DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen F et al. | Fish oil attenuates liver injury caused by LPS in weaned pigs associated with inhibition of TLR4 and nucleotide-binding oligomerization domain protein signaling pathways. | 2013 | Innate Immun | pmid:23339927 |
| Tikhonenko M et al. | N-3 polyunsaturated Fatty acids prevent diabetic retinopathy by inhibition of retinal vascular damage and enhanced endothelial progenitor cell reparative function. | 2013 | PLoS ONE | pmid:23383097 |
| Li H et al. | Production of sophorolipids with eicosapentaenoic acid and docosahexaenoic acid from Wickerhamiella domercqiae var. sophorolipid using fish oil as a hydrophobic carbon source. | 2013 | Biotechnol. Lett. | pmid:23386226 |
| Wang TM et al. | Docosahexaenoic acid and eicosapentaenoic acid reduce C-reactive protein expression and STAT3 activation in IL-6-treated HepG2 cells. | 2013 | Mol. Cell. Biochem. | pmid:23361365 |
| Suganuma H et al. | Effect of hypoxic-ischemic insults on the composition of fatty acids in the brain of neonatal rats. | 2013 | Ann. Nutr. Metab. | pmid:23364132 |
| Lee HN et al. | Resolution of inflammation as a novel chemopreventive strategy. | 2013 | Semin Immunopathol | pmid:23370700 |
| Chang CY et al. | Docosahexaenoic acid reduces cellular inflammatory response following permanent focal cerebral ischemia in rats. | 2013 | J. Nutr. Biochem. | pmid:24139673 |
| Fernández-Iglesias A et al. | DHA sensitizes FaO cells to tert-BHP-induced oxidative effects. Protective role of EGCG. | 2013 | Food Chem. Toxicol. | pmid:24140970 |
| Song YJ et al. | Regulatory functions of docosahexaenoic acid on ion channels in rat ventricular myocytes. | 2013 | Eur Rev Med Pharmacol Sci | pmid:24142611 |
| Tai EK et al. | An update on adding docosahexaenoic acid (DHA) and arachidonic acid (AA) to baby formula. | 2013 | Food Funct | pmid:24150114 |
| Miller BJ et al. | Dietary supplements for preventing postnatal depression. | 2013 | Cochrane Database Syst Rev | pmid:24158923 |
| Jansen D et al. | Effects of specific multi-nutrient enriched diets on cerebral metabolism, cognition and neuropathology in AβPPswe-PS1dE9 mice. | 2013 | PLoS ONE | pmid:24086523 |
| Stamey Lanier J et al. | Mammary uptake of fatty acids supplied by intravenous triacylglycerol infusion to lactating dairy cows. | 2013 | Lipids | pmid:23504269 |
| Mussi SV et al. | New approach to improve encapsulation and antitumor activity of doxorubicin loaded in solid lipid nanoparticles. | 2013 | Eur J Pharm Sci | pmid:23178339 |
| Braga SF and Almgren MM | Complementary therapies in cystic fibrosis: nutritional supplements and herbal products. | 2013 | J Pharm Pract | pmid:23178411 |
| Gurzell EA et al. | DHA-enriched fish oil targets B cell lipid microdomains and enhances ex vivo and in vivo B cell function. | 2013 | J. Leukoc. Biol. | pmid:23180828 |
| Faber J et al. | Rapid EPA and DHA incorporation and reduced PGE2 levels after one week intervention with a medical food in cancer patients receiving radiotherapy, a randomized trial. | 2013 | Clin Nutr | pmid:23123043 |
| Meher AP et al. | Preconceptional omega-3 fatty acid supplementation on a micronutrient-deficient diet improves the reproductive cycle in Wistar rats. | 2013 | Reprod. Fertil. Dev. | pmid:23137932 |
| Robinson DT et al. | Docosahexaenoic and arachidonic acid levels in extremely low birth weight infants with prolonged exposure to intravenous lipids. | 2013 | J. Pediatr. | pmid:22878111 |
| Hsiao HM et al. | A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation. | 2013 | PLoS ONE | pmid:23484005 |
| Hoshi T et al. | Omega-3 fatty acids lower blood pressure by directly activating large-conductance Ca²âº-dependent K⺠channels. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23487785 |
