DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Diabetes Mellitus, Experimental D003921 85 associated lipids
Atherosclerosis D050197 85 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Alzheimer Disease D000544 76 associated lipids
Stomach Ulcer D013276 75 associated lipids
Leukemia D007938 74 associated lipids
Hyperlipidemias D006949 73 associated lipids
Coronary Disease D003327 70 associated lipids
Melanoma D008545 69 associated lipids
Colitis D003092 69 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Türkez H et al. Ameliorative effect of docosahexaenoic acid on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced histological changes, oxidative stress, and DNA damage in rat liver. 2012 Toxicol Ind Health pmid:21996711
Oliver E et al. Docosahexaenoic acid attenuates macrophage-induced inflammation and improves insulin sensitivity in adipocytes-specific differential effects between LC n-3 PUFA. 2012 J. Nutr. Biochem. pmid:22137266
Hall JC et al. Docosahexaenoic acid, but not eicosapentaenoic acid, reduces the early inflammatory response following compression spinal cord injury in the rat. 2012 J. Neurochem. pmid:22404382
Nakamoto K et al. Involvement of the long-chain fatty acid receptor GPR40 as a novel pain regulatory system. 2012 Brain Res. pmid:22137657
Cruz-Hernandez C et al. Benefits of structured and free monoacylglycerols to deliver eicosapentaenoic (EPA) in a model of lipid malabsorption. 2012 Nutrients pmid:23201848
Stanley WC et al. Update on lipids and mitochondrial function: impact of dietary n-3 polyunsaturated fatty acids. 2012 Curr Opin Clin Nutr Metab Care pmid:22248591
Will BrainStrong boost your brain? 2012 Consum Rep pmid:22891387
Shearer GC et al. Effects of prescription niacin and omega-3 fatty acids on lipids and vascular function in metabolic syndrome: a randomized controlled trial. 2012 J. Lipid Res. pmid:22892157
Liu Y et al. Fish oil enhances intestinal integrity and inhibits TLR4 and NOD2 signaling pathways in weaned pigs after LPS challenge. 2012 J. Nutr. pmid:23014495
Adolph S et al. Unsaturated fatty acids promote the phagocytosis of P. aeruginosa and R. equi by RAW264.7 macrophages. 2012 Curr. Microbiol. pmid:22903555
Norling LV et al. Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions. 2012 Arterioscler. Thromb. Vasc. Biol. pmid:22499990
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Harris WS et al. Changes in erythrocyte membrane trans and marine fatty acids between 1999 and 2006 in older Americans. 2012 J. Nutr. pmid:22623386
An WS et al. Effect of omega-3 fatty acids on the modification of erythrocyte membrane fatty acid content including oleic acid in peritoneal dialysis patients. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22071008
Jacobson TA et al. Effects of eicosapentaenoic acid and docosahexaenoic acid on low-density lipoprotein cholesterol and other lipids: a review. 2012 Jan-Feb J Clin Lipidol pmid:22264569
Widgerow AD Cellular resolution of inflammation--catabasis. 2012 Jan-Feb Wound Repair Regen pmid:22276585
Kuipers RS et al. Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22115845
Brenna T Tissue-specific LCPUFA accretion in fetal humans. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22078006
Helmersson-Karlqvist J et al. Enhanced prostaglandin F2α formation in human pregnancy and the effect of increased oily fish intake: results from the Salmon in Pregnancy Study. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22047909
Kuipers RS et al. Gestational age dependent content, composition and intrauterine accretion rates of fatty acids in fetal white adipose tissue. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22093549
Abad S and Turon X Valorization of biodiesel derived glycerol as a carbon source to obtain added-value metabolites: Focus on polyunsaturated fatty acids. 2012 May-Jun Biotechnol. Adv. pmid:22261015
Ma L et al. Arginyl-glutamine dipeptide or docosahexaenoic acid attenuate hyperoxia-induced lung injury in neonatal mice. 2012 Nov-Dec Nutrition pmid:23044165
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Davidson MH et al. A novel omega-3 free fatty acid formulation has dramatically improved bioavailability during a low-fat diet compared with omega-3-acid ethyl esters: the ECLIPSE (Epanova(®) compared to Lovaza(®) in a pharmacokinetic single-dose evaluation) study. 2012 Nov-Dec J Clin Lipidol pmid:23312053
