Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Luquain C et al. | Bis(monoacylglycerol) phosphate in rat uterine stromal cells: structural characterization and specific esterification of docosahexaenoic acid. | 2000 | Biochem. J. | pmid:11042136 |
Garcia HS et al. | Synthesis of glycerides containing n-3 fatty acids and conjugated linoleic acid by solvent-free acidolysis of fish oil. | 2000 | Biotechnol. Bioeng. | pmid:11042555 |
Gerber MJ et al. | Profiles of a healthful diet and its relationship to biomarkers in a population sample from Mediterranean southern France. | 2000 | J Am Diet Assoc | pmid:11043701 |
Hosokawa M et al. | Conversion to docosahexaenoic acid-containing phosphatidylserine from squid skin lecithin by phospholipase D-mediated transphosphatidylation. | 2000 | J. Agric. Food Chem. | pmid:11052698 |
Surai PF et al. | Effect of long-term supplementation with arachidonic or docosahexaenoic acids on sperm production in the broiler chicken. | 2000 | J. Reprod. Fertil. | pmid:11058441 |
Pakala R et al. | Vascular smooth muscle cells preloaded with eicosapentaenoic acid and docosahexaenoic acid fail to respond to serotonin stimulation. | 2000 | Atherosclerosis | pmid:11058699 |
Salem ML et al. | N-3 polyunsaturated fatty acids accentuate B16 melanoma growth and metastasis through suppression of tumoricidal function of T cells and macrophages. | 2000 Sep-Oct | Anticancer Res. | pmid:11062743 |
Sherman MP | Human milk, fatty acids, and the immune response: a new glimpse. | 2000 | Am. J. Clin. Nutr. | pmid:11063429 |
Granot E et al. | Breast-fed and formula-fed infants do not differ in immunocompetent cell cytokine production despite differences in cell membrane fatty acid composition. | 2000 | Am. J. Clin. Nutr. | pmid:11063450 |
Smit EN et al. | Docosahexaenoic acid (DHA) status of breastfed malnourished infants and their mothers in North Pakistan. | 2000 | Adv. Exp. Med. Biol. | pmid:11065099 |
Lauritizen L et al. | Dietary fish and the docosahexaenoic acid (DHA) content of human milk. | 2000 | Adv. Exp. Med. Biol. | pmid:11065103 |
Savino F et al. | Arachidonic (AA) and docosahexaenoic (DHA) acid content in healthy infants fed with an HA milk formula supplemented with LCPUFA and in breast fed infants. | 2000 | Adv. Exp. Med. Biol. | pmid:11065107 |
Decsi T et al. | Low contribution of docosahexaenoic acid to the fatty acid composition of mature human milk in Hungary. | 2000 | Adv. Exp. Med. Biol. | pmid:11065108 |
Lopez-Alarcon M et al. | Illness-induced anorexia in the breast-fed infants. Role of IL-1beta and TNF-alpha. | 2000 | Adv. Exp. Med. Biol. | pmid:11065112 |
Lim SY and Suzuki H | Effect of dietary docosahexaenoic acid and phosphatidylcholine on maze behavior and fatty acid composition of plasma and brain lipids in mice. | 2000 | Int J Vitam Nutr Res | pmid:11068705 |
Totland GK et al. | Proliferation of mitochondria and gene expression of carnitine palmitoyltransferase and fatty acyl-CoA oxidase in rat skeletal muscle, heart and liver by hypolipidemic fatty acids. | 2000 | Biol. Cell | pmid:11071041 |
Contreras MA et al. | Nutritional deprivation of alpha-linolenic acid decreases but does not abolish turnover and availability of unacylated docosahexaenoic acid and docosahexaenoyl-CoA in rat brain. | 2000 | J. Neurochem. | pmid:11080190 |
Moriguchi T et al. | Behavioral deficits associated with dietary induction of decreased brain docosahexaenoic acid concentration. | 2000 | J. Neurochem. | pmid:11080210 |
Diep QN et al. | Docosahexaenoic acid, a peroxisome proliferator-activated receptor-alpha ligand, induces apoptosis in vascular smooth muscle cells by stimulation of p38 mitogen-activated protein kinase. | 2000 | Hypertension | pmid:11082155 |