| Hoshi T et al. | Mechanism of the modulation of BK potassium channel complexes with different auxiliary subunit compositions by the omega-3 fatty acid DHA. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23487786 |
| Gerstenblith AT et al. | Electroretinographic effects of omega-3 Fatty Acid supplementation on dry age-related macular degeneration. | 2013 | JAMA Ophthalmol | pmid:23494041 |
| Betancor MB et al. | Oxidative stress in sea bass Dicentrarchus labrax larvae: interaction of high dietary DHA contents and several antioxidant nutrients. | 2013 | Commun. Agric. Appl. Biol. Sci. | pmid:25141617 |
| Hagemann A et al. | Content of essential fatty acids in cultivated Acartia tonsa nauplii fed a DHA-deficient Tetraselmis sp. concentrate. | 2013 | Commun. Agric. Appl. Biol. Sci. | pmid:25141657 |
| Lund I et al. | Importance of DHA for first feeding pikeperch larvae--influence on behavioural responses. | 2013 | Commun. Agric. Appl. Biol. Sci. | pmid:25141683 |
| Mesa-Rodriguez A et al. | Effect of increasing DHA content in new weaning diets for longfin yellowtail (Seriola rivoliana). | 2013 | Commun. Agric. Appl. Biol. Sci. | pmid:25141689 |
| Miyashima A et al. | DHA requirement of larval Japanese flounder Paralichthys olivaceus in the rotifer feeding period. | 2013 | Commun. Agric. Appl. Biol. Sci. | pmid:25141691 |
| Morais S et al. | Effect of Senegalese sole broodstock nutrition on early larval performance and metabolism of long-chain polyunsaturated fatty acids (DHA and EPA). | 2013 | Commun. Agric. Appl. Biol. Sci. | pmid:25141693 |
| Botelho PB et al. | Effect of Echium oil compared with marine oils on lipid profile and inhibition of hepatic steatosis in LDLr knockout mice. | 2013 | Lipids Health Dis | pmid:23510369 |
| van den Elsen LW et al. | n-3 Long-chain PUFA reduce allergy-related mediator release by human mast cells in vitro via inhibition of reactive oxygen species. | 2013 | Br. J. Nutr. | pmid:23021516 |
| Bazan NG | The docosanoid neuroprotectin D1 induces homeostatic regulation of neuroinflammation and cell survival. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23022417 |
| Del Bó C et al. | Horse meat consumption affects iron status, lipid profile and fatty acid composition of red blood cells in healthy volunteers. | 2013 | Int J Food Sci Nutr | pmid:23025273 |
| Lim SN et al. | Improved outcome after spinal cord compression injury in mice treated with docosahexaenoic acid. | 2013 | Exp. Neurol. | pmid:23026410 |
| Cieslik M et al. | Docosahexaenoic acid and tetracyclines as promising neuroprotective compounds with poly(ADP-ribose) polymerase inhibitory activities for oxidative/genotoxic stress treatment. | 2013 | Neurochem. Int. | pmid:23439385 |
| Oken E et al. | A pilot randomized controlled trial to promote healthful fish consumption during pregnancy: the Food for Thought Study. | 2013 | Nutr J | pmid:23496848 |
| Huang HL et al. | Docosahexaenoic acid in maternal and neonatal plasma phospholipids and milk lipids of Taiwanese women in Kinmen: fatty acid composition of maternal blood, neonatal blood and breast milk. | 2013 | Lipids Health Dis | pmid:23496882 |
| Lau BY et al. | Investigating the role of polyunsaturated fatty acids in bone development using animal models. | 2013 | Molecules | pmid:24248147 |
| Fahrmann JF and Hardman WE | Omega 3 fatty acids increase the chemo-sensitivity of B-CLL-derived cell lines EHEB and MEC-2 and of B-PLL-derived cell line JVM-2 to anti-cancer drugs doxorubicin, vincristine and fludarabine. | 2013 | Lipids Health Dis | pmid:23497075 |
