DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ajami M et al. | Expression of Bcl-2 and Bax after hippocampal ischemia in DHA + EPA treated rats. | 2011 | Neurol. Sci. | pmid:21617951 |
| Li HX et al. | Increasing DHA and EPA concentrations prolong action potential durations and reduce transient outward potassium currents in rat ventricular myocytes. | 2011 | Lipids | pmid:21140236 |
| Ott J et al. | Lipids in critical care medicine. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21546231 |
| Vinayavekhin N and Saghatelian A | Discovery of a protein-metabolite interaction between unsaturated fatty acids and the nuclear receptor Nur77 using a metabolomics approach. | 2011 | J. Am. Chem. Soc. | pmid:21973308 |
| Hung ND et al. | Oral administration of 2-docosahexaenoyl lysophosphatidylcholine displayed anti-inflammatory effects on zymosan A-induced peritonitis. | 2011 | Inflammation | pmid:20490641 |
| Mozaffarian D et al. | Circulating long-chain ω-3 fatty acids and incidence of congestive heart failure in older adults: the cardiovascular health study: a cohort study. | 2011 | Ann. Intern. Med. | pmid:21810709 |
| Jiang T et al. | Omega-3 fatty acids affected human perception of ground beef negatively. | 2011 | Meat Sci. | pmid:21621335 |
| Ichihara H et al. | Therapeutic effects of hybrid liposomes composed of phosphatidylcholine and docosahexaenoic acid on the hepatic metastasis of colon carcinoma along with apoptosis in vivo. | 2011 | Biol. Pharm. Bull. | pmid:21628892 |
| Flachs P et al. | Synergistic induction of lipid catabolism and anti-inflammatory lipids in white fat of dietary obese mice in response to calorie restriction and n-3 fatty acids. | 2011 | Diabetologia | pmid:21779874 |
| Molinari R et al. | The n3-polyunsaturated fatty acid docosahexaenoic acid induces immunogenic cell death in human cancer cell lines via pre-apoptotic calreticulin exposure. | 2011 | Cancer Immunol. Immunother. | pmid:21779875 |
| Maqbool A et al. | The skinny on tuna fat: health implications. | 2011 | Public Health Nutr | pmid:21324226 |
| Ramakrishnan U | Fatty acid status and maternal mental health. | 2011 | Matern Child Nutr | pmid:21366870 |
| Diaz Encarnacion MM et al. | n-3 Fatty acids block TNF-α-stimulated MCP-1 expression in rat mesangial cells. | 2011 | Am. J. Physiol. Renal Physiol. | pmid:21367920 |
| Rossi PC et al. | Optimization of molecular distillation to concentrate ethyl esters of eicosapentaenoic (20:5 ω-3) and docosahexaenoic acids (22:6 ω-3) using simplified phenomenological modeling. | 2011 | J. Sci. Food Agric. | pmid:21384378 |
| Meldrum SJ et al. | The Infant Fish Oil Supplementation Study (IFOS): design and research protocol of a double-blind, randomised controlled n--3 LCPUFA intervention trial in term infants. | 2011 | Contemp Clin Trials | pmid:21718804 |
| Maki KC et al. | Effects of prescription omega-3-acid ethyl esters on fasting lipid profile in subjects with primary hypercholesterolemia. | 2011 | J. Cardiovasc. Pharmacol. | pmid:21297494 |
| Chen P et al. | Poxytrins, a class of oxygenated products from polyunsaturated fatty acids, potently inhibit blood platelet aggregation. | 2011 | FASEB J. | pmid:20833872 |
| Kitayama A et al. | Correlations of fish intake and plasma docosahexaenoic acid levels with each congener of PCDDs/PCDFs/dioxin-like PCBs in blood from the Japanese population. | 2011 | Int Arch Occup Environ Health | pmid:21298441 |
| Rogers LK et al. | Maternal docosahexaenoic acid supplementation decreases lung inflammation in hyperoxia-exposed newborn mice. | 2011 | J. Nutr. | pmid:21178083 |
| Neff LM et al. | Algal docosahexaenoic acid affects plasma lipoprotein particle size distribution in overweight and obese adults. | 2011 | J. Nutr. | pmid:21178084 |
