Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Unagul P et al. | Coconut water as a medium additive for the production of docosahexaenoic acid (C22:6 n3) by Schizochytrium mangrovei Sk-02. | 2007 | Bioresour. Technol. | pmid:16563749 |
Wang Y et al. | Synthesis and preliminary antitumor activity evaluation of a DHA and doxorubicin conjugate. | 2006 | Bioorg. Med. Chem. Lett. | pmid:16563756 |
German OL et al. | Ceramide is a mediator of apoptosis in retina photoreceptors. | 2006 | Invest. Ophthalmol. Vis. Sci. | pmid:16565407 |
Geppert J et al. | Microalgal docosahexaenoic acid decreases plasma triacylglycerol in normolipidaemic vegetarians: a randomised trial. | 2006 | Br. J. Nutr. | pmid:16571158 |
Knudsen VK et al. | Fish oil in various doses or flax oil in pregnancy and timing of spontaneous delivery: a randomised controlled trial. | 2006 | BJOG | pmid:16579802 |
Bazan NG | Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors. | 2006 | Trends Neurosci. | pmid:16580739 |
Kawai Y et al. | Formation of Nepsilon-(succinyl)lysine in vivo: a novel marker for docosahexaenoic acid-derived protein modification. | 2006 | J. Lipid Res. | pmid:16582421 |
Aldámiz-EchevarrÃa L et al. | Effect of docosahexaenoic acid administration on plasma lipid profile and metabolic parameters of children with methylmalonic acidaemia. | 2006 | J. Inherit. Metab. Dis. | pmid:16601869 |
Truksa M et al. | Metabolic engineering of plants to produce very long-chain polyunsaturated fatty acids. | 2006 | Transgenic Res. | pmid:16604455 |
O'Keefe JH et al. | Effects of omega-3 fatty acids on resting heart rate, heart rate recovery after exercise, and heart rate variability in men with healed myocardial infarctions and depressed ejection fractions. | 2006 | Am. J. Cardiol. | pmid:16616012 |
Xue H et al. | Eicosapentaenoic acid and docosahexaenoic acid modulate mitogen-activated protein kinase activity in endothelium. | 2006 | Vascul. Pharmacol. | pmid:16616699 |
Catalá A | An overview of lipid peroxidation with emphasis in outer segments of photoreceptors and the chemiluminescence assay. | 2006 | Int. J. Biochem. Cell Biol. | pmid:16621670 |
Berger A et al. | How dietary arachidonic- and docosahexaenoic- acid rich oils differentially affect the murine hepatic transcriptome. | 2006 | Lipids Health Dis | pmid:16623957 |
Burja AM et al. | Isolation and characterization of polyunsaturated fatty acid producing Thraustochytrium species: screening of strains and optimization of omega-3 production. | 2006 | Appl. Microbiol. Biotechnol. | pmid:16625394 |
Wurtman RJ et al. | Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally. | 2006 | Brain Res. | pmid:16631143 |
Wright K et al. | Formula supplemented with docosahexaenoic acid (DHA) and arachidonic acid (ARA): a critical review of the research. | 2006 | J Spec Pediatr Nurs | pmid:16635189 |
Hirunpanich V and Sato H | Docosahexaenoic acid (DHA) inhibits saquinavir metabolism in-vitro and enhances its bioavailability in rats. | 2006 | J. Pharm. Pharmacol. | pmid:16640834 |
King VR et al. | Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat. | 2006 | J. Neurosci. | pmid:16641248 |
Azevedo-Martins AK et al. | Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells. | 2006 | Toxicol In Vitro | pmid:16644178 |
Narayanan NK et al. | Docosahexaenoic acid in combination with celecoxib modulates HSP70 and p53 proteins in prostate cancer cells. | 2006 | Int. J. Cancer | pmid:16646082 |
Coetzee M et al. | Effects of arachidonic acid, docosahexaenoic acid, prostaglandin E(2) and parathyroid hormone on osteoprotegerin and RANKL secretion by MC3T3-E1 osteoblast-like cells. | 2007 | J. Nutr. Biochem. | pmid:16650751 |
Alnajjar A et al. | Effect of n-3 and n-6 polyunsaturated fatty acids on lymphocyte proliferation, interleukin production and phospholipid fatty acids composition in type 2 diabetic and healthy subjects in Jordan people. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16650969 |
Waterhouse KE et al. | Within and between breed differences in freezing tolerance and plasma membrane fatty acid composition of boar sperm. | 2006 | Reproduction | pmid:16672353 |
Igarashi M et al. | Low liver conversion rate of alpha-linolenic to docosahexaenoic acid in awake rats on a high-docosahexaenoate-containing diet. | 2006 | J. Lipid Res. | pmid:16687661 |