Louw L and Dannhauser A | Keloids in rural black South Africans. Part 2: dietary fatty acid intake and total phospholipid fatty acid profile in the blood of keloid patients. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090250 |
Fokkema MR et al. | Short-term supplementation of low-dose gamma-linolenic acid (GLA), alpha-linolenic acid (ALA), or GLA plus ALA does not augment LCP omega 3 status of Dutch vegans to an appreciable extent. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090255 |
Chen ZY and Istfan NW | Docosahexaenoic acid is a potent inducer of apoptosis in HT-29 colon cancer cells. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090257 |
Otto SJ et al. | The effect of supplementation with docosahexaenoic and arachidonic acid derived from single cell oils on plasma and erythrocyte fatty acids of pregnant women in the second trimester. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090260 |
Rissanen T et al. | Fish oil-derived fatty acids, docosahexaenoic acid and docosapentaenoic acid, and the risk of acute coronary events: the Kuopio ischaemic heart disease risk factor study. | 2000 | Circulation | pmid:11094031 |
Freedman SD et al. | Fatty acids in cystic fibrosis. | 2000 | Curr Opin Pulm Med | pmid:11100964 |
Lapillonne A et al. | The use of low-EPA fish oil for long-chain polyunsaturated fatty acid supplementation of preterm infants. | 2000 | Pediatr. Res. | pmid:11102555 |
Wang M et al. | Induction of mammary differentiation by mammary-derived growth inhibitor-related gene that interacts with an omega-3 fatty acid on growth inhibition of breast cancer cells. | 2000 | Cancer Res. | pmid:11103817 |
Ikemoto A et al. | Effect of n-3 fatty acid deficiency on fatty acid composition and metabolism of aminophospholipids in rat brain synaptosomes. | 2000 | Lipids | pmid:11104017 |
Decsi T et al. | Fatty acid composition of human milk in Hungary. | 2000 | Acta Paediatr. | pmid:11106060 |
Baldessarini RJ et al. | Fatty acid derivatives of clozapine: prolonged antidopaminergic activity of docosahexaenoylclozapine in the rat. | 2001 | Neuropsychopharmacology | pmid:11106876 |
Mezzano D et al. | Cardiovascular risk factors in vegetarians. Normalization of hyperhomocysteinemia with vitamin B(12) and reduction of platelet aggregation with n-3 fatty acids. | 2000 | Thromb. Res. | pmid:11108902 |
Song JH et al. | Polyunsaturated (n-3) fatty acids susceptible to peroxidation are increased in plasma and tissue lipids of rats fed docosahexaenoic acid-containing oils. | 2000 | J. Nutr. | pmid:11110863 |
Auestad N | Infant nutrition--brain development--disease in later life. An introduction. | 2000 Sep-Dec | Dev. Neurosci. | pmid:11111164 |
Innis SM | The role of dietary n-6 and n-3 fatty acids in the developing brain. | 2000 Sep-Dec | Dev. Neurosci. | pmid:11111165 |
Stockard JE et al. | Effect of docosahexaenoic acid content of maternal diet on auditory brainstem conduction times in rat pups. | 2000 Sep-Dec | Dev. Neurosci. | pmid:11111168 |
de Urquiza AM et al. | Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain. | 2000 | Science | pmid:11118147 |
Haban P et al. | Supplementation with long-chain n-3 fatty acids in non-insulin-dependent diabetes mellitus (NIDDM) patients leads to the lowering of oleic acid content in serum phospholipids. | 2000 | Eur J Nutr | pmid:11131366 |
Harel M et al. | Modulation of arachidonate and docosahexaenoate in Morone chrysops larval tissues and the effect on growth and survival. | 2000 | Lipids | pmid:11132186 |
