DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

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Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

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What functions are associated with DHA?


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What lipids are associated with DHA?

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What genes are associated with DHA?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with DHA

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Authors Title Published Journal PubMed Link
van Goor SA et al. The influence of supplemental docosahexaenoic and arachidonic acids during pregnancy and lactation on neurodevelopment at eighteen months. 2011 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:21316208
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Jones JL et al. A Mediterranean-style low-glycemic-load diet improves variables of metabolic syndrome in women, and addition of a phytochemical-rich medical food enhances benefits on lipoprotein metabolism. 2011 May-Jun J Clin Lipidol pmid:21600524
Gladyshev MI et al. Effect of water temperature on the content of essential polyunsaturated fatty acids in freshwater zooplankton. 2011 Mar-Apr Dokl. Biochem. Biophys. pmid:21590375
Larson MK et al. Omega-3 fatty acids modulate collagen signaling in human platelets. 2011 Mar-Apr Prostaglandins Leukot. Essent. Fatty Acids pmid:21177087
McDaniel JC et al. Fish oil supplementation alters levels of lipid mediators of inflammation in microenvironment of acute human wounds. 2011 Mar-Apr Wound Repair Regen pmid:21362086
Lam YY et al. Insulin-stimulated glucose uptake and pathways regulating energy metabolism in skeletal muscle cells: the effects of subcutaneous and visceral fat, and long-chain saturated, n-3 and n-6 polyunsaturated fatty acids. 2011 Jul-Aug Biochim. Biophys. Acta pmid:21570480
Mason CM et al. Prescription omega-3s: an overview for nurse practitioners. 2011 Jul-Aug J Cardiovasc Nurs pmid:21666421
Gao F et al. Liver conversion of docosahexaenoic and arachidonic acids from their 18-carbon precursors in rats on a DHA-free but α-LNA-containing n-3 PUFA adequate diet. 2011 Jul-Aug Biochim. Biophys. Acta pmid:21651989
Trimarco B et al. [The Alpha Omega study]. 2011 Jul-Aug G Ital Cardiol (Rome) pmid:21779112
Lamaziere A et al. Differential distribution of DHA-phospholipids in rat brain after feeding: A lipidomic approach. 2011 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:21109411
Vilaseca MA et al. Long-chain polyunsaturated fatty acid concentration in patients with inborn errors of metabolism. 2011 Jan-Feb Nutr Hosp pmid:21519739
Sato SB et al. Differential roles of internal and terminal double bonds in docosahexaenoic acid: Comparative study of cytotoxicity of polyunsaturated fatty acids to HT-29 human colorectal tumor cell line. 2011 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:20952172
Kulkarni AV et al. Reduced placental docosahexaenoic acid levels associated with increased levels of sFlt-1 in preeclampsia. 2011 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:20956072
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Solakivi T et al. Serum fatty acid profile in subjects with irritable bowel syndrome. 2011 Scand. J. Gastroenterol. pmid:21073373
Vasickova L et al. Possible effect of DHA intake on body weight reduction and lipid metabolism in obese children. 2011 Neuro Endocrinol. Lett. pmid:22101886
Wang RX et al. [Mechanism related to docosahexaenoic acid induced large conductance calcium-activated potassium channel currents increase in coronary smooth muscle cells]. 2011 Zhonghua Xin Xue Guan Bing Za Zhi pmid:21624312
Amano T et al. Impact of omega-3 polyunsaturated fatty acids on coronary plaque instability: an integrated backscatter intravascular ultrasound study. 2011 Atherosclerosis pmid:21684546
Ajami M et al. Expression of Bcl-2 and Bax after hippocampal ischemia in DHA + EPA treated rats. 2011 Neurol. Sci. pmid:21617951
Li HX et al. Increasing DHA and EPA concentrations prolong action potential durations and reduce transient outward potassium currents in rat ventricular myocytes. 2011 Lipids pmid:21140236
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Huang MC et al. Placental docosahexaenoic and arachidonic acids correlate weakly with placental polychlorinated dibenzofurans (PCDF) and are uncorrelated with polychlorinated dibenzo-p-dioxins (PCDD) or polychlorinated biphenyls (PCB) at delivery: a pilot study. 2011 Food Chem. Toxicol. pmid:21549173