| Sriram K | Confusion between gamma-linolenic acid and gamma-linoleic acid. | 2011 | Crit. Care Med. | pmid:22094528 |
| Leon MM et al. | [Resolution of inflammation--pharmacological aspects]. | 2011 Apr-Jun | Rev Med Chir Soc Med Nat Iasi | pmid:21870743 |
| Lamaziere A et al. | Differential distribution of DHA-phospholipids in rat brain after feeding: A lipidomic approach. | 2011 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21109411 |
| Vilaseca MA et al. | Long-chain polyunsaturated fatty acid concentration in patients with inborn errors of metabolism. | 2011 Jan-Feb | Nutr Hosp | pmid:21519739 |
| Sato SB et al. | Differential roles of internal and terminal double bonds in docosahexaenoic acid: Comparative study of cytotoxicity of polyunsaturated fatty acids to HT-29 human colorectal tumor cell line. | 2011 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20952172 |
| Kulkarni AV et al. | Reduced placental docosahexaenoic acid levels associated with increased levels of sFlt-1 in preeclampsia. | 2011 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20956072 |
| Lam YY et al. | Insulin-stimulated glucose uptake and pathways regulating energy metabolism in skeletal muscle cells: the effects of subcutaneous and visceral fat, and long-chain saturated, n-3 and n-6 polyunsaturated fatty acids. | 2011 Jul-Aug | Biochim. Biophys. Acta | pmid:21570480 |
| Mason CM et al. | Prescription omega-3s: an overview for nurse practitioners. | 2011 Jul-Aug | J Cardiovasc Nurs | pmid:21666421 |
| Gao F et al. | Liver conversion of docosahexaenoic and arachidonic acids from their 18-carbon precursors in rats on a DHA-free but α-LNA-containing n-3 PUFA adequate diet. | 2011 Jul-Aug | Biochim. Biophys. Acta | pmid:21651989 |
| Trimarco B et al. | [The Alpha Omega study]. | 2011 Jul-Aug | G Ital Cardiol (Rome) | pmid:21779112 |
| Gladyshev MI et al. | Effect of water temperature on the content of essential polyunsaturated fatty acids in freshwater zooplankton. | 2011 Mar-Apr | Dokl. Biochem. Biophys. | pmid:21590375 |
| Larson MK et al. | Omega-3 fatty acids modulate collagen signaling in human platelets. | 2011 Mar-Apr | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21177087 |
| McDaniel JC et al. | Fish oil supplementation alters levels of lipid mediators of inflammation in microenvironment of acute human wounds. | 2011 Mar-Apr | Wound Repair Regen | pmid:21362086 |
| Kawabata T et al. | Age-related changes of dietary intake and blood eicosapentaenoic acid, docosahexaenoic acid, and arachidonic acid levels in Japanese men and women. | 2011 May-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21420843 |
| van Goor SA et al. | The influence of supplemental docosahexaenoic and arachidonic acids during pregnancy and lactation on neurodevelopment at eighteen months. | 2011 May-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21316208 |
| Kilari A et al. | Associations of long-chain polyunsaturated fatty acid concentrations with birth outcome in term Indian mothers and their neonates. | 2011 May-Jun | Am. J. Hum. Biol. | pmid:21484911 |
| Jones JL et al. | A Mediterranean-style low-glycemic-load diet improves variables of metabolic syndrome in women, and addition of a phytochemical-rich medical food enhances benefits on lipoprotein metabolism. | 2011 May-Jun | J Clin Lipidol | pmid:21600524 |
| Maki KC et al. | Effects of prescription omega-3-acid ethyl esters, coadministered with atorvastatin, on circulating levels of lipoprotein particles, apolipoprotein CIII, and lipoprotein-associated phospholipase A2 mass in men and women with mixed dyslipidemia. | 2011 Nov-Dec | J Clin Lipidol | pmid:22108152 |
