Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Igarashi M et al. | Dietary n-6 polyunsaturated fatty acid deprivation increases docosahexaenoic acid metabolism in rat brain. | 2012 | J. Neurochem. | pmid:22117540 |
Figueroa JD et al. | Docosahexaenoic acid pretreatment confers protection and functional improvements after acute spinal cord injury in adult rats. | 2012 | J. Neurotrauma | pmid:21970623 |
Lim SJ et al. | Docosahexaenoic acid sensitizes colon cancer cells to sulindac sulfide-induced apoptosis. | 2012 | Oncol. Rep. | pmid:22395735 |
Sørensen IM et al. | Serum long chain n-3 fatty acids (EPA and DHA) in the pregnant mother are independent of risk of type 1 diabetes in the offspring. | 2012 | Diabetes Metab. Res. Rev. | pmid:22396195 |
Hutchins-Wiese HL et al. | Hind limb suspension and long-chain omega-3 PUFA increase mRNA endocannabinoid system levels in skeletal muscle. | 2012 | J. Nutr. Biochem. | pmid:22051448 |
Meesapyodsuk D and Qiu X | The front-end desaturase: structure, function, evolution and biotechnological use. | 2012 | Lipids | pmid:22009657 |
Rontoyanni VG et al. | A comparison of the changes in cardiac output and systemic vascular resistance during exercise following high-fat meals containing DHA or EPA. | 2012 | Br. J. Nutr. | pmid:22348439 |
Jayashankar S et al. | Cerebral gene expression and neurobehavioural responses in mice pups exposed to methylmercury and docosahexaenoic acid through the maternal diet. | 2012 | Environ. Toxicol. Pharmacol. | pmid:22056564 |
Ozogul Y et al. | The effects of extraction methods on the contents of fatty acids, especially EPA and DHA in marine lipids. | 2012 | Int J Food Sci Nutr | pmid:22010951 |
Meldrum SJ et al. | Effects of high-dose fish oil supplementation during early infancy on neurodevelopment and language: a randomised controlled trial. | 2012 | Br. J. Nutr. | pmid:22348468 |
Kariv-Inbal Z et al. | The isoform-specific pathological effects of apoE4 in vivo are prevented by a fish oil (DHA) diet and are modified by cholesterol. | 2012 | J. Alzheimers Dis. | pmid:22057027 |
Cheon Y et al. | Disturbed brain phospholipid and docosahexaenoic acid metabolism in calcium-independent phospholipase A(2)-VIA (iPLA(2)β)-knockout mice. | 2012 | Biochim. Biophys. Acta | pmid:22349267 |
Antonietta Ajmone-Cat M et al. | Docosahexaenoic acid modulates inflammatory and antineurogenic functions of activated microglial cells. | 2012 | J. Neurosci. Res. | pmid:22057807 |
Poloschek CM and Jägle H | [Pharmacological concepts to treat hereditary retinal degenerations]. | 2012 | Ophthalmologe | pmid:22350547 |
Amann-Gassner U and Hastreiter L | [Nutrition during pregnancy]. | 2012 | MMW Fortschr Med | pmid:22352251 |
Feng GM et al. | Effect of docosahexaenoic acid on hypoxia/reoxygenation injury in human coronary arterial smooth muscle cells. | 2012 | Eur J Nutr | pmid:22105312 |
Ayas D et al. | The effects of season and sex on fat, fatty acids and protein contents of Sepia officinalis in the northeastern Mediterranean Sea. | 2012 | Int J Food Sci Nutr | pmid:22106841 |
Noreen EE and Brandauer J | The effects of supplemental fish oil on blood pressure and morning cortisol in normotensive adults: a pilot study. | 2012 | J Complement Integr Med | pmid:23104856 |
Kautharapu KB and Jarboe LR | Genome sequence of the psychrophilic deep-sea bacterium Moritella marina MP-1 (ATCC 15381). | 2012 | J. Bacteriol. | pmid:23105048 |
Wang X et al. | The effect of insulin, TNFα and DHA on the proliferation, differentiation and lipolysis of preadipocytes isolated from large yellow croaker (Pseudosciaena Crocea R.). | 2012 | PLoS ONE | pmid:23110176 |
