DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Trophoblastic Tumor, Placental Site D018245 1 associated lipids
Phenylketonuria, Maternal D017042 1 associated lipids
Refsum Disease, Infantile D052919 1 associated lipids
Pulmonary Valve Stenosis D011666 1 associated lipids
Cerebrovascular Trauma D020214 1 associated lipids
Histiocytoma, Malignant Fibrous D051677 1 associated lipids
Decapitation D049248 2 associated lipids
Communication Disorders D003147 1 associated lipids
Geographic Atrophy D057092 1 associated lipids
Lordosis D008141 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Liu J and Ma DW The role of n-3 polyunsaturated fatty acids in the prevention and treatment of breast cancer. 2014 Nutrients pmid:25412153
Bernhard W et al. Plasma phospholipids indicate impaired fatty acid homeostasis in preterm infants. 2014 Eur J Nutr pmid:24464176
Schuster GU et al. Dietary long-chain omega-3 fatty acids do not diminish eosinophilic pulmonary inflammation in mice. 2014 Am. J. Respir. Cell Mol. Biol. pmid:24134486
Lagarde M et al. Structure-function relationships of non-cyclic dioxygenase products from polyunsaturated fatty acids: poxytrins as a class of bioactive derivatives. 2014 Biochimie pmid:25223888
Maitin V et al. Docosahexaenoic acid impairs the maturation of very low density lipoproteins in rat hepatic cells. 2014 J. Lipid Res. pmid:24136824
Browning LM et al. Compared with daily, weekly n-3 PUFA intake affects the incorporation of eicosapentaenoic acid and docosahexaenoic acid into platelets and mononuclear cells in humans. 2014 J. Nutr. pmid:24647395
Polavarapu S et al. Effect of polyunsaturated fatty acids and their metabolites on bleomycin-induced cytotoxic action on human neuroblastoma cells in vitro. 2014 PLoS ONE pmid:25536345
Hoogeveen EK et al. Effect of omega-3 fatty acids on kidney function after myocardial infarction: the Alpha Omega Trial. 2014 Clin J Am Soc Nephrol pmid:25104273
Bispo P et al. Preparation of triacylglycerols rich in omega-3 fatty acids from sardine oil using a Rhizomucor miehei lipase: focus in the EPA/DHA ratio. 2014 Appl. Biochem. Biotechnol. pmid:24293255
Li L et al. Resolvin D1 promotes the interleukin-4-induced alternative activation in BV-2 microglial cells. 2014 J Neuroinflammation pmid:24708771
Skender B et al. DHA-mediated enhancement of TRAIL-induced apoptosis in colon cancer cells is associated with engagement of mitochondria and specific alterations in sphingolipid metabolism. 2014 Biochim. Biophys. Acta pmid:24953781
Zhao Z and Zlokovic BV Blood-brain barrier: a dual life of MFSD2A? 2014 Neuron pmid:24853933
Hoffman DR et al. Four-year placebo-controlled trial of docosahexaenoic acid in X-linked retinitis pigmentosa (DHAX trial): a randomized clinical trial. 2014 JAMA Ophthalmol pmid:24805262
Chatterjee A et al. The pro-resolving lipid mediator maresin 1 (MaR1) attenuates inflammatory signaling pathways in vascular smooth muscle and endothelial cells. 2014 PLoS ONE pmid:25409514
Gong J et al. Maresin 1 mitigates LPS-induced acute lung injury in mice. 2014 Br. J. Pharmacol. pmid:24697684
Abe E et al. Novel lysophospholipid acyltransferase PLAT1 of Aurantiochytrium limacinum F26-b responsible for generation of palmitate-docosahexaenoate-phosphatidylcholine and phosphatidylethanolamine. 2014 PLoS ONE pmid:25090090
Li S et al. The targeting mechanism of DHA ligand and its conjugate with Gemcitabine for the enhanced tumor therapy. 2014 Oncotarget pmid:25004114
