DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Trophoblastic Tumor, Placental Site D018245 1 associated lipids
Phenylketonuria, Maternal D017042 1 associated lipids
Refsum Disease, Infantile D052919 1 associated lipids
Pulmonary Valve Stenosis D011666 1 associated lipids
Cerebrovascular Trauma D020214 1 associated lipids
Histiocytoma, Malignant Fibrous D051677 1 associated lipids
Decapitation D049248 2 associated lipids
Communication Disorders D003147 1 associated lipids
Geographic Atrophy D057092 1 associated lipids
Lordosis D008141 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Liu J and Ma DW The role of n-3 polyunsaturated fatty acids in the prevention and treatment of breast cancer. 2014 Nutrients pmid:25412153
Bernhard W et al. Plasma phospholipids indicate impaired fatty acid homeostasis in preterm infants. 2014 Eur J Nutr pmid:24464176
Ponnampalam EN et al. Health beneficial long chain omega-3 fatty acid levels in Australian lamb managed under extensive finishing systems. 2014 Meat Sci. pmid:23643471
Hennebelle M et al. Ageing and apoE change DHA homeostasis: relevance to age-related cognitive decline. 2014 Proc Nutr Soc pmid:24103099
Schuster GU et al. Dietary long-chain omega-3 fatty acids do not diminish eosinophilic pulmonary inflammation in mice. 2014 Am. J. Respir. Cell Mol. Biol. pmid:24134486
Maitin V et al. Docosahexaenoic acid impairs the maturation of very low density lipoproteins in rat hepatic cells. 2014 J. Lipid Res. pmid:24136824
Wang S et al. Lipid content in hepatic and gonadal adipose tissue parallel aortic cholesterol accumulation in mice fed diets with different omega-6 PUFA to EPA plus DHA ratios. 2014 Clin Nutr pmid:23672804
De Mel D and Suphioglu C Fishy business: effect of omega-3 fatty acids on zinc transporters and free zinc availability in human neuronal cells. 2014 Nutrients pmid:25195602
Katakura M et al. Omega-3 fatty acids protect renal functions by increasing docosahexaenoic acid-derived metabolite levels in SHR.Cg-Lepr(cp)/NDmcr rats, a metabolic syndrome model. 2014 Molecules pmid:24642910
Browning LM et al. Compared with daily, weekly n-3 PUFA intake affects the incorporation of eicosapentaenoic acid and docosahexaenoic acid into platelets and mononuclear cells in humans. 2014 J. Nutr. pmid:24647395
Polavarapu S et al. Effect of polyunsaturated fatty acids and their metabolites on bleomycin-induced cytotoxic action on human neuroblastoma cells in vitro. 2014 PLoS ONE pmid:25536345
Hoogeveen EK et al. Effect of omega-3 fatty acids on kidney function after myocardial infarction: the Alpha Omega Trial. 2014 Clin J Am Soc Nephrol pmid:25104273
Bispo P et al. Preparation of triacylglycerols rich in omega-3 fatty acids from sardine oil using a Rhizomucor miehei lipase: focus in the EPA/DHA ratio. 2014 Appl. Biochem. Biotechnol. pmid:24293255
Tungen JE et al. Synthesis and anti-inflammatory and pro-resolving activities of 22-OH-PD1, a monohydroxylated metabolite of protectin D1. 2014 J. Nat. Prod. pmid:25247845
Serhan CN Pro-resolving lipid mediators are leads for resolution physiology. 2014 Nature pmid:24899309
[Recommendations of the Polish Gynecological Society concerning docosahexaenoic acid supplementation in the prevention of preterm birth]. 2014 Ginekol. Pol. pmid:24834713
[Recommendations of the Polish Gynecological Society concerning docosahexaenoic acid supplementation in the prevention of preterm birth]. 2014 Ginekol. Pol. pmid:25011224
Skender B et al. DHA-mediated enhancement of TRAIL-induced apoptosis in colon cancer cells is associated with engagement of mitochondria and specific alterations in sphingolipid metabolism. 2014 Biochim. Biophys. Acta pmid:24953781
Zhao Z and Zlokovic BV Blood-brain barrier: a dual life of MFSD2A? 2014 Neuron pmid:24853933
Hoffman DR et al. Four-year placebo-controlled trial of docosahexaenoic acid in X-linked retinitis pigmentosa (DHAX trial): a randomized clinical trial. 2014 JAMA Ophthalmol pmid:24805262
Abdulnour RE et al. Maresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25369934
Shimamoto C et al. Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies. 2014 Hum. Mol. Genet. pmid:25027319
