Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Otto SJ et al. | The effect of supplementation with docosahexaenoic and arachidonic acid derived from single cell oils on plasma and erythrocyte fatty acids of pregnant women in the second trimester. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090260 |
Brenna T | Tissue-specific LCPUFA accretion in fetal humans. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22078006 |
Wittwer J and Hersberger M | The two faces of the 15-lipoxygenase in atherosclerosis. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17869078 |
Van Biervliet S et al. | Oral DHA supplementation in DeltaF508 homozygous cystic fibrosis patients. | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18276127 |
Westphal C et al. | CYP-eicosanoids--a new link between omega-3 fatty acids and cardiac disease? | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21945326 |
Weylandt KH et al. | Omega-3 fatty acids and their lipid mediators: towards an understanding of resolvin and protectin formation. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:22326554 |
Giudetti AM and Cagnazzo R | Beneficial effects of n-3 PUFA on chronic airway inflammatory diseases. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:23064030 |
Kim HY et al. | A synaptogenic amide N-docosahexaenoylethanolamide promotes hippocampal development. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21810478 |
Recchiuti A | Resolvin D1 and its GPCRs in resolution circuits of inflammation. | 2013 | Prostaglandins Other Lipid Mediat. | pmid:23500003 |
Gladyshev MI et al. | Production of EPA and DHA in aquatic ecosystems and their transfer to the land. | 2013 | Prostaglandins Other Lipid Mediat. | pmid:23500063 |
Serhan CN et al. | Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabasis. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15290791 |
Wagner K et al. | Soluble epoxide hydrolase inhibition, epoxygenated fatty acids and nociception. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21854866 |
von Schacky C | The Omega-3 Index as a risk factor for cardiovascular diseases. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21726658 |
Monia ZA et al. | Docosahexaenoic acid reduces both cyclic nucleotide and melatonin synthesis in rat pinealocytes. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9653768 |
Rapoport SI et al. | Docosahexaenoic acid (DHA) incorporation into the brain from plasma, as an in vivo biomarker of brain DHA metabolism and neurotransmission. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21704722 |
Taber DF and Jackson Roberts L | Nomenclature systems for the neuroprostanes and for the neurofurans. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16303600 |
Hong S et al. | Rainbow trout (Oncorhynchus mykiss) brain cells biosynthesize novel docosahexaenoic acid-derived resolvins and protectins-Mediator lipidomic analysis. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16303609 |
Yuan J et al. | The effects of polyunsaturated fatty acids and their metabolites on osteoclastogenesis in vitro. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:20394833 |
Seki H et al. | Omega-3 PUFA derived anti-inflammatory lipid mediator resolvin E1. | 2009 | Prostaglandins Other Lipid Mediat. | pmid:19737659 |
Hishinuma T et al. | Effects of long-term supplementation of eicosapentanoic and docosahexanoic acid on the 2-, 3-series prostacyclin production by endothelial cells. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10480487 |
Shi H et al. | VIP protects human retinal microvascular endothelial cells against high glucose-induced increases in TNF-α and enhances RvD1. | 2016 | Prostaglandins Other Lipid Mediat. | pmid:27026343 |
Niemoller TD and Bazan NG | Docosahexaenoic acid neurolipidomics. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:19804838 |
Shaikh IA et al. | Docosahexaenoic acid enhances the efficacy of docetaxel in prostate cancer cells by modulation of apoptosis: the role of genes associated with the NF-kappaB pathway. | 2008 | Prostate | pmid:18668525 |
Cavazos DA et al. | Docosahexaenoic acid selectively induces human prostate cancer cell sensitivity to oxidative stress through modulation of NF-κB. | 2011 | Prostate | pmid:21360560 |
Nadalin S et al. | Niacin skin flush test: a research tool for studying schizophrenia. | 2010 | Psychiatr Danub | pmid:20305586 |
