Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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pmid:28379169 | ||||
pmid:28373143 | ||||
pmid:28372209 | ||||
pmid:28369884 | ||||
Burak C et al. | Effects of the flavonol quercetin and α-linolenic acid on n-3 PUFA status in metabolically healthy men and women: a randomised, double-blinded, placebo-controlled, crossover trial. | 2017 | Br. J. Nutr. | pmid:28366181 |
Garg ML et al. | Effect of dietary cholesterol and/or omega 3 fatty acids on lipid composition and delta 5-desaturase activity of rat liver microsomes. | 1988 | J. Nutr. | pmid:2836574 |
pmid:28365353 | ||||
pmid:28364876 | ||||
Mottola G et al. | Aspirin-triggered resolvin D1 attenuates PDGF-induced vascular smooth muscle cell migration via the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) pathway. | 2017 | PLoS ONE | pmid:28362840 |
Nielsen M et al. | [3H]diazepam specific binding to rat cortex in vitro is enhanced by oleic, arachidonic and docosahexenoic acid isolated from pig brain. | 1988 | Eur. J. Pharmacol. | pmid:2836212 |
pmid:28359716 | ||||
pmid:28356106 | ||||
pmid:28355511 | ||||
pmid:28347928 | ||||
pmid:28347768 | ||||
Blachier F et al. | Arachidonic acid metabolism and casein secretion in lactating rabbit mammary epithelial cells: effects of inhibitors of prostaglandins and leukotrienes synthesis. | 1988 | Prostaglandins | pmid:2834771 |
pmid:28346830 | ||||
pmid:28343553 | ||||
pmid:28342842 | ||||
pmid:28342772 | ||||
pmid:28342541 | ||||
pmid:28341437 | ||||
pmid:28338369 | ||||
pmid:28335828 | ||||
pmid:28335478 | ||||
pmid:28333036 | ||||
Ackman RG | Some possible effects on lipid biochemistry of differences in the distribution on glycerol of long-chain n-3 fatty acids in the fats of marine fish and marine mammals. | 1988 | Atherosclerosis | pmid:2833284 |
pmid:28330911 | ||||
pmid:28330907 | ||||
pmid:28330470 | ||||
pmid:28324081 | ||||
pmid:28322829 | ||||
Covens AL et al. | The effect of dietary supplementation with fish oil fatty acids on surgically induced endometriosis in the rabbit. | 1988 | Fertil. Steril. | pmid:2832216 |
pmid:28319894 | ||||
Karmali RA et al. | The effects of dietary omega-3 fatty acids on the DU-145 transplantable human prostatic tumor. | 1987 Nov-Dec | Anticancer Res. | pmid:2831791 |
pmid:28316988 | ||||
pmid:28314803 | ||||
van Acker BA et al. | The effect of fish oil on lipid profile and viscosity of erythrocyte suspensions in CAPD patients. | 1987 | Nephrol. Dial. Transplant. | pmid:2831474 |
pmid:28301979 | ||||
pmid:28301845 | ||||
pmid:28299384 | ||||
Fischer S et al. | Dietary docosahexaenoic acid is retroconverted in man to eicosapentaenoic acid, which can be quickly transformed to prostaglandin I3. | 1987 | Prostaglandins | pmid:2829279 |
Wang Y et al. | N-Docosahexaenoyl Dopamine, an Endocannabinoid-like Conjugate of Dopamine and the n-3 Fatty Acid Docosahexaenoic Acid, Attenuates Lipopolysaccharide-Induced Activation of Microglia and Macrophages via COX-2. | 2017 | ACS Chem Neurosci | pmid:28292183 |
pmid:28291551 | ||||
pmid:28288702 | ||||
Mori TA et al. | New findings in the fatty acid composition of individual platelet phospholipids in man after dietary fish oil supplementation. | 1987 | Lipids | pmid:2828811 |
Lefort N et al. | Dietary Buglossoides Arvensis Oil Increases Circulating n-3 Polyunsaturated Fatty Acids in a Dose-Dependent Manner and Enhances Lipopolysaccharide-Stimulated Whole Blood Interleukin-10-A Randomized Placebo-Controlled Trial. | 2017 | Nutrients | pmid:28287415 |
pmid:28285140 | ||||
pmid:28284730 | ||||
pmid:28284721 | ||||
