Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Mustafa M et al. | Resolvin D1 protects periodontal ligament. | 2013 | Am. J. Physiol., Cell Physiol. | pmid:23864609 |
Gelsomino G et al. | Omega 3 fatty acids chemosensitize multidrug resistant colon cancer cells by down-regulating cholesterol synthesis and altering detergent resistant membranes composition. | 2013 | Mol. Cancer | pmid:24225025 |
Cederholm T et al. | ω-3 fatty acids in the prevention of cognitive decline in humans. | 2013 | Adv Nutr | pmid:24228198 |
Amminger GP et al. | Omega-3 fatty acid supplementation in adolescents with borderline personality disorder and ultra-high risk criteria for psychosis: a post hoc subgroup analysis of a double-blind, randomized controlled trial. | 2013 | Can J Psychiatry | pmid:23870722 |
Lotrich FE et al. | Anger induced by interferon-alpha is moderated by ratio of arachidonic acid to omega-3 fatty acids. | 2013 | J Psychosom Res | pmid:24182638 |
Pande G et al. | Enzymatic synthesis of extra virgin olive oil based infant formula fat analogues containing ARA and DHA: one-stage and two-stage syntheses. | 2013 | J. Agric. Food Chem. | pmid:24117100 |
Murphy EJ | A lipid neurochemist's siren: docosahexaenoic acid and its elusive function in the central nervous system. | 2013 | J. Neurochem. | pmid:24117623 |
Flock MR et al. | Long-chain omega-3 fatty acids: time to establish a dietary reference intake. | 2013 | Nutr. Rev. | pmid:24117792 |
Milic I et al. | Simultaneous detection of low and high molecular weight carbonylated compounds derived from lipid peroxidation by electrospray ionization-tandem mass spectrometry. | 2013 | Anal. Chem. | pmid:23186270 |
Mizwicki MT et al. | 1α,25-dihydroxyvitamin D3 and resolvin D1 retune the balance between amyloid-β phagocytosis and inflammation in Alzheimer's disease patients. | 2013 | J. Alzheimers Dis. | pmid:23186989 |
Carlson SJ et al. | The role of the ω-3 fatty acid DHA in the human life cycle. | 2013 | JPEN J Parenter Enteral Nutr | pmid:23192455 |
Le HD et al. | The effect of varying ratios of docosahexaenoic acid and arachidonic acid in the prevention and reversal of biochemical essential fatty acid deficiency in a murine model. | 2013 | Metab. Clin. Exp. | pmid:23151438 |
Lee LK et al. | The role of long chain omega-3 polyunsaturated fatty acids in reducing lipid peroxidation among elderly patients with mild cognitive impairment: a case-control study. | 2013 | J. Nutr. Biochem. | pmid:22898566 |
Nozue T et al. | Effects of statins on serum n-3 to n-6 polyunsaturated fatty acid ratios in patients with coronary artery disease. | 2013 | J. Cardiovasc. Pharmacol. Ther. | pmid:23324995 |
Fiol-deRoque MA et al. | Cognitive recovery and restoration of cell proliferation in the dentate gyrus in the 5XFAD transgenic mice model of Alzheimer's disease following 2-hydroxy-DHA treatment. | 2013 | Biogerontology | pmid:24114505 |
Olson MV et al. | Docosahexaenoic acid reduces inflammation and joint destruction in mice with collagen-induced arthritis. | 2013 | Inflamm. Res. | pmid:24008816 |
Marze S et al. | In vitro digestion of fish oils rich in n-3 polyunsaturated fatty acids studied in emulsion and at the oil-water interface. | 2013 | Food Funct | pmid:23086175 |
Paschoal VA et al. | Eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid differentially modulate rat neutrophil function in vitro. | 2013 | Lipids | pmid:23086551 |
Isosapent ethyl (Vascepa) for severe hypertriglyceridemia. | 2013 | Med Lett Drugs Ther | pmid:23836343 | |
Carlson SE et al. | DHA supplementation and pregnancy outcomes. | 2013 | Am. J. Clin. Nutr. | pmid:23426033 |
Cartiff SE et al. | Eicosapentaenoic and docosahexaenoic acids increase insulin sensitivity in growing steers. | 2013 | J. Anim. Sci. | pmid:23463554 |
Kataoka Y et al. | Epanova(®) and hypertriglyceridemia: pharmacological mechanisms and clinical efficacy. | 2013 | Future Cardiol | pmid:23463969 |
Mocking RJ et al. | Relationship between the hypothalamic-pituitary-adrenal-axis and fatty acid metabolism in recurrent depression. | 2013 | Psychoneuroendocrinology | pmid:23465556 |
Gao M et al. | Isolation and characterization of Aurantiochytrium species: high docosahexaenoic acid (DHA) production by the newly isolated microalga, Aurantiochytrium sp. SD116. | 2013 | J Oleo Sