DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

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Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

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What functions are associated with DHA?


Related references are published most in these journals:

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What lipids are associated with DHA?

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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with DHA

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Authors Title Published Journal PubMed Link
Qu L et al. Enhancement of docosahexaenoic acid production by Schizochytrium sp. using a two-stage oxygen supply control strategy based on oxygen transfer coefficient. 2011 Lett. Appl. Microbiol. pmid:21070268
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Solakivi T et al. Serum fatty acid profile in subjects with irritable bowel syndrome. 2011 Scand. J. Gastroenterol. pmid:21073373
Vasickova L et al. Possible effect of DHA intake on body weight reduction and lipid metabolism in obese children. 2011 Neuro Endocrinol. Lett. pmid:22101886
Wang RX et al. [Mechanism related to docosahexaenoic acid induced large conductance calcium-activated potassium channel currents increase in coronary smooth muscle cells]. 2011 Zhonghua Xin Xue Guan Bing Za Zhi pmid:21624312
Amano T et al. Impact of omega-3 polyunsaturated fatty acids on coronary plaque instability: an integrated backscatter intravascular ultrasound study. 2011 Atherosclerosis pmid:21684546
Morin C et al. Docosahexaenoic acid derivative prevents inflammation and hyperreactivity in lung: implication of PKC-Potentiated inhibitory protein for heterotrimeric myosin light chain phosphatase of 17 kD in asthma. 2011 Am. J. Respir. Cell Mol. Biol. pmid:21057106
Yui K et al. [Therapeutic effects of larger doses of arachidonic acid added to DHA on social impairment and its relation to alterations of polyunsaturated fatty acids in individuals with autism spectrum disorders]. 2011 Nihon Shinkei Seishin Yakurigaku Zasshi pmid:21800702
Stoeckel K et al. Fatty acid patterns of dog erythrocyte membranes after feeding of a fish-oil based DHA-rich supplement with a base diet low in n-3 fatty acids versus a diet containing added n-3 fatty acids. 2011 Acta Vet. Scand. pmid:22024384
Curatolo N et al. Oral administration of docosahexaenoic acid/eicosapentaeinoic acids is not anticonvulsant in rats: implications for translational research. 2011 Pediatr. Res. pmid:21857379
Bazan NG et al. Endogenous signaling by omega-3 docosahexaenoic acid-derived mediators sustains homeostatic synaptic and circuitry integrity. 2011 Mol. Neurobiol. pmid:21918832
Schuchardt JP et al. Moderate doses of EPA and DHA from re-esterified triacylglycerols but not from ethyl-esters lower fasting serum triacylglycerols in statin-treated dyslipidemic subjects: Results from a six month randomized controlled trial. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21862301
Sanders TA et al. Effect of low doses of long-chain n-3 PUFAs on endothelial function and arterial stiffness: a randomized controlled trial. 2011 Am. J. Clin. Nutr. pmid:21865334
Altenburg JD et al. A novel 2,6-diisopropylphenyl-docosahexaenoamide conjugate induces apoptosis in T cell acute lymphoblastic leukemia cell lines. 2011 Biochem. Biophys. Res. Commun. pmid:21749860
Liu JC et al. Long-chain omega-3 fatty acids and blood pressure. 2011 Am. J. Hypertens. pmid:21753804
Luan HM et al. Antioxidant activities and antioxidative components in the surf clam, Mactra veneriformis. 2011 Nat. Prod. Res. pmid:21756123
Westerberg AC et al. Attention among very low birth weight infants following early supplementation with docosahexaenoic and arachidonic acid. 2011 Acta Paediatr. pmid:20624152
Frisardi V et al. Glycerophospholipids and glycerophospholipid-derived lipid mediators: a complex meshwork in Alzheimer's disease pathology. 2011 Prog. Lipid Res. pmid:21703303
Brignardello J et al. Increase of plasma fatty acids without changes in n-6/n-3-PUFA ratio in asymptomatic obese subjects. 2011 Arch Latinoam Nutr pmid:22308941
Walczewska A et al. [The role of docosahexaenoic acid in neuronal function]. 2011 Postepy Hig Med Dosw (Online) pmid:21677356