Arafiles KH et al. Value-added lipid production from brown seaweed biomass by two-stage fermentation using acetic acid bacterium and thraustochytrid. 2014 Appl. Microbiol. Biotechnol. pmid:25086614
Lane K et al. Bioavailability and potential uses of vegetarian sources of omega-3 fatty acids: a review of the literature. 2014 Crit Rev Food Sci Nutr pmid:24261532
Siddesha JM et al. Docosahexaenoic acid reverses angiotensin II-induced RECK suppression and cardiac fibroblast migration. 2014 Cell. Signal. pmid:24447911
Shao Z et al. Cytochrome P450 2C8 ω3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report. 2014 Arterioscler. Thromb. Vasc. Biol. pmid:24458713
Steffens JP et al. Testosterone regulates bone response to inflammation. 2014 Horm. Metab. Res. pmid:24526374
Maffei S et al. Effects of ω-3 PUFAs supplementation on myocardial function and oxidative stress markers in typical Rett syndrome. 2014 Mediators Inflamm. pmid:24526821
Saito H and Ishikawa S Lipid classes and fatty acid profile of cultured and wild black rockfish, Sebastes schlegeli. 2014 J Oleo Sci pmid:24829130
Koutsos A et al. Greater impact of dietary fat manipulation than apolipoprotein E genotype on ex vivo cytokine production - insights from the SATgenε study. 2014 Cytokine pmid:24485322
Prostek A et al. The influence of EPA and DHA on markers of inflammation in 3T3-L1 cells at different stages of cellular maturation. 2014 Lipids Health Dis pmid:24387137
Yaxin W et al. Resolvin D1 attenuates lipopolysaccharide induced acute lung injury through CXCL-12/CXCR4 pathway. 2014 J. Surg. Res. pmid:24387839
Shaikh NA et al. Efficacy of a unique omega-3 formulation on the correction of nutritional deficiency and its effects on cardiovascular disease risk factors in a randomized controlled VASCAZEN(®) REVEAL Trial. 2014 Mol. Cell. Biochem. pmid:25185754
Leigh NJ et al. Expression of resolvin D1 biosynthetic pathways in salivary epithelium. 2014 J. Dent. Res. pmid:24389810
O'Connor-Robison CI et al. The impact of dietary long-chain polyunsaturated fatty acids on bone and cartilage in gilts and sows. 2014 J. Anim. Sci. pmid:25184850
Norris JM et al. Erythrocyte membrane docosapentaenoic acid levels are associated with islet autoimmunity: the Diabetes Autoimmunity Study in the Young. 2014 Diabetologia pmid:24240437
Nakagawa F et al. 4-Hydroxy hexenal derived from dietary n-3 polyunsaturated fatty acids induces anti-oxidative enzyme heme oxygenase-1 in multiple organs. 2014 Biochem. Biophys. Res. Commun. pmid:24361890
Wójcik C et al. Modulation of adipocyte differentiation by omega-3 polyunsaturated fatty acids involves the ubiquitin-proteasome system. 2014 J. Cell. Mol. Med. pmid:24834523
Saito H Lipid characteristics of five epinephelinae fishes, Epinephelus fasciatus, Epinephelus retouti, Cephalopholis aurantia, Cephalopholis miniatus, and Variola louti, in the Coral Reef. 2014 J Oleo Sci pmid:24717545
Yamanushi TT et al. Oral administration of eicosapentaenoic acid or docosahexaenoic acid modifies cardiac function and ameliorates congestive heart failure in male rats. 2014 J. Nutr. pmid:24523492
Meagher KA et al. Regarding macular xanthophylls and ω-3 long-chain polyunsaturated fatty acids in age-related macular degeneration. 2014 JAMA Ophthalmol pmid:24525935
Sánchez-Reyes OB et al. Free fatty acids and protein kinase C activation induce GPR120 (free fatty acid receptor 4) phosphorylation. 2014 Eur. J. Pharmacol. pmid:24239485
Asai M et al. [Cellular models for individualized medicine in Alzheimer's disease using patient-derived induced pluripotent stem cells]. 2014 Nippon Yakurigaku Zasshi pmid:24420133
