Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Foreman-van Drongelen MM et al. | Influence of feeding artificial-formula milks containing docosahexaenoic and arachidonic acids on the postnatal long-chain polyunsaturated fatty acid status of healthy preterm infants. | 1996 | Br. J. Nutr. | pmid:8958000 |
Futamura Y | Toxicity of amiodarone on mouse pulmonary endothelial cells cultured with or without alveolar macrophages. | 1996 | J Toxicol Sci | pmid:8959650 |
Brossard N et al. | Metabolic fate of an oral tracer dose of [13C]docosahexaenoic acid triglycerides in the rat. | 1996 | Am. J. Physiol. | pmid:8967415 |
Khalfoun B et al. | Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human lymphocyte-endothelial cell adhesion. | 1996 | Transplantation | pmid:8970622 |
Martin DD et al. | The fatty acid composition of human gliomas differs from that found in nonmalignant brain tissue. | 1996 | Lipids | pmid:8972462 |
Fritsche KL and Cassity NA | Metabolism of [3H]arachidonic acid by n-3 polyunsaturated fatty acid-enriched piglet alveolar macrophages. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8981628 |
Pregnolato P et al. | Effect of diets containing different amounts of precursor and derivative fatty acids on serum TXB2. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8981629 |
Taugbøl O et al. | An experimental study on transcutaneous absorption of ethylesters of eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3) in pigs. | 1996 | Acta Vet. Scand. | pmid:8996873 |
Liutova LV et al. | [Effect of docanol on the status of hemostasis and fibrinolysis systems, as well as lipid spectrum in patients with ischemic heart disease depending on the initial level of fibrinolytic activity]. | 1996 Jan-Mar | Vopr. Med. Khim. | pmid:8999661 |
Herber SM and Van Elswyk ME | Dietary marine algae promotes efficient deposition of n-3 fatty acids for the production of enriched shell eggs. | 1996 | Poult. Sci. | pmid:9000275 |
Conquer JA and Holub BJ | Supplementation with an algae source of docosahexaenoic acid increases (n-3) fatty acid status and alters selected risk factors for heart disease in vegetarian subjects. | 1996 | J. Nutr. | pmid:9001371 |
Tamura M and Suzuki H | Effects of docosahexaenoic acid and sardine oil diets on the ultrastructure of jejunal absorptive cells in adult mice. | 1996 | Ann. Nutr. Metab. | pmid:9001686 |
Sheaff Greiner RC et al. | Linoleate, alpha-linolenate, and docosahexaenoate recycling into saturated and monounsaturated fatty acids is a major pathway in pregnant or lactating adults and fetal or infant rhesus monkeys. | 1996 | J. Lipid Res. | pmid:9017518 |
Noguchi M et al. | Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA. | 1997 | Br. J. Cancer | pmid:9020478 |
Badalamenti S et al. | Lack of renal effects of fish oil administration in patients with advanced cirrhosis and impaired glomerular filtration. | 1997 | Hepatology | pmid:9021940 |
Sauerwald TU et al. | Intermediates in endogenous synthesis of C22:6 omega 3 and C20:4 omega 6 by term and preterm infants. | 1997 | Pediatr. Res. | pmid:9029636 |
Delton-Vandenbroucke I et al. | Polyunsaturated fatty acid metabolism in retinal and cerebral microvascular endothelial cells. | 1997 | J. Lipid Res. | pmid:9034209 |
Kresiun VI et al. | [The membrane-protective action of a new preparation of n-3 polyenic acids in the adrenaline-damaged myocardium]. | 1996 Mar-Apr | Lik. Sprava | pmid:9035880 |
Wainwright PE et al. | Arachidonic acid offsets the effects on mouse brain and behavior of a diet with a low (n-6):(n-3) ratio and very high levels of docosahexaenoic acid. | 1997 | J. Nutr. | pmid:9040564 |
Iigo M et al. | Inhibitory effects of docosahexaenoic acid on colon carcinoma 26 metastasis to the lung. | 1997 | Br. J. Cancer | pmid:9043019 |
Dacremont G and Vincent G | Assay of plasmalogens and polyunsaturated fatty acids (PUFA) in erythrocytes and fibroblasts. | 1995 | J. Inherit. Metab. Dis. | pmid:9053558 |
Orth M and Luley C | Diagnostic pitfalls during therapy for extreme hypertriglyceridaemia. | 1997 | Eur J Clin Chem Clin Biochem | pmid:9056751 |
Infante JP and Huszagh VA | On the molecular etiology of decreased arachidonic (20:4n-6), docosapentaenoic (22:5n-6) and docosahexaenoic (22:6n-3) acids in Zellweger syndrome and other peroxisomal disorders. | 1997 | Mol. Cell. Biochem. | pmid:9062899 |
