Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Qu L et al. | Enhancement of docosahexaenoic acid production by Schizochytrium sp. using a two-stage oxygen supply control strategy based on oxygen transfer coefficient. | 2011 | Lett. Appl. Microbiol. | pmid:21070268 |
Kim HW et al. | Dietary n-6 PUFA deprivation downregulates arachidonate but upregulates docosahexaenoate metabolizing enzymes in rat brain. | 2011 | Biochim. Biophys. Acta | pmid:21070866 |
Hashimoto M and Hossain S | Neuroprotective and ameliorative actions of polyunsaturated fatty acids against neuronal diseases: beneficial effect of docosahexaenoic acid on cognitive decline in Alzheimer's disease. | 2011 | J. Pharmacol. Sci. | pmid:21606627 |
Madden J et al. | The impact of common gene variants on the response of biomarkers of cardiovascular disease (CVD) risk to increased fish oil fatty acids intakes. | 2011 | Annu. Rev. Nutr. | pmid:21568708 |
Musto AE et al. | The omega-3 fatty acid-derived neuroprotectin D1 limits hippocampal hyperexcitability and seizure susceptibility in kindling epileptogenesis. | 2011 | Epilepsia | pmid:21569016 |
Corsetto PA et al. | Effects of n-3 PUFAs on breast cancer cells through their incorporation in plasma membrane. | 2011 | Lipids Health Dis | pmid:21569413 |
Eckert GP et al. | Liposome-incorporated DHA increases neuronal survival by enhancing non-amyloidogenic APP processing. | 2011 | Biochim. Biophys. Acta | pmid:21036142 |
Bonnet N and Ferrari SL | Effects of long-term supplementation with omega-3 fatty acids on longitudinal changes in bone mass and microstructure in mice. | 2011 | J. Nutr. Biochem. | pmid:21036590 |
Freeman MP et al. | Omega-3 fatty acids for major depressive disorder associated with the menopausal transition: a preliminary open trial. | 2011 | Menopause | pmid:21037490 |
Chang WK et al. | The comparison of protein-entrapped liposomes and lipoparticles: preparation, characterization, and efficacy of cellular uptake. | 2011 | Int J Nanomedicine | pmid:22072876 |
Vinayavekhin N and Saghatelian A | Discovery of a protein-metabolite interaction between unsaturated fatty acids and the nuclear receptor Nur77 using a metabolomics approach. | 2011 | J. Am. Chem. Soc. | pmid:21973308 |
Hull MA | Omega-3 polyunsaturated fatty acids. | 2011 | Best Pract Res Clin Gastroenterol | pmid:22122770 |
Wei MY and Jacobson TA | Effects of eicosapentaenoic acid versus docosahexaenoic acid on serum lipids: a systematic review and meta-analysis. | 2011 | Curr Atheroscler Rep | pmid:21975919 |
Turgut S et al. | The effects of docosahexaenoic acid supplementation and exercise on growth hormone and insulin-like growth factor I serum levels during chronic hypoxia in rats. | 2011 | J Basic Clin Physiol Pharmacol | pmid:22865430 |
Kumosani TA and Moselhy SS | Modulatory effect of cod-liver oil on Na(+)-K(+) ATPase in rats' brain. | 2011 | Hum Exp Toxicol | pmid:20488854 |
Hung ND et al. | Oral administration of 2-docosahexaenoyl lysophosphatidylcholine displayed anti-inflammatory effects on zymosan A-induced peritonitis. | 2011 | Inflammation | pmid:20490641 |
Zeng Y et al. | Development of a temperature shift strategy for efficient docosahexaenoic acid production by a marine fungoid protist, Schizochytrium sp. HX-308. | 2011 | Appl. Biochem. Biotechnol. | pmid:21120635 |
Itakura H et al. | Relationships between plasma fatty acid composition and coronary artery disease. | 2011 | J. Atheroscler. Thromb. | pmid:21099130 |
Sullivan JC et al. | Modeling the primary oxidation in commercial fish oil preparations. | 2011 | Lipids | pmid:21104333 |