| Siddiqui RA et al. | Docosahexaenoic acid: a natural powerful adjuvant that improves efficacy for anticancer treatment with no adverse effects. | 2011 Nov-Dec | Biofactors | pmid:22038684 |
| Opperman M et al. | Analysis of omega-3 fatty acid content of South African fish oil supplements. | 2011 Nov-Dec | Cardiovasc J Afr | pmid:22159321 |
| Kim Y and Ilich JZ | Implications of dietary α-linolenic acid in bone health. | 2011 Nov-Dec | Nutrition | pmid:21726979 |
| Maki KC et al. | Prescription omega-3-acid ethyl esters reduce fasting and postprandial triglycerides and modestly reduce pancreatic β-cell response in subjects with primary hypertriglyceridemia. | 2011 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21775113 |
| Luxwolda MF et al. | The relation between the omega-3 index and arachidonic acid is bell shaped: synergistic at low EPA+DHA status and antagonistic at high EPA+DHA status. | 2011 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21715149 |
| Fabelo N et al. | Severe alterations in lipid composition of frontal cortex lipid rafts from Parkinson's disease and incidental Parkinson's disease. | 2011 Sep-Oct | Mol. Med. | pmid:21717034 |
| Shilina NM et al. | [Changes in the fatty acid composition of blood cell membranes in children with inflammatory diseases]. | 2011 Sep-Oct | Biomed Khim | pmid:22629608 |
| Dhobale MV et al. | Reduced levels of placental long chain polyunsaturated fatty acids in preterm deliveries. | 2011 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21816593 |
| Petrie JR et al. | Metabolic engineering plant seeds with fish oil-like levels of DHA. | 2012 | PLoS ONE | pmid:23145108 |
| Tillman EM et al. | Eicosapentaenoic acid and docosahexaenoic acid synergistically attenuate bile acid-induced hepatocellular apoptosis. | 2012 | JPEN J Parenter Enteral Nutr | pmid:22038211 |
| Fasano E et al. | DHA induces apoptosis by altering the expression and cellular location of GRP78 in colon cancer cell lines. | 2012 | Biochim. Biophys. Acta | pmid:22898250 |
| Jackson PA et al. | DHA-rich oil modulates the cerebral haemodynamic response to cognitive tasks in healthy young adults: a near IR spectroscopy pilot study. | 2012 | Br. J. Nutr. | pmid:22018509 |
| Tyburczy C et al. | Growth, clinical chemistry and immune function in domestic piglets fed varying ratios of arachidonic acid and DHA. | 2012 | Br. J. Nutr. | pmid:22040360 |
| Schmitt D et al. | Toxicologic evaluation of DHA-rich algal oil: Genotoxicity, acute and subchronic toxicity in rats. | 2012 | Food Chem. Toxicol. | pmid:22898615 |
| Serini S et al. | DHA induces apoptosis and differentiation in human melanoma cells in vitro: involvement of HuR-mediated COX-2 mRNA stabilization and β-catenin nuclear translocation. | 2012 | Carcinogenesis | pmid:22045024 |
| An WS et al. | Omega-3 fatty acid supplementation increases 1,25-dihydroxyvitamin D and fetuin-A levels in dialysis patients. | 2012 | Nutr Res | pmid:22901557 |
| Rondanelli M et al. | Effects of a diet integration with an oily emulsion of DHA-phospholipids containing melatonin and tryptophan in elderly patients suffering from mild cognitive impairment. | 2012 | Nutr Neurosci | pmid:22334085 |
| Rockett BD et al. | Fish oil increases raft size and membrane order of B cells accompanied by differential effects on function. | 2012 | J. Lipid Res. | pmid:22315394 |
| Hjorth E and Freund-Levi Y | Immunomodulation of microglia by docosahexaenoic acid and eicosapentaenoic acid. | 2012 | Curr Opin Clin Nutr Metab Care | pmid:22316559 |
| Liu RZ et al. | A fatty acid-binding protein 7/RXRβ pathway enhances survival and proliferation in triple-negative breast cancer. | 2012 | J. Pathol. | pmid:22322885 |