Yamane M and Abe A | Properties of the omega-hydroxylation system of docosahexaenoic or arachidonic acid in brain or liver homogenate of rat. | 1995 | Neurosci. Lett. | pmid:9064612 |
Kelso KA et al. | Lipid and antioxidant changes in spermatozoa and seminal plasma throughout the reproductive period of bulls. | 1997 | J. Reprod. Fertil. | pmid:9068407 |
Horimoto N et al. | Arachidonic acid activation of potassium channels in rat visual cortex neurons. | 1997 | Neuroscience | pmid:9070743 |
Kimura S et al. | Dietary docosahexaenoic acid (22: 6n-3) prevents the development of hypertension in SHRSP. | 1995 | Clin Exp Pharmacol Physiol Suppl | pmid:9072405 |
Atkinson TG et al. | Incorporation of long-chain n-3 fatty acids in tissues and enhanced bone marrow cellularity with docosahexaenoic acid feeding in post-weanling Fischer 344 rats. | 1997 | Lipids | pmid:9076666 |
Conquer JA and Holub BJ | Dietary docosahexaenoic acid as a source of eicosapentaenoic acid in vegetarians and omnivores. | 1997 | Lipids | pmid:9076673 |
Bouglé D et al. | Relationships between red blood cell vitamin E and polyunsaturated fatty acid in the premature infant. | 1996 | Ann. Nutr. Metab. | pmid:9087310 |
Mohan IK and Das UN | Oxidant stress, anti-oxidants and essential fatty acids in systemic lupus erythematosus. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9089797 |
Rodriguez de Turco EB et al. | Post-Golgi vesicles cotransport docosahexaenoyl-phospholipids and rhodopsin during frog photoreceptor membrane biogenesis. | 1997 | J. Biol. Chem. | pmid:9099692 |
McKeone BJ et al. | Alterations in serum phosphatidylcholine fatty acyl species by eicosapentaenoic and docosahexaenoic ethyl esters in patients with severe hypertriglyceridemia. | 1997 | J. Lipid Res. | pmid:9101424 |
Mandell IB et al. | Effects of fish meal in beef cattle diets on growth performance, carcass characteristics, and fatty acid composition of longissimus muscle. | 1997 | J. Anim. Sci. | pmid:9110201 |
Ndiaye J and Hayashi S | Effect of docosahexaenoic acid on lipoprotein synthesis and secretion by cultured eel hepatocytes. | 1996 | Cell Struct. Funct. | pmid:9118236 |
Kikugawa K et al. | beta-Carotene effectively scavenges toxic nitrogen oxides: nitrogen dioxide and peroxynitrous acid. | 1997 | FEBS Lett. | pmid:9119059 |
Khalfoun B et al. | In vitro effects of docosahexaenoic and eicosapentaenoic acids in association with cyclosporine A on human lymphocyte proliferation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123309 |
Heird WC et al. | Docosahexaenoic acid and the development and function of the infant retina. | 1997 | Curr. Opin. Lipidol. | pmid:9127705 |
Tamura M and Suzuki H | Effect of docosahexaenoic acid and linoleic acid diets on the ultrastructure of liver cells in adult mice. | 1997 | Int J Vitam Nutr Res | pmid:9129257 |
Harris WS | n-3 fatty acids and serum lipoproteins: human studies. | 1997 | Am. J. Clin. Nutr. | pmid:9129504 |
Oski FA | What we eat may determine who we can be. | 1997 | Nutrition | pmid:9131682 |
Gordon N | Nutrition and cognitive function. | 1997 | Brain Dev. | pmid:9134186 |
Andreassen AK et al. | Hypertension prophylaxis with omega-3 fatty acids in heart transplant recipients. | 1997 | J. Am. Coll. Cardiol. | pmid:9137231 |
Buzzi M et al. | Biosynthesis of docosahexaenoic acid in trout hepatocytes proceeds via 24-carbon intermediates. | 1997 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:9159889 |
Green P et al. | Replenishment of docosahexaenoic acid in n-3 fatty acid-deficient fetal rats by intraamniotic ethyl-docosahexaenoate administration. | 1997 | J. Neurosci. Res. | pmid:9160249 |
Benassayag C et al. | High polyunsaturated fatty acid, thromboxane A2, and alpha-fetoprotein concentrations at the human feto-maternal interface. | 1997 | J. Lipid Res. | pmid:9162747 |
Jumpsen J et al. | Small changes of dietary (n-6) and (n-3)/fatty acid content ration alter phosphatidylethanolamine and phosphatidylcholine fatty acid composition during development of neuronal and glial cells in rats. | 1997 | J. Nutr. | pmid:9164993 |
Stillwell W et al. | Effect of docosahexaenoic acid on mouse mitochondrial membrane properties. | 1997 | Lipids | pmid:9168456 |
Bell JG et al. | The effect of dietary lipid on polyunsaturated fatty acid metabolism in Atlantic salmon (Salmo salar) undergoing parr-smolt transformation. | 1997 | Lipids | pmid:9168458 |
Allard JP et al. | Lipid peroxidation during n-3 fatty acid and vitamin E supplementation in humans. | 1997 | Lipids | pmid:9168460 |