Lokesh BR and Kinsella JE | Modulation of prostaglandin synthesis in mouse peritoneal macrophages by enrichment of lipids with either eicosapentaenoic or docosahexaenoic acids in vitro. | 1987 | Immunobiology | pmid:2828226 |
pmid:28281303 | ||||
Hatmi M et al. | Interference of eicosapentaenoic and docosahexaenoic acids with arachidonate-and U46619-induced platelet activation and desensitization. | 1988 | Biochem. Pharmacol. | pmid:2827688 |
pmid:28272345 | ||||
pmid:28272299 | ||||
Sperling RI et al. | The effects of N-3 polyunsaturated fatty acids on the generation of platelet-activating factor-acether by human monocytes. | 1987 | J. Immunol. | pmid:2826583 |
pmid:28264466 | ||||
Zijlstra JG et al. | Influence of docosahexaenoic acid in vitro on intracellular adriamycin concentration in lymphocytes and human adriamycin-sensitive and -resistant small-cell lung cancer cell lines, and on cytotoxicity in the tumor cell lines. | 1987 | Int. J. Cancer | pmid:2826341 |
pmid:28262093 | ||||
pmid:28260396 | ||||
pmid:28260322 | ||||
Lokesh BR et al. | Differential effects of docosahexaenoic acid and eicosapentaenoic acid on suppression of lipoxygenase pathway in peritoneal macrophages. | 1988 | Biochim. Biophys. Acta | pmid:2825816 |
Takayama H et al. | Preferential incorporation of eicosanoid precursor fatty acids into human umbilical vein endothelial cell phospholipids. | 1987 | Biochim. Biophys. Acta | pmid:2825796 |
von Schacky C | Prophylaxis of atherosclerosis with marine omega-3 fatty acids. A comprehensive strategy. | 1987 | Ann. Intern. Med. | pmid:2825573 |
pmid:28255345 | ||||
Urakaze M et al. | Infusion of fish oil emulsion: effects on platelet aggregation and fatty acid composition in phospholipids of plasma, platelets, and red blood cell membranes in rabbits. | 1987 | Am. J. Clin. Nutr. | pmid:2825504 |
pmid:28254441 | ||||
pmid:28245632 | ||||
pmid:28244708 | ||||
pmid:28241993 | ||||
Bjørneboe A et al. | Effect of dietary supplementation with eicosapentaenoic acid in the treatment of atopic dermatitis. | 1987 | Br. J. Dermatol. | pmid:2823859 |
pmid:28237088 | ||||
pmid:28237087 | ||||
pmid:28237084 | ||||
pmid:28235903 | ||||
pmid:28235892 | ||||
Liu YJ | [Biological activity and mechanism of action of eicosapentaenic acid and docosahexaenoic acid from fish oil]. | 1987 | Sheng Li Ke Xue Jin Zhan | pmid:2823380 |
pmid:28232489 | ||||
Philbrick DJ et al. | Ingestion of fish oil or a derived n-3 fatty acid concentrate containing eicosapentaenoic acid (EPA) affects fatty acid compositions of individual phospholipids of rat brain, sciatic nerve and retina. | 1987 | J. Nutr. | pmid:2822876 |
pmid:28218740 | ||||
pmid:28218722 | ||||
pmid:28218420 | ||||
pmid:28218036 | ||||
pmid:28215317 | ||||
Liu CC et al. | Increase in plasma phospholipid docosahexaenoic and eicosapentaenoic acids as a reflection of their intake and mode of administration. | 1987 | Pediatr. Res. | pmid:2821474 |
pmid:28213094 | ||||
pmid:28212859 | ||||
pmid:28212390 | ||||
Yoshino S and Ellis EF | Effect of a fish-oil-supplemented diet on inflammation and immunological processes in rats. | 1987 | Int. Arch. Allergy Appl. Immunol. | pmid:2820885 |
pmid:28208746 | ||||
Yilmaz JL et al. | Determination of Substrate Preferences for Desaturases and Elongases for Production of Docosahexaenoic Acid from Oleic Acid in Engineered Canola. | 2017 | Lipids | pmid:28197856 |
pmid:28195518 | ||||
pmid:28193189 | ||||
pmid:28189365 | ||||
pmid:28189364 | ||||
pmid:28189115 | ||||
pmid:28188173 | ||||
Tang S et al. | Maresin 1 Mitigates High Glucose-Induced Mouse Glomerular Mesangial Cell Injury by Inhibiting Inflammation and Fibrosis. | 2017 | Mediators Inflamm. | pmid:28182085 |
pmid:28179495 | ||||
pmid:28177707 |