Taha AY et al. | Upregulated expression of brain enzymatic markers of arachidonic and docosahexaenoic acid metabolism in a rat model of the metabolic syndrome. | 2012 | BMC Neurosci | pmid:23110484 |
Jackson PA et al. | Docosahexaenoic acid-rich fish oil modulates the cerebral hemodynamic response to cognitive tasks in healthy young adults. | 2012 | Biol Psychol | pmid:22020134 |
Li N et al. | Arginyl-glutamine dipeptide or docosahexaenoic acid attenuates hyperoxia-induced small intestinal injury in neonatal mice. | 2012 | J. Pediatr. Gastroenterol. Nutr. | pmid:22020559 |
Morris MC | Nutritional determinants of cognitive aging and dementia. | 2012 | Proc Nutr Soc | pmid:22067138 |
Samaee SM and Estévez A | Embryo and larva development in Dentex dentex, a marine pelagophil teleost: an endeavor to find a series of new fatty acid interrelations. | 2012 | J Exp Zool A Ecol Genet Physiol | pmid:22021057 |
Yang ZH et al. | Ingestion of a single serving of saury alters postprandial levels of plasma n-3 polyunsaturated fatty acids and long-chain monounsaturated fatty acids in healthy human adults. | 2012 | Lipids Health Dis | pmid:22846384 |
Jackson PA et al. | No effect of 12 weeks' supplementation with 1 g DHA-rich or EPA-rich fish oil on cognitive function or mood in healthy young adults aged 18-35 years. | 2012 | Br. J. Nutr. | pmid:21864417 |
Judge MP et al. | Maternal consumption of a DHA-containing functional food benefits infant sleep patterning: an early neurodevelopmental measure. | 2012 | Early Hum. Dev. | pmid:22269042 |
Morse NL | Benefits of docosahexaenoic acid, folic acid, vitamin D and iodine on foetal and infant brain development and function following maternal supplementation during pregnancy and lactation. | 2012 | Nutrients | pmid:22852064 |
Jørgensen MH et al. | Long-chain PUFA in granulocytes, mononuclear cells, and RBC in patients with cystic fibrosis: relation to liver disease. | 2012 | J. Pediatr. Gastroenterol. Nutr. | pmid:22241510 |
Williams JA et al. | Docosahexaenoic and eicosapentaenoic acids segregate differently between raft and nonraft domains. | 2012 | Biophys. J. | pmid:22853900 |
Gutiérrez-Mata AP et al. | [Neurological, neuropsychological, and ophthalmological evolution after one year of docosahexaenoic acid supplementation in phenylketonuric patients]. | 2012 | Rev Neurol | pmid:22829083 |
Deckelbaum RJ et al. | Conclusions and recommendations from the symposium, Heart Healthy Omega-3s for Food: Stearidonic Acid (SDA) as a Sustainable Choice. | 2012 | J. Nutr. | pmid:22323767 |
Harden CJ et al. | Effect of different long-chain fatty acids on cholecystokinin release in vitro and energy intake in free-living healthy males. | 2012 | Br. J. Nutr. | pmid:22313587 |
Komatsuzaki N and Shima J | Effects of live Lactobacillus paracasei on plasma lipid concentration in rats fed an ethanol-containing diet. | 2012 | Biosci. Biotechnol. Biochem. | pmid:22313752 |
Silva Jde A et al. | Fish oil supplement alters markers of inflammatory and nutritional status in colorectal cancer patients. | 2012 | Nutr Cancer | pmid:22295891 |
Mackay I et al. | Effect of Omega-3 fatty acid supplementation on markers of platelet and endothelial function in patients with peripheral arterial disease. | 2012 | Atherosclerosis | pmid:22296885 |
Serini S et al. | EPA and DHA differentially affect in vitro inflammatory cytokine release by peripheral blood mononuclear cells from Alzheimer's patients. | 2012 | Curr Alzheimer Res | pmid:22299617 |
Tan Z et al. | Enzymatic synthesis of phytosteryl docosahexaneates and evaluation of their anti-atherogenic effects in apo-E deficient mice. | 2012 | Food Chem | pmid:23442661 |