Kanno S et al. Albumin modulates docosahexaenoic acid-induced cytotoxicity in human hepatocellular carcinoma cell lines. 2011 Toxicol. Lett. pmid:21108996
Kuipers RS et al. Intrauterine, postpartum and adult relationships between arachidonic acid (AA) and docosahexaenoic acid (DHA). 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21561751
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Draper E et al. Omega-3 fatty acids attenuate dendritic cell function via NF-κB independent of PPARγ. 2011 J. Nutr. Biochem. pmid:21111596
Yan J et al. Enzymatic enrichment of polyunsaturated fatty acids using novel lipase preparations modified by combination of immobilization and fish oil treatment. 2011 Bioresour. Technol. pmid:21565494
Tian H et al. 14S,21R-dihydroxydocosahexaenoic acid remedies impaired healing and mesenchymal stem cell functions in diabetic wounds. 2011 J. Biol. Chem. pmid:21112969
Stoeckel K et al. Fatty acid patterns of dog erythrocyte membranes after feeding of a fish-oil based DHA-rich supplement with a base diet low in n-3 fatty acids versus a diet containing added n-3 fatty acids. 2011 Acta Vet. Scand. pmid:22024384
Curatolo N et al. Oral administration of docosahexaenoic acid/eicosapentaeinoic acids is not anticonvulsant in rats: implications for translational research. 2011 Pediatr. Res. pmid:21857379
Bazan NG et al. Endogenous signaling by omega-3 docosahexaenoic acid-derived mediators sustains homeostatic synaptic and circuitry integrity. 2011 Mol. Neurobiol. pmid:21918832
Schuchardt JP et al. Moderate doses of EPA and DHA from re-esterified triacylglycerols but not from ethyl-esters lower fasting serum triacylglycerols in statin-treated dyslipidemic subjects: Results from a six month randomized controlled trial. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21862301
Sanders TA et al. Effect of low doses of long-chain n-3 PUFAs on endothelial function and arterial stiffness: a randomized controlled trial. 2011 Am. J. Clin. Nutr. pmid:21865334
Altenburg JD et al. A novel 2,6-diisopropylphenyl-docosahexaenoamide conjugate induces apoptosis in T cell acute lymphoblastic leukemia cell lines. 2011 Biochem. Biophys. Res. Commun. pmid:21749860
Liu JC et al. Long-chain omega-3 fatty acids and blood pressure. 2011 Am. J. Hypertens. pmid:21753804
Luan HM et al. Antioxidant activities and antioxidative components in the surf clam, Mactra veneriformis. 2011 Nat. Prod. Res. pmid:21756123
Bazan NG et al. Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseases. 2011 Annu. Rev. Nutr. pmid:21756134
Westerberg AC et al. Attention among very low birth weight infants following early supplementation with docosahexaenoic and arachidonic acid. 2011 Acta Paediatr. pmid:20624152
Jiang T et al. Omega-3 fatty acids affected human perception of ground beef negatively. 2011 Meat Sci. pmid:21621335
Ichihara H et al. Therapeutic effects of hybrid liposomes composed of phosphatidylcholine and docosahexaenoic acid on the hepatic metastasis of colon carcinoma along with apoptosis in vivo. 2011 Biol. Pharm. Bull. pmid:21628892
Colombo J et al. Long-chain polyunsaturated fatty acid supplementation in infancy reduces heart rate and positively affects distribution of attention. 2011 Pediatr. Res. pmid:21705959
Manley BJ et al. High-dose docosahexaenoic acid supplementation of preterm infants: respiratory and allergy outcomes. 2011 Pediatrics pmid:21708809
Fredman G and Serhan CN Specialized proresolving mediator targets for RvE1 and RvD1 in peripheral blood and mechanisms of resolution. 2011 Biochem. J. pmid:21711247
Oh SF et al. Chiral lipidomics of E-series resolvins: aspirin and the biosynthesis of novel mediators. 2011 Biochim. Biophys. Acta pmid:21712098
Zargar A and Ito MK Long chain omega-3 dietary supplements: a review of the National Library of Medicine Herbal Supplement Database. 2011 Metab Syndr Relat Disord pmid:21787228
Garcia C et al. French mothers' milk deficient in DHA contains phospholipid species of potential interest for infant development. 2011 J. Pediatr. Gastroenterol. Nutr. pmid:21788764
Hu H et al. Isolation and characterization of a mesophilic Arthrospira maxima strain capable of producing docosahexaenoic acid. 2011 J. Microbiol. Biotechnol. pmid:21791955
