN J Parenter Enteral Nutr pmid:21224438
Burrows T et al. Omega-3 index, obesity and insulin resistance in children. 2011 Int J Pediatr Obes pmid:21226540
Zhao Y et al. Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARγ-mediated mechanisms in Alzheimer's disease models. 2011 PLoS ONE pmid:21246057
Gomez-Pinilla F The combined effects of exercise and foods in preventing neurological and cognitive disorders. 2011 Prev Med pmid:21281667
Ueda Y et al. Effect of dietary lipids on longevity and memory in the SAMP8 mice. 2011 J. Nutr. Sci. Vitaminol. pmid:21512289
Yi SH et al. A cross-sectional study of docosahexaenoic acid status and cognitive outcomes in females of reproductive age with phenylketonuria. 2011 J. Inherit. Metab. Dis. pmid:21305356
Yano Y et al. Regional differences in hypertensive cardiovascular remodeling between fishing and farming communities in Japan. 2011 Am. J. Hypertens. pmid:21311505
Dartt DA et al. Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation. 2011 J. Immunol. pmid:21357260
Kawabata T et al. [Comparison of long-chain polyunsaturated fatty acids in plasma and erythrocyte phospholipids for biological monitoring]. 2011 Nihon Eiseigaku Zasshi pmid:21358141
Cavazos DA et al. Docosahexaenoic acid selectively induces human prostate cancer cell sensitivity to oxidative stress through modulation of NF-κB. 2011 Prostate pmid:21360560
Murphy RA et al. Nutritional intervention with fish oil provides a benefit over standard of care for weight and skeletal muscle mass in patients with nonsmall cell lung cancer receiving chemotherapy. 2011 Cancer pmid:21360698
Swenne I et al. Essential fatty acid status in teenage girls with eating disorders and weight loss. 2011 Acta Paediatr. pmid:21362034
Konkel A and Schunck WH Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids. 2011 Biochim. Biophys. Acta pmid:20869469
Shimshoni JA et al. Valproate uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: relevance to valproate's efficacy against bipolar disorder. 2011 Biochim. Biophys. Acta pmid:21184843
Serini S et al. Docosahexaenoic acid reverts resistance to UV-induced apoptosis in human keratinocytes: involvement of COX-2 and HuR. 2011 J. Nutr. Biochem. pmid:21185708
Wang RX et al. Activation of vascular BK channels by docosahexaenoic acid is dependent on cytochrome P450 epoxygenase activity. 2011 Cardiovasc. Res. pmid:21187320
Riedel M et al. Membrane lipid modification by docosahexaenoic acid (DHA) promotes the formation of α-synuclein inclusion bodies immunopositive for SUMO-1 in oligodendroglial cells after oxidative stress. 2011 J. Mol. Neurosci. pmid:20725866
Hamazaki K et al. Docosahexaenoic acid is an independent predictor of all-cause mortality in hemodialysis patients. 2011 Am. J. Nephrol. pmid:21196723
Cho JY et al. Oral administration of docosahexaenoic acid attenuates colitis induced by dextran sulfate sodium in mice. 2011 Mol Nutr Food Res pmid:20824662
Pawlik D et al. Fish-oil fat emulsion supplementation may reduce the risk of severe retinopathy in VLBW infants. 2011 Pediatrics pmid:21199856
Toufektsian MC et al. Dietary flavonoids increase plasma very long-chain (n-3) fatty acids in rats. 2011 J. Nutr. pmid:21068183