Damsgaard CT et al. | The effects of n-3 long-chain polyunsaturated fatty acids on bone formation and growth factors in adolescent boys. | 2012 | Pediatr. Res. | pmid:22337227 |
Kirkegaard E et al. | Marine n-3 fatty acids, atrial fibrillation and QT interval in haemodialysis patients. | 2012 | Br. J. Nutr. | pmid:21791142 |
Lopez HL | Nutritional interventions to prevent and treat osteoarthritis. Part I: focus on fatty acids and macronutrients. | 2012 | PM R | pmid:22632694 |
O'Flaherty JT et al. | 15-lipoxygenase metabolites of docosahexaenoic acid inhibit prostate cancer cell proliferation and survival. | 2012 | PLoS ONE | pmid:23029040 |
Cazzola R et al. | Effects of DHA-phospholipids, melatonin and tryptophan supplementation on erythrocyte membrane physico-chemical properties in elderly patients suffering from mild cognitive impairment. | 2012 | Exp. Gerontol. | pmid:23000875 |
Hajjaji N et al. | DHA effect on chemotherapy-induced body weight loss: an exploratory study in a rodent model of mammary tumors. | 2012 | Nutr Cancer | pmid:23035949 |
Contreras GA et al. | Enhanced n-3 phospholipid content reduces inflammatory responses in bovine endothelial cells. | 2012 | J. Dairy Sci. | pmid:23040031 |
Norris PC and Dennis EA | Omega-3 fatty acids cause dramatic changes in TLR4 and purinergic eicosanoid signaling. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22586114 |
Xue C et al. | Differences in lipid characteristics among populations: low-temperature adaptability of ayu, Plecoglossus altivelis. | 2012 | Lipids | pmid:22120618 |
Chiu CY et al. | Omega-6 docosapentaenoic acid-derived resolvins and 17-hydroxydocosahexaenoic acid modulate macrophage function and alleviate experimental colitis. | 2012 | Inflamm. Res. | pmid:22618200 |
Pan XX et al. | Efficient display of active Geotrichum sp. lipase on Pichia pastoris cell wall and its application as a whole-cell biocatalyst to enrich EPA and DHA in fish oil. | 2012 | J. Agric. Food Chem. | pmid:22934819 |
Zhao M et al. | Marginal vitamin B-6 deficiency decreases plasma (n-3) and (n-6) PUFA concentrations in healthy men and women. | 2012 | J. Nutr. | pmid:22955512 |
Bazan NG | Neuroinflammation and proteostasis are modulated by endogenously biosynthesized neuroprotectin D1. | 2012 | Mol. Neurobiol. | pmid:22956271 |
Zicker SC et al. | Evaluation of cognitive learning, memory, psychomotor, immunologic, and retinal functions in healthy puppies fed foods fortified with docosahexaenoic acid-rich fish oil from 8 to 52 weeks of age. | 2012 | J. Am. Vet. Med. Assoc. | pmid:22916855 |
Muldoon MF | Discerning whether and how long-chain, n-3 fatty acids lower blood pressure: a comment on Skulas-Ray et al. | 2012 | Ann Behav Med | pmid:22918613 |
Zou XQ et al. | Preparation of human milk fat substitutes from palm stearin with arachidonic and docosahexaenoic acid: combination of enzymatic and physical methods. | 2012 | J. Agric. Food Chem. | pmid:22920386 |
Ramadeen A et al. | Docosahexaenoic acid, but not eicosapentaenoic acid, supplementation reduces vulnerability to atrial fibrillation. | 2012 | Circ Arrhythm Electrophysiol | pmid:22923273 |
Martin N et al. | Primary human airway epithelial cell-dependent inhibition of human lung mast cell degranulation. | 2012 | PLoS ONE | pmid:22970103 |
Richardson AJ et al. | Docosahexaenoic acid for reading, cognition and behavior in children aged 7-9 years: a randomized, controlled trial (the DOLAB Study). | 2012 | PLoS ONE | pmid:22970149 |
Valentine CJ | Maternal dietary DHA supplementation to improve inflammatory outcomes in the preterm infant. | 2012 | Adv Nutr | pmid:22585914 |
