Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Croft KD et al. | The effect of dietary fish oil on platelet metabolism of 14C arachidonic acid. | 1986 | Thromb. Res. | pmid:3705024 |
Lee KW et al. | Effects of omega-3 polyunsaturated fatty acids on plasma indices of thrombogenesis and inflammation in patients post-myocardial infarction. | 2006 | Thromb. Res. | pmid:16154181 |
Prisco D et al. | Effect of medium-term supplementation with a moderate dose of n-3 polyunsaturated fatty acids on blood pressure in mild hypertensive patients. | 1998 | Thromb. Res. | pmid:9733153 |
Ishii H et al. | The effect of plasma on platelet function in hypercholesterolemic rabbits and the changes in fatty acid composition of the plasma. | 1984 | Thromb. Res. | pmid:6234679 |
Gaudette DC and Holub BJ | Effect of albumin-bound DHA on phosphoinositide phosphorylation in collagen stimulated human platelets. | 1990 | Thromb. Res. | pmid:2162088 |
Mezzano D et al. | Cardiovascular risk factors in vegetarians. Normalization of hyperhomocysteinemia with vitamin B(12) and reduction of platelet aggregation with n-3 fatty acids. | 2000 | Thromb. Res. | pmid:11108902 |
Chen LY et al. | Reduction in human neutrophil superoxide anion generation by n-3 polyunsaturated fatty acids: role of cyclooxygenase products and endothelium-derived relaxing factor. | 1994 | Thromb. Res. | pmid:7871491 |
Eritsland J et al. | Effect of long-term, moderate-dose supplementation with omega-3 fatty acids on monocyte procoagulant activity and release of interleukin-6 in patients with coronary artery disease. | 1995 | Thromb. Res. | pmid:7740525 |
Landmark K and Alm CS | [Fish and omega-3 fatty acids and heart failure]. | 2012 | Tidsskr. Nor. Laegeforen. | pmid:23736195 |
Weil A | Why I still take my daily fish oil. | 2006 | Time | pmid:16827433 |
Morisaki N et al. | In vivo effects of cis-5,8,11,14,17-20:5 (n-3) and cis-4,7,10,13,16,19-22:6(n-3) on serum lipoproteins, platelet aggregation, and lipid metabolism in the aorta of rats. | 1983 | Tohoku J. Exp. Med. | pmid:6322383 |
Munakata M et al. | The nutrient formula containing eicosapentaenoic acid and docosahexaenoic acid benefits the fatty acid status of patients receiving long-term enteral nutrition. | 2009 | Tohoku J. Exp. Med. | pmid:19155604 |
de Lima TM et al. | Docosahexaenoic acid enhances the toxic effect of imatinib on Bcr-Abl expressing HL-60 cells. | 2007 | Toxicol In Vitro | pmid:17604596 |
Azevedo-Martins AK et al. | Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells. | 2006 | Toxicol In Vitro | pmid:16644178 |
Blum JL et al. | Profiling of fatty acids released during calcium-induced mitochondrial permeability transition in isolated rabbit kidney cortex mitochondria. | 2011 | Toxicol In Vitro | pmid:21443943 |
Türkez H et al. | Ameliorative effect of docosahexaenoic acid on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced histological changes, oxidative stress, and DNA damage in rat liver. | 2012 | Toxicol Ind Health | pmid:21996711 |
Chen J et al. | Aspirin-triggered resolvin D1 down-regulates inflammatory responses and protects against endotoxin-induced acute kidney injury. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24709673 |
Li CC et al. | DHA down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes by attenuating CAR translocation. | 2007 | Toxicol. Appl. Pharmacol. | pmid:17904175 |
Majkova Z et al. | Omega-3 fatty acid oxidation products prevent vascular endothelial cell activation by coplanar polychlorinated biphenyls. | 2011 | Toxicol. Appl. Pharmacol. | pmid:21130106 |
Kanno S et al. | Albumin modulates docosahexaenoic acid-induced cytotoxicity in human hepatocellular carcinoma cell lines. | 2011 | Toxicol. Lett. | pmid:21108996 |
Qadhi R et al. | Differential responses to docosahexaenoic acid in primary and immortalized cardiac cells. | 2013 | Toxicol. Lett. | pmid:23523905 |
Samokhvalov V et al. | PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. | 2015 | Toxicol. Lett. | pmid:25300478 |
Nikolakopoulou Z et al. | The induction of apoptosis in pre-malignant keratinocytes by omega-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) is inhibited by albumin. | 2013 | Toxicol. Lett. | pmid:23391486 |
Kaur P et al. | Role of docosahexaenoic acid in modulating methylmercury-induced neurotoxicity. | 2007 | Toxicol. Sci. | pmid:17728287 |