| Moate PJ et al. | Effects of feeding algal meal high in docosahexaenoic acid on feed intake, milk production, and methane emissions in dairy cows. | 2013 | J. Dairy Sci. | pmid:23498011 |
| Ajami M et al. | Effect of DHA+EPA on oxidative stress and apoptosis induced by ischemia-reperfusion in rat kidneys. | 2013 | Fundam Clin Pharmacol | pmid:22943605 |
| Ruiz-Lopez N et al. | Reconstitution of EPA and DHA biosynthesis in arabidopsis: iterative metabolic engineering for the synthesis of n-3 LC-PUFAs in transgenic plants. | 2013 | Metab. Eng. | pmid:23500000 |
| Scholtz SA et al. | Clinical overview of effects of dietary long-chain polyunsaturated fatty acids during the perinatal period. | 2013 | Nestle Nutr Inst Workshop Ser | pmid:24107504 |
| McNamara RK et al. | Low docosahexaenoic acid status is associated with reduced indices in cortical integrity in the anterior cingulate of healthy male children: a 1H MRS Study. | 2013 | Nutr Neurosci | pmid:23582513 |
| Li J et al. | Comparative metabolomics analysis of docosahexaenoic acid fermentation processes by Schizochytrium sp. under different oxygen availability conditions. | 2013 | OMICS | pmid:23586678 |
| Barros KV et al. | Fatty acids in plasma, white and red blood cells, and tissues after oral or intravenous administration of fish oil in rats. | 2013 | Clin Nutr | pmid:23541913 |
| Bruins MJ et al. | Plasma oxylipin profiling identifies polyunsaturated vicinal diols as responsive to arachidonic acid and docosahexaenoic acid intake in growing piglets. | 2013 | J. Lipid Res. | pmid:23543770 |
| Calder PC | Editorial: Fat chance to enhance B cell function. | 2013 | J. Leukoc. Biol. | pmid:23547174 |
| Aarak KE et al. | Release of EPA and DHA from salmon oil - a comparison of in vitro digestion with human and porcine gastrointestinal enzymes. | 2013 | Br. J. Nutr. | pmid:23510480 |
| Rahmawaty S et al. | Dietary intake and food sources of EPA, DPA and DHA in Australian children. | 2013 | Lipids | pmid:23881381 |
| Singhal A et al. | Docosahexaenoic acid supplementation, vascular function and risk factors for cardiovascular disease: a randomized controlled trial in young adults. | 2013 | J Am Heart Assoc | pmid:23817470 |
| Hoss E et al. | Control of late cornified envelope genes relevant to psoriasis risk: upregulation by 1,25-dihydroxyvitamin D3 and plant-derived delphinidin. | 2013 | Arch. Dermatol. Res. | pmid:23839497 |
| Zhang X et al. | Resolvin D1 protects podocytes in adriamycin-induced nephropathy through modulation of 14-3-3β acetylation. | 2013 | PLoS ONE | pmid:23840712 |
| Shin S et al. | The omega-3 polyunsaturated fatty acid DHA induces simultaneous apoptosis and autophagy via mitochondrial ROS-mediated Akt-mTOR signaling in prostate cancer cells expressing mutant p53. | 2013 | Biomed Res Int | pmid:23841076 |
| Baillie JK and Digard P | Influenza--time to target the host? | 2013 | N. Engl. J. Med. | pmid:23841736 |
| Mozaffarian D et al. | Plasma phospholipid long-chain ω-3 fatty acids and total and cause-specific mortality in older adults: a cohort study. | 2013 | Ann. Intern. Med. | pmid:23546563 |
| Sun YB et al. | Endothelial dysfunction exacerbates renal interstitial fibrosis through enhancing fibroblast Smad3 linker phosphorylation in the mouse obstructed kidney. | 2013 | PLoS ONE | pmid:24391884 |
| Zhang X et al. | Resolvin D1 reverts lipopolysaccharide-induced TJ proteins disruption and the increase of cellular permeability by regulating IκBα signaling in human vascular endothelial cells. | 2013 | Oxid Med Cell Longev | pmid:24381712 |
| Correia Bacarin C et al. | Fish oil provides robust and sustained memory recovery after cerebral ischemia: influence of treatment regimen. | 2013 | Physiol. Behav. | pmid:23770426 |