MarÃn MC et al. | Dietary long-chain fatty acids and visual response in malnourished nursing infants. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11133176 |
Sorbera LA et al. | Effects of polyunsaturated fatty acids and prostaglandins on oocyte maturation in a marine teleost, the European sea bass (Dicentrarchus labrax). | 2001 | Biol. Reprod. | pmid:11133697 |
Mizota A et al. | Protective effects of dietary docosahexaenoic acid against kainate-induced retinal degeneration in rats. | 2001 | Invest. Ophthalmol. Vis. Sci. | pmid:11133871 |
Lauritzen L et al. | The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina. | 2001 Jan-Mar | Prog. Lipid Res. | pmid:11137568 |
Reich EE et al. | Brain regional quantification of F-ring and D-/E-ring isoprostanes and neuroprostanes in Alzheimer's disease. | 2001 | Am. J. Pathol. | pmid:11141503 |
Hoffman DR et al. | Impact of early dietary intake and blood lipid composition of long-chain polyunsaturated fatty acids on later visual development. | 2000 | J. Pediatr. Gastroenterol. Nutr. | pmid:11144440 |
Yokoyama A et al. | Effect of aerosolized docosahexaenoic acid in a mouse model of atopic asthma. | 2000 | Int. Arch. Allergy Immunol. | pmid:11146390 |
Nagakura T et al. | Dietary supplementation with fish oil rich in omega-3 polyunsaturated fatty acids in children with bronchial asthma. | 2000 | Eur. Respir. J. | pmid:11153584 |
Cho E et al. | Prospective study of dietary fat and the risk of age-related macular degeneration. | 2001 | Am. J. Clin. Nutr. | pmid:11157315 |
Otto SJ et al. | Changes in the maternal essential fatty acid profile during early pregnancy and the relation of the profile to diet. | 2001 | Am. J. Clin. Nutr. | pmid:11157328 |
Williams C et al. | Stereoacuity at age 3.5 y in children born full-term is associated with prenatal and postnatal dietary factors: a report from a population-based cohort study. | 2001 | Am. J. Clin. Nutr. | pmid:11157330 |
Brand A et al. | Lipid constituents in oligodendroglial cells alter susceptibility to H2O2-induced apoptotic cell death via ERK activation. | 2001 | J. Neurochem. | pmid:11158263 |
Helge JW et al. | Training affects muscle phospholipid fatty acid composition in humans. | 2001 | J. Appl. Physiol. | pmid:11160068 |
Lim S and Suzuki H | Changes in maze behavior of mice occur after sufficient accumulation of docosahexaenoic acid in brain. | 2001 | J. Nutr. | pmid:11160553 |
Tocher DR and Dick JR | Effects of essential fatty acid deficiency and supplementation with docosahexaenoic acid (DHA; 22:6n-3) on cellular fatty acid compositions and fatty acyl desaturation in a cell culture model. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11161581 |
Chen ZY and Istfan NW | Docosahexaenoic acid, a major constituent of fish oil diets, prevents activation of cyclin-dependent kinases and S-phase entry by serum stimulation in HT-29 cells. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11161587 |
Infante JP and Huszagh VA | Zellweger syndrome knockout mouse models challenge putative peroxisomal beta-oxidation involvement in docosahexaenoic acid (22:6n-3) biosynthesis. | 2001 | Mol. Genet. Metab. | pmid:11161822 |
Wiesenfeld PW et al. | Effect of long-chain fatty acids in the culture medium on fatty acid composition of WEHI-3 and J774A.1 cells. | 2001 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:11163311 |
Ito Y et al. | Effects of polyunsaturated fatty acids on atrophic gastritis in a Japanese population. | 2001 | Cancer Lett. | pmid:11165751 |
Morita N et al. | Biosynthesis of fatty acids in the docosahexaenoic acid-producing bacterium Moritella marina strain MP-1. | 2000 | Biochem. Soc. Trans. | pmid:11171265 |
Du M et al. | Effects of dietary conjugated linoleic acid and linoleic:linolenic acid ratio on polyunsaturated fatty acid status in laying hens. | 2000 | Poult. Sci. | pmid:11194037 |
Conquer JA et al. | Fatty acid analysis of blood plasma of patients with Alzheimer's disease, other types of dementia, and cognitive impairment. | 2000 | Lipids | pmid:11201991 |
Ashford A et al. | Electron microscopy may reveal structure of docosahexaenoic acid-rich oil within Schizochytrium sp. | 2000 | Lipids | pmid:11202000 |
al-Awadhi AM and Dunn CD | Effects of fish-oil constituents and plasma lipids on fibrinolysis in vitro. | 2000 | Br. J. Biomed. Sci. | pmid:11204855 |
Lance VA et al. | Hyperlipidemia and reproductive failure in captive-reared alligators: vitamin E, vitamin A, plasma lipids, fatty acids, and steroid hormones. | 2001 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:11207442 |
Frenoux JM et al. | A polyunsaturated fatty acid diet lowers blood pressure and improves antioxidant status in spontaneously hypertensive rats. | 2001 | J. Nutr. | pmid:11208936 |
Hung P et al. | Dietary effects of eicosapentaenoic and docosahexaenoic acid esters on lipid metabolism and immune parameters in Sprague-Dawley rats. | 2000 | Biosci. Biotechnol. Biochem. | pmid:11210121 |
Song JH and Miyazawa T | Enhanced level of n-3 fatty acid in membrane phospholipids induces lipid peroxidation in rats fed dietary docosahexaenoic acid oil. | 2001 | Atherosclerosis | pmid:11223421 |
Christophe A and Robberecht E | Directed modification instead of normalization of fatty acid patterns in cystic fibrosis: an emerging concept. | 2001 | Curr Opin Clin Nutr Metab Care | pmid:11224654 |
Saito M | Dietary docosahexaenoic acid does not promote tissue lipid peroxide formation to the extent expected from the peroxidizability index of the lipids. | 2000 | Biofactors | pmid:11237175 |
Hamazaki T et al. | Anti-stress effects of DHA. | 2000 | Biofactors | pmid:11237197 |
Agostoni C et al. | Biochemical effects of supplemented long-chain polyunsaturated fatty acids in hyperphenylalaninemia. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11237478 |
Thies F et al. | Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y. | 2001 | Am. J. Clin. Nutr. | pmid:11237929 |
van den Ham EC et al. | Evaluation of the relation between n-3 and n-6 fatty acid status and parity in nonpregnant women from the Netherlands. | 2001 | Am. J. Clin. Nutr. | pmid:11237941 |
Infante JP and Huszagh VA | Impaired arachidonic (20:4n-6) and docosahexaenoic (22:6n-3) acid synthesis by phenylalanine metabolites as etiological factors in the neuropathology of phenylketonuria. | 2001 | Mol. Genet. Metab. | pmid:11243724 |
Xiao YF et al. | Single point mutations affect fatty acid block of human myocardial sodium channel alpha subunit Na+ channels. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11248125 |
Al MD et al. | Relation between birth order and the maternal and neonatal docosahexaenoic acid status. | 1997 | Eur J Clin Nutr | pmid:11248881 |
Gamoh S et al. | Chronic administration of docosahexaenoic acid improves the performance of radial arm maze task in aged rats. | 2001 | Clin. Exp. Pharmacol. Physiol. | pmid:11251638 |
Wood H | An X-orphan. | 2001 | Nat. Rev. Neurosci. | pmid:11252996 |
Pound EM et al. | Partitioning of polyunsaturated fatty acids, which prevent cardiac arrhythmias, into phospholipid cell membranes. | 2001 | J. Lipid Res. | pmid:11254745 |
Higdon JV et al. | Supplementation of postmenopausal women with fish oil does not increase overall oxidation of LDL ex vivo compared to dietary oils rich in oleate and linoleate. | 2001 | J. Lipid Res. | pmid:11254753 |
