DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yang R et al. | Metabolomics-lipidomics of eicosanoids and docosanoids generated by phagocytes. | 2011 | Curr Protoc Immunol | pmid:22048801 |
| Asensio-Sánchez VM | [Essential polyunsaturated fatty acids]. | 2011 | Arch Soc Esp Oftalmol | pmid:21569923 |
| Yates CM et al. | Docosahexaenoic acid inhibits the adhesion of flowing neutrophils to cytokine stimulated human umbilical vein endothelial cells. | 2011 | J. Nutr. | pmid:21613456 |
| Mills JD et al. | Dietary supplementation with the omega-3 fatty acid docosahexaenoic acid in traumatic brain injury. | 2011 | Neurosurgery | pmid:21135750 |
| Bilal S et al. | Fat-1 transgenic mice with elevated omega-3 fatty acids are protected from allergic airway responses. | 2011 | Biochim. Biophys. Acta | pmid:21616147 |
| Hamazaki-Fujita N et al. | Polyunsaturated fatty acids and blood circulation in the forebrain during a mental arithmetic task. | 2011 | Brain Res. | pmid:21616479 |
| Uddin MS et al. | Isolation and characterization of lecithin from squid (Todarodes pacificus) viscera deoiled by supercritical carbon dioxide extraction. | 2011 | J. Food Sci. | pmid:21535756 |
| Ajami M et al. | Expression of Bcl-2 and Bax after hippocampal ischemia in DHA + EPA treated rats. | 2011 | Neurol. Sci. | pmid:21617951 |
| Li HX et al. | Increasing DHA and EPA concentrations prolong action potential durations and reduce transient outward potassium currents in rat ventricular myocytes. | 2011 | Lipids | pmid:21140236 |
| Ott J et al. | Lipids in critical care medicine. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21546231 |
| Huang MC et al. | Placental docosahexaenoic and arachidonic acids correlate weakly with placental polychlorinated dibenzofurans (PCDF) and are uncorrelated with polychlorinated dibenzo-p-dioxins (PCDD) or polychlorinated biphenyls (PCB) at delivery: a pilot study. | 2011 | Food Chem. Toxicol. | pmid:21549173 |
| Kanno S et al. | Albumin modulates docosahexaenoic acid-induced cytotoxicity in human hepatocellular carcinoma cell lines. | 2011 | Toxicol. Lett. | pmid:21108996 |
| Yepuri G et al. | Dietary modulation of body composition and insulin sensitivity during catch-up growth in rats: effects of oils rich in n-6 or n-3 PUFA. | 2011 | Br. J. Nutr. | pmid:21281526 |
| Golub N et al. | Greasing the wheels of managing overweight and obesity with omega-3 fatty acids. | 2011 | Med. Hypotheses | pmid:21981905 |
| Sanden M et al. | Atlantic salmon (Salmo salar L.) as a net producer of long-chain marine ω-3 fatty acids. | 2011 | J. Agric. Food Chem. | pmid:22017199 |
| Ruusunen A et al. | Serum polyunsaturated fatty acids are not associated with the risk of severe depression in middle-aged Finnish men: Kuopio Ischaemic Heart Disease Risk Factor (KIHD) study. | 2011 | Eur J Nutr | pmid:20574779 |
| Yui K et al. | [Therapeutic effects of larger doses of arachidonic acid added to DHA on social impairment and its relation to alterations of polyunsaturated fatty acids in individuals with autism spectrum disorders]. | 2011 | Nihon Shinkei Seishin Yakurigaku Zasshi | pmid:21800702 |
| Stoeckel K et al. | Fatty acid patterns of dog erythrocyte membranes after feeding of a fish-oil based DHA-rich supplement with a base diet low in n-3 fatty acids versus a diet containing added n-3 fatty acids. | 2011 | Acta Vet. Scand. | pmid:22024384 |
| Curatolo N et al. | Oral administration of docosahexaenoic acid/eicosapentaeinoic acids is not anticonvulsant in rats: implications for translational research. | 2011 | Pediatr. Res. | pmid:21857379 |