Turner N et al. | Scaling of Na+,K+-ATPase molecular activity and membrane fatty acid composition in mammalian and avian hearts. | 2006 May-Jun | Physiol. Biochem. Zool. | pmid:16691518 |
Gorjão R et al. | Effect of docosahexaenoic acid-rich fish oil supplementation on human leukocyte function. | 2006 | Clin Nutr | pmid:16697494 |
Camuesco D et al. | Intestinal anti-inflammatory activity of combined quercitrin and dietary olive oil supplemented with fish oil, rich in EPA and DHA (n-3) polyunsaturated fatty acids, in rats with DSS-induced colitis. | 2006 | Clin Nutr | pmid:16698151 |
Kishida E et al. | Docosahexaenoic acid enrichment can reduce L929 cell necrosis induced by tumor necrosis factor. | 2006 | Biochim. Biophys. Acta | pmid:16698313 |
Mjøs SA | Prediction of equivalent chain lengths from two-dimensional fatty acid retention indices. | 2006 | J Chromatogr A | pmid:16701676 |
Coti Bertrand P et al. | Maternal dietary (n-3) fatty acid deficiency alters neurogenesis in the embryonic rat brain. | 2006 | J. Nutr. | pmid:16702323 |
Mantovani G et al. | A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and anti-cyclooxygenase-2 showing efficacy and safety in patients with cancer-related anorexia/cachexia and oxidative stress. | 2006 | Cancer Epidemiol. Biomarkers Prev. | pmid:16702388 |
Mairesse G et al. | Effects of geographic source, rearing system, and season on the nutritional quality of wild and farmed Perca fluviatilis. | 2006 | Lipids | pmid:16711596 |
Li D et al. | Omega 6 to omega 3 fatty acid imbalance early in life leads to persistent reductions in DHA levels in glycerophospholipids in rat hypothalamus even after long-term omega 3 fatty acid repletion. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16716580 |
Friedman AN et al. | Fish consumption and omega-3 fatty acid status and determinants in long-term hemodialysis. | 2006 | Am. J. Kidney Dis. | pmid:16731302 |
Gladyshev MI et al. | [Influence of different methods of cooking of hunchback salmon on contents of polyunsaturatedfatty acids]. | 2006 | Vopr Pitan | pmid:16739608 |
Parker G et al. | Omega-3 fatty acids and mood disorders. | 2006 | Am J Psychiatry | pmid:16741195 |
Nemets H et al. | Omega-3 treatment of childhood depression: a controlled, double-blind pilot study. | 2006 | Am J Psychiatry | pmid:16741212 |
Sublette ME et al. | Omega-3 polyunsaturated essential fatty acid status as a predictor of future suicide risk. | 2006 | Am J Psychiatry | pmid:16741213 |
López-Alarcón M et al. | Docosahexaenoic acid administered in the acute phase protects the nutritional status of septic neonates. | 2006 Jul-Aug | Nutrition | pmid:16750345 |
Schwab JM and Serhan CN | Lipoxins and new lipid mediators in the resolution of inflammation. | 2006 | Curr Opin Pharmacol | pmid:16750421 |
Hamam F and Shahidi F | Synthesis of structured lipids containing medium-chain and omega-3 fatty acids. | 2006 | J. Agric. Food Chem. | pmid:16756372 |
Hamazaki K et al. | Fish oil reduces tooth loss mainly through its anti-inflammatory effects? | 2006 | Med. Hypotheses | pmid:16759817 |
Morita E et al. | Docosahexaenoic acid production and lipid-body formation in Schizochytrium limacinum SR21. | 2006 May-Jun | Mar. Biotechnol. | pmid:16763939 |
Oksman M et al. | Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice. | 2006 | Neurobiol. Dis. | pmid:16765602 |
Wasowska I et al. | Influence of fish oil on ruminal biohydrogenation of C18 unsaturated fatty acids. | 2006 | Br. J. Nutr. | pmid:16768845 |
Walser B et al. | Supplementation with omega-3 polyunsaturated fatty acids augments brachial artery dilation and blood flow during forearm contraction. | 2006 | Eur. J. Appl. Physiol. | pmid:16770472 |
Bauer JE et al. | Docosahexaenoic acid accumulates in plasma of canine puppies raised on alpha-linolenic acid-rich milk during suckling but not when fed alpha-linolenic acid-rich diets after weaning. | 2006 | J. Nutr. | pmid:16772507 |
Patel JV et al. | Effects of omega-3 polyunsaturated fatty acids on metabolically active hormones in patients post-myocardial infarction. | 2007 | Int. J. Cardiol. | pmid:16781788 |
Weldon SM et al. | Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimulated human THP-1 macrophages more effectively than eicosapentaenoic acid. | 2007 | J. Nutr. Biochem. | pmid:16781858 |