Jin M et al. Eicosapentaenoic acid and docosahexaenoic acid suppress Th2 cytokine expression in RBL-2H3 basophilic leukemia cells. 2014 J Med Food pmid:24460246
Chen MY et al. Quantitative risk-benefit analysis of fish consumption for women of child-bearing age in Hong Kong. 2014 Food Addit Contam Part A Chem Anal Control Expo Risk Assess pmid:24444393
Nozue T et al. Low serum docosahexaenoic acid is associated with progression of coronary atherosclerosis in statin-treated patients with diabetes mellitus: results of the treatment with statin on atheroma regression evaluated by intravascular ultrasound with virtual histology (TRUTH) study. 2014 Cardiovasc Diabetol pmid:24410834
Freund Levi Y et al. Transfer of omega-3 fatty acids across the blood-brain barrier after dietary supplementation with a docosahexaenoic acid-rich omega-3 fatty acid preparation in patients with Alzheimer's disease: the OmegAD study. 2014 J. Intern. Med. pmid:24410954
Russell CD and Schwarze J The role of pro-resolution lipid mediators in infectious disease. 2014 Immunology pmid:24400794
AlSaleh A et al. Interaction between a CSK gene variant and fish oil intake influences blood pressure in healthy adults. 2014 J. Nutr. pmid:24401815
Paterniti I et al. Docosahexaenoic acid attenuates the early inflammatory response following spinal cord injury in mice: in-vivo and in-vitro studies. 2014 J Neuroinflammation pmid:24405628
Patterson AC et al. The percentage of DHA in erythrocytes can detect non-adherence to advice to increase EPA and DHA intakes. 2014 Br. J. Nutr. pmid:23920312
Chen J et al. Aspirin-triggered resolvin D1 down-regulates inflammatory responses and protects against endotoxin-induced acute kidney injury. 2014 Toxicol. Appl. Pharmacol. pmid:24709673
Recchiuti A et al. Immunoresolving actions of oral resolvin D1 include selective regulation of the transcription machinery in resolution-phase mouse macrophages. 2014 FASEB J. pmid:24692596
Létondor A et al. Erythrocyte DHA level as a biomarker of DHA status in specific brain regions of n-3 long-chain PUFA-supplemented aged rats. 2014 Br. J. Nutr. pmid:25331622
Kermack AJ et al. A randomised controlled trial of a preconceptional dietary intervention in women undergoing IVF treatment (PREPARE trial). 2014 BMC Womens Health pmid:25407227
Wang JL et al. Preparation and characterization of novel lipid carriers containing microalgae oil for food applications. 2014 J. Food Sci. pmid:24446860
von Schacky C Omega-3 index and cardiovascular health. 2014 Nutrients pmid:24566438
Nehra D et al. Docosahexaenoic acid, G protein-coupled receptors, and melanoma: is G protein-coupled receptor 40 a potential therapeutic target? 2014 J. Surg. Res. pmid:24576779
Rutkowsky JM et al. Acylcarnitines activate proinflammatory signaling pathways. 2014 Am. J. Physiol. Endocrinol. Metab. pmid:24760988
Zhao H et al. Pulmonary delivery of docosahexaenoic acid mitigates bleomycin-induced pulmonary fibrosis. 2014 BMC Pulm Med pmid:24742272
DiNicolantonio JJ et al. A higher dietary ratio of long-chain omega-3 to total omega-6 fatty acids for prevention of COX-2-dependent adenocarcinomas. 2014 Nutr Cancer pmid:25356937
Boca SM et al. Testing multiple biological mediators simultaneously. 2014 Bioinformatics pmid:24202540
Peoples GE and McLennan PL Long-chain n-3 DHA reduces the extent of skeletal muscle fatigue in the rat in vivo hindlimb model. 2014 Br. J. Nutr. pmid:24229620
Wu A et al. Dietary strategy to repair plasma membrane after brain trauma: implications for plasticity and cognition. 2014 Neurorehabil Neural Repair pmid:23911971
