| MeSH term | MeSH ID | Detail |
|---|---|---|
| Myoglobinuria | D009212 | 3 associated lipids |
| Dyslexia | D004410 | 3 associated lipids |
| Albinism | D000417 | 3 associated lipids |
| Short Bowel Syndrome | D012778 | 3 associated lipids |
| Depression, Postpartum | D019052 | 3 associated lipids |
| Chondrodysplasia Punctata, Rhizomelic | D018902 | 4 associated lipids |
| Biliary Atresia | D001656 | 4 associated lipids |
| Milk Hypersensitivity | D016269 | 4 associated lipids |
| Spinocerebellar Ataxias | D020754 | 4 associated lipids |
| Diabetes Complications | D048909 | 4 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Timmer-Bosscha H et al. | Influence of docosahexaenoic acid on cisplatin resistance in a human small cell lung carcinoma cell line. | 1989 | J. Natl. Cancer Inst. | pmid:2544740 |
| Mueller BA et al. | Comparative effects of omega-3 fatty acids in men and women. | 1989 | Clin Pharm | pmid:2545407 |
| Goodnight SH | The effects of omega-3 fatty acids on thrombosis and atherogenesis. | 1989 | Hematol Pathol | pmid:2545665 |
| Lee TH and Arm JP | The effects of a fish oil enriched diet on experimentally-induced and clinical asthma. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2546399 |
| Hirai A et al. | Effect of oral administration of highly purified eicosapentaenoic acid and docosahexaenoic acid on platelet function and serum lipids in hyperlipidemic patients. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2546401 |
| Schaffer HK | Essential fatty acids and eicosanoids in cutaneous inflammation. | 1989 | Int. J. Dermatol. | pmid:2546896 |
| Steiner A et al. | Effect of fish oil on blood pressure and serum lipids in hypertension and hyperlipidaemia. | 1989 | J Hypertens Suppl | pmid:2547916 |
| Thomson AB et al. | Influence of dietary fat composition on intestinal absorption in the rat. | 1989 | Lipids | pmid:2549323 |
| Somers SD et al. | Alteration of in vitro murine peritoneal macrophage function by dietary enrichment with eicosapentaenoic and docosahexaenoic acids in menhaden fish oil. | 1989 | Cell. Immunol. | pmid:2550148 |
| Yoshino S and Ellis EF | Stimulation of anaphylaxis in the mouse footpad by dietary fish oil fatty acids. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2550967 |
| Bégin ME et al. | Plasma fatty acid levels in patients with acquired immune deficiency syndrome and in controls. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2550969 |
| Aoki N et al. | Acute effects of unsaturated fatty acids in splanchnic artery occlusion shock. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2550971 |
| Vreeken J et al. | Transient aggregation resistance of human blood platelets in fresh plasma. II. Physiological relevance: influence of fish oil. | 1989 | Thromb. Res. | pmid:2551059 |
| Vacek JL et al. | Short-term effects of omega-3 fatty acids on exercise stress test parameters, angina and lipoproteins. | 1989 | Biomed. Pharmacother. | pmid:2551411 |
| Simopoulos AP | Summary of the NATO advanced research workshop on dietary omega 3 and omega 6 fatty acids: biological effects and nutritional essentiality. | 1989 | J. Nutr. | pmid:2564887 |
| DiGiacomo RA et al. | Fish-oil dietary supplementation in patients with Raynaud's phenomenon: a double-blind, controlled, prospective study. | 1989 | Am. J. Med. | pmid:2536517 |
| Swann PG et al. | Eicosapentaenoic acid and docosahexaenoic acid are antagonists at the thromboxane A2/prostaglandin H2 receptor in human platelets. | 1989 | FEBS Lett. | pmid:2537230 |
