Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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pmid:27637335 | ||||
pmid:27634339 | ||||
Devassy JG et al. | Omega-3 Polyunsaturated Fatty Acids and Oxylipins in Neuroinflammation and Management of Alzheimer Disease. | 2016 | Adv Nutr | pmid:27633106 |
pmid:27632672 | ||||
Luo B et al. | Resolvin D1 Programs Inflammation Resolution by Increasing TGF-β Expression Induced by Dying Cell Clearance in Experimental Autoimmune Neuritis. | 2016 | J. Neurosci. | pmid:27629711 |
pmid:27619672 | ||||
pmid:27618287 | ||||
pmid:27614801 | ||||
pmid:27613800 | ||||
pmid:27613620 | ||||
pmid:27609281 | ||||
pmid:27604770 | ||||
pmid:27604086 | ||||
pmid:27603970 | ||||
pmid:27600927 | ||||
pmid:27600795 | ||||
pmid:27598198 | ||||
pmid:27597963 | ||||
pmid:27596393 | ||||
pmid:27594375 | ||||
pmid:27594339 | ||||
pmid:27592363 | ||||
Meesawatsom P et al. | Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models. | 2016 | J Neuroinflammation | pmid:27589850 |
pmid:27589090 | ||||
pmid:27579313 | ||||
pmid:27578110 | ||||
pmid:27578106 | ||||
pmid:27576529 | ||||
pmid:27573422 | ||||
pmid:27571688 | ||||
pmid:27571269 | ||||
Wechsler JG et al. | [Effect of omega-3-fatty acids on biliary lipids and lithogenicity]. | 1989 | Z Gastroenterol | pmid:2756729 |
pmid:27566736 | ||||
pmid:27565090 | ||||
Wilding TJ et al. | Chimeric Glutamate Receptor Subunits Reveal the Transmembrane Domain Is Sufficient for NMDA Receptor Pore Properties but Some Positive Allosteric Modulators Require Additional Domains. | 2016 | J. Neurosci. | pmid:27559165 |
pmid:27559094 | ||||
Nuez-OrtÃn WG et al. | Preliminary Validation of a High Docosahexaenoic Acid (DHA) and -Linolenic Acid (ALA) Dietary Oil Blend: Tissue Fatty Acid Composition and Liver Proteome Response in Atlantic Salmon (Salmo salar) Smolts. | 2016 | PLoS ONE | pmid:27556399 |
pmid:27554670 | ||||
pmid:27552592 | ||||
pmid:27546289 | ||||
Park HG et al. | Metabolic fate of docosahexaenoic acid (DHA; 22:6n-3) in human cells: direct retroconversion of DHA to eicosapentaenoic acid (20:5n-3) dominates over elongation to tetracosahexaenoic acid (24:6n-3). | 2016 | FEBS Lett. | pmid:27543786 |
pmid:27542462 | ||||
pmid:27539313 | ||||
pmid:27538010 | ||||
pmid:27536971 | ||||
pmid:27535497 | ||||
pmid:27532692 | ||||
Viola JR et al. | Resolving Lipid Mediators Maresin 1 and Resolvin D2 Prevent Atheroprogression in Mice. | 2016 | Circ. Res. | pmid:27531933 |
pmid:27530945 | ||||
pmid:27527148 | ||||
pmid:27519299 | ||||
Lam SM et al. | Biological relevance of fatty acyl heterogeneity to the neural membrane dynamics of rhesus macaques during normative aging. | 2016 | Oncotarget | pmid:27517158 |
pmid:27514858 | ||||
pmid:27513935 | ||||
pmid:27513579 | ||||
pmid:27508346 | ||||
Zhang MJ et al. | Resolvin D2 Enhances Postischemic Revascularization While Resolving Inflammation. | 2016 | Circulation | pmid:27507404 |
pmid:27507074 | ||||
pmid:27502791 | ||||
pmid:27500566 | ||||
pmid:27499449 | ||||
pmid:27499448 | ||||
pmid:27496755 | ||||
Lo Van A et al. | Mechanisms of DHA transport to the brain and potential therapy to neurodegenerative diseases. | 2016 | Biochimie | pmid:27496085 |
pmid:27490922 | ||||
pmid:27480845 | ||||
Graciano MF et al. | Omega-3 fatty acids control productions of superoxide and nitrogen oxide and insulin content in INS-1E cells. | 2016 | J. Physiol. Biochem. | pmid:27474043 |
pmid:27473885 | ||||
pmid:27470615 | ||||
Gao J et al. | Maternal DHA supplementation protects rat offspring against impairment of learning and memory following prenatal exposure to valproic acid. | 2016 | J. Nutr. Biochem. | pmid:27469996 |
pmid:27461654 | ||||
pmid:27457215 | ||||
pmid:27454884 | ||||
pmid:27444154 | ||||
pmid:27440746 | ||||
pmid:27436589 | ||||
pmid:27433934 | ||||
pmid:27429125 | ||||
Chernenko GA et al. | Intestinal absorption and lymphatic transport of fish oil (MaxEPA) in the rat. | 1989 | Biochim. Biophys. Acta | pmid:2742878 |
pmid:27428262 | ||||
pmid:27426911 | ||||
pmid:27426008 | ||||
pmid:27426000 | ||||
pmid:27424661 | ||||
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pmid:27398790 | ||||
pmid:27397734 | ||||
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pmid:27394149 | ||||
Visentin S et al. | Red blood cell membrane fatty acid composition in infants fed formulas with different lipid profiles. | 2016 | Early Hum. Dev. | pmid:27391868 |
pmid:27388608 | ||||
pmid:27387342 | ||||
pmid:27384606 | ||||
pmid:27374575 | ||||
pmid:27374222 |