Davis-Bruno K and Tassinari MS Essential fatty acid supplementation of DHA and ARA and effects on neurodevelopment across animal species: a review of the literature. 2011 Birth Defects Res. B Dev. Reprod. Toxicol. pmid:21678548
Klingler M et al. Fatty acid status determination by cheek cell sampling combined with methanol-based ultrasound extraction of glycerophospholipids. 2011 Lipids pmid:21681560
Imhoff-Kunsch B et al. Prenatal docosahexaenoic acid supplementation and infant morbidity: randomized controlled trial. 2011 Pediatrics pmid:21807696
Kim HY et al. A synaptogenic amide N-docosahexaenoylethanolamide promotes hippocampal development. 2011 Prostaglandins Other Lipid Mediat. pmid:21810478
Friedrichs W et al. Omega-3 fatty acid inhibition of prostate cancer progression to hormone independence is associated with suppression of mTOR signaling and androgen receptor expression. 2011 Nutr Cancer pmid:21667400
Sakayori N et al. Distinctive effects of arachidonic acid and docosahexaenoic acid on neural stem /progenitor cells. 2011 Genes Cells pmid:21668588
Jing K et al. Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53. 2011 Autophagy pmid:21811093
Zargar A and Ito MK Long chain omega-3 dietary supplements: a review of the National Library of Medicine Herbal Supplement Database. 2011 Metab Syndr Relat Disord pmid:21787228
Shulse CN and Allen EE Widespread occurrence of secondary lipid biosynthesis potential in microbial lineages. 2011 PLoS ONE pmid:21629834
Garcia C et al. French mothers' milk deficient in DHA contains phospholipid species of potential interest for infant development. 2011 J. Pediatr. Gastroenterol. Nutr. pmid:21788764
Hu H et al. Isolation and characterization of a mesophilic Arthrospira maxima strain capable of producing docosahexaenoic acid. 2011 J. Microbiol. Biotechnol. pmid:21791955
Abu-Saad K et al. Rapid assessment tools for ranking pregnant minority women into multi-nutrient exposure groups. 2011 Public Health Nutr pmid:20519048
McGee SL et al. DHA protects against zinc mediated alterations in neuronal cellular bioenergetics. 2011 Cell. Physiol. Biochem. pmid:21865858
Ethier S et al. Continuous culture of the microalgae Schizochytrium limacinum on biodiesel-derived crude glycerol for producing docosahexaenoic acid. 2011 Bioresour. Technol. pmid:20570140
Serhan CN et al. Novel proresolving aspirin-triggered DHA pathway. 2011 Chem. Biol. pmid:21867913
O'Sullivan TA et al. Dietary intake and food sources of fatty acids in Australian adolescents. 2011 Nutrition pmid:20338727
Kuipers RS et al. Postpartum changes in maternal and infant erythrocyte fatty acids are likely to be driven by restoring insulin sensitivity and DHA status. 2011 Med. Hypotheses pmid:21388747
Boucher O et al. Neurophysiologic and neurobehavioral evidence of beneficial effects of prenatal omega-3 fatty acid intake on memory function at school age. 2011 Am. J. Clin. Nutr. pmid:21389181
Grant GE et al. Enhanced formation of 5-oxo-6,8,11,14-eicosatetraenoic acid by cancer cells in response to oxidative stress, docosahexaenoic acid and neutrophil-derived 5-hydroxy-6,8,11,14-eicosatetraenoic acid. 2011 Carcinogenesis pmid:21393477
Trofimiuk E and Braszko JJ Long-term administration of cod liver oil ameliorates cognitive impairment induced by chronic stress in rats. 2011 Lipids pmid:21442272
Chauveau F et al. Brain-targeting form of docosahexaenoic acid for experimental stroke treatment: MRI evaluation and anti-oxidant impact. 2011 Curr Neurovasc Res pmid:21443458
Collins CT et al. Pre- and post-term growth in pre-term infants supplemented with higher-dose DHA: a randomised controlled trial. 2011 Br. J. Nutr. pmid:21443815
Sala-Vila A et al. Determinants of the omega-3 index in a Mediterranean population at increased risk for CHD. 2011 Br. J. Nutr. pmid:21450116
Vincentini O et al. Docosahexaenoic acid modulates in vitro the inflammation of celiac disease in intestinal epithelial cells via the inhibition of cPLA2. 2011 Clin Nutr pmid:21421277
Fedorova-Dahms I et al. Safety evaluation of DHA-rich Algal Oil from Schizochytrium sp. 2011 Food Chem. Toxicol. pmid:21914458
Lebbadi M et al. Endogenous conversion of omega-6 into omega-3 fatty acids improves neuropathology in an animal model of Alzheimer's disease. 2011 J. Alzheimers Dis. pmid:21914946
Kuan CY et al. Long-chain polyunsaturated fatty acids promote paclitaxel cytotoxicity via inhibition of the MDR1 gene in the human colon cancer Caco-2 cell line. 2011 J Am Coll Nutr pmid:21917707