Shulse CN and Allen EE | Diversity and distribution of microbial long-chain fatty acid biosynthetic genes in the marine environment. | 2011 | Environ. Microbiol. | pmid:21105981 |
Koletzko B et al. | Genetic variants of the fatty acid desaturase gene cluster predict amounts of red blood cell docosahexaenoic and other polyunsaturated fatty acids in pregnant women: findings from the Avon Longitudinal Study of Parents and Children. | 2011 | Am. J. Clin. Nutr. | pmid:21106917 |
Lu FS et al. | Oxidative stability of marine phospholipids in the liposomal form and their applications. | 2011 | Lipids | pmid:21088919 |
Kalupahana NS et al. | (n-3) Fatty acids alleviate adipose tissue inflammation and insulin resistance: mechanistic insights. | 2011 | Adv Nutr | pmid:22332072 |
Wiese DM et al. | The effects of an oral supplement enriched with fish oil, prebiotics, and antioxidants on nutrition status in Crohn's disease patients. | 2011 | Nutr Clin Pract | pmid:21775642 |
Madec S et al. | CYP4F3B expression is associated with differentiation of HepaRG human hepatocytes and unaffected by fatty acid overload. | 2011 | Drug Metab. Dispos. | pmid:21778351 |
Flachs P et al. | Synergistic induction of lipid catabolism and anti-inflammatory lipids in white fat of dietary obese mice in response to calorie restriction and n-3 fatty acids. | 2011 | Diabetologia | pmid:21779874 |
Molinari R et al. | The n3-polyunsaturated fatty acid docosahexaenoic acid induces immunogenic cell death in human cancer cell lines via pre-apoptotic calreticulin exposure. | 2011 | Cancer Immunol. Immunother. | pmid:21779875 |
Lai LH et al. | [Effects of docosahexaenoic acid on sodium channel current and transient outward potassium channel current in rat ventricular myocytes]. | 2011 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:21781602 |
Shulse CN and Allen EE | Widespread occurrence of secondary lipid biosynthesis potential in microbial lineages. | 2011 | PLoS ONE | pmid:21629834 |
Okpala I et al. | Pilot study of omega-3 fatty acid supplements in sickle cell disease. | 2011 | APMIS | pmid:21635551 |
Hajjaji N et al. | Determinants of DHA incorporation into tumor tissue during dietary DHA supplementation. | 2011 | Lipids | pmid:21638063 |
Kuang YL et al. | Docosahexaenoic acid suppresses apolipoprotein A-I gene expression through hepatocyte nuclear factor-3β. | 2011 | Am. J. Clin. Nutr. | pmid:21653803 |
Roqueta-Rivera M et al. | Deficiency in the omega-3 fatty acid pathway results in failure of acrosome biogenesis in mice. | 2011 | Biol. Reprod. | pmid:21653892 |
Nakamoto K et al. | Possible involvement of β-endorphin in docosahexaenoic acid-induced antinociception. | 2011 | Eur. J. Pharmacol. | pmid:21658380 |
Martin CR et al. | Decreased postnatal docosahexaenoic and arachidonic acid blood levels in premature infants are associated with neonatal morbidities. | 2011 | J. Pediatr. | pmid:21658712 |
McLaren JE et al. | Eicosapentaenoic acid and docosahexaenoic acid regulate modified LDL uptake and macropinocytosis in human macrophages. | 2011 | Lipids | pmid:21822944 |
Kawabata T et al. | Associations between dietary n-6 and n-3 fatty acids and arachidonic acid compositions in plasma and erythrocytes in young and elderly Japanese volunteers. | 2011 | Lipids Health Dis | pmid:21838914 |
Tian H et al. | Autacoid 14S,21R-dihydroxy-docosahexaenoic acid counteracts diabetic impairment of macrophage prohealing functions. | 2011 | Am. J. Pathol. | pmid:21839062 |
Kimura F et al. | Supplementation of DHA-rich microalgal oil or fish oil during the suckling period in mildly n-3 fatty acid-deficient rat pups. | 2011 | Lipids | pmid:21901511 |