White PJ et al. Protectin DX alleviates insulin resistance by activating a myokine-liver glucoregulatory axis. 2014 Nat. Med. pmid:24813250
Balas L et al. Confusion between protectin D1 (PD1) and its isomer protectin DX (PDX). An overview on the dihydroxy-docosatrienes described to date. 2014 Biochimie pmid:24262603
Evans SJ et al. Dietary intake and plasma metabolomic analysis of polyunsaturated fatty acids in bipolar subjects reveal dysregulation of linoleic acid metabolism. 2014 J Psychiatr Res pmid:24953860
Siddesha JM et al. Docosahexaenoic acid reverses angiotensin II-induced RECK suppression and cardiac fibroblast migration. 2014 Cell. Signal. pmid:24447911
Shao Z et al. Cytochrome P450 2C8 ω3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report. 2014 Arterioscler. Thromb. Vasc. Biol. pmid:24458713
Santos S et al. Fatty acids derived from a food frequency questionnaire and measured in the erythrocyte membrane in relation to adiponectin and leptin concentrations. 2014 Eur J Clin Nutr pmid:24642786
Vandal M et al. Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2. 2014 J. Neurochem. pmid:24345162
Prostek A et al. The influence of EPA and DHA on markers of inflammation in 3T3-L1 cells at different stages of cellular maturation. 2014 Lipids Health Dis pmid:24387137
Yaxin W et al. Resolvin D1 attenuates lipopolysaccharide induced acute lung injury through CXCL-12/CXCR4 pathway. 2014 J. Surg. Res. pmid:24387839
Shaikh NA et al. Efficacy of a unique omega-3 formulation on the correction of nutritional deficiency and its effects on cardiovascular disease risk factors in a randomized controlled VASCAZEN(®) REVEAL Trial. 2014 Mol. Cell. Biochem. pmid:25185754
O'Connor-Robison CI et al. The impact of dietary long-chain polyunsaturated fatty acids on bone and cartilage in gilts and sows. 2014 J. Anim. Sci. pmid:25184850
Wójcik C et al. Modulation of adipocyte differentiation by omega-3 polyunsaturated fatty acids involves the ubiquitin-proteasome system. 2014 J. Cell. Mol. Med. pmid:24834523
Berasategi I et al. Healthy reduced-fat Bologna sausages enriched in ALA and DHA and stabilized with Melissa officinalis extract. 2014 Meat Sci. pmid:24334039
Wang Q et al. Resolvin D1 stimulates alveolar fluid clearance through alveolar epithelial sodium channel, Na,K-ATPase via ALX/cAMP/PI3K pathway in lipopolysaccharide-induced acute lung injury. 2014 J. Immunol. pmid:24646745
Pottala JV et al. Higher RBC EPA + DHA corresponds with larger total brain and hippocampal volumes: WHIMS-MRI study. 2014 Neurology pmid:24453077
Zhao JP et al. Circulating docosahexaenoic acid levels are associated with fetal insulin sensitivity. 2014 PLoS ONE pmid:24454790
Harden CJ et al. Long-chain polyunsaturated fatty acid supplementation had no effect on body weight but reduced energy intake in overweight and obese women. 2014 Nutr Res pmid:24418242
Asai M et al. [Cellular models for individualized medicine in Alzheimer's disease using patient-derived induced pluripotent stem cells]. 2014 Nippon Yakurigaku Zasshi pmid:24420133
Jin M et al. Eicosapentaenoic acid and docosahexaenoic acid suppress Th2 cytokine expression in RBL-2H3 basophilic leukemia cells. 2014 J Med Food pmid:24460246
Chen MY et al. Quantitative risk-benefit analysis of fish consumption for women of child-bearing age in Hong Kong. 2014 Food Addit Contam Part A Chem Anal Control Expo Risk Assess pmid:24444393
Nozue T et al. Low serum docosahexaenoic acid is associated with progression of coronary atherosclerosis in statin-treated patients with diabetes mellitus: results of the treatment with statin on atheroma regression evaluated by intravascular ultrasound with virtual histology (TRUTH) study. 2014 Cardiovasc Diabetol pmid:24410834
O'Callaghan N et al. Telomere shortening in elderly individuals with mild cognitive impairment may be attenuated with ω-3 fatty acid supplementation: a randomized controlled pilot study. 2014 Nutrition pmid:24342530
Patterson AC et al. The percentage of DHA in erythrocytes can detect non-adherence to advice to increase EPA and DHA intakes. 2014 Br. J. Nutr. pmid:23920312
Fredman G et al. Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25246560