Hashimoto M et al. Protective effects of prescription n-3 fatty acids against impairment of spatial cognitive learning ability in amyloid β-infused rats. 2011 Food Funct pmid:21894325
Ladesich JB et al. Membrane level of omega-3 docosahexaenoic acid is associated with severity of obstructive sleep apnea. 2011 J Clin Sleep Med pmid:21897776
Raatz SK et al. Baking reduces prostaglandin, resolvin, and hydroxy-fatty acid content of farm-raised Atlantic salmon (Salmo salar). 2011 J. Agric. Food Chem. pmid:21919483
Wiedemann HP Fish oil is not the fix for acute lung injury. 2011 Crit. Care Med. pmid:21685749
Berry KA et al. MALDI imaging MS of phospholipids in the mouse lung. 2011 J. Lipid Res. pmid:21508254
Nochera CL et al. Consumption of DHA + EPA by low-income women during pregnancy and lactation. 2011 Nutr Clin Pract pmid:21724916
Klebanoff MA et al. Fish consumption, erythrocyte fatty acids, and preterm birth. 2011 Obstet Gynecol pmid:21508745
Bento AF et al. Omega-3 fatty acid-derived mediators 17(R)-hydroxy docosahexaenoic acid, aspirin-triggered resolvin D1 and resolvin D2 prevent experimental colitis in mice. 2011 J. Immunol. pmid:21724996
Altenburg JD et al. A synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: unique signaling not explained by the effects of either compound alone. 2011 BMC Cancer pmid:21510869
Mancini I et al. Fatty acid composition of common barbel (Barbus barbus) roe and evaluation of its haemolytic and cytotoxic activities. 2011 Toxicon pmid:21510968
Hadders-Algra M Prenatal and early postnatal supplementation with long-chain polyunsaturated fatty acids: neurodevelopmental considerations. 2011 Am. J. Clin. Nutr. pmid:21525202
Rapoport SI et al. Docosahexaenoic acid (DHA) incorporation into the brain from plasma, as an in vivo biomarker of brain DHA metabolism and neurotransmission. 2011 Prostaglandins Other Lipid Mediat. pmid:21704722
Escolano-Margarit MV et al. Prenatal DHA status and neurological outcome in children at age 5.5 years are positively associated. 2011 J. Nutr. pmid:21525247
Rockett BD et al. Membrane raft organization is more sensitive to disruption by (n-3) PUFA than nonraft organization in EL4 and B cells. 2011 J. Nutr. pmid:21525263
De Franceschi G et al. Structural and morphological characterization of aggregated species of α-synuclein induced by docosahexaenoic acid. 2011 J. Biol. Chem. pmid:21527634
Siddiqui NF et al. Enhanced generation of megakaryocytes from umbilical cord blood-derived CD34(+) cells expanded in the presence of two nutraceuticals, docosahexanoic acid and arachidonic acid, as supplements to the cytokine-containing medium. 2011 Cytotherapy pmid:20230224
Schnebelen C et al. Dietary polyunsaturated fatty acids reduce retinal stress induced by an elevation of intraocular pressure in rats. 2011 Nutr Res pmid:21530802
Decsi T and Kennedy K Sex-specific differences in essential fatty acid metabolism. 2011 Am. J. Clin. Nutr. pmid:22089435
Sengupta A and Ghosh M Integrity of erythrocytes of hypercholesterolemic and normocholesterolemic rats during ingestion of different structured lipids. 2011 Eur J Nutr pmid:21127890
Lin YH et al. Altered essential fatty acid metabolism and composition in rat liver, plasma, heart and brain after microalgal DHA addition to the diet. 2011 J. Nutr. Biochem. pmid:21111595
Pomponi MF et al. Why docosahexaenoic acid and aspirin supplementation could be useful in women as a primary prevention therapy against Alzheimer's disease? 2011 Ageing Res. Rev. pmid:20920611
Wojcicki JM and Heyman MB Maternal omega-3 fatty acid supplementation and risk for perinatal maternal depression. 2011 J. Matern. Fetal. Neonatal. Med. pmid:20925595
Kim SH et al. Prospective randomized comparison between omega-3 fatty acid supplements plus simvastatin versus simvastatin alone in Korean patients with mixed dyslipidemia: lipoprotein profiles and heart rate variability. 2011 Eur J Clin Nutr pmid:20877395
Myhrstad MC et al. Effect of the fat composition of a single high-fat meal on inflammatory markers in healthy young women. 2011 Br. J. Nutr. pmid:21736782
Zhao J et al. Deposition of docosahexaenoic acid (DHA) is limited in forebrain of young obese fa/fa Zucker rats fed a diet high in α-linolenic acid but devoid of DHA. 2011 J. Nutr. Biochem. pmid:21129946