Lewis MD et al. | Suicide deaths of active-duty US military and omega-3 fatty-acid status: a case-control comparison. | 2011 | J Clin Psychiatry | pmid:21903029 |
Kuipers RS et al. | Differences in preterm and term milk fatty acid compositions may be caused by the different hormonal milieu of early parturition. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21903369 |
Mayurasakorn K et al. | Docosahexaenoic acid: brain accretion and roles in neuroprotection after brain hypoxia and ischemia. | 2011 | Curr Opin Clin Nutr Metab Care | pmid:21178607 |
Vincentini O et al. | Docosahexaenoic acid modulates in vitro the inflammation of celiac disease in intestinal epithelial cells via the inhibition of cPLA2. | 2011 | Clin Nutr | pmid:21421277 |
Weylandt KH et al. | Suppressed liver tumorigenesis in fat-1 mice with elevated omega-3 fatty acids is associated with increased omega-3 derived lipid mediators and reduced TNF-α. | 2011 | Carcinogenesis | pmid:21421544 |
Stapleton RD et al. | A phase II randomized placebo-controlled trial of omega-3 fatty acids for the treatment of acute lung injury. | 2011 | Crit. Care Med. | pmid:21423000 |
Kulkarni A et al. | Effects of altered maternal folic acid, vitamin B12 and docosahexaenoic acid on placental global DNA methylation patterns in Wistar rats. | 2011 | PLoS ONE | pmid:21423696 |
Hong WK et al. | Production of lipids containing high levels of docosahexaenoic acid by a newly isolated microalga, Aurantiochytrium sp. KRS101. | 2011 | Appl. Biochem. Biotechnol. | pmid:21424706 |
Farias SE et al. | Lipid mediators in cerebral spinal fluid of traumatic brain injured patients. | 2011 | J Trauma | pmid:21427623 |
Makhoul Z et al. | Associations of obesity with triglycerides and C-reactive protein are attenuated in adults with high red blood cell eicosapentaenoic and docosahexaenoic acids. | 2011 | Eur J Clin Nutr | pmid:21427737 |
Nelson TL et al. | Omega-3 fatty acids and lipoprotein associated phospholipase A(2) in healthy older adult males and females. | 2011 | Eur J Nutr | pmid:20706728 |
Bhatia HS et al. | Omega-3 fatty acid deficiency during brain maturation reduces neuronal and behavioral plasticity in adulthood. | 2011 | PLoS ONE | pmid:22163304 |
Wagner K et al. | Soluble epoxide hydrolase inhibition, epoxygenated fatty acids and nociception. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21854866 |
Park CK et al. | Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1. | 2011 | J. Neurosci. | pmid:22171045 |
Zúñiga J et al. | N-3 PUFA supplementation triggers PPAR-α activation and PPAR-α/NF-κB interaction: anti-inflammatory implications in liver ischemia-reperfusion injury. | 2011 | PLoS ONE | pmid:22174823 |
Legrand P et al. | Update of French nutritional recommendations for fatty acids. | 2011 | World Rev Nutr Diet | pmid:21865827 |
Song KS et al. | Omega-3-polyunsaturated fatty acids suppress pancreatic cancer cell growth in vitro and in vivo via downregulation of Wnt/Beta-catenin signaling. | 2011 | Pancreatology | pmid:22213040 |
Meldrum SJ et al. | The Infant Fish Oil Supplementation Study (IFOS): design and research protocol of a double-blind, randomised controlled n--3 LCPUFA intervention trial in term infants. | 2011 | Contemp Clin Trials | pmid:21718804 |
D'Alessandro A et al. | Docosohaexanoic acid-supplemented PACA44 cell lines and over-activation of Krebs cycle: an integrated proteomic, metabolomic and interactomic overview. | 2011 | J Proteomics | pmid:21723426 |