| Saito H and Ishikawa S | Characteristic of lipids and fatty acid compositions of the neon flying squid, Ommastrephes bartramii. | 2012 | J Oleo Sci | pmid:23018852 |
| Felbinger TW et al. | Supplementation in acute lung injury. | 2012 | JAMA | pmid:22235078 |
| Bistrian BR | Supplementation in acute lung injury. | 2012 | JAMA | pmid:22235079 |
| Schmitt D et al. | Toxicologic evaluations of DHA-rich algal oil in rats: developmental toxicity study and 3-month dietary toxicity study with an in utero exposure phase. | 2012 | Food Chem. Toxicol. | pmid:22960629 |
| Huang TY et al. | A fermentation strategy for producing docosahexaenoic acid in Aurantiochytrium limacinum SR21 and increasing C22:6 proportions in total fatty acid. | 2012 | Bioresour. Technol. | pmid:22929740 |
| Browning LM et al. | Incorporation of eicosapentaenoic and docosahexaenoic acids into lipid pools when given as supplements providing doses equivalent to typical intakes of oily fish. | 2012 | Am. J. Clin. Nutr. | pmid:22932281 |
| Moreno-Indias I et al. | The effect of diet and DHA addition on the sensory quality of goat kid meat. | 2012 | Meat Sci. | pmid:21907501 |
| Alvarez-Nölting R et al. | Protection by DHA of early hippocampal changes in diabetes: possible role of CREB and NF-κB. | 2012 | Neurochem. Res. | pmid:21909958 |
| Pifferi F et al. | Fatty acid composition of the brain, retina, liver and adipose tissue of the grey mouse lemur (Microcebus murinus, primate). | 2012 | Lipids | pmid:22684890 |
| Cortina MS et al. | Recovery of corneal sensitivity, calcitonin gene-related peptide-positive nerves, and increased wound healing induced by pigment epithelial-derived factor plus docosahexaenoic acid after experimental surgery. | 2012 | Arch. Ophthalmol. | pmid:21911652 |
| Heinze VM and Actis AB | Dietary conjugated linoleic acid and long-chain n-3 fatty acids in mammary and prostate cancer protection: a review. | 2012 | Int J Food Sci Nutr | pmid:21762028 |
| Chen WY et al. | Beneficial effect of docosahexaenoic acid on cholestatic liver injury in rats. | 2012 | J. Nutr. Biochem. | pmid:21497498 |
| Munro IA and Garg ML | Dietary supplementation with n-3 PUFA does not promote weight loss when combined with a very-low-energy diet. | 2012 | Br. J. Nutr. | pmid:22214842 |
| Basselin M et al. | Imaging brain signal transduction and metabolism via arachidonic and docosahexaenoic acid in animals and humans. | 2012 | Brain Res. Bull. | pmid:22178644 |
| van der Meij BS et al. | Oral nutritional supplements containing n-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment: an RCT. | 2012 | Eur J Clin Nutr | pmid:22234041 |
| Deike E et al. | The effects of fish oil supplementation on markers of inflammation in chronic kidney disease patients. | 2012 | J Ren Nutr | pmid:22285316 |
| Trépanier MO et al. | Increases in seizure latencies induced by subcutaneous docosahexaenoic acid are lost at higher doses. | 2012 | Epilepsy Res. | pmid:22285511 |
| Signori C et al. | Administration of omega-3 fatty acids and Raloxifene to women at high risk of breast cancer: interim feasibility and biomarkers analysis from a clinical trial. | 2012 | Eur J Clin Nutr | pmid:22669332 |
| Wu MH et al. | Eicosapentaenoic acid and docosahexaenoic acid inhibit macrophage-induced gastric cancer cell migration by attenuating the expression of matrix metalloproteinase 10. | 2012 | J. Nutr. Biochem. | pmid:22285823 |
| Rasic-Milutinovic Z et al. | Lower serum paraoxonase-1 activity is related to linoleic and docosahexanoic fatty acids in type 2 diabetic patients. | 2012 | Arch. Med. Res. | pmid:22222492 |
| Quinn EA and Kuzawa CW | A dose-response relationship between fish consumption and human milk DHA content among Filipino women in Cebu City, Philippines. | 2012 | Acta Paediatr. | pmid:22759234 |