Abu-Saad K et al. Rapid assessment tools for ranking pregnant minority women into multi-nutrient exposure groups. 2011 Public Health Nutr pmid:20519048
McGee SL et al. DHA protects against zinc mediated alterations in neuronal cellular bioenergetics. 2011 Cell. Physiol. Biochem. pmid:21865858
Ethier S et al. Continuous culture of the microalgae Schizochytrium limacinum on biodiesel-derived crude glycerol for producing docosahexaenoic acid. 2011 Bioresour. Technol. pmid:20570140
Serhan CN et al. Novel proresolving aspirin-triggered DHA pathway. 2011 Chem. Biol. pmid:21867913
O'Sullivan TA et al. Dietary intake and food sources of fatty acids in Australian adolescents. 2011 Nutrition pmid:20338727
Ramakrishnan U Fatty acid status and maternal mental health. 2011 Matern Child Nutr pmid:21366870
Diaz Encarnacion MM et al. n-3 Fatty acids block TNF-α-stimulated MCP-1 expression in rat mesangial cells. 2011 Am. J. Physiol. Renal Physiol. pmid:21367920
Farina EK et al. Protective effects of fish intake and interactive effects of long-chain polyunsaturated fatty acid intakes on hip bone mineral density in older adults: the Framingham Osteoporosis Study. 2011 Am. J. Clin. Nutr. pmid:21367955
Ohtsuka Y et al. ω-3 fatty acids attenuate mucosal inflammation in premature rat pups. 2011 J. Pediatr. Surg. pmid:21376198
Stark DT and Bazan NG Neuroprotectin D1 induces neuronal survival and downregulation of amyloidogenic processing in Alzheimer's disease cellular models. 2011 Mol. Neurobiol. pmid:21431475
Kiso Y Pharmacology in health foods: effects of arachidonic acid and docosahexaenoic acid on the age-related decline in brain and cardiovascular system function. 2011 J. Pharmacol. Sci. pmid:21436600
Fernandes FS et al. Maternal intake of flaxseed-based diet (Linum usitatissimum) on hippocampus fatty acid profile: implications for growth, locomotor activity and spatial memory. 2011 Nutrition pmid:21439792
Kuan CY et al. Long-chain polyunsaturated fatty acids promote paclitaxel cytotoxicity via inhibition of the MDR1 gene in the human colon cancer Caco-2 cell line. 2011 J Am Coll Nutr pmid:21917707
Hashimoto M et al. Protective effects of prescription n-3 fatty acids against impairment of spatial cognitive learning ability in amyloid β-infused rats. 2011 Food Funct pmid:21894325
Ladesich JB et al. Membrane level of omega-3 docosahexaenoic acid is associated with severity of obstructive sleep apnea. 2011 J Clin Sleep Med pmid:21897776
Raatz SK et al. Baking reduces prostaglandin, resolvin, and hydroxy-fatty acid content of farm-raised Atlantic salmon (Salmo salar). 2011 J. Agric. Food Chem. pmid:21919483
Arsenault D et al. DHA improves cognition and prevents dysfunction of entorhinal cortex neurons in 3xTg-AD mice. 2011 PLoS ONE pmid:21383850
Wiedemann HP Fish oil is not the fix for acute lung injury. 2011 Crit. Care Med. pmid:21685749
Rossi PC et al. Optimization of molecular distillation to concentrate ethyl esters of eicosapentaenoic (20:5 ω-3) and docosahexaenoic acids (22:6 ω-3) using simplified phenomenological modeling. 2011 J. Sci. Food Agric. pmid:21384378
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Lin YH et al. Altered essential fatty acid metabolism and composition in rat liver, plasma, heart and brain after microalgal DHA addition to the diet. 2011 J. Nutr. Biochem. pmid:21111595
Kong W et al. Docosahexaenoic acid prevents dendritic cell maturation, inhibits antigen-specific Th1/Th17 differentiation and suppresses experimental autoimmune encephalomyelitis. 2011 Brain Behav. Immun. pmid:20854895
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Teichert SA and Akoh CC Modifications of stearidonic acid soybean oil by enzymatic acidolysis for the production of human milk fat analogues. 2011 J. Agric. Food Chem. pmid:22097918
The brainy omega-3 fails an Alzheimer's test. 2011 Harv Health Lett pmid:21344681
Itoh T et al. Efficient synthesis of the very-long-chain n-3 fatty acids, tetracosahexaenoic acid (C24:6n-3) and tricosahexaenoic acid (C23:6n-3). 2011 Lipids pmid:21347745
Cottin SC et al. The differential effects of EPA and DHA on cardiovascular risk factors. 2011 Proc Nutr Soc pmid:21349231
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Rogers LK et al. Maternal docosahexaenoic acid supplementation decreases lung inflammation in hyperoxia-exposed newborn mice. 2011 J. Nutr. pmid:21178083
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