Guesnet P et al. | α-Linolenate reduces the dietary requirement for linoleate in the growing rat. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21880475 |
De Franceschi G et al. | Structural and morphological characterization of aggregated species of α-synuclein induced by docosahexaenoic acid. | 2011 | J. Biol. Chem. | pmid:21527634 |
Schnebelen C et al. | Dietary polyunsaturated fatty acids reduce retinal stress induced by an elevation of intraocular pressure in rats. | 2011 | Nutr Res | pmid:21530802 |
Glew RH et al. | Low docosahexaenoic acid in the diet and milk of American Indian women in New Mexico. | 2011 | J Am Diet Assoc | pmid:21515123 |
Courville AB et al. | Consumption of a DHA-containing functional food during pregnancy is associated with lower infant ponderal index and cord plasma insulin concentration. | 2011 | Br. J. Nutr. | pmid:21521543 |
Ferreira M et al. | Effect of the nutritional status of semi-continuous microalgal cultures on the productivity and biochemical composition of Brachionus plicatilis. | 2011 | Mar. Biotechnol. | pmid:21487686 |
Michaelsen KF et al. | Food sources and intake of n-6 and n-3 fatty acids in low-income countries with emphasis on infants, young children (6-24 months), and pregnant and lactating women. | 2011 | Matern Child Nutr | pmid:21366872 |
Sun C et al. | DHA regulates lipogenesis and lipolysis genes in mice adipose and liver. | 2011 | Mol. Biol. Rep. | pmid:20383747 |
Kim SH et al. | Prospective randomized comparison between omega-3 fatty acid supplements plus simvastatin versus simvastatin alone in Korean patients with mixed dyslipidemia: lipoprotein profiles and heart rate variability. | 2011 | Eur J Clin Nutr | pmid:20877395 |
Hutchins HL et al. | Eicosapentaenoic acid decreases expression of anandamide synthesis enzyme and cannabinoid receptor 2 in osteoblast-like cells. | 2011 | J. Nutr. Biochem. | pmid:20951563 |
Recchiuti A et al. | MicroRNAs in resolution of acute inflammation: identification of novel resolvin D1-miRNA circuits. | 2011 | FASEB J. | pmid:20956612 |
Basselin M et al. | Imaging upregulated brain arachidonic acid metabolism in HIV-1 transgenic rats. | 2011 | J. Cereb. Blood Flow Metab. | pmid:20664612 |
Gibson RA et al. | Conversion of linoleic acid and alpha-linolenic acid to long-chain polyunsaturated fatty acids (LCPUFAs), with a focus on pregnancy, lactation and the first 2 years of life. | 2011 | Matern Child Nutr | pmid:21366864 |
Lauritzen L and Carlson SE | Maternal fatty acid status during pregnancy and lactation and relation to newborn and infant status. | 2011 | Matern Child Nutr | pmid:21366866 |
Brenna JT | Animal studies of the functional consequences of suboptimal polyunsaturated fatty acid status during pregnancy, lactation and early post-natal life. | 2011 | Matern Child Nutr | pmid:21366867 |
Blasbalg TL et al. | Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. | 2011 | Am. J. Clin. Nutr. | pmid:21367944 |
Klein CM and Jenkins TC | Docosahexaenoic acid elevates trans-18:1 isomers but is not directly converted into trans-18:1 isomers in ruminal batch cultures. | 2011 | J. Dairy Sci. | pmid:21854940 |
Miyazawa D et al. | Biochemical responses to dietary α-linolenic acid restriction proceed differently among brain regions in mice. | 2011 | Biomed. Res. | pmid:21878731 |
Mazaki-Tovi M et al. | Effect of omega-3 fatty acids on serum concentrations of adipokines in healthy cats. | 2011 | Am. J. Vet. Res. | pmid:21879986 |
Kim HW et al. | Regulation of rat brain polyunsaturated fatty acid (PUFA) metabolism during graded dietary n-3 PUFA deprivation. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21880477 |