| Turk HF et al. | Alteration of EGFR spatiotemporal dynamics suppresses signal transduction. | 2012 | PLoS ONE | pmid:22761867 |
| Hacioglu G et al. | Docosahexaenoic acid provides protective mechanism in bilaterally MPTP-lesioned rat model of Parkinson's disease. | 2012 | Folia Histochem. Cytobiol. | pmid:22763967 |
| Roy S et al. | Maternal micronutrients (folic acid and vitamin B(12)) and omega 3 fatty acids: implications for neurodevelopmental risk in the rat offspring. | 2012 | Brain Dev. | pmid:21300490 |
| Oblozinský M et al. | New pharmaceutical insights related to the pathways of PUFAs. | 2012 | Ceska Slov Farm | pmid:23251954 |
| Turchini GM et al. | Jumping on the omega-3 bandwagon: distinguishing the role of long-chain and short-chain omega-3 fatty acids. | 2012 | Crit Rev Food Sci Nutr | pmid:22698270 |
| Trikalinos TA et al. | Concordance of randomized and nonrandomized studies was unrelated to translational patterns of two nutrient-disease associations. | 2012 | J Clin Epidemiol | pmid:22047889 |
| Passos PP et al. | Dopaminergic cell populations of the rat substantia nigra are differentially affected by essential fatty acid dietary restriction over two generations. | 2012 | J. Chem. Neuroanat. | pmid:22687395 |
| Phang M et al. | Gender-specific inhibition of platelet aggregation following omega-3 fatty acid supplementation. | 2012 | Nutr Metab Cardiovasc Dis | pmid:20708391 |
| Lorenzetti A et al. | Improving sperm quality and spermatogenesis through a bioactive marine compound: an experimental study. | 2012 | Acta Biomed | pmid:23393918 |
| Bell S et al. | The effect of omega-3 fatty acids on the atherogenic lipoprotein phenotype in patients with nephrotic range proteinuria. | 2012 | Clin. Nephrol. | pmid:22595386 |
| Hajjaji N et al. | Tumor and non-tumor tissues differential oxidative stress response to supplemental DHA and chemotherapy in rats. | 2012 | Cancer Chemother. Pharmacol. | pmid:22610354 |
| Njoroge SW et al. | DHA and EPA reverse cystic fibrosis-related FA abnormalities by suppressing FA desaturase expression and activity. | 2012 | J. Lipid Res. | pmid:22095831 |
| Angulo J et al. | Dietary fatty acid intervention of lactating cows simultaneously affects lipid profiles of meat and milk. | 2012 | J. Sci. Food Agric. | pmid:22549272 |
| Zhou SJ et al. | Fish-oil supplementation in pregnancy does not reduce the risk of gestational diabetes or preeclampsia. | 2012 | Am. J. Clin. Nutr. | pmid:22552037 |
| Correia M et al. | Docosahexaenoic acid inhibits Helicobacter pylori growth in vitro and mice gastric mucosa colonization. | 2012 | PLoS ONE | pmid:22529974 |
| Calder PC | Long-chain fatty acids and inflammation. | 2012 | Proc Nutr Soc | pmid:22369781 |
| Kelley DS and Adkins Y | Similarities and differences between the effects of EPA and DHA on markers of atherosclerosis in human subjects. | 2012 | Proc Nutr Soc | pmid:22369859 |
| Bernstein AM et al. | A meta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease. | 2012 | J. Nutr. | pmid:22113870 |
| Yui K et al. | Effects of large doses of arachidonic acid added to docosahexaenoic acid on social impairment in individuals with autism spectrum disorders: a double-blind, placebo-controlled, randomized trial. | 2012 | J Clin Psychopharmacol | pmid:22370992 |
| Finocchiaro C et al. | Effect of n-3 fatty acids on patients with advanced lung cancer: a double-blind, placebo-controlled study. | 2012 | Br. J. Nutr. | pmid:22114792 |
| Crnkovic S et al. | Docosahexaenoic acid-induced unfolded protein response, cell cycle arrest, and apoptosis in vascular smooth muscle cells are triggered by Ca²âº-dependent induction of oxidative stress. | 2012 | Free Radic. Biol. Med. | pmid:22391221 |