| Bazan NG et al. | Endogenous signaling by omega-3 docosahexaenoic acid-derived mediators sustains homeostatic synaptic and circuitry integrity. | 2011 | Mol. Neurobiol. | pmid:21918832 |
| Schuchardt JP et al. | Moderate doses of EPA and DHA from re-esterified triacylglycerols but not from ethyl-esters lower fasting serum triacylglycerols in statin-treated dyslipidemic subjects: Results from a six month randomized controlled trial. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21862301 |
| Sanders TA et al. | Effect of low doses of long-chain n-3 PUFAs on endothelial function and arterial stiffness: a randomized controlled trial. | 2011 | Am. J. Clin. Nutr. | pmid:21865334 |
| Mozaffarian D et al. | Circulating long-chain ω-3 fatty acids and incidence of congestive heart failure in older adults: the cardiovascular health study: a cohort study. | 2011 | Ann. Intern. Med. | pmid:21810709 |
| Rioux FM et al. | Relationship between maternal DHA and iron status and infants' cognitive performance. | 2011 | Can J Diet Pract Res | pmid:21645426 |
| Westerberg AC et al. | Attention among very low birth weight infants following early supplementation with docosahexaenoic and arachidonic acid. | 2011 | Acta Paediatr. | pmid:20624152 |
| Torshin IIu et al. | [Systematic analysis of molecular mechanisms of action of omega-3 polyunsaturated fatty acids on arrhythmia]. | 2011 | Kardiologiia | pmid:21649594 |
| Palmer CD et al. | 17(R)-Resolvin D1 differentially regulates TLR4-mediated responses of primary human macrophages to purified LPS and live E. coli. | 2011 | J. Leukoc. Biol. | pmid:21653234 |
| Jiang T et al. | Omega-3 fatty acids affected human perception of ground beef negatively. | 2011 | Meat Sci. | pmid:21621335 |
| Ichihara H et al. | Therapeutic effects of hybrid liposomes composed of phosphatidylcholine and docosahexaenoic acid on the hepatic metastasis of colon carcinoma along with apoptosis in vivo. | 2011 | Biol. Pharm. Bull. | pmid:21628892 |
| Colombo J et al. | Long-chain polyunsaturated fatty acid supplementation in infancy reduces heart rate and positively affects distribution of attention. | 2011 | Pediatr. Res. | pmid:21705959 |
| Manley BJ et al. | High-dose docosahexaenoic acid supplementation of preterm infants: respiratory and allergy outcomes. | 2011 | Pediatrics | pmid:21708809 |
| Brignardello J et al. | Increase of plasma fatty acids without changes in n-6/n-3-PUFA ratio in asymptomatic obese subjects. | 2011 | Arch Latinoam Nutr | pmid:22308941 |
| Serhan CN and Petasis NA | Resolvins and protectins in inflammation resolution. | 2011 | Chem. Rev. | pmid:21766791 |
| Pan JP et al. | Some subtypes of endocannabinoid/endovanilloid receptors mediate docosahexaenoic acid-induced enhanced spatial memory in rats. | 2011 | Brain Res. | pmid:21803345 |
| Imhoff-Kunsch B et al. | Prenatal docosahexaenoic acid supplementation and infant morbidity: randomized controlled trial. | 2011 | Pediatrics | pmid:21807696 |
| Kim HY et al. | A synaptogenic amide N-docosahexaenoylethanolamide promotes hippocampal development. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21810478 |
| Jing K et al. | Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53. | 2011 | Autophagy | pmid:21811093 |
| Zargar A and Ito MK | Long chain omega-3 dietary supplements: a review of the National Library of Medicine Herbal Supplement Database. | 2011 | Metab Syndr Relat Disord | pmid:21787228 |
| Garcia C et al. | French mothers' milk deficient in DHA contains phospholipid species of potential interest for infant development. | 2011 | J. Pediatr. Gastroenterol. Nutr. | pmid:21788764 |