| Jones ML et al. | Maternal dietary omega-3 fatty acid intake increases resolvin and protectin levels in the rat placenta. | 2013 | J. Lipid Res. | pmid:23723388 |
| German OL et al. | Retinoid X receptor activation is essential for docosahexaenoic acid protection of retina photoreceptors. | 2013 | J. Lipid Res. | pmid:23723389 |
| Hiratsuka S et al. | Effects of dietary sialic acid in n-3 fatty acid-deficient dams during pregnancy and lactation on the learning abilities of their pups after weaning. | 2013 | J. Nutr. Sci. Vitaminol. | pmid:23727644 |
| Willatts P et al. | Effects of long-chain PUFA supplementation in infant formula on cognitive function in later childhood. | 2013 | Am. J. Clin. Nutr. | pmid:23783296 |
| Li Q et al. | A comparative study: In vitro effects of EPA and DHA on immune functions of head-kidney macrophages isolated from large yellow croaker (Larmichthys crocea). | 2013 | Fish Shellfish Immunol. | pmid:23859878 |
| Chen S and Subbaiah PV | Regioisomers of phosphatidylcholine containing DHA and their potential to deliver DHA to the brain: role of phospholipase specificities. | 2013 | Lipids | pmid:23604781 |
| Long SJ and Benton D | A double-blind trial of the effect of docosahexaenoic acid and vitamin and mineral supplementation on aggression, impulsivity, and stress. | 2013 | Hum Psychopharmacol | pmid:23625531 |
| Das UN | Polyunsaturated fatty acids in heart failure. | 2013 | Circ. J. | pmid:23628915 |
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| Klek S et al. | Four-week parenteral nutrition using a third generation lipid emulsion (SMOFlipid)--a double-blind, randomised, multicentre study in adults. | 2013 | Clin Nutr | pmid:22796064 |
| Baselga-Escudero L et al. | Chronic administration of proanthocyanidins or docosahexaenoic acid reverses the increase of miR-33a and miR-122 in dyslipidemic obese rats. | 2013 | PLoS ONE | pmid:23922812 |
| Bjorgvinsdottir L et al. | Inflammatory response following heart surgery and association with n-3 and n-6 long-chain polyunsaturated fatty acids in plasma and red blood cell membrane lipids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23999253 |
| Iwasaka H et al. | Utilization of waste syrup for production of polyunsaturated fatty acids and xanthophylls by Aurantiochytrium. | 2013 | J Oleo Sci | pmid:24005017 |
| Liu Y et al. | Fish oil alleviates activation of the hypothalamic-pituitary-adrenal axis associated with inhibition of TLR4 and NOD signaling pathways in weaned piglets after a lipopolysaccharide challenge. | 2013 | J. Nutr. | pmid:24005609 |
| Li X et al. | Cyclooxygenase-2 induction in macrophages is modulated by docosahexaenoic acid via interactions with free fatty acid receptor 4 (FFA4). | 2013 | FASEB J. | pmid:24005906 |
| Gordon WC and Bazan NG | Mediator lipidomics in ophthalmology: targets for modulation in inflammation, neuroprotection and nerve regeneration. | 2013 | Curr. Eye Res. | pmid:23981028 |
| Chen J et al. | Docosahexaenoic acid (DHA) attenuated paraquat induced lung damage in mice. | 2013 | Inhal Toxicol | pmid:23293968 |
| Figueroa JD et al. | Dietary omega-3 polyunsaturated fatty acids improve the neurolipidome and restore the DHA status while promoting functional recovery after experimental spinal cord injury. | 2013 | J. Neurotrauma | pmid:23294084 |
| Lang JE et al. | Nutrigenetic response to omega-3 fatty acids in obese asthmatics (NOOA): rationale and methods. | 2013 | Contemp Clin Trials | pmid:23298524 |
| Hutchins-Wiese HL et al. | The impact of supplemental n-3 long chain polyunsaturated fatty acids and dietary antioxidants on physical performance in postmenopausal women. | 2013 | J Nutr Health Aging | pmid:23299384 |