Kitessa SM et al. DHA-containing oilseed: a timely solution for the sustainability issues surrounding fish oil sources of the health-benefitting long-chain omega-3 oils. 2014 Nutrients pmid:24858407
O'Sullivan A et al. Habitual diets rich in dark-green vegetables are associated with an increased response to ω-3 fatty acid supplementation in Americans of African ancestry. 2014 J. Nutr. pmid:24259553
Cipollina C et al. Dual anti-oxidant and anti-inflammatory actions of the electrophilic cyclooxygenase-2-derived 17-oxo-DHA in lipopolysaccharide- and cigarette smoke-induced inflammation. 2014 Biochim. Biophys. Acta pmid:24594225
Siddiqui RA et al. Characterization of lovastatin-docosahexaenoate anticancer properties against breast cancer cells. 2014 Bioorg. Med. Chem. pmid:24556504
Hashimoto M et al. Possibility of polyunsaturated fatty acids for the prevention and treatment of neuropsychiatric illnesses. 2014 J. Pharmacol. Sci. pmid:24561447
Ciaccio CE and Girdhar M Effect of maternal ω3 fatty acid supplementation on infant allergy. 2014 Ann. Allergy Asthma Immunol. pmid:24565593
von Schacky C Omega-3 index and cardiovascular health. 2014 Nutrients pmid:24566438
Bauer I et al. Does omega-3 fatty acid supplementation enhance neural efficiency? A review of the literature. 2014 Hum Psychopharmacol pmid:24285504
Nehra D et al. Docosahexaenoic acid, G protein-coupled receptors, and melanoma: is G protein-coupled receptor 40 a potential therapeutic target? 2014 J. Surg. Res. pmid:24576779
Abdel-Dayem MA et al. Valproate-induced liver injury: modulation by the omega-3 fatty acid DHA proposes a novel anticonvulsant regimen. 2014 Drugs R D pmid:24733439
Höper AC et al. Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice. 2014 J. Nutr. pmid:24285691
Rutkowsky JM et al. Acylcarnitines activate proinflammatory signaling pathways. 2014 Am. J. Physiol. Endocrinol. Metab. pmid:24760988
Zhao H et al. Pulmonary delivery of docosahexaenoic acid mitigates bleomycin-induced pulmonary fibrosis. 2014 BMC Pulm Med pmid:24742272
DiNicolantonio JJ et al. A higher dietary ratio of long-chain omega-3 to total omega-6 fatty acids for prevention of COX-2-dependent adenocarcinomas. 2014 Nutr Cancer pmid:25356937
Boca SM et al. Testing multiple biological mediators simultaneously. 2014 Bioinformatics pmid:24202540
Peoples GE and McLennan PL Long-chain n-3 DHA reduces the extent of skeletal muscle fatigue in the rat in vivo hindlimb model. 2014 Br. J. Nutr. pmid:24229620
Sublimi Saponetti M et al. Aggregation of Aß(25-35) on DOPC and DOPC/DHA bilayers: an atomic force microscopy study. 2014 PLoS ONE pmid:25551704
Cho Y et al. Colon cancer cell apoptosis is induced by combined exposure to the n-3 fatty acid docosahexaenoic acid and butyrate through promoter methylation. 2014 Exp. Biol. Med. (Maywood) pmid:24495951
Tang H et al. Protective actions of aspirin-triggered (17R) resolvin D1 and its analogue, 17R-hydroxy-19-para-fluorophenoxy-resolvin D1 methyl ester, in C5a-dependent IgG immune complex-induced inflammation and lung injury. 2014 J. Immunol. pmid:25172497
Montgomery P et al. Fatty acids and sleep in UK children: subjective and pilot objective sleep results from the DOLAB study--a randomized controlled trial. 2014 J Sleep Res pmid:24605819
Walker CG et al. Age and sex differences in the incorporation of EPA and DHA into plasma fractions, cells and adipose tissue in humans. 2014 Br. J. Nutr. pmid:24063767
Zheng MG et al. Cloning, expression and stress-respondent transcription of long-chain acyl-coenzyme A synthetase cDNA gene of Nannochloropsis gaditana and its involvement in the biosynthesis of eicosapentaenoic and decosahexaenoic acids. 2014 Biotechnol. Lett. pmid:24068506
Bahety P et al. Metabotyping of docosahexaenoic acid - treated Alzheimer's disease cell model. 2014 PLoS ONE pmid:24587236
Gregory MK et al. Effect of dietary canola oil on long-chain omega-3 fatty acid content in broiler hearts. 2014 J Anim Physiol Anim Nutr (Berl) pmid:23510129
Kwon B et al. Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells. 2014 Biochim. Biophys. Acta pmid:24732014
Hernández E et al. Prenatal determinants of cord blood total immunoglobulin E levels in Mexican newborns. 2013 Sep-Oct Allergy Asthma Proc pmid:23998234