| Hu H et al. | Isolation and characterization of a mesophilic Arthrospira maxima strain capable of producing docosahexaenoic acid. | 2011 | J. Microbiol. Biotechnol. | pmid:21791955 |
| Abu-Saad K et al. | Rapid assessment tools for ranking pregnant minority women into multi-nutrient exposure groups. | 2011 | Public Health Nutr | pmid:20519048 |
| Vargas ML et al. | Metabolic and endocrine effects of long-chain versus essential omega-3 polyunsaturated fatty acids in polycystic ovary syndrome. | 2011 | Metab. Clin. Exp. | pmid:21640360 |
| German JB | Dietary lipids from an evolutionary perspective: sources, structures and functions. | 2011 | Matern Child Nutr | pmid:21366863 |
| Glaser C et al. | Genetic variation in polyunsaturated fatty acid metabolism and its potential relevance for human development and health. | 2011 | Matern Child Nutr | pmid:21366865 |
| Maqbool A et al. | The skinny on tuna fat: health implications. | 2011 | Public Health Nutr | pmid:21324226 |
| Ramakrishnan U | Fatty acid status and maternal mental health. | 2011 | Matern Child Nutr | pmid:21366870 |
| Diaz Encarnacion MM et al. | n-3 Fatty acids block TNF-α-stimulated MCP-1 expression in rat mesangial cells. | 2011 | Am. J. Physiol. Renal Physiol. | pmid:21367920 |
| Farina EK et al. | Protective effects of fish intake and interactive effects of long-chain polyunsaturated fatty acid intakes on hip bone mineral density in older adults: the Framingham Osteoporosis Study. | 2011 | Am. J. Clin. Nutr. | pmid:21367955 |
| Ohtsuka Y et al. | ω-3 fatty acids attenuate mucosal inflammation in premature rat pups. | 2011 | J. Pediatr. Surg. | pmid:21376198 |
| Tyburczy C et al. | Heart arachidonic acid is uniquely sensitive to dietary arachidonic acid and docosahexaenoic acid content in domestic piglets. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21885269 |
| Fedorova-Dahms I et al. | Safety evaluation of DHA-rich Algal Oil from Schizochytrium sp. | 2011 | Food Chem. Toxicol. | pmid:21914458 |
| Lebbadi M et al. | Endogenous conversion of omega-6 into omega-3 fatty acids improves neuropathology in an animal model of Alzheimer's disease. | 2011 | J. Alzheimers Dis. | pmid:21914946 |
| Kuan CY et al. | Long-chain polyunsaturated fatty acids promote paclitaxel cytotoxicity via inhibition of the MDR1 gene in the human colon cancer Caco-2 cell line. | 2011 | J Am Coll Nutr | pmid:21917707 |
| Hashimoto M et al. | Protective effects of prescription n-3 fatty acids against impairment of spatial cognitive learning ability in amyloid β-infused rats. | 2011 | Food Funct | pmid:21894325 |
| Abelsohn A et al. | Healthy fish consumption and reduced mercury exposure: counseling women in their reproductive years. | 2011 | Can Fam Physician | pmid:21322285 |
| da Costa KA et al. | Docosahexaenoic acid in plasma phosphatidylcholine may be a potential marker for in vivo phosphatidylethanolamine N-methyltransferase activity in humans. | 2011 | Am. J. Clin. Nutr. | pmid:21411618 |
| Freeman MP and Rapaport MH | Omega-3 fatty acids and depression: from cellular mechanisms to clinical care. | 2011 | J Clin Psychiatry | pmid:21382308 |
| Arsenault D et al. | DHA improves cognition and prevents dysfunction of entorhinal cortex neurons in 3xTg-AD mice. | 2011 | PLoS ONE | pmid:21383850 |
| Rossi PC et al. | Optimization of molecular distillation to concentrate ethyl esters of eicosapentaenoic (20:5 ω-3) and docosahexaenoic acids (22:6 ω-3) using simplified phenomenological modeling. | 2011 | J. Sci. Food Agric. | pmid:21384378 |
