DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Trophoblastic Tumor, Placental Site D018245 1 associated lipids
Phenylketonuria, Maternal D017042 1 associated lipids
Refsum Disease, Infantile D052919 1 associated lipids
Pulmonary Valve Stenosis D011666 1 associated lipids
Cerebrovascular Trauma D020214 1 associated lipids
Histiocytoma, Malignant Fibrous D051677 1 associated lipids
Decapitation D049248 2 associated lipids
Communication Disorders D003147 1 associated lipids
Geographic Atrophy D057092 1 associated lipids
Lordosis D008141 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Authors Title Published Journal PubMed Link
Fokkema MR et al. Short-term supplementation of low-dose gamma-linolenic acid (GLA), alpha-linolenic acid (ALA), or GLA plus ALA does not augment LCP omega 3 status of Dutch vegans to an appreciable extent. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11090255
Chen ZY and Istfan NW Docosahexaenoic acid is a potent inducer of apoptosis in HT-29 colon cancer cells. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11090257
Otto SJ et al. The effect of supplementation with docosahexaenoic and arachidonic acid derived from single cell oils on plasma and erythrocyte fatty acids of pregnant women in the second trimester. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11090260
Rissanen T et al. Fish oil-derived fatty acids, docosahexaenoic acid and docosapentaenoic acid, and the risk of acute coronary events: the Kuopio ischaemic heart disease risk factor study. 2000 Circulation pmid:11094031
Freedman SD et al. Fatty acids in cystic fibrosis. 2000 Curr Opin Pulm Med pmid:11100964
Lapillonne A et al. The use of low-EPA fish oil for long-chain polyunsaturated fatty acid supplementation of preterm infants. 2000 Pediatr. Res. pmid:11102555
Wang M et al. Induction of mammary differentiation by mammary-derived growth inhibitor-related gene that interacts with an omega-3 fatty acid on growth inhibition of breast cancer cells. 2000 Cancer Res. pmid:11103817
Ikemoto A et al. Effect of n-3 fatty acid deficiency on fatty acid composition and metabolism of aminophospholipids in rat brain synaptosomes. 2000 Lipids pmid:11104017
Decsi T et al. Fatty acid composition of human milk in Hungary. 2000 Acta Paediatr. pmid:11106060
Baldessarini RJ et al. Fatty acid derivatives of clozapine: prolonged antidopaminergic activity of docosahexaenoylclozapine in the rat. 2001 Neuropsychopharmacology pmid:11106876
Mezzano D et al. Cardiovascular risk factors in vegetarians. Normalization of hyperhomocysteinemia with vitamin B(12) and reduction of platelet aggregation with n-3 fatty acids. 2000 Thromb. Res. pmid:11108902
Song JH et al. Polyunsaturated (n-3) fatty acids susceptible to peroxidation are increased in plasma and tissue lipids of rats fed docosahexaenoic acid-containing oils. 2000 J. Nutr. pmid:11110863
Auestad N Infant nutrition--brain development--disease in later life. An introduction. 2000 Sep-Dec Dev. Neurosci. pmid:11111164
Innis SM The role of dietary n-6 and n-3 fatty acids in the developing brain. 2000 Sep-Dec Dev. Neurosci. pmid:11111165
Stockard JE et al. Effect of docosahexaenoic acid content of maternal diet on auditory brainstem conduction times in rat pups. 2000 Sep-Dec Dev. Neurosci. pmid:11111168
de Urquiza AM et al. Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain. 2000 Science pmid:11118147
Haban P et al. Supplementation with long-chain n-3 fatty acids in non-insulin-dependent diabetes mellitus (NIDDM) patients leads to the lowering of oleic acid content in serum phospholipids. 2000 Eur J Nutr pmid:11131366
Harel M et al. Modulation of arachidonate and docosahexaenoate in Morone chrysops larval tissues and the effect on growth and survival. 2000 Lipids pmid:11132186
Marín MC et al. Dietary long-chain fatty acids and visual response in malnourished nursing infants. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11133176
Sorbera LA et al. Effects of polyunsaturated fatty acids and prostaglandins on oocyte maturation in a marine teleost, the European sea bass (Dicentrarchus labrax). 2001 Biol. Reprod. pmid:11133697