| Blank ML et al. | Effects of eicosapentaenoic and docosahexaenoic acid supplements on phospholipid composition and plasmalogen biosynthesis in P388D1 cells. | 1989 | Arch. Biochem. Biophys. | pmid:2537603 |
| Hearn JA et al. | Marine lipid concentrate and atherosclerosis in the rabbit model. | 1989 | Atherosclerosis | pmid:2539167 |
| Shimokawa H and Vanhoutte PM | Dietary omega 3 fatty acids and endothelium-dependent relaxations in porcine coronary arteries. | 1989 | Am. J. Physiol. | pmid:2539756 |
| Lands WE | n-3 fatty acids as precursors for active metabolic substances: dissonance between expected and observed events. | 1989 | J Intern Med Suppl | pmid:2539828 |
| Karmali RA | n-3 fatty acids and cancer. | 1989 | J Intern Med Suppl | pmid:2539832 |
| Fischer S | How should we measure n-3 polyunsaturated fatty acids and their metabolites in humans? | 1989 | J Intern Med Suppl | pmid:2539833 |
| Dyerberg J and Nordøy A | Prospectives on n-3 fatty acids in medical research. | 1989 | J Intern Med Suppl | pmid:2539834 |
| Rustan AC and Drevon CA | Eicosapentaenoic acid inhibits hepatic production of very low density lipoprotein. | 1989 | J Intern Med Suppl | pmid:2539835 |
| Hirai A et al. | Eicosapentaenoic acid and adult diseases in Japan: epidemiological and clinical aspects. | 1989 | J Intern Med Suppl | pmid:2539836 |
| Sanders TA et al. | Influence of n-3 fatty acids on blood lipids in normal subjects. | 1989 | J Intern Med Suppl | pmid:2539838 |
| Bates D et al. | A double-blind controlled trial of long chain n-3 polyunsaturated fatty acids in the treatment of multiple sclerosis. | 1989 | J. Neurol. Neurosurg. Psychiatr. | pmid:2540285 |
| Kim HY and Salem N | Preparation and the structural determination of hydroperoxy derivatives of docosahexaenoic acid and other polyunsaturates by thermospray LC/MS. | 1989 | Prostaglandins | pmid:2541468 |
| Burns CP et al. | Effect of docosahexaenoic acid on rate of differentiation of HL-60 human leukemia. | 1989 | Cancer Res. | pmid:2541901 |
| Westberg G et al. | Effect of eicosapentaenoic acid rich menhaden oil and MaxEPA on the autoimmune disease of Mrl/l mice. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2542168 |
| Anderson GJ et al. | Rapid modulation of the n-3 docosahexaenoic acid levels in the brain and retina of the newly hatched chick. | 1989 | J. Lipid Res. | pmid:2542425 |
| Mori TA et al. | Dietary fish oils increase serum lipids in insulin-dependent diabetics compared with healthy controls. | 1989 | Metab. Clin. Exp. | pmid:2542722 |
| Leaf DA | Omega-3 fatty acids and coronary artery disease. More than a fish tale. | 1989 | Postgrad Med | pmid:2542914 |
| Arm JP et al. | The effects of dietary supplementation with fish oil lipids on the airways response to inhaled allergen in bronchial asthma. | 1989 | Am. Rev. Respir. Dis. | pmid:2543246 |
| Yeo YK et al. | The effect of long-term consumption of fish oil on platelet-activating factor synthesis in rat renal microsomes. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2543394 |
| Gupta AK et al. | Double-blind, placebo-controlled study to evaluate the efficacy of fish oil and low-dose UVB in the treatment of psoriasis. | 1989 | Br. J. Dermatol. | pmid:2667615 |
| Kürkçüoğlu N and Tandoğdu R | The effect of 'MaxEPA' in the treatment of patients with Behçet's disease. | 1989 | Br. J. Dermatol. | pmid:2597640 |