Imhoff-Kunsch B et al. Docosahexaenoic acid supplementation from mid-pregnancy to parturition influenced breast milk fatty acid concentrations at 1 month postpartum in Mexican women. 2011 J. Nutr. pmid:21178076
Teichert SA and Akoh CC Modifications of stearidonic acid soybean oil by enzymatic acidolysis for the production of human milk fat analogues. 2011 J. Agric. Food Chem. pmid:22097918
Sasaki K et al. Total synthesis and bioactivities of two proposed structures of maresin. 2011 Chem Asian J pmid:21254430
Huang L et al. Enduring prevention and transient reduction of postoperative pain by intrathecal resolvin D1. 2011 Pain pmid:21255928
van der Pols JC et al. Serum omega-3 and omega-6 fatty acids and cutaneous p53 expression in an Australian population. 2011 Cancer Epidemiol. Biomarkers Prev. pmid:21217086
Poudel-Tandukar K et al. Long chain n-3 fatty acids intake, fish consumption and suicide in a cohort of Japanese men and women--the Japan Public Health Center-based (JPHC) prospective study. 2011 J Affect Disord pmid:20692041
Mariee AD and Abd-Ellah MF Protective effect of docosahexaenoic acid against cyclosporine A-induced nephrotoxicity in rats: a possible mechanism of action. 2011 Ren Fail pmid:21219208
Safarinejad MR Effect of omega-3 polyunsaturated fatty acid supplementation on semen profile and enzymatic anti-oxidant capacity of seminal plasma in infertile men with idiopathic oligoasthenoteratospermia: a double-blind, placebo-controlled, randomised study. 2011 Andrologia pmid:21219381
Cotogni P et al. Impact of the omega-3 to omega-6 polyunsaturated fatty acid ratio on cytokine release in human alveolar cells. 2011 JPEN J Parenter Enteral Nutr pmid:21224438
Burrows T et al. Omega-3 index, obesity and insulin resistance in children. 2011 Int J Pediatr Obes pmid:21226540
Zhao Y et al. Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARγ-mediated mechanisms in Alzheimer's disease models. 2011 PLoS ONE pmid:21246057
Gomez-Pinilla F The combined effects of exercise and foods in preventing neurological and cognitive disorders. 2011 Prev Med pmid:21281667
Feucht C and Patel DR Herbal medicines in pediatric neuropsychiatry. 2011 Pediatr. Clin. North Am. pmid:21281847
The brainy omega-3 fails an Alzheimer's test. 2011 Harv Health Lett pmid:21344681
Itoh T et al. Efficient synthesis of the very-long-chain n-3 fatty acids, tetracosahexaenoic acid (C24:6n-3) and tricosahexaenoic acid (C23:6n-3). 2011 Lipids pmid:21347745
Cottin SC et al. The differential effects of EPA and DHA on cardiovascular risk factors. 2011 Proc Nutr Soc pmid:21349231
Sapieha P et al. 5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of ω-3 polyunsaturated fatty acids. 2011 Sci Transl Med pmid:21307302
Shimshoni JA et al. Valproate uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: relevance to valproate's efficacy against bipolar disorder. 2011 Biochim. Biophys. Acta pmid:21184843
Serini S et al. Docosahexaenoic acid reverts resistance to UV-induced apoptosis in human keratinocytes: involvement of COX-2 and HuR. 2011 J. Nutr. Biochem. pmid:21185708
Wang RX et al. Activation of vascular BK channels by docosahexaenoic acid is dependent on cytochrome P450 epoxygenase activity. 2011 Cardiovasc. Res. pmid:21187320
Riedel M et al. Membrane lipid modification by docosahexaenoic acid (DHA) promotes the formation of α-synuclein inclusion bodies immunopositive for SUMO-1 in oligodendroglial cells after oxidative stress. 2011 J. Mol. Neurosci. pmid:20725866
Hamazaki K et al. Docosahexaenoic acid is an independent predictor of all-cause mortality in hemodialysis patients. 2011 Am. J. Nephrol. pmid:21196723
Cho JY et al. Oral administration of docosahexaenoic acid attenuates colitis induced by dextran sulfate sodium in mice. 2011 Mol Nutr Food Res pmid:20824662
Pawlik D et al. Fish-oil fat emulsion supplementation may reduce the risk of severe retinopathy in VLBW infants. 2011 Pediatrics pmid:21199856
Turk HF et al. Linoleic acid and butyrate synergize to increase Bcl-2 levels in colonocytes. 2011 Int. J. Cancer pmid:20232381
Lecchi C et al. In vitro modulation of caprine monocyte immune functions by ω-3 polyunsaturated fatty acids. 2011 Vet. J. pmid:20889357
Ji RR et al. Emerging roles of resolvins in the resolution of inflammation and pain. 2011 Trends Neurosci. pmid:21963090
Toufektsian MC et al. Dietary flavonoids increase plasma very long-chain (n-3) fatty acids in rats. 2011 J. Nutr. pmid:21068183