Ribeiro P et al. | Effect of fish oil supplementation in pregnancy on the fatty acid composition of erythrocyte phospholipids and breast milk lipids. | 2012 | Int J Food Sci Nutr | pmid:21707451 |
Steffen BT et al. | Ethnicity, plasma phospholipid fatty acid composition and inflammatory/endothelial activation biomarkers in the Multi-Ethnic Study of Atherosclerosis (MESA). | 2012 | Eur J Clin Nutr | pmid:22215136 |
Chen HF and Su HM | Fish oil supplementation of maternal rats on an n-3 fatty acid-deficient diet prevents depletion of maternal brain regional docosahexaenoic acid levels and has a postpartum anxiolytic effect. | 2012 | J. Nutr. Biochem. | pmid:21543216 |
Alessandri JM et al. | Influence of gender on DHA synthesis: the response of rat liver to low dietary α-linolenic acid evidences higher ω3 ∆4-desaturation index in females. | 2012 | Eur J Nutr | pmid:21647669 |
Odusanwo O et al. | Resolvin D1 prevents TNF-α-mediated disruption of salivary epithelial formation. | 2012 | Am. J. Physiol., Cell Physiol. | pmid:22237406 |
Stein AD et al. | Auditory- and visual-evoked potentials in Mexican infants are not affected by maternal supplementation with 400 mg/d docosahexaenoic acid in the second half of pregnancy. | 2012 | J. Nutr. | pmid:22739364 |
Virtanen JK et al. | Serum long-chain n-3 polyunsaturated fatty acids, mercury, and risk of sudden cardiac death in men: a prospective population-based study. | 2012 | PLoS ONE | pmid:22815906 |
Thomas MC et al. | Rapid identification of long-chain polyunsaturated fatty acids in a marine extract by HPLC-MS using data-dependent acquisition. | 2012 | Anal. Chem. | pmid:22816781 |
Ramon S et al. | Specialized proresolving mediators enhance human B cell differentiation to antibody-secreting cells. | 2012 | J. Immunol. | pmid:22711890 |
Han CY et al. | NADPH oxidase-derived reactive oxygen species increases expression of monocyte chemotactic factor genes in cultured adipocytes. | 2012 | J. Biol. Chem. | pmid:22287546 |
Landmark K and Alm CS | [Fish and omega-3 fatty acids and heart failure]. | 2012 | Tidsskr. Nor. Laegeforen. | pmid:23736195 |
Scheltens P et al. | Efficacy of Souvenaid in mild Alzheimer's disease: results from a randomized, controlled trial. | 2012 | J. Alzheimers Dis. | pmid:22766770 |
Reinders I et al. | Association of serum n-3 polyunsaturated fatty acids with C-reactive protein in men. | 2012 | Eur J Clin Nutr | pmid:22113248 |
Moreno-Indias I et al. | Docosahexaenoic acid in the goat kid diet: effects on immune system and meat quality. | 2012 | J. Anim. Sci. | pmid:22665635 |
Holly LT et al. | Dietary therapy to promote neuroprotection in chronic spinal cord injury. | 2012 | J Neurosurg Spine | pmid:22735048 |
Khairallah RJ et al. | Improved mitochondrial function with diet-induced increase in either docosahexaenoic acid or arachidonic acid in membrane phospholipids. | 2012 | PLoS ONE | pmid:22479624 |
Baracos VE et al. | Survival: the relevant primary outcome for nutrition therapy in cancer patients. | 2012 | Curr Opin Clin Nutr Metab Care | pmid:22466928 |
Hoffmire CA et al. | Associations between omega-3 poly-unsaturated fatty acids from fish consumption and severity of depressive symptoms: an analysis of the 2005-2008 National Health and Nutrition Examination Survey. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22472486 |
Kuipers RS et al. | Fatty acid compositions of preterm and term colostrum, transitional and mature milks in a sub-Saharan population with high fish intakes. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22425684 |