| Hellmann J et al. | Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice. | 2011 | FASEB J. | pmid:21478260 |
| Koletzko B | Health claims: let science prevail. | 2011 | Ann. Nutr. Metab. | pmid:21454969 |
| Nochera CL et al. | Consumption of DHA + EPA by low-income women during pregnancy and lactation. | 2011 | Nutr Clin Pract | pmid:21724916 |
| Bento AF et al. | Omega-3 fatty acid-derived mediators 17(R)-hydroxy docosahexaenoic acid, aspirin-triggered resolvin D1 and resolvin D2 prevent experimental colitis in mice. | 2011 | J. Immunol. | pmid:21724996 |
| Siddiqui NF et al. | Enhanced generation of megakaryocytes from umbilical cord blood-derived CD34(+) cells expanded in the presence of two nutraceuticals, docosahexanoic acid and arachidonic acid, as supplements to the cytokine-containing medium. | 2011 | Cytotherapy | pmid:20230224 |
| Maki KC et al. | Effects of prescription omega-3-acid ethyl esters on fasting lipid profile in subjects with primary hypercholesterolemia. | 2011 | J. Cardiovasc. Pharmacol. | pmid:21297494 |
| Bradbury J | Docosahexaenoic acid (DHA): an ancient nutrient for the modern human brain. | 2011 | Nutrients | pmid:22254110 |
| Smithers LG et al. | Maternal supplementation with docosahexaenoic acid during pregnancy does not affect early visual development in the infant: a randomized controlled trial. | 2011 | Am. J. Clin. Nutr. | pmid:21490140 |
| Yalçın S et al. | Effect of maternal corticosterone on utilisation of residual yolk sac fatty acids by developing broiler embryo. | 2011 | Br. Poult. Sci. | pmid:21491250 |
| Morris MC and Tangney CC | A potential design flaw of randomized trials of vitamin supplements. | 2011 | JAMA | pmid:21467288 |
| Shoji H et al. | Effects of parenteral soybean oil lipid emulsion on the long-chain polyunsaturated fatty acid profile in very-low-birth-weight infants. | 2011 | Acta Paediatr. | pmid:21366690 |
| Madsen T et al. | Marine n-3 polyunsaturated fatty acids in patients with end-stage renal failure and in subjects without kidney disease: a comparative study. | 2011 | J Ren Nutr | pmid:20833075 |
| Chen P et al. | Poxytrins, a class of oxygenated products from polyunsaturated fatty acids, potently inhibit blood platelet aggregation. | 2011 | FASEB J. | pmid:20833872 |
| Kong W et al. | Docosahexaenoic acid prevents dendritic cell maturation, inhibits antigen-specific Th1/Th17 differentiation and suppresses experimental autoimmune encephalomyelitis. | 2011 | Brain Behav. Immun. | pmid:20854895 |
| Myhrstad MC et al. | Effect of the fat composition of a single high-fat meal on inflammatory markers in healthy young women. | 2011 | Br. J. Nutr. | pmid:21736782 |
| Egert S and Stehle P | Impact of n-3 fatty acids on endothelial function: results from human interventions studies. | 2011 | Curr Opin Clin Nutr Metab Care | pmid:21252652 |
| Arshad A et al. | Potential applications of fish oils rich in n-3 fatty acids in the palliative treatment of advanced pancreatic cancer. | 2011 | Br. J. Nutr. | pmid:21745426 |
| Poudyal H et al. | Omega-3 fatty acids and metabolic syndrome: effects and emerging mechanisms of action. | 2011 | Prog. Lipid Res. | pmid:21762726 |
| Weise C et al. | Dietary docosahexaenoic acid in combination with arachidonic acid ameliorates allergen-induced dermatitis in mice. | 2011 | Pediatr Allergy Immunol | pmid:21294775 |
| Meijerink J et al. | The ethanolamide metabolite of DHA, docosahexaenoylethanolamine, shows immunomodulating effects in mouse peritoneal and RAW264.7 macrophages: evidence for a new link between fish oil and inflammation. | 2011 | Br. J. Nutr. | pmid:21294934 |