Giovannelli J et al. Validation of a short, qualitative food frequency questionnaire in French adults participating in the MONA LISA-NUT study 2005-2007. 2014 J Acad Nutr Diet pmid:24083967
Ganesan B et al. Fortification of foods with omega-3 polyunsaturated fatty acids. 2014 Crit Rev Food Sci Nutr pmid:24188235
Chang G et al. The relationship of oxygen uptake rate and k(L)a with rheological properties in high cell density cultivation of docosahexaenoic acid by Schizochytrium sp. S31. 2014 Bioresour. Technol. pmid:24292203
Rius B et al. Resolvin D1 primes the resolution process initiated by calorie restriction in obesity-induced steatohepatitis. 2014 FASEB J. pmid:24249635
Choi EY et al. DHA suppresses Prevotella intermedia lipopolysaccharide-induced production of proinflammatory mediators in murine macrophages. 2014 Br. J. Nutr. pmid:24252501
Ponnampalam EN et al. Sources of variation of health claimable long chain omega-3 fatty acids in meat from Australian lamb slaughtered at similar weights. 2014 Meat Sci. pmid:23265412
Gregory MK et al. Effect of dietary canola oil on long-chain omega-3 fatty acid content in broiler hearts. 2014 J Anim Physiol Anim Nutr (Berl) pmid:23510129
Kwon B et al. Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells. 2014 Biochim. Biophys. Acta pmid:24732014
Liu L et al. Higher efficacy of dietary DHA provided as a phospholipid than as a triglyceride for brain DHA accretion in neonatal piglets. 2014 J. Lipid Res. pmid:24470588
de Waal H et al. The effect of souvenaid on functional brain network organisation in patients with mild Alzheimer's disease: a randomised controlled study. 2014 PLoS ONE pmid:24475144
Desai A et al. Depletion of brain docosahexaenoic acid impairs recovery from traumatic brain injury. 2014 PLoS ONE pmid:24475126
Amiri-Jami M et al. Engineering of EPA/DHA omega-3 fatty acid production by Lactococcus lactis subsp. cremoris MG1363. 2014 Appl. Microbiol. Biotechnol. pmid:24389665
Hernández E et al. Prenatal determinants of cord blood total immunoglobulin E levels in Mexican newborns. 2013 Sep-Oct Allergy Asthma Proc pmid:23998234
Harris WS et al. Comparative effects of an acute dose of fish oil on omega-3 fatty acid levels in red blood cells versus plasma: implications for clinical utility. 2013 Sep-Oct J Clin Lipidol pmid:24079284
Tatsuno I et al. Long-term safety and efficacy of TAK-085 in Japanese subjects with hypertriglyceridemia undergoing lifestyle modification: the omega-3 fatty acids randomized long-term (ORL) study. 2013 Nov-Dec J Clin Lipidol pmid:24314359
Igarashi M et al. Kinetics of eicosapentaenoic acid in brain, heart and liver of conscious rats fed a high n-3 PUFA containing diet. 2013 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:24209500
Fenton JI et al. Immunomodulation by dietary long chain omega-3 fatty acids and the potential for adverse health outcomes. 2013 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:24183073
Docosahexaenoic and arachidonic acid levels in ELBW infants with prolonged exposure to intravenous lipids. 2013 May-Jun Neonatal Netw pmid:23807965
Tatsuno I et al. Efficacy and safety of TAK-085 compared with eicosapentaenoic acid in Japanese subjects with hypertriglyceridemia undergoing lifestyle modification: the omega-3 fatty acids randomized double-blind (ORD) study. 2013 May-Jun J Clin Lipidol pmid:23725919
Nishimura RY et al. Breast milk fatty acid composition of women living far from the coastal area in Brazil. 2013 May-Jun J Pediatr (Rio J) pmid:23669215