Buretić-Tomljanović A et al. | Phospholipid membrane abnormalities and reduced niacin skin flush response in schizophrenia. | 2008 | Psychiatr Danub | pmid:18827766 |
Mischoulon D and Freeman MP | Omega-3 fatty acids in psychiatry. | 2013 | Psychiatr. Clin. North Am. | pmid:23538073 |
Rees AM et al. | Omega-3 deficiency associated with perinatal depression: case control study. | 2009 | Psychiatry Res | pmid:19268372 |
Parker GB et al. | Low levels of docosahexaenoic acid identified in acute coronary syndrome patients with depression. | 2006 | Psychiatry Res | pmid:16499974 |
Lucas M et al. | Plasma omega-3 and psychological distress among Nunavik Inuit (Canada). | 2009 | Psychiatry Res | pmid:19394089 |
Kale A et al. | Reduced folic acid, vitamin B12 and docosahexaenoic acid and increased homocysteine and cortisol in never-medicated schizophrenia patients: implications for altered one-carbon metabolism. | 2010 | Psychiatry Res | pmid:19969375 |
Buydens-Branchey L and Branchey M | Long-chain n-3 polyunsaturated fatty acids decrease feelings of anger in substance abusers. | 2008 | Psychiatry Res | pmid:17900705 |
McNamara RK et al. | Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder. | 2008 | Psychiatry Res | pmid:18715653 |
Conklin SM et al. | Serum omega-3 fatty acids are associated with variation in mood, personality and behavior in hypercholesterolemic community volunteers. | 2007 | Psychiatry Res | pmid:17383013 |
Mocking RJ et al. | Relationship between the hypothalamic-pituitary-adrenal-axis and fatty acid metabolism in recurrent depression. | 2013 | Psychoneuroendocrinology | pmid:23465556 |
Levant B et al. | Decreased brain docosahexaenoic acid content produces neurobiological effects associated with depression: Interactions with reproductive status in female rats. | 2008 | Psychoneuroendocrinology | pmid:18707812 |
Mitsuhashi N and Kato J | Modulation of steroid hormone receptors in the brain--inhibitory effect of fatty acids on the binding between cytosol progestin receptors in the rat cortex and R5020. | 1987 | Psychoneuroendocrinology | pmid:2955444 |
McNamara RK et al. | Gender differences in rat erythrocyte and brain docosahexaenoic acid composition: role of ovarian hormones and dietary omega-3 fatty acid composition. | 2009 | Psychoneuroendocrinology | pmid:19046819 |
Kim HW et al. | Effects of chronic clozapine administration on markers of arachidonic acid cascade and synaptic integrity in rat brain. | 2012 | Psychopharmacology (Berl.) | pmid:22414961 |
Bazinet RP et al. | Valproic acid selectively inhibits conversion of arachidonic acid to arachidonoyl-CoA by brain microsomal long-chain fatty acyl-CoA synthetases: relevance to bipolar disorder. | 2006 | Psychopharmacology (Berl.) | pmid:16344985 |
Lee LK et al. | Docosahexaenoic acid-concentrated fish oil supplementation in subjects with mild cognitive impairment (MCI): a 12-month randomised, double-blind, placebo-controlled trial. | 2013 | Psychopharmacology (Berl.) | pmid:22932777 |
Bazinet RP et al. | Chronic valproate does not alter the kinetics of docosahexaenoic acid within brain phospholipids of the unanesthetized rat. | 2005 | Psychopharmacology (Berl.) | pmid:15986187 |
Conklin SM et al. | High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism. | 2007 | Psychosom Med | pmid:17991818 |
Amin AA et al. | Acute coronary syndrome patients with depression have low blood cell membrane omega-3 fatty acid levels. | 2008 | Psychosom Med | pmid:18842751 |
Lucas M et al. | Plasma n-3 fatty acids and psychological distress in aboriginal Cree Indians (Canada). | 2009 | Public Health Nutr | pmid:19243672 |
Abu-Saad K et al. | Rapid assessment tools for ranking pregnant minority women into multi-nutrient exposure groups. | 2011 | Public Health Nutr | pmid:20519048 |
Maqbool A et al. | The skinny on tuna fat: health implications. | 2011 | Public Health Nutr | pmid:21324226 |
Lucas M et al. | n-3 Fatty acid intake from marine food products among Quebecers: comparison to worldwide recommendations. | 2010 | Public Health Nutr | pmid:19433004 |
Mendez MA et al. | Maternal fish and other seafood intakes during pregnancy and child neurodevelopment at age 4 years. | 2009 | Public Health Nutr | pmid:19026093 |
Lucas M et al. | Validation of an FFQ for evaluation of EPA and DHA intake. | 2009 | Public Health Nutr | pmid:19102810 |