Moriguchi T et al. | Reversal of docosahexaenoic acid deficiency in the rat brain, retina, liver, and serum. | 2001 | J. Lipid Res. | pmid:11254754 |
Assies J et al. | Significantly reduced docosahexaenoic and docosapentaenoic acid concentrations in erythrocyte membranes from schizophrenic patients compared with a carefully matched control group. | 2001 | Biol. Psychiatry | pmid:11257236 |
Fujita S et al. | Docosahexaenoic acid improves long-term potentiation attenuated by phospholipase A(2) inhibitor in rat hippocampal slices. | 2001 | Br. J. Pharmacol. | pmid:11264234 |
Hayashi M et al. | Uptake and accumulation of exogenous docosahexaenoic acid by Chlorella. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11272831 |
Rump P et al. | Essential fatty acid composition of plasma phospholipids and birth weight: a study in term neonates. | 2001 | Am. J. Clin. Nutr. | pmid:11273856 |
Elias SL and Innis SM | Infant plasma trans, n-6, and n-3 fatty acids and conjugated linoleic acids are related to maternal plasma fatty acids, length of gestation, and birth weight and length. | 2001 | Am. J. Clin. Nutr. | pmid:11273857 |
Donadio JV et al. | A randomized trial of high-dose compared with low-dose omega-3 fatty acids in severe IgA nephropathy. | 2001 | J. Am. Soc. Nephrol. | pmid:11274240 |
Green P et al. | Ethyl docosahexaenoate-associated decrease in fetal brain lipid peroxide production is mediated by activation of prostanoid and nitric oxide pathways. | 2001 | Biochim. Biophys. Acta | pmid:11278180 |
Lee JY et al. | Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. | 2001 | J. Biol. Chem. | pmid:11278967 |
Arrington JL et al. | Docosahexaenoic acid suppresses function of the CD28 costimulatory membrane receptor in primary murine and Jurkat T cells. | 2001 | J. Nutr. | pmid:11285317 |
Ikeda I et al. | Reduced hepatic triglyceride secretion in rats fed docosahexaenoic acid-rich fish oil suppresses postprandial hypertriglyceridemia. | 2001 | J. Nutr. | pmid:11285319 |
Collett ED et al. | n-6 and n-3 polyunsaturated fatty acids differentially modulate oncogenic Ras activation in colonocytes. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11287318 |
Su HM et al. | Fetal baboons convert 18:3n-3 to 22:6n-3 in vivo. A stable isotope tracer study. | 2001 | J. Lipid Res. | pmid:11290830 |
Schneider SM et al. | Activity of the leukocyte NADPH oxidase in whole neutrophils and cell-free neutrophil preparations stimulated with long-chain polyunsaturated fatty acids. | 2001 | Inflammation | pmid:11293662 |
Delton-Vandenbroucke I et al. | Dual regulation of glutathione peroxidase by docosahexaenoic acid in endothelial cells depending on concentration and vascular bed origin. | 2001 | Free Radic. Biol. Med. | pmid:11295532 |
Rudra PK and Krokan HE | Cell-specific enhancement of doxorubicin toxicity in human tumour cells by docosahexaenoic acid. | 2001 Jan-Feb | Anticancer Res. | pmid:11299749 |
Durrington PN et al. | An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia. | 2001 | Heart | pmid:11303007 |
Seung Kim HF et al. | Inhibitory effects of omega-3 fatty acids on protein kinase C activity in vitro. | 2001 | Mol. Psychiatry | pmid:11317232 |
Modeste AB et al. | [Hydroa vacciniforme: dietary fish oil]. | 2001 | Ann Dermatol Venereol | pmid:11319390 |
Umegaki K et al. | Docosahexaenoic acid supplementation-increased oxidative damage in bone marrow DNA in aged rats and its relation to antioxidant vitamins. | 2001 | Free Radic. Res. | pmid:11328678 |
Colquhoun A et al. | Eicosapentaenoic acid and docosahexaenoic acid effects on tumour mitochondrial metabolism, acyl CoA metabolism and cell proliferation. | 2001 | Cell Biochem. Funct. | pmid:11335934 |