Harris WS et al. Comparative effects of an acute dose of fish oil on omega-3 fatty acid levels in red blood cells versus plasma: implications for clinical utility. 2013 Sep-Oct J Clin Lipidol pmid:24079284
Tatsuno I et al. Long-term safety and efficacy of TAK-085 in Japanese subjects with hypertriglyceridemia undergoing lifestyle modification: the omega-3 fatty acids randomized long-term (ORL) study. 2013 Nov-Dec J Clin Lipidol pmid:24314359
Igarashi M et al. Kinetics of eicosapentaenoic acid in brain, heart and liver of conscious rats fed a high n-3 PUFA containing diet. 2013 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:24209500
Fenton JI et al. Immunomodulation by dietary long chain omega-3 fatty acids and the potential for adverse health outcomes. 2013 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:24183073
Docosahexaenoic and arachidonic acid levels in ELBW infants with prolonged exposure to intravenous lipids. 2013 May-Jun Neonatal Netw pmid:23807965
Tatsuno I et al. Efficacy and safety of TAK-085 compared with eicosapentaenoic acid in Japanese subjects with hypertriglyceridemia undergoing lifestyle modification: the omega-3 fatty acids randomized double-blind (ORD) study. 2013 May-Jun J Clin Lipidol pmid:23725919
Nishimura RY et al. Breast milk fatty acid composition of women living far from the coastal area in Brazil. 2013 May-Jun J Pediatr (Rio J) pmid:23669215
Zajdel A et al. Polyunsaturated fatty acids inhibit melanoma cell growth in vitro. 2013 Mar-Apr Acta Pol Pharm pmid:23614295
Bohr S et al. Resolvin D2 prevents secondary thrombosis and necrosis in a mouse burn wound model. 2013 Jan-Feb Wound Repair Regen pmid:23110665
Piñeiro-Corrales G et al. [Role of omega-3 fatty acids in cardiovascular disease prevention]. 2013 Jan-Feb Nutr Hosp pmid:23808424
Lecchi C et al. Effects of EPA and DHA on lipid droplet accumulation and mRNA abundance of PAT proteins in caprine monocytes. 2013 Res. Vet. Sci. pmid:23102647
Fernández-Iglesias A et al. DHA sensitizes FaO cells to tert-BHP-induced oxidative effects. Protective role of EGCG. 2013 Food Chem. Toxicol. pmid:24140970
Hagemann A et al. Content of essential fatty acids in cultivated Acartia tonsa nauplii fed a DHA-deficient Tetraselmis sp. concentrate. 2013 Commun. Agric. Appl. Biol. Sci. pmid:25141657
Dobson EP et al. Controlled formation of mono- and dihydroxy-resolvins from EPA and DHA using soybean 15-lipoxygenase. 2013 J. Lipid Res. pmid:23471029
van den Elsen LW et al. n-3 Long-chain PUFA reduce allergy-related mediator release by human mast cells in vitro via inhibition of reactive oxygen species. 2013 Br. J. Nutr. pmid:23021516
Bazan NG The docosanoid neuroprotectin D1 induces homeostatic regulation of neuroinflammation and cell survival. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23022417
Morita M et al. The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza. 2013 Cell pmid:23477864
Samieri C et al. Relationship between diet and plasma long-chain n-3 PUFAs in older people: impact of apolipoprotein E genotype. 2013 J. Lipid Res. pmid:23801662
Jones ML et al. Maternal dietary omega-3 fatty acid intake increases resolvin and protectin levels in the rat placenta. 2013 J. Lipid Res. pmid:23723388
German OL et al. Retinoid X receptor activation is essential for docosahexaenoic acid protection of retina photoreceptors. 2013 J. Lipid Res. pmid:23723389
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Giroud S et al. Membrane phospholipid fatty acid composition regulates cardiac SERCA activity in a hibernator, the Syrian hamster (Mesocricetus auratus). 2013 PLoS ONE pmid:23650545
Bjorgvinsdottir L et al. Inflammatory response following heart surgery and association with n-3 and n-6 long-chain polyunsaturated fatty acids in plasma and red blood cell membrane lipids. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23999253
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Gadaria-Rathod N et al. Red blood cell fatty acid analysis for determining compliance with omega3 supplements in dry eye disease trials. 2013 J Ocul Pharmacol Ther pmid:23971620
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