Blum JL et al. | Profiling of fatty acids released during calcium-induced mitochondrial permeability transition in isolated rabbit kidney cortex mitochondria. | 2011 | Toxicol In Vitro | pmid:21443943 |
Salem N and Kuratko CN | Lack of evidence for increased α-linolenic acid metabolism in vegetarians. | 2011 | Am. J. Clin. Nutr. | pmid:21430120 |
Parra-Cabrera S et al. | Dietary intakes of polyunsaturated fatty acids among pregnant Mexican women. | 2011 | Matern Child Nutr | pmid:21410881 |
Wang F et al. | Docosahexaenoic acid (DHA) sensitizes brain tumor cells to etoposide-induced apoptosis. | 2011 | Curr. Mol. Med. | pmid:21663587 |
Min Y et al. | Relationship between red cell membrane fatty acids and adipokines in individuals with varying insulin sensitivity. | 2011 | Eur J Clin Nutr | pmid:21386858 |
Gomez-Pinilla F | The combined effects of exercise and foods in preventing neurological and cognitive disorders. | 2011 | Prev Med | pmid:21281667 |
Feucht C and Patel DR | Herbal medicines in pediatric neuropsychiatry. | 2011 | Pediatr. Clin. North Am. | pmid:21281847 |
Galicia-Connolly EZ et al. | Complementary, holistic, and integrative medicine: therapies for learning disabilities. | 2011 | Pediatr Rev | pmid:21285298 |
Nobili V et al. | Docosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease: double-blind randomised controlled clinical trial. | 2011 | Arch. Dis. Child. | pmid:21233083 |
Aarsetoey H et al. | Low levels of the omega-3 index are associated with sudden cardiac arrest and remain stable in survivors in the subacute phase. | 2011 | Lipids | pmid:21234696 |
Salm P et al. | Simultaneous quantification of total eicosapentaenoic acid, docosahexaenoic acid and arachidonic acid in plasma by high-performance liquid chromatography-tandem mass spectrometry. | 2011 | Biomed. Chromatogr. | pmid:20737653 |
Ozsoy O et al. | The effect of docosahexaenoic Acid on visual evoked potentials in a mouse model of Parkinson's disease: the role of cyclooxygenase-2 and nuclear factor kappa-B. | 2011 | Neurotox Res | pmid:21234736 |
McNamara RK | Omega-3 fatty acid deficiency: a preventable risk factor for schizophrenia? | 2011 | Schizophr. Res. | pmid:21276713 |
Umhau JC | Docosahexaenoic acid supplementation and Alzheimer disease. | 2011 | JAMA | pmid:21325181 |
Nowak M et al. | Impact of polyunsaturated fatty acids on oxidized low density lipoprotein-induced U937 cell apoptosis. | 2011 | J. Atheroscler. Thromb. | pmid:21325776 |
Murphy RA et al. | Supplementation with fish oil increases first-line chemotherapy efficacy in patients with advanced nonsmall cell lung cancer. | 2011 | Cancer | pmid:21328326 |
Valera B et al. | Influence of n-3 fatty acids on cardiac autonomic activity among Nunavik Inuit adults. | 2011 | Int J Circumpolar Health | pmid:21329579 |
Furuhjelm C et al. | Allergic disease in infants up to 2 years of age in relation to plasma omega-3 fatty acids and maternal fish oil supplementation in pregnancy and lactation. | 2011 | Pediatr Allergy Immunol | pmid:21332799 |
Sriram K | Confusion between gamma-linolenic acid and gamma-linoleic acid. | 2011 | Crit. Care Med. | pmid:22094528 |
Lecchi C et al. | In vitro modulation of caprine monocyte immune functions by ω-3 polyunsaturated fatty acids. | 2011 | Vet. J. | pmid:20889357 |
Toufektsian MC et al. | Dietary flavonoids increase plasma very long-chain (n-3) fatty acids in rats. | 2011 | J. Nutr. | pmid:21068183 |
Liu C and Cai WX | [Correlation between the eicosapentaenoic acid, docosahexaenoic acid and the aggressive behavior in mice]. | 2011 | Fa Yi Xue Za Zhi | pmid:21604451 |