| Dart AM et al. | Effects of Maxepa on serum lipids in hypercholesterolaemic subjects. | 1989 | Atherosclerosis | pmid:2692571 |
| Pilley G | Fish oil controversy. | 1989 | DICP | pmid:2718495 |
| Wechsler JG et al. | [Effect of omega-3-fatty acids on biliary lipids and lithogenicity]. | 1989 | Z Gastroenterol | pmid:2756729 |
| Dewsbury CE et al. | Topical eicosapentaenoic acid (EPA) in the treatment of psoriasis. | 1989 | Br. J. Dermatol. | pmid:2730847 |
| Chernenko GA et al. | Intestinal absorption and lymphatic transport of fish oil (MaxEPA) in the rat. | 1989 | Biochim. Biophys. Acta | pmid:2742878 |
| Bandyopadhyay GK et al. | Docosahexaenoic acid is neither synthesized nor retroconverted by the normal and tumor mouse mammary epithelial cells in primary culture. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2522001 |
| Wetzel MG et al. | Metabolic labeling of normal canine rod outer segment phospholipids in vivo and in vitro. | 1989 | Exp. Eye Res. | pmid:2522054 |
| Scott BL and Bazan NG | Membrane docosahexaenoate is supplied to the developing brain and retina by the liver. | 1989 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2523075 |
| VanRollins M et al. | Synthesis of epoxide and vicinal diol regioisomers from docosahexaenoate methyl esters. | 1989 | J. Lipid Res. | pmid:2523946 |
| Ekström B et al. | Lipolysis of polyenoic fatty acid esters of human chylomicrons by lipoprotein lipase. | 1989 | Eur. J. Clin. Invest. | pmid:2553422 |
| Aukema HM and Holub BJ | Effect of dietary supplementation with a fish oil concentrate on the alkenylacyl class of ethanolamine phospholipid in human platelets. | 1989 | J. Lipid Res. | pmid:2918250 |
| Clark WF et al. | Omega-3 fatty acid dietary supplementation in systemic lupus erythematosus. | 1989 | Kidney Int. | pmid:2811063 |
| Wong SH et al. | Effects of eicosapentaenoic and docosahexaenoic acids on apoprotein B mRNA and secretion of very low density lipoprotein in HepG2 cells. | 1989 Nov-Dec | Arteriosclerosis | pmid:2556098 |
| Jones RE and Plymate SR | Phosphatidylcholine synthesis in human spermatozoa. | 1989 Sep-Oct | J. Androl. | pmid:2531732 |
| Uauy R | Are omega-3 fatty acids required for normal eye and brain development in the human? | 1990 | J. Pediatr. Gastroenterol. Nutr. | pmid:1978859 |
| Mori TA et al. | Fish oil-induced changes in apolipoproteins in IDDM subjects. | 1990 | Diabetes Care | pmid:2201495 |
| Chin HP et al. | Very early aortic responses during atherosclerosis induction in rabbits: measurement by duplex ultrasound. I. Non-invasive study of aortic hyperresponsiveness to serotonin. | 1990 | Atherosclerosis | pmid:2202316 |
| Yeh YY et al. | Enrichment of (n-3) fatty acids of suckling rats by maternal dietary menhaden oil. | 1990 | J. Nutr. | pmid:2140410 |
| Ellis EF et al. | Effect of fish oil n-3 fatty acids on cerebral microcirculation. | 1990 | Am. J. Physiol. | pmid:2141767 |
| Wainwright PE et al. | Effects of prenatal ethanol and long-chain n-3 fatty acid supplementation on development in mice. 2. Fatty acid composition of brain membrane phospholipids. | 1990 | Alcohol. Clin. Exp. Res. | pmid:2143055 |
| Gaudette DC and Holub BJ | Effect of albumin-bound DHA on phosphoinositide phosphorylation in collagen stimulated human platelets. | 1990 | Thromb. Res. | pmid:2162088 |
| Zhu BQ et al. | Regression of atherosclerosis in cholesterol-fed rabbits: effects of fish oil and verapamil. | 1990 | J. Am. Coll. Cardiol. | pmid:2136876 |