Sakamoto M et al. | Mercury and docosahexaenoic acid levels in maternal and cord blood in relation to segmental maternal hair mercury concentrations at parturition. | 2012 | Environ Int | pmid:22425897 |
Dornstauder B et al. | Dietary docosahexaenoic acid supplementation prevents age-related functional losses and A2E accumulation in the retina. | 2012 | Invest. Ophthalmol. Vis. Sci. | pmid:22427551 |
de Goede J et al. | Gender-specific associations of marine n-3 fatty acids and fish consumption with 10-year incidence of stroke. | 2012 | PLoS ONE | pmid:22496770 |
Sczaniecka AK et al. | Dietary intake of specific fatty acids and breast cancer risk among postmenopausal women in the VITAL cohort. | 2012 | Nutr Cancer | pmid:23137008 |
Liao Z et al. | Resolvin D1 attenuates inflammation in lipopolysaccharide-induced acute lung injury through a process involving the PPARγ/NF-κB pathway. | 2012 | Respir. Res. | pmid:23199346 |
Russell FD and Bürgin-Maunder CS | Distinguishing health benefits of eicosapentaenoic and docosahexaenoic acids. | 2012 | Mar Drugs | pmid:23203276 |
Jiang LH et al. | Pure docosahexaenoic acid can improve depression behaviors and affect HPA axis in mice. | 2012 | Eur Rev Med Pharmacol Sci | pmid:23208960 |
Calder PC and Yaqoob P | Marine omega-3 fatty acids and coronary heart disease. | 2012 | Curr. Opin. Cardiol. | pmid:22565141 |
Sciotto C and Mjøs SA | Trans isomers of EPA and DHA in omega-3 products on the European market. | 2012 | Lipids | pmid:22566205 |
Bianchini F et al. | 22Â :Â 6n-3 DHA inhibits differentiation of prostate fibroblasts into myofibroblasts and tumorigenesis. | 2012 | Br. J. Nutr. | pmid:22390897 |
Sparvero LJ et al. | Mapping of phospholipids by MALDI imaging (MALDI-MSI): realities and expectations. | 2012 | Chem. Phys. Lipids | pmid:22692104 |
Das UN | Is multiple sclerosis a proresolution deficiency disorder? | 2012 | Nutrition | pmid:22521616 |
Szabó A et al. | Negative allometry of docosahexaenoic acid in the fowl lung and pulmonary surfactant phospholipids. | 2012 | Acta. Biol. Hung. | pmid:22695520 |
Aldai N et al. | Evaluating the in vitro metabolism of docosahexaenoic acid in sheep rumen fluid. | 2012 | Lipids | pmid:22695744 |
Jin F et al. | Supplementation of milled chia seeds increases plasma ALA and EPA in postmenopausal women. | 2012 | Plant Foods Hum Nutr | pmid:22538527 |
Tu WC et al. | An alternative n-3 fatty acid elongation pathway utilising 18:3n-3 in barramundi (Lates calcarifer). | 2012 | Biochem. Biophys. Res. Commun. | pmid:22640739 |
Itakura H et al. | The change in low-density lipoprotein cholesterol concentration is positively related to plasma docosahexaenoic acid but not eicosapentaenoic acid. | 2012 | J. Atheroscler. Thromb. | pmid:22653220 |
Lee HN and Surh YJ | Therapeutic potential of resolvins in the prevention and treatment of inflammatory disorders. | 2012 | Biochem. Pharmacol. | pmid:23330154 |
Drzymała-Czyż S et al. | Discrepancy between clinical and histological effects of DHA supplementation in a rat model of pouchitis. | 2012 | Folia Histochem. Cytobiol. | pmid:22532147 |
Daud ZA et al. | Effects of protein and omega-3 supplementation, provided during regular dialysis sessions, on nutritional and inflammatory indices in hemodialysis patients. | 2012 | Vasc Health Risk Manag | pmid:22536073 |
Ginty AT and Conklin SM | Preliminary evidence that acute long-chain omega-3 supplementation reduces cardiovascular reactivity to mental stress: a randomized and placebo controlled trial. | 2012 | Biol Psychol | pmid:21967854 |
Aisen PS et al. | Symptomatic and nonamyloid/tau based pharmacologic treatment for Alzheimer disease. | 2012 | Cold Spring Harb Perspect Med | pmid:22393531 |