Domingo JL et al. | Benefits and risks of fish consumption Part I. A quantitative analysis of the intake of omega-3 fatty acids and chemical contaminants. | 2007 | Toxicology | pmid:17161894 |
Aspenström-Fagerlund B et al. | Oleic acid and docosahexaenoic acid cause an increase in the paracellular absorption of hydrophilic compounds in an experimental model of human absorptive enterocytes. | 2007 | Toxicology | pmid:17560003 |
Balaji T et al. | Localization of cyclooxygenase-2 in mice vas deferens and its effects on fertility upon suppression using nimesulide: a preferential cyclooxygenase-2 inhibitor. | 2007 | Toxicology | pmid:17382448 |
Mancini I et al. | Fatty acid composition of common barbel (Barbus barbus) roe and evaluation of its haemolytic and cytotoxic activities. | 2011 | Toxicon | pmid:21510968 |
Zhu G et al. | A modified n-3 fatty acid desaturase gene from Caenorhabditis briggsae produced high proportion of DHA and DPA in transgenic mice. | 2008 | Transgenic Res. | pmid:18322818 |
Truksa M et al. | Metabolic engineering of plants to produce very long-chain polyunsaturated fatty acids. | 2006 | Transgenic Res. | pmid:16604455 |
Alimuddin G et al. | Enhancement of EPA and DHA biosynthesis by over-expression of masu salmon delta6-desaturase-like gene in zebrafish. | 2005 | Transgenic Res. | pmid:16022387 |
Le-Niculescu H et al. | Convergent functional genomic studies of ω-3 fatty acids in stress reactivity, bipolar disorder and alcoholism. | 2011 | Transl Psychiatry | pmid:22832392 |
Amminger GP et al. | Predictors of treatment response in young people at ultra-high risk for psychosis who received long-chain omega-3 fatty acids. | 2015 | Transl Psychiatry | pmid:25585167 |
Nordgren TM et al. | Maresin-1 reduces airway inflammation associated with acute and repetitive exposures to organic dust. | 2015 | Transl Res | pmid:25655838 |
Begum G et al. | ER stress and effects of DHA as an ER stress inhibitor. | 2013 | Transl Stroke Res | pmid:24323417 |
Chambon M et al. | Influence of orthotopic liver transplantation on docosehexaenoic acid deficiency in cholestatic children. | 1996 | Transplant. Proc. | pmid:8908096 |
Khalfoun B et al. | Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human lymphocyte proliferation induced by allogenic cells. | 1997 | Transplant. Proc. | pmid:9270778 |
Khalfoun B et al. | In vitro effects of docosahexaenoic and eicosapentaenoic acids in association with cyclosporine A on human lymphocyte proliferation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123309 |
Khalfoun B et al. | Docosahexaenoic and eicosapentaenoic acids inhibit the CD28-lymphocyte activation pathway in vitro. | 1998 | Transplant. Proc. | pmid:9865267 |
Khalfoun B et al. | Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human lymphocyte-endothelial cell adhesion. | 1996 | Transplantation | pmid:8970622 |
Ku K et al. | The effects of omega-3 polyunsaturated (correction of polyunsatulated) fatty acids on the recovery of cardiac function following cold preservation and reperfusion in hyperlipidemic rats. | 1996 | Transplantation | pmid:8824469 |
Kielar ML et al. | Docosahexaenoic acid decreases IRF-1 mRNA and thus inhibits activation of both the IRF-E and NFkappa d response elements of the iNOS promoter. | 2000 | Transplantation | pmid:10852612 |
Wallis JG et al. | Polyunsaturated fatty acid synthesis: what will they think of next? | 2002 | Trends Biochem. Sci. | pmid:12217522 |
Hejazi MA and Wijffels RH | Milking of microalgae. | 2004 | Trends Biotechnol. | pmid:15038924 |
Ariel A and Serhan CN | Resolvins and protectins in the termination program of acute inflammation. | 2007 | Trends Immunol. | pmid:17337246 |
Bazan NG | Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors. | 2006 | Trends Neurosci. | pmid:16580739 |
Ji RR et al. | Emerging roles of resolvins in the resolution of inflammation and pain. | 2011 | Trends Neurosci. | pmid:21963090 |
Nguyen LQ et al. | Feeding of spinach or sweet-potato leaves and growth performance of growing pigs kept on smallholder farms in Central Vietnam. | 2004 | Trop Anim Health Prod | pmid:15643817 |
Danchenko OO et al. | [Ontogenic characteristics of changes in fatty acid composition of the liver lipids as a main substrate for peroxidation in geese]. | 2003 May-Jun | Ukr Biokhim Zh (1999) | pmid:14577163 |
Bazan NG and Scott BL | Dietary omega-3 fatty acids and accumulation of docosahexaenoic acid in rod photoreceptor cells of the retina and at synapses. | 1990 | Ups J Med Sci Suppl | pmid:2150242 |