| Anderson GJ et al. | Docosahexaenoic acid is the preferred dietary n-3 fatty acid for the development of the brain and retina. | 1990 | Pediatr. Res. | pmid:2136947 |
| Düsing R et al. | Effects of n-3 fatty acids on renal function and renal prostaglandin E metabolism. | 1990 | Kidney Int. | pmid:2402124 |
| Grønn M et al. | The Zellweger syndrome: deficient conversion of docosahexaenoic acid (22:6(n-3)) to eicosapentaenoic acid (20:5(n-3)) and normal delta 4-desaturase activity in cultured skin fibroblasts. | 1990 | Biochim. Biophys. Acta | pmid:2140517 |
| Weisser B et al. | Fish oil and baroreceptor function in man. | 1990 | Klin. Wochenschr. | pmid:2140590 |
| Beckman JK et al. | Identification of hydroxyalkenals formed from omega-3 fatty acids. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2140937 |
| Dustin LB et al. | Docosahexaenoic acid, a constituent of rodent fetal serum and fish oil diets, inhibits acquisition of macrophage tumoricidal function. | 1990 | J. Immunol. | pmid:2141046 |
| Blonk MC et al. | Dose-response effects of fish-oil supplementation in healthy volunteers. | 1990 | Am. J. Clin. Nutr. | pmid:2141757 |
| Ehringer W et al. | A comparison of the effects of linolenic (18:3 omega 3) and docosahexaenoic (22:6 omega 3) acids on phospholipid bilayers. | 1990 | Chem. Phys. Lipids | pmid:2142021 |
| DeCaterina R et al. | Vascular prostacyclin is increased in patients ingesting omega-3 polyunsaturated fatty acids before coronary artery bypass graft surgery. | 1990 | Circulation | pmid:2142635 |
| Dehmer GJ | Another piece of the fish oil puzzle. | 1990 | Circulation | pmid:2142636 |
| Gordon WC and Bazan NG | Docosahexaenoic acid utilization during rod photoreceptor cell renewal. | 1990 | J. Neurosci. | pmid:2142959 |
| MartÃnez M | Severe deficiency of docosahexaenoic acid in peroxisomal disorders: a defect of delta 4 desaturation? | 1990 | Neurology | pmid:2143272 |
| Kestin M et al. | n-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants. | 1990 | Am. J. Clin. Nutr. | pmid:1971991 |
| Singer P et al. | A possible contribution of decrease in free fatty acids to low serum triglyceride levels after diets supplemented with n-6 and n-3 polyunsaturated fatty acids. | 1990 | Atherosclerosis | pmid:2146966 |
| Hendra TJ et al. | Effects of fish oil supplements in NIDDM subjects. Controlled study. | 1990 | Diabetes Care | pmid:2209315 |
| Westberg G and Tarkowski A | Effect of MaxEPA in patients with SLE. A double-blind, crossover study. | 1990 | Scand. J. Rheumatol. | pmid:2186476 |
| Beckermann B et al. | [Comparative bioavailability of eicosapentaenoic acid and docasahexaenoic acid from triglycerides, free fatty acids and ethyl esters in volunteers]. | 1990 | Arzneimittelforschung | pmid:2144420 |
| Bilo HJ and Gans RO | Fish oil: a panacea? | 1990 | Biomed. Pharmacother. | pmid:2144459 |
| O'Keefe SF et al. | Trans n-3 eicosapentaenoic and docosahexaenoic acid isomers exhibit different inhibitory effects on arachidonic acid metabolism in human platelets compared to the respective cis fatty acids. | 1990 | J. Lipid Res. | pmid:2144870 |
| Childs MT et al. | Divergent lipoprotein responses to fish oils with various ratios of eicosapentaenoic acid and docosahexaenoic acid. | 1990 | Am. J. Clin. Nutr. | pmid:2144941 |
| Anel A et al. | Cytotoxicity of chlorambucil and chlorambucil-fatty acid conjugates against human lymphomas and normal human peripheral blood lymphocytes. | 1990 | Biochem. Pharmacol. | pmid:2144962 |
| Malnoë A et al. | Effect of in vivo modulation of membrane docosahexaenoic acid levels on the dopamine-dependent adenylate cyclase activity in the rat retina. | 1990 | J. Neurochem. | pmid:2145395 |
| Raguenez-Viotte G et al. | Evidence for 4-hydroxyalkenals in rat renal cortex peroxidized by N2-methyl-9-hydroxyellipticinium acetate or Celiptium. | 1990 | Biochim. Biophys. Acta | pmid:2145981 |
| Sullivan DR et al. | The effects of dietary n - 3 fatty acid in animal models of type 1 and type 2 diabetes. | 1990 | Diabetes Res. Clin. Pract. | pmid:2146101 |
| Singer P et al. | Fish oil amplifies the effect of propranolol in mild essential hypertension. | 1990 | Hypertension | pmid:2147175 |
| Engler MB et al. | Docosahexaenoic acid (22:6n3)-induced relaxation of the rat aorta. | 1990 | Eur. J. Pharmacol. | pmid:2147654 |
| Swann PG et al. | Enrichment of platelet phospholipids with eicosapentaenoic acid and docosahexaenoic acid inhibits thromboxane A2/prostaglandin H2 receptor binding and function. | 1990 | J. Biol. Chem. | pmid:2147687 |
| Kim HY et al. | Stereochemical analysis of hydroxylated docosahexaenoates produced by human platelets and rat brain homogenate. | 1990 | Prostaglandins | pmid:2147773 |
| Kim HY et al. | Formation of 15-lipoxygenase product from docosahexaenoic acid (22:6w3) by human platelets. | 1990 | Prostaglandins | pmid:2147774 |
| Wilkinson DI | Do dietary supplements of fish oils improve psoriasis? | 1990 | Cutis | pmid:2148141 |
| Simonelli F et al. | [Possible role of altered levels of plasma docosahexaenoic acid in the pathogenesis of retinitis pigmentosa. Preliminary results]. | 1990 | Boll. Soc. Ital. Biol. Sper. | pmid:2149985 |
| Bazan NG and Scott BL | Dietary omega-3 fatty acids and accumulation of docosahexaenoic acid in rod photoreceptor cells of the retina and at synapses. | 1990 | Ups J Med Sci Suppl | pmid:2150242 |
| Rodriguez de Turco EB et al. | Preferential uptake and metabolism of docosahexaenoic acid in membrane phospholipids from rod and cone photoreceptor cells of human and monkey retinas. | 1990 | J. Neurosci. Res. | pmid:2150417 |
| McLachlan T et al. | A longitudinal study of plasma n-3 fatty acid levels in a family with X-linked retinitis pigmentosa. | 1990 | Biochem. Soc. Trans. | pmid:2150655 |
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| Lang CA and Davis RA | Fish oil fatty acids impair VLDL assembly and/or secretion by cultured rat hepatocytes. | 1990 | J. Lipid Res. | pmid:2150855 |
| Holbrook PG and Wurtman RJ | Calcium-dependent incorporation of choline into phosphatidylcholine (PC) by base-exchange in rat brain membranes occurs preferentially with phospholipid substrates containing docosahexaenoic acid (22:6(n-3)). | 1990 | Biochim. Biophys. Acta | pmid:2171666 |
| Lin DS and Conner WE | Are the n-3 fatty acids from dietary fish oil deposited in the triglyceride stores of adipose tissue? | 1990 | Am. J. Clin. Nutr. | pmid:2138861 |
| Silverman DI et al. | Usefulness of plasma phospholipid N-3 fatty acid levels in predicting dietary fish intake in patients with coronary artery disease. | 1990 | Am. J. Cardiol. | pmid:2145737 |
| Saito M et al. | Influence of different types and levels of dietary lipids on liver microsomal mixed function oxidase system in rats. | 1990 | Ann. Nutr. Metab. | pmid:2147097 |