Zajdel A et al. Polyunsaturated fatty acids inhibit melanoma cell growth in vitro. 2013 Mar-Apr Acta Pol Pharm pmid:23614295
Bohr S et al. Resolvin D2 prevents secondary thrombosis and necrosis in a mouse burn wound model. 2013 Jan-Feb Wound Repair Regen pmid:23110665
Piñeiro-Corrales G et al. [Role of omega-3 fatty acids in cardiovascular disease prevention]. 2013 Jan-Feb Nutr Hosp pmid:23808424
Teague H et al. Dendritic cell activation, phagocytosis and CD69 expression on cognate T cells are suppressed by n-3 long-chain polyunsaturated fatty acids. 2013 Immunology pmid:23373457
Herba CM et al. Breastfeeding and early brain development: the Generation R study. 2013 Matern Child Nutr pmid:23167730
Rovito D et al. Omega-3 PUFA ethanolamides DHEA and EPEA induce autophagy through PPARγ activation in MCF-7 breast cancer cells. 2013 J. Cell. Physiol. pmid:23168911
Poudyal H et al. Effects of ALA, EPA and DHA in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. 2013 J. Nutr. Biochem. pmid:23026492
Dallaire R et al. Exposure to organochlorines and mercury through fish and marine mammal consumption: associations with growth and duration of gestation among Inuit newborns. 2013 Environ Int pmid:23422685
Miyata J et al. Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma. 2013 J. Allergy Clin. Immunol. pmid:23006546
Gladyshev MI et al. Production of EPA and DHA in aquatic ecosystems and their transfer to the land. 2013 Prostaglandins Other Lipid Mediat. pmid:23500063
Zhuang W et al. Omega-3 polyunsaturated fatty acids reduce vascular endothelial growth factor production and suppress endothelial wound repair. 2013 J Cardiovasc Transl Res pmid:22993129
Lu Y et al. Spinal injection of docosahexaenoic acid attenuates carrageenan-induced inflammatory pain through inhibition of microglia-mediated neuroinflammation in the spinal cord. 2013 Neuroscience pmid:23500096
Mozaffari-Khosravi H et al. Eicosapentaenoic acid versus docosahexaenoic acid in mild-to-moderate depression: a randomized, double-blind, placebo-controlled trial. 2013 Eur Neuropsychopharmacol pmid:22910528
Fagan P and Wijesundera C Rapid isolation of omega-3 long-chain polyunsaturated fatty acids using monolithic high performance liquid chromatography columns. 2013 J Sep Sci pmid:23559561
Jans JJ et al. Supplementation with a powdered blend of PUFAs normalizes DHA and AA levels in patients with PKU. 2013 Mol. Genet. Metab. pmid:23562298
Markhus MW et al. Low omega-3 index in pregnancy is a possible biological risk factor for postpartum depression. 2013 PLoS ONE pmid:23844041
Wang Y et al. DHA inhibits protein degradation more efficiently than EPA by regulating the PPARγ/NFκB pathway in C2C12 myotubes. 2013 Biomed Res Int pmid:23984342
Santos VC et al. Effects of DHA-rich fish oil supplementation on lymphocyte function before and after a marathon race. 2013 Int J Sport Nutr Exerc Metab pmid:23239683
Flock MR et al. Determinants of erythrocyte omega-3 fatty acid content in response to fish oil supplementation: a dose-response randomized controlled trial. 2013 J Am Heart Assoc pmid:24252845
Alicandro G et al. A randomized placebo-controlled study on high-dose oral algal docosahexaenoic acid supplementation in children with cystic fibrosis. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23266209
Aliche-Djoudi F et al. A role for lipid rafts in the protection afforded by docosahexaenoic acid against ethanol toxicity in primary rat hepatocytes. 2013 Food Chem. Toxicol. pmid:23907024