Block RC et al. The combination of EPA+DHA and low-dose aspirin ingestion reduces platelet function acutely whereas each alone may not in healthy humans. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:23017325
Kartikasari LR et al. Dietary alpha-linolenic acid enhances omega-3 long chain polyunsaturated fatty acid levels in chicken tissues. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:22925778
Dalal JJ et al. Role of omega-3 ethyl ester concentrate in reducing sudden cardiac death following myocardial infarction and in management of hypertriglyceridemia: an Indian consensus statement. 2012 Sep-Oct Indian Heart J pmid:23102390
Baum SJ EPA and DHA: distinct yet essential n-3 fatty acids. 2012 Sep-Oct J Clin Lipidol pmid:23009786
Castro González MI et al. [Renal patient's diet: Can fish be included?]. 2012 Sep-Oct Nutr Hosp pmid:23478696
Yu Y et al. DHA prevents altered 5-HT1A, 5-HT2A, CB1 and GABAA receptor binding densities in the brain of male rats fed a high-saturated-fat diet. 2013 J. Nutr. Biochem. pmid:23337348
Chen F et al. Fish oil attenuates liver injury caused by LPS in weaned pigs associated with inhibition of TLR4 and nucleotide-binding oligomerization domain protein signaling pathways. 2013 Innate Immun pmid:23339927
Tikhonenko M et al. N-3 polyunsaturated Fatty acids prevent diabetic retinopathy by inhibition of retinal vascular damage and enhanced endothelial progenitor cell reparative function. 2013 PLoS ONE pmid:23383097
Li H et al. Production of sophorolipids with eicosapentaenoic acid and docosahexaenoic acid from Wickerhamiella domercqiae var. sophorolipid using fish oil as a hydrophobic carbon source. 2013 Biotechnol. Lett. pmid:23386226
Casey JM et al. Effect of stearidonic acid-enriched soybean oil on fatty acid profile and metabolic parameters in lean and obese Zucker rats. 2013 Lipids Health Dis pmid:24139088
Chang CY et al. Docosahexaenoic acid reduces cellular inflammatory response following permanent focal cerebral ischemia in rats. 2013 J. Nutr. Biochem. pmid:24139673
Fernández-Iglesias A et al. DHA sensitizes FaO cells to tert-BHP-induced oxidative effects. Protective role of EGCG. 2013 Food Chem. Toxicol. pmid:24140970
Song YJ et al. Regulatory functions of docosahexaenoic acid on ion channels in rat ventricular myocytes. 2013 Eur Rev Med Pharmacol Sci pmid:24142611
Larson MK et al. Exogenous modification of platelet membranes with the omega-3 fatty acids EPA and DHA reduces platelet procoagulant activity and thrombus formation. 2013 Am. J. Physiol., Cell Physiol. pmid:23174566
Mussi SV et al. New approach to improve encapsulation and antitumor activity of doxorubicin loaded in solid lipid nanoparticles. 2013 Eur J Pharm Sci pmid:23178339
Braga SF and Almgren MM Complementary therapies in cystic fibrosis: nutritional supplements and herbal products. 2013 J Pharm Pract pmid:23178411
Gurzell EA et al. DHA-enriched fish oil targets B cell lipid microdomains and enhances ex vivo and in vivo B cell function. 2013 J. Leukoc. Biol. pmid:23180828
Klingler M et al. Comparison of the incorporation of orally administered DHA into plasma, erythrocyte and cheek cell glycerophospholipids. 2013 Br. J. Nutr. pmid:22874641
Tu WC et al. Dietary alpha-linolenic acid does not enhance accumulation of omega-3 long-chain polyunsaturated fatty acids in barramundi (Lates calcarifer). 2013 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:23085323
Robinson DT et al. Docosahexaenoic and arachidonic acid levels in extremely low birth weight infants with prolonged exposure to intravenous lipids. 2013 J. Pediatr. pmid:22878111
Hsiao HM et al. A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation. 2013 PLoS ONE pmid:23484005
Betancor MB et al. Oxidative stress in sea bass Dicentrarchus labrax larvae: interaction of high dietary DHA contents and several antioxidant nutrients. 2013 Commun. Agric. Appl. Biol. Sci. pmid:25141617
Hagemann A et al. Content of essential fatty acids in cultivated Acartia tonsa nauplii fed a DHA-deficient Tetraselmis sp. concentrate. 2013 Commun. Agric. Appl. Biol. Sci. pmid:25141657
Lund I et al. Importance of DHA for first feeding pikeperch larvae--influence on behavioural responses. 2013 Commun. Agric. Appl. Biol. Sci. pmid:25141683