| Takayama M et al. | Association of marine-origin n-3 polyunsaturated fatty acids consumption and functional mobility in the community-dwelling oldest old. | 2013 | J Nutr Health Aging | pmid:23299385 |
| Lovegrove JA and Griffin BA | The acute and long-term effects of dietary fatty acids on vascular function in health and disease. | 2013 | Curr Opin Clin Nutr Metab Care | pmid:23299700 |
| Raza Shaikh S and Brown DA | Models of plasma membrane organization can be applied to mitochondrial membranes to target human health and disease with polyunsaturated fatty acids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22464052 |
| Derogis PB et al. | The development of a specific and sensitive LC-MS-based method for the detection and quantification of hydroperoxy- and hydroxydocosahexaenoic acids as a tool for lipidomic analysis. | 2013 | PLoS ONE | pmid:24204871 |
| Wang D et al. | Organochlorine pesticides in fish from Taihu Lake, China, and associated human health risk assessment. | 2013 | Ecotoxicol. Environ. Saf. | pmid:24125867 |
| Hoshi T et al. | A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid. | 2013 | J. Gen. Physiol. | pmid:24127525 |
| Latorre R and Contreras G | Keeping you healthy: BK channel activation by omega-3 fatty acids. | 2013 | J. Gen. Physiol. | pmid:24127527 |
| Nagai T et al. | Actual ratios of triacylglycerol positional isomers and enantiomers comprising saturated fatty acids and highly unsaturated fatty acids in fishes and marine mammals. | 2013 | J Oleo Sci | pmid:24292353 |
| Atwell K et al. | Respiratory hospitalisation of infants supplemented with docosahexaenoic acid as preterm neonates. | 2013 | J Paediatr Child Health | pmid:23279074 |
| Barros KV et al. | Supplemental intravenous n-3 fatty acids and n-3 fatty acid status and outcome in critically ill elderly patients in the ICU receiving enteral nutrition. | 2013 | Clin Nutr | pmid:23260750 |
| Ryu BG et al. | Use of organic waste from the brewery industry for high-density cultivation of the docosahexaenoic acid-rich microalga, Aurantiochytrium sp. KRS101. | 2013 | Bioresour. Technol. | pmid:23262011 |
| Chaung HC et al. | Docosahexaenoic acid and phosphatidylserine improves the antioxidant activities in vitro and in vivo and cognitive functions of the developing brain. | 2013 | Food Chem | pmid:23265497 |
| Akanbi TO et al. | Selective concentration of EPA and DHA using Thermomyces lanuginosus lipase is due to fatty acid selectivity and not regioselectivity. | 2013 | Food Chem | pmid:23265531 |
| Engel S et al. | Docosahexaenoic acid status at 9 months is inversely associated with communicative skills in 3-year-old girls. | 2013 | Matern Child Nutr | pmid:22642227 |
| Gadaria-Rathod N et al. | Red blood cell fatty acid analysis for determining compliance with omega3 supplements in dry eye disease trials. | 2013 | J Ocul Pharmacol Ther | pmid:23971620 |
| Stulnig G et al. | Docosahexaenoic acid (DHA)-induced heme oxygenase-1 attenuates cytotoxic effects of DHA in vascular smooth muscle cells. | 2013 | Atherosclerosis | pmid:24075775 |
| Nagachinta S and Akoh CC | Spray-dried structured lipid containing long-chain polyunsaturated fatty acids for use in infant formulas. | 2013 | J. Food Sci. | pmid:24024870 |
| Kennedy DO | Reply to MP Pase and C Stough. | 2013 | Am. J. Clin. Nutr. | pmid:24027792 |
| Gruszfeld D and Socha P | Early nutrition and health: short- and long-term outcomes. | 2013 | World Rev Nutr Diet | pmid:24029784 |
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| Lyons MR et al. | Impact of sex on the heart's metabolic and functional responses to diabetic therapies. | 2013 | Am. J. Physiol. Heart Circ. Physiol. | pmid:24043256 |