DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ozias MK et al. | Maternal parity and diet (n-3) polyunsaturated fatty acid concentration influence accretion of brain phospholipid docosahexaenoic acid in developing rats. | 2007 | J. Nutr. | pmid:17182812 |
| Levant B et al. | Specific brain regions of female rats are differentially depleted of docosahexaenoic acid by reproductive activity and an (n-3) fatty acid-deficient diet. | 2007 | J. Nutr. | pmid:17182813 |
| Calviello G et al. | Docosahexaenoic acid induces proteasome-dependent degradation of beta-catenin, down-regulation of survivin and apoptosis in human colorectal cancer cells not expressing COX-2. | 2007 | Carcinogenesis | pmid:17183061 |
| Dunstan JA et al. | Cognitive assessment of children at age 2(1/2) years after maternal fish oil supplementation in pregnancy: a randomised controlled trial. | 2008 | Arch. Dis. Child. Fetal Neonatal Ed. | pmid:17185423 |
| Kan I et al. | Docosahexaenoic acid and arachidonic acid are fundamental supplements for the induction of neuronal differentiation. | 2007 | J. Lipid Res. | pmid:17185746 |
| Mincke E et al. | Lower omega-3 polyunsaturated fatty acids and lower docosahexaenoic acid in men with pedophilia. | 2006 | Neuro Endocrinol. Lett. | pmid:17187003 |
| Chattipakorn N et al. | Fish oil does not improve defibrillation efficacy. | 2007 | Int. J. Cardiol. | pmid:17187881 |
| McNamara RK et al. | Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients with major depressive disorder. | 2007 | Biol. Psychiatry | pmid:17188654 |
| Machová E et al. | Docosahexaenoic acid supports cell growth and expression of choline acetyltransferase and muscarinic receptors in NG108-15 cell line. | 2006 | J. Mol. Neurosci. | pmid:17192613 |
| Ito MK et al. | Omacor effects on serum lipids and clinical outcome. | 2007 | Am. J. Cardiol. | pmid:17196478 |
| Chen W et al. | Inhibition of cytokine signaling in human retinal endothelial cells through modification of caveolae/lipid rafts by docosahexaenoic acid. | 2007 | Invest. Ophthalmol. Vis. Sci. | pmid:17197511 |
| Liu W et al. | Formation of high-molecular-weight protein adducts by methyl docosahexaenoate peroxidation products. | 2007 | Biochim. Biophys. Acta | pmid:17207667 |
| Singhal A et al. | Infant nutrition and stereoacuity at age 4-6 y. | 2007 | Am. J. Clin. Nutr. | pmid:17209191 |
| Kloareg M et al. | Deposition of dietary fatty acids, de novo synthesis and anatomical partitioning of fatty acids in finishing pigs. | 2007 | Br. J. Nutr. | pmid:17217558 |
| Xu Z et al. | Fish oil significantly alters fatty acid profiles in various lipid fractions but not atherogenesis in apo E-KO mice. | 2007 | Eur J Nutr | pmid:17225919 |
| Johansson AS et al. | Docosahexaenoic acid stabilizes soluble amyloid-beta protofibrils and sustains amyloid-beta-induced neurotoxicity in vitro. | 2007 | FEBS J. | pmid:17227385 |
| Gousset-Dupont A et al. | The effect of n-3 PUFA on eNOS activity and expression in Ea hy 926 cells. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17229561 |
| Schwellenbach LJ et al. | The triglyceride-lowering effects of a modest dose of docosahexaenoic acid alone versus in combination with low dose eicosapentaenoic acid in patients with coronary artery disease and elevated triglycerides. | 2006 | J Am Coll Nutr | pmid:17229894 |
| Castro IA et al. | Effect of eicosapentaenoic/docosahexaenoic fatty acids and soluble fibers on blood lipids of individuals classified into different levels of lipidemia. | 2007 | Nutrition | pmid:17234506 |
| pmid:17234605 | ||||
| McNamara RK et al. | Abnormalities in the fatty acid composition of the postmortem orbitofrontal cortex of schizophrenic patients: gender differences and partial normalization with antipsychotic medications. | 2007 | Schizophr. Res. | pmid:17236749 |
| Pitel S et al. | At low doses, a gamma-linolenic acid-lipoic acid conjugate is more effective than docosahexaenoic acid-enriched phospholipids in preventing neuropathy in diabetic rats. | 2007 | J. Nutr. | pmid:17237313 |
| Birch EE et al. | Visual acuity and cognitive outcomes at 4 years of age in a double-blind, randomized trial of long-chain polyunsaturated fatty acid-supplemented infant formula. | 2007 | Early Hum. Dev. | pmid:17240089 |