Roman AS et al. | Omega-3 fatty acids and decidual cell prostaglandin production in response to the inflammatory cytokine IL-1beta. | 2006 | Am. J. Obstet. Gynecol. | pmid:16792994 |
McGuinness J et al. | Myocardial protection using an omega-3 fatty acid infusion: quantification and mechanism of action. | 2006 | J. Thorac. Cardiovasc. Surg. | pmid:16798305 |
Garelli A et al. | Docosahexaenoic acid promotes photoreceptor differentiation without altering Crx expression. | 2006 | Invest. Ophthalmol. Vis. Sci. | pmid:16799048 |
Chiang N and Serhan CN | Cell-cell interaction in the transcellular biosynthesis of novel omega-3-derived lipid mediators. | 2006 | Methods Mol. Biol. | pmid:16799203 |
Amiri-Jami M et al. | Enhancement of polyunsaturated fatty acid production by Tn5 transposon in Shewanella baltica. | 2006 | Biotechnol. Lett. | pmid:16799757 |
Bryhn M et al. | The bioavailability and pharmacodynamics of different concentrations of omega-3 acid ethyl esters. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16806871 |
Bitsanis D et al. | Gestational diabetes mellitus enhances arachidonic and docosahexaenoic acids in placental phospholipids. | 2006 | Lipids | pmid:16808147 |
Rhodes PG et al. | Effects of different levels of intravenous alpha-linolenic acid and supplemental breast milk on red blood cell docosahexaenoic acid in very low birth-weight infants. | 1991 | J. Pediatr. Gastroenterol. Nutr. | pmid:1681044 |
Sakurai Y et al. | Effects of long-term continuous use of immune-enhancing enteral formula on nutritional and immunologic status in non-surgical patients. | 2006 Jul-Aug | Nutrition | pmid:16815486 |
Schønberg SA et al. | Closely related colon cancer cell lines display different sensitivity to polyunsaturated fatty acids, accumulate different lipid classes and downregulate sterol regulatory element-binding protein 1. | 2006 | FEBS J. | pmid:16817902 |
GarcÃa-Ródenas CL et al. | Nutritional approach to restore impaired intestinal barrier function and growth after neonatal stress in rats. | 2006 | J. Pediatr. Gastroenterol. Nutr. | pmid:16819372 |
Harmon SD et al. | Oxygenation of omega-3 fatty acids by human cytochrome P450 4F3B: effect on 20-hydroxyeicosatetraenoic acid production. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16820285 |
Niu K et al. | Dietary long-chain n-3 fatty acids of marine origin and serum C-reactive protein concentrations are associated in a population with a diet rich in marine products. | 2006 | Am. J. Clin. Nutr. | pmid:16825699 |
Weil A | Why I still take my daily fish oil. | 2006 | Time | pmid:16827433 |
Burdge GC | Metabolism of alpha-linolenic acid in humans. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16828546 |
Namani T et al. | Vesicles from docosahexaenoic acid. | 2007 | Colloids Surf B Biointerfaces | pmid:16829059 |
Abe E et al. | A novel phosphatidylcholine which contains pentadecanoic acid at sn-1 and docosahexaenoic acid at sn-2 in Schizochytrium sp. F26-b. | 2006 | J. Biochem. | pmid:16829536 |
Polozova A et al. | Effect of docosahexaenoic acid on tissue targeting and metabolism of plasma lipoproteins. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16837179 |
Murphy KJ et al. | Low dose supplementation with two different marine oils does not reduce pro-inflammatory eicosanoids and cytokines in vivo. | 2006 | Asia Pac J Clin Nutr | pmid:16837436 |
Ganga R et al. | Modulation of ACTH-induced cortisol release by polyunsaturated fatty acids in interrenal cells from gilthead seabream, Sparus aurata. | 2006 | J. Endocrinol. | pmid:16837609 |
Yavin E | Versatile roles of docosahexaenoic acid in the prenatal brain: from pro- and anti-oxidant features to regulation of gene expression. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16839753 |
Cheatham CL et al. | N-3 fatty acids and cognitive and visual acuity development: methodologic and conceptual considerations. | 2006 | Am. J. Clin. Nutr. | pmid:16841855 |
Arterburn LM et al. | Distribution, interconversion, and dose response of n-3 fatty acids in humans. | 2006 | Am. J. Clin. Nutr. | pmid:16841856 |
Breslow JL | n-3 fatty acids and cardiovascular disease. | 2006 | Am. J. Clin. Nutr. | pmid:16841857 |
Johnson EJ and Schaefer EJ | Potential role of dietary n-3 fatty acids in the prevention of dementia and macular degeneration. | 2006 | Am. J. Clin. Nutr. | pmid:16841859 |
Carlson SE et al. | Long-term feeding of formulas high in linolenic acid and marine oil to very low birth weight infants: phospholipid fatty acids. | 1991 | Pediatr. Res. | pmid:1684416 |
Khan NA et al. | Docosahexaenoic acid inhibits cancer cell growth via p27Kip1, CDK2, ERK1/ERK2, and retinoblastoma phosphorylation. | 2006 | J. Lipid Res. | pmid:16847309 |
Bouwstra H et al. | Neurologic condition of healthy term infants at 18 months: positive association with venous umbilical DHA status and negative association with umbilical trans-fatty acids. | 2006 | Pediatr. Res. | pmid:16857765 |
Levant B et al. | Diet (n-3) polyunsaturated fatty acid content and parity interact to alter maternal rat brain phospholipid fatty acid composition. | 2006 | J. Nutr. | pmid:16857847 |
Omega-3 fatty acids may prevent sudden cardiac death. | 2006 | Health News | pmid:16858748 | |
Kindler DD et al. | Update on therapies for acute ischemic stroke. | 2000 | Neurosurg Focus | pmid:16859280 |
Shin SY et al. | Antibacterial activity of bioconverted eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) against foodborne pathogenic bacteria. | 2007 | Int. J. Food Microbiol. | pmid:16860896 |
Cao D et al. | Chronic daily administration of ethyl docosahexaenoate protects against gerbil brain ischemic damage through reduction of arachidonic acid liberation and accumulation. | 2007 | J. Nutr. Biochem. | pmid:16860980 |
Kubo K et al. | Induction of multidrug resistance-associated protein MRP3 in the liver of rats fed with docosahexaenoic acid. | 2006 | Biosci. Biotechnol. Biochem. | pmid:16861802 |
Langdon JH | Has an aquatic diet been necessary for hominin brain evolution and functional development? | 2006 | Br. J. Nutr. | pmid:16869985 |
Bakewell L et al. | Polyunsaturated fatty acid concentrations in young men and women consuming their habitual diets. | 2006 | Br. J. Nutr. | pmid:16869996 |
Ouguerram K et al. | Effect of n-3 fatty acids on metabolism of apoB100-containing lipoprotein in type 2 diabetic subjects. | 2006 | Br. J. Nutr. | pmid:16869997 |
Klingler M et al. | The effect of docosahexaenoic acid and folic acid supplementation on placental apoptosis and proliferation. | 2006 | Br. J. Nutr. | pmid:16870008 |
Milne GL et al. | Elevated oxidation of docosahexaenoic acid, 22:6 (n-3), in brain regions of rats undergoing ethanol withdrawal. | 2006 | Neurosci. Lett. | pmid:16875780 |
Saraswathy S et al. | Retinal microglial activation and chemotaxis by docosahexaenoic acid hydroperoxide. | 2006 | Invest. Ophthalmol. Vis. Sci. | pmid:16877440 |
Hacioglu G et al. | The role of docosahexaenoic acid on visual evoked potentials in one kidney-one clip hypertension. | 2006 | Acta Ophthalmol Scand | pmid:16879569 |
Jørgensen MH et al. | The composition of polyunsaturated fatty acids in erythrocytes of lactating mothers and their infants. | 2006 | Matern Child Nutr | pmid:16881912 |
Owada Y et al. | Altered emotional behavioral responses in mice lacking brain-type fatty acid-binding protein gene. | 2006 | Eur. J. Neurosci. | pmid:16882015 |
Hussar DA | New drugs 06, part II. | 2006 | Nursing | pmid:16888514 |
Ding WQ et al. | Clioquinol and docosahexaenoic acid act synergistically to kill tumor cells. | 2006 | Mol. Cancer Ther. | pmid:16891473 |
Sliwinski S et al. | Polyunsaturated fatty acids: do they have a role in the pathophysiology of autism? | 2006 | Neuro Endocrinol. Lett. | pmid:16891996 |
Quilici S et al. | A cost-effectiveness analysis of n-3 PUFA (Omacor) treatment in post-MI patients. | 2006 | Int. J. Clin. Pract. | pmid:16893435 |
Fournier V et al. | Analysis of eicosapentaenoic and docosahexaenoic acid geometrical isomers formed during fish oil deodorization. | 2006 | J Chromatogr A | pmid:16893549 |
Li Z et al. | Dehydroepiandrosterone sulfate prevents ischemia-induced impairment of long-term potentiation in rat hippocampal CA1 by up-regulating tyrosine phosphorylation of NMDA receptor. | 2006 | Neuropharmacology | pmid:16895729 |
Bazan NG | The onset of brain injury and neurodegeneration triggers the synthesis of docosanoid neuroprotective signaling. | 2006 Jul-Aug | Cell. Mol. Neurobiol. | pmid:16897369 |
Butovich IA et al. | Dihydroxydocosahexaenoic acids of the neuroprotectin D family: synthesis, structure, and inhibition of human 5-lipoxygenase. | 2006 | J. Lipid Res. | pmid:16899822 |