| Drover JR et al. | Cognitive function in 18-month-old term infants of the DIAMOND study: a randomized, controlled clinical trial with multiple dietary levels of docosahexaenoic acid. | 2011 | Early Hum. Dev. | pmid:21295417 |
| Barden A et al. | The effects of oxidation products of arachidonic acid and n3 fatty acids on vascular and platelet function. | 2011 | Free Radic. Res. | pmid:21235285 |
| Stephensen CB et al. | ALOX5 gene variants affect eicosanoid production and response to fish oil supplementation. | 2011 | J. Lipid Res. | pmid:21296957 |
| Zhao J et al. | Deposition of docosahexaenoic acid (DHA) is limited in forebrain of young obese fa/fa Zucker rats fed a diet high in α-linolenic acid but devoid of DHA. | 2011 | J. Nutr. Biochem. | pmid:21129946 |
| Kitayama A et al. | Correlations of fish intake and plasma docosahexaenoic acid levels with each congener of PCDDs/PCDFs/dioxin-like PCBs in blood from the Japanese population. | 2011 | Int Arch Occup Environ Health | pmid:21298441 |
| Imhoff-Kunsch B et al. | Docosahexaenoic acid supplementation from mid-pregnancy to parturition influenced breast milk fatty acid concentrations at 1 month postpartum in Mexican women. | 2011 | J. Nutr. | pmid:21178076 |
| Suzuki T | Maternal depression and child development after prenatal DHA supplementation. | 2011 | JAMA | pmid:21266681 |
| Lima-Garcia JF et al. | The precursor of resolvin D series and aspirin-triggered resolvin D1 display anti-hyperalgesic properties in adjuvant-induced arthritis in rats. | 2011 | Br. J. Pharmacol. | pmid:21418187 |
| Xu ZZ and Ji RR | Resolvins are potent analgesics for arthritic pain. | 2011 | Br. J. Pharmacol. | pmid:21418190 |
| Taoka Y et al. | Effect of Tween 80 on the growth, lipid accumulation and fatty acid composition of Thraustochytrium aureum ATCC 34304. | 2011 | J. Biosci. Bioeng. | pmid:21216665 |
| The brainy omega-3 fails an Alzheimer's test. | 2011 | Harv Health Lett | pmid:21344681 | |
| Majkova Z et al. | Omega-3 fatty acid oxidation products prevent vascular endothelial cell activation by coplanar polychlorinated biphenyls. | 2011 | Toxicol. Appl. Pharmacol. | pmid:21130106 |
| Yi SH et al. | A cross-sectional study of docosahexaenoic acid status and cognitive outcomes in females of reproductive age with phenylketonuria. | 2011 | J. Inherit. Metab. Dis. | pmid:21305356 |
| Patterson RE et al. | Marine fatty acid intake is associated with breast cancer prognosis. | 2011 | J. Nutr. | pmid:21178081 |
| Stein AD et al. | Growth to age 18 months following prenatal supplementation with docosahexaenoic acid differs by maternal gravidity in Mexico. | 2011 | J. Nutr. | pmid:21178082 |
| Rogers LK et al. | Maternal docosahexaenoic acid supplementation decreases lung inflammation in hyperoxia-exposed newborn mice. | 2011 | J. Nutr. | pmid:21178083 |
| Neff LM et al. | Algal docosahexaenoic acid affects plasma lipoprotein particle size distribution in overweight and obese adults. | 2011 | J. Nutr. | pmid:21178084 |
| Li X et al. | Docosahexanoic acid-induced coronary arterial dilation: actions of 17S-hydroxy docosahexanoic acid on K+ channel activity. | 2011 | J. Pharmacol. Exp. Ther. | pmid:21156816 |
| Cortina MS and Bazan HE | Docosahexaenoic acid, protectins and dry eye. | 2011 | Curr Opin Clin Nutr Metab Care | pmid:21157308 |
| Scott SD et al. | Use of raw glycerol to produce oil rich in polyunsaturated fatty acids by a thraustochytrid. | 2011 | Enzyme Microb. Technol. | pmid:22112910 |
| Ji RR et al. | Emerging roles of resolvins in the resolution of inflammation and pain. | 2011 | Trends Neurosci. | pmid:21963090 |