| Sun YP et al. | Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. | 2007 | J. Biol. Chem. | pmid:17244615 |
| Bazan NG | Survival signaling in retinal pigment epithelial cells in response to oxidative stress: significance in retinal degenerations. | 2006 | Adv. Exp. Med. Biol. | pmid:17249620 |
| Golovko MY et al. | Alpha-synuclein gene ablation increases docosahexaenoic acid incorporation and turnover in brain phospholipids. | 2007 | J. Neurochem. | pmid:17250657 |
| Bourre JM | Dietary omega-3 fatty acids for women. | 2007 Feb-Apr | Biomed. Pharmacother. | pmid:17254747 |
| Weylandt KH et al. | Lipoxins and resolvins in inflammatory bowel disease. | 2007 | Inflamm. Bowel Dis. | pmid:17262807 |
| Jensen LD et al. | Regulation of endothelial cell migration by amphiphiles - are changes in cell membrane physical properties involved? | 2007 | Angiogenesis | pmid:17265099 |
| Nakazawa T et al. | Pitavastatin prevents NMDA-induced retinal ganglion cell death by suppressing leukocyte recruitment. | 2007 | J. Neurochem. | pmid:17266736 |
| Hallahan B et al. | Omega-3 fatty acid supplementation in patients with recurrent self-harm. Single-centre double-blind randomised controlled trial. | 2007 | Br J Psychiatry | pmid:17267927 |
| Bryan DL et al. | Polyunsaturated fatty acids regulate cytokine and prostaglandin E2 production by respiratory cells in response to mast cell mediators. | 2006 | Lipids | pmid:17269555 |
| Elvevoll EO et al. | Enhanced incorporation of n-3 fatty acids from fish compared with fish oils. | 2006 | Lipids | pmid:17269556 |
| Attar-Bashi NM et al. | Failure of conjugated linoleic acid supplementation to enhance biosynthesis of docosahexaenoic acid from alpha-linolenic acid in healthy human volunteers. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17275274 |
| Trombetta A et al. | Arachidonic and docosahexaenoic acids reduce the growth of A549 human lung-tumor cells increasing lipid peroxidation and PPARs. | 2007 | Chem. Biol. Interact. | pmid:17275799 |
| Huynh MD et al. | Comparison of fatty acid profiles of spawning and non-spawning Pacific herring, Clupea harengus pallasi. | 2007 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:17276118 |
| Igarashi M et al. | Docosahexaenoic acid synthesis from alpha-linolenic acid by rat brain is unaffected by dietary n-3 PUFA deprivation. | 2007 | J. Lipid Res. | pmid:17277380 |
| Ookawa K et al. | Effect of ovary lipid of skipjack tuna on rat serum components after stress application. | 2007 | J. Vet. Med. Sci. | pmid:17283400 |
| Racine RA and Deckelbaum RJ | Sources of the very-long-chain unsaturated omega-3 fatty acids: eicosapentaenoic acid and docosahexaenoic acid. | 2007 | Curr Opin Clin Nutr Metab Care | pmid:17284998 |
| von Schacky C | Omega-3 fatty acids and cardiovascular disease. | 2007 | Curr Opin Clin Nutr Metab Care | pmid:17284999 |
| Bazan NG | Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection. | 2007 | Curr Opin Clin Nutr Metab Care | pmid:17285000 |
| New Alzheimer's clinical trials to be undertaken by NIA nationwide consortium. | 2006 Dec-2007 Jan | Am J Alzheimers Dis Other Demen | pmid:17288014 | |
| Zhou XR et al. | Isolation and characterization of genes from the marine microalga Pavlova salina encoding three front-end desaturases involved in docosahexaenoic acid biosynthesis. | 2007 | Phytochemistry | pmid:17291553 |
| Vibet S et al. | Differential subcellular distribution of mitoxantrone in relation to chemosensitization in two human breast cancer cell lines. | 2007 | Drug Metab. Dispos. | pmid:17296624 |
| Koletzko B et al. | Placental transfer of long-chain polyunsaturated fatty acids (LC-PUFA). | 2007 | J Perinat Med | pmid:17302540 |
| López-Alarcón M et al. | Breastfeeding's protection against illness-induced anorexia is mediated partially by docosahexaenoic acid. | 2008 | Eur J Clin Nutr | pmid:17311056 |
| Schley PD et al. | (n-3) PUFA alter raft lipid composition and decrease epidermal growth factor receptor levels in lipid rafts of human breast cancer cells. | 2007 | J. Nutr. | pmid:17311938 |
| Coste TC et al. | An overview of monitoring and supplementation of omega 3 fatty acids in cystic fibrosis. | 2007 | Clin. Biochem. | pmid:17316592 |
| de Groot RH et al. | Exploratory study into the relation between plasma phospholipid fatty acid status and cognitive performance. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17317131 |
| Xiao Y et al. | DHA depletion in rat brain is associated with impairment on spatial learning and memory. | 2006 | Biomed. Environ. Sci. | pmid:17319274 |
| Decsi T et al. | Low contribution of n-3 polyunsaturated fatty acids to plasma and erythrocyte membrane lipids in diabetic young adults. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17321122 |
| Zhang Y et al. | Neuroprotection by tamoxifen in focal cerebral ischemia is not mediated by an agonist action at estrogen receptors but is associated with antioxidant activity. | 2007 | Exp. Neurol. | pmid:17321521 |
| von Schacky C | A review of omega-3 ethyl esters for cardiovascular prevention and treatment of increased blood triglyceride levels. | 2006 | Vasc Health Risk Manag | pmid:17326331 |
| Moghaddami N et al. | Novel action of n-3 polyunsaturated fatty acids: inhibition of arachidonic acid-induced increase in tumor necrosis factor receptor expression on neutrophils and a role for proteases. | 2007 | Arthritis Rheum. | pmid:17328054 |
| The dish on fish. Benefits outweigh risks, according to two recent reviews. | 2007 | Harv Health Lett | pmid:17328140 | |
| Pettersson U and Dahlqvist R | [Fish oil for prevention of thrombosis and blood lipid lowering?]. | 2007 Jan 24-30 | Lakartidningen | pmid:17328472 |
| Shirai N et al. | Effect of lipids extracted from a salted herring roe food product on maze-behavior in mice. | 2006 | J. Nutr. Sci. Vitaminol. | pmid:17330509 |
| Jakel RJ et al. | Nrf2-mediated protection against 6-hydroxydopamine. | 2007 | Brain Res. | pmid:17336276 |
| Ariel A and Serhan CN | Resolvins and protectins in the termination program of acute inflammation. | 2007 | Trends Immunol. | pmid:17337246 |
| Panza F et al. | Dietary polyunsaturated fatty acid supplementation, pre-dementia syndromes, and Alzheimer's disease. | 2007 | J Am Geriatr Soc | pmid:17341255 |
| Jourdan ML et al. | Increased BRCA1 protein in mammary tumours of rats fed marine omega-3 fatty acids. | 2007 | Oncol. Rep. | pmid:17342305 |
| Maillard MH | [Resolvins: new derivates of fatty acids, polyunsaturated (omega-3) with therapeutic potential in inflammatory intestinal diseases]. | 2006 | Rev Med Suisse | pmid:17343155 |
| Anil E | The impact of EPA and DHA on blood lipids and lipoprotein metabolism: influence of apoE genotype. | 2007 | Proc Nutr Soc | pmid:17343773 |
| Bassaganya-Riera J et al. | Arachidonic acid-and docosahexaenoic acid-enriched formulas modulate antigen-specific T cell responses to influenza virus in neonatal piglets. | 2007 | Am. J. Clin. Nutr. | pmid:17344506 |
| Murphy KJ et al. | Impact of foods enriched with n-3 long-chain polyunsaturated fatty acids on erythrocyte n-3 levels and cardiovascular risk factors. | 2007 | Br. J. Nutr. | pmid:17349088 |
| Richardson UI and Wurtman RJ | Polyunsaturated fatty acids stimulate phosphatidylcholine synthesis in PC12 cells. | 2007 | Biochim. Biophys. Acta | pmid:17350887 |
| Innis SM | Dietary (n-3) fatty acids and brain development. | 2007 | J. Nutr. | pmid:17374644 |
| Theobald HE et al. | Low-dose docosahexaenoic acid lowers diastolic blood pressure in middle-aged men and women. | 2007 | J. Nutr. | pmid:17374663 |
| Fan KW et al. | Lipid characterization of mangrove thraustochytrid--Schizochytrium mangrovei. | 2007 | J. Agric. Food Chem. | pmid:17381126 |
| Balaji T et al. | Localization of cyclooxygenase-2 in mice vas deferens and its effects on fertility upon suppression using nimesulide: a preferential cyclooxygenase-2 inhibitor. | 2007 | Toxicology | pmid:17382448 |
| Conklin SM et al. | Serum omega-3 fatty acids are associated with variation in mood, personality and behavior in hypercholesterolemic community volunteers. | 2007 | Psychiatry Res | pmid:17383013 |
| Kuipers RS et al. | Milk in the island of Chole [Tanzania] is high in lauric, myristic, arachidonic and docosahexaenoic acids, and low in linoleic acid reconstructed diet of infants born to our ancestors living in tropical coastal regions. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17383169 |
| Hill AM et al. | n-3 Fatty acid supplementation and regular moderate exercise: differential effects of a combined intervention on neutrophil function. | 2007 | Br. J. Nutr. | pmid:17391558 |
| Meyer BJ et al. | Dose-dependent effects of docosahexaenoic acid supplementation on blood lipids in statin-treated hyperlipidaemic subjects. | 2007 | Lipids | pmid:17393216 |
| Judge MP et al. | A docosahexaenoic acid-functional food during pregnancy benefits infant visual acuity at four but not six months of age. | 2007 | Lipids | pmid:17393217 |
| Vancassel S et al. | Hyperactivity in the rat is associated with spontaneous low level of n-3 polyunsaturated fatty acids in the frontal cortex. | 2007 | Behav. Brain Res. | pmid:17397943 |
| Mozaffarian D | JELIS, fish oil, and cardiac events. | 2007 | Lancet | pmid:17398290 |
| Portier K et al. | The effects of dietary N-3 and antioxidant supplementation on erythrocyte membrane fatty acid composition and fluidity in exercising horses. | 2006 | Equine Vet J Suppl | pmid:17402432 |
| Kebir MV et al. | Fatty acids in liver, muscle and gonad of three tropical rays including non-methylene-interrupted dienoic fatty acids. | 2007 | Lipids | pmid:17404769 |
| Harris WS et al. | Stearidonic acid increases the red blood cell and heart eicosapentaenoic acid content in dogs. | 2007 | Lipids | pmid:17406927 |
| Hwang I et al. | N-3 polyunsaturated fatty acids and atopy in Korean preschoolers. | 2007 | Lipids | pmid:17406929 |
| Cunnane SC | Docosahexaenoic acid and human brain evolution: missing the forest for the trees--comments by Cunnane. | 2007 | Br. J. Nutr. | pmid:17408531 |
| Milligan LA and Bazinet RP | Is docosahexaenoic acid a red herring for the aquatic diet?--Comments by Milligan and Bazinet. | 2007 | Br. J. Nutr. | pmid:17408532 |
| Portolesi R et al. | Competition between 24:5n-3 and ALA for Delta 6 desaturase may limit the accumulation of DHA in HepG2 cell membranes. | 2007 | J. Lipid Res. | pmid:17409318 |
| Payne M et al. | DHA-paclitaxel (Taxoprexin) as first-line treatment in patients with stage IIIB or IV non-small cell lung cancer: report of a phase II open-label multicenter trial. | 2006 | J Thorac Oncol | pmid:17409983 |
| Connor WE and Connor SL | The importance of fish and docosahexaenoic acid in Alzheimer disease. | 2007 | Am. J. Clin. Nutr. | pmid:17413088 |
| van Gelder BM et al. | Fish consumption, n-3 fatty acids, and subsequent 5-y cognitive decline in elderly men: the Zutphen Elderly Study. | 2007 | Am. J. Clin. Nutr. | pmid:17413117 |
| Salem N | What is the right level of DHA in the infant diet? Commentary on article by Hsieh et al. on page 537. | 2007 | Pediatr. Res. | pmid:17413853 |
| Hsieh AT et al. | The influence of moderate and high dietary long chain polyunsaturated fatty acids (LCPUFA) on baboon neonate tissue fatty acids. | 2007 | Pediatr. Res. | pmid:17413857 |
| Tanaka K et al. | Early dietary treatments with Lorenzo's oil and docosahexaenoic acid for neurological development in a case with Zellweger syndrome. | 2007 | Brain Dev. | pmid:17418516 |
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| Serkov IV et al. | Effect of derivatives of docosahexaenoic acid on AMPA receptors in Purkinje neurons. | 2006 Nov-Dec | Dokl. Biol. Sci. | pmid:17425032 |
| Kothapalli KS et al. | Differential cerebral cortex transcriptomes of baboon neonates consuming moderate and high docosahexaenoic acid formulas. | 2007 | PLoS ONE | pmid:17426818 |
| Ding WQ and Lind SE | Phospholipid hydroperoxide glutathione peroxidase plays a role in protecting cancer cells from docosahexaenoic acid-induced cytotoxicity. | 2007 | Mol. Cancer Ther. | pmid:17431126 |
| Busch B | Polyunsaturated fatty acid supplementation for ADHD? Fishy, fascinating, and far from clear. | 2007 | J Dev Behav Pediatr | pmid:17435465 |
| Green KN et al. | Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels. | 2007 | J. Neurosci. | pmid:17442823 |
| Kusumoto A et al. | Effects of arachidonate-enriched triacylglycerol supplementation on serum fatty acids and platelet aggregation in healthy male subjects with a fish diet. | 2007 | Br. J. Nutr. | pmid:17445350 |
| Fournier V et al. | Quantification of eicosapentaenoic and docosahexaenoic acid geometrical isomers formed during fish oil deodorization by gas-liquid chromatography. | 2007 | J Chromatogr A | pmid:17449039 |
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