DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Pneumonia, Bacterial D018410 16 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Premature Birth D047928 6 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Long QT Syndrome D008133 10 associated lipids
Short Bowel Syndrome D012778 3 associated lipids
Retinoblastoma D012175 12 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Vibrio Infections D014735 5 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Intracranial Hemorrhages D020300 2 associated lipids
Intermittent Claudication D007383 6 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Depression, Postpartum D019052 3 associated lipids
Dyskinesias D020820 3 associated lipids
Dysbiosis D064806 2 associated lipids
Glaucoma, Open-Angle D005902 3 associated lipids
Milk Hypersensitivity D016269 4 associated lipids
Dementia, Vascular D015140 7 associated lipids
Plaque, Amyloid D058225 19 associated lipids
Eye Abnormalities D005124 7 associated lipids
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma D054218 5 associated lipids
Chondrodysplasia Punctata, Rhizomelic D018902 4 associated lipids
Chronic Pain D059350 5 associated lipids
Neuroaxonal Dystrophies D019150 3 associated lipids
Spinocerebellar Ataxias D020754 4 associated lipids
Paracoccidioidomycosis D010229 2 associated lipids
Leukemia, Prolymphocytic D015463 2 associated lipids
Hydroa Vacciniforme D006837 1 associated lipids
Trophoblastic Tumor, Placental Site D018245 1 associated lipids
Phenylketonuria, Maternal D017042 1 associated lipids
Refsum Disease, Infantile D052919 1 associated lipids
Pulmonary Valve Stenosis D011666 1 associated lipids
Cerebrovascular Trauma D020214 1 associated lipids
Histiocytoma, Malignant Fibrous D051677 1 associated lipids
Decapitation D049248 2 associated lipids
Communication Disorders D003147 1 associated lipids
Geographic Atrophy D057092 1 associated lipids
Lordosis D008141 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Hammond BG et al. Safety assessment of DHA-rich microalgae from Schizochytrium sp. 2001 Regul. Toxicol. Pharmacol. pmid:11350203
Blum R et al. Genotoxicity and subchronic toxicity studies of DHA-rich oil in rats. 2007 Regul. Toxicol. Pharmacol. pmid:17933446
Alexopoulos E et al. Treatment of severe IgA nephropathy with omega-3 fatty acids: the effect of a "very low dose" regimen. 2004 Ren Fail pmid:15462115
Mariee AD and Abd-Ellah MF Protective effect of docosahexaenoic acid against cyclosporine A-induced nephrotoxicity in rats: a possible mechanism of action. 2011 Ren Fail pmid:21219208
Kaeoket K et al. Effect of docosahexaenoic acid on quality of cryopreserved boar semen in different breeds. 2010 Reprod. Domest. Anim. pmid:19090818
Meher AP et al. Preconceptional omega-3 fatty acid supplementation on a micronutrient-deficient diet improves the reproductive cycle in Wistar rats. 2013 Reprod. Fertil. Dev. pmid:23137932
Kiernan M et al. The effect of the in vitro supplementation of exogenous long-chain fatty acids on bovine sperm cell function. 2013 Reprod. Fertil. Dev. pmid:23036717
Alessandri JM et al. Polyunsaturated fatty acids in the central nervous system: evolution of concepts and nutritional implications throughout life. 2004 Nov-Dec Reprod. Nutr. Dev. pmid:15762297
Alessandri JM et al. Polyunsaturated fatty acids status in blood, heart, liver, intestine, retina and brain of newborn piglets fed either sow milk or a milk replacer diet. 1996 Reprod. Nutr. Dev. pmid:8881596
Lauritzen L et al. Maternal fish oil supplementation in lactation: effect on developmental outcome in breast-fed infants. 2005 Sep-Oct Reprod. Nutr. Dev. pmid:16188206
Young GS et al. Effect of randomized supplementation with high dose olive, flax or fish oil on serum phospholipid fatty acid levels in adults with attention deficit hyperactivity disorder. 2005 Sep-Oct Reprod. Nutr. Dev. pmid:16188207
Stillwell W et al. Docosahexaenoic acid affects cell signaling by altering lipid rafts. 2005 Sep-Oct Reprod. Nutr. Dev. pmid:16188208
Sergeeva M et al. Regulation of intracellular calcium levels by polyunsaturated fatty acids, arachidonic acid and docosahexaenoic acid, in astrocytes: possible involvement of phospholipase A2. 2005 Sep-Oct Reprod. Nutr. Dev. pmid:16188212
Burdge GC and Calder PC Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults. 2005 Sep-Oct Reprod. Nutr. Dev. pmid:16188209
Burdge GC et al. Docosahexaenoic acid is selectively enriched in plasma phospholipids during pregnancy in Trinidadian women--results of a pilot study. 2006 Jan-Feb Reprod. Nutr. Dev. pmid:16438916
Sundrani D et al. Matrix metalloproteinases-2, -3 and tissue inhibitors of metalloproteinases-1, -2 in placentas from preterm pregnancies and their association with one-carbon metabolites. 2013 Reproduction pmid:23412981
Moallem U et al. Dietary α-linolenic acid from flaxseed oil improved folliculogenesis and IVF performance in dairy cows, similar to eicosapentaenoic and docosahexaenoic acids from fish oil. 2013 Reproduction pmid:24062566
Stark MJ et al. Differential effects of docosahexaenoic acid on preterm and term placental pro-oxidant/antioxidant balance. 2013 Reproduction pmid:23813449
Bender K et al. Metabolite concentrations in follicular fluid may explain differences in fertility between heifers and lactating cows. 2010 Reproduction pmid:20385782
Waterhouse KE et al. Within and between breed differences in freezing tolerance and plasma membrane fatty acid composition of boar sperm. 2006 Reproduction pmid:16672353