Rai AK et al. Bioefficacy of EPA-DHA from lipids recovered from fish processing wastes through biotechnological approaches. 2013 Food Chem pmid:23017395
van den Elsen LW et al. n-3 Long-chain PUFA reduce allergy-related mediator release by human mast cells in vitro via inhibition of reactive oxygen species. 2013 Br. J. Nutr. pmid:23021516
Bazan NG The docosanoid neuroprotectin D1 induces homeostatic regulation of neuroinflammation and cell survival. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23022417
Kamolrat T and Gray SR The effect of eicosapentaenoic and docosahexaenoic acid on protein synthesis and breakdown in murine C2C12 myotubes. 2013 Biochem. Biophys. Res. Commun. pmid:23438435
Cieslik M et al. Docosahexaenoic acid and tetracyclines as promising neuroprotective compounds with poly(ADP-ribose) polymerase inhibitory activities for oxidative/genotoxic stress treatment. 2013 Neurochem. Int. pmid:23439385
Oken E et al. A pilot randomized controlled trial to promote healthful fish consumption during pregnancy: the Food for Thought Study. 2013 Nutr J pmid:23496848
Huang HL et al. Docosahexaenoic acid in maternal and neonatal plasma phospholipids and milk lipids of Taiwanese women in Kinmen: fatty acid composition of maternal blood, neonatal blood and breast milk. 2013 Lipids Health Dis pmid:23496882
Koltsida O et al. Toll-like receptor 7 stimulates production of specialized pro-resolving lipid mediators and promotes resolution of airway inflammation. 2013 EMBO Mol Med pmid:23584892
Li J et al. Comparative metabolomics analysis of docosahexaenoic acid fermentation processes by Schizochytrium sp. under different oxygen availability conditions. 2013 OMICS pmid:23586678
Barros KV et al. Fatty acids in plasma, white and red blood cells, and tissues after oral or intravenous administration of fish oil in rats. 2013 Clin Nutr pmid:23541913
Berman DR et al. Docosahexaenoic acid augments hypothermic neuroprotection in a neonatal rat asphyxia model. 2013 Neonatology pmid:23817197
Singhal A et al. Docosahexaenoic acid supplementation, vascular function and risk factors for cardiovascular disease: a randomized controlled trial in young adults. 2013 J Am Heart Assoc pmid:23817470
Hoss E et al. Control of late cornified envelope genes relevant to psoriasis risk: upregulation by 1,25-dihydroxyvitamin D3 and plant-derived delphinidin. 2013 Arch. Dermatol. Res. pmid:23839497
Zhang X et al. Resolvin D1 protects podocytes in adriamycin-induced nephropathy through modulation of 14-3-3β acetylation. 2013 PLoS ONE pmid:23840712
Meijerink J et al. N-Acyl amines of docosahexaenoic acid and other n-3 polyunsatured fatty acids - from fishy endocannabinoids to potential leads. 2013 Br. J. Pharmacol. pmid:23088259
Mozaffarian D et al. Plasma phospholipid long-chain ω-3 fatty acids and total and cause-specific mortality in older adults: a cohort study. 2013 Ann. Intern. Med. pmid:23546563
Sun YB et al. Endothelial dysfunction exacerbates renal interstitial fibrosis through enhancing fibroblast Smad3 linker phosphorylation in the mouse obstructed kidney. 2013 PLoS ONE pmid:24391884
Codabaccus MB et al. Restoration of EPA and DHA in rainbow trout (Oncorhynchus mykiss) using a finishing fish oil diet at two different water temperatures. 2013 Food Chem pmid:23768353
Correia Bacarin C et al. Fish oil provides robust and sustained memory recovery after cerebral ischemia: influence of treatment regimen. 2013 Physiol. Behav. pmid:23770426
Jones ML et al. Maternal dietary omega-3 fatty acid intake increases resolvin and protectin levels in the rat placenta. 2013 J. Lipid Res. pmid:23723388
German OL et al. Retinoid X receptor activation is essential for docosahexaenoic acid protection of retina photoreceptors. 2013 J. Lipid Res. pmid:23723389
Xie W et al. Resolvin D1 reduces deterioration of tight junction proteins by upregulating HO-1 in LPS-induced mice. 2013 Lab. Invest. pmid:23857007
Li Q et al. A comparative study: In vitro effects of EPA and DHA on immune functions of head-kidney macrophages isolated from large yellow croaker (Larmichthys crocea). 2013 Fish Shellfish Immunol. pmid:23859878
Chen S and Subbaiah PV Regioisomers of phosphatidylcholine containing DHA and their potential to deliver DHA to the brain: role of phospholipase specificities. 2013 Lipids pmid:23604781
Long SJ and Benton D A double-blind trial of the effect of docosahexaenoic acid and vitamin and mineral supplementation on aggression, impulsivity, and stress. 2013 Hum Psychopharmacol pmid:23625531
Titova OE et al. Dietary intake of eicosapentaenoic and docosahexaenoic acids is linked to gray matter volume and cognitive function in elderly. 2013 Age (Dordr) pmid:22791395
Klek S et al. Four-week parenteral nutrition using a third generation lipid emulsion (SMOFlipid)--a double-blind, randomised, multicentre study in adults. 2013 Clin Nutr pmid:22796064
Barber E et al. Comparative actions of omega-3 fatty acids on in-vitro lipid droplet formation. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:24012207
Sheets KG et al. Microglial ramification and redistribution concomitant with the attenuation of choroidal neovascularization by neuroprotectin D1. 2013 Mol. Vis. pmid:23922492
Baselga-Escudero L et al. Chronic administration of proanthocyanidins or docosahexaenoic acid reverses the increase of miR-33a and miR-122 in dyslipidemic obese rats. 2013 PLoS ONE pmid:23922812
Bjorgvinsdottir L et al. Inflammatory response following heart surgery and association with n-3 and n-6 long-chain polyunsaturated fatty acids in plasma and red blood cell membrane lipids. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23999253
Iwasaka H et al. Utilization of waste syrup for production of polyunsaturated fatty acids and xanthophylls by Aurantiochytrium. 2013 J Oleo Sci pmid:24005017
Cheng R et al. Cloning and functional analysis of putative malonyl-CoA:acyl-carrier protein transacylase gene from the docosahexaenoic acid-producer Schizochytrium sp. TIO1101. 2013 World J. Microbiol. Biotechnol. pmid:23292648
Chen J et al. Docosahexaenoic acid (DHA) attenuated paraquat induced lung damage in mice. 2013 Inhal Toxicol pmid:23293968
Figueroa JD et al. Dietary omega-3 polyunsaturated fatty acids improve the neurolipidome and restore the DHA status while promoting functional recovery after experimental spinal cord injury. 2013 J. Neurotrauma pmid:23294084
Lang JE et al. Nutrigenetic response to omega-3 fatty acids in obese asthmatics (NOOA): rationale and methods. 2013 Contemp Clin Trials pmid:23298524
Gibson RA et al. Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22515943
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Derogis PB et al. The development of a specific and sensitive LC-MS-based method for the detection and quantification of hydroperoxy- and hydroxydocosahexaenoic acids as a tool for lipidomic analysis. 2013 PLoS ONE pmid:24204871
Wang D et al. Organochlorine pesticides in fish from Taihu Lake, China, and associated human health risk assessment. 2013 Ecotoxicol. Environ. Saf. pmid:24125867
Storck Lindholm E et al. Different fatty acid pattern in breast milk of obese compared to normal-weight mothers. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23273824
Atwell K et al. Respiratory hospitalisation of infants supplemented with docosahexaenoic acid as preterm neonates. 2013 J Paediatr Child Health pmid:23279074
Barros KV et al. Supplemental intravenous n-3 fatty acids and n-3 fatty acid status and outcome in critically ill elderly patients in the ICU receiving enteral nutrition. 2013 Clin Nutr pmid:23260750
Sato K et al. Selective and potent inhibitory effect of docosahexaenoic acid (DHA) on U46619-induced contraction in rat aorta. 2013 J Smooth Muscle Res pmid:24304639
Engel S et al. Docosahexaenoic acid status at 9 months is inversely associated with communicative skills in 3-year-old girls. 2013 Matern Child Nutr pmid:22642227
Gadaria-Rathod N et al. Red blood cell fatty acid analysis for determining compliance with omega3 supplements in dry eye disease trials. 2013 J Ocul Pharmacol Ther pmid:23971620
Weintraub H Update on marine omega-3 fatty acids: management of dyslipidemia and current omega-3 treatment options. 2013 Atherosclerosis pmid:24075771
Stulnig G et al. Docosahexaenoic acid (DHA)-induced heme oxygenase-1 attenuates cytotoxic effects of DHA in vascular smooth muscle cells. 2013 Atherosclerosis pmid:24075775
Nagachinta S and Akoh CC Spray-dried structured lipid containing long-chain polyunsaturated fatty acids for use in infant formulas. 2013 J. Food Sci. pmid:24024870
Kennedy DO Reply to MP Pase and C Stough. 2013 Am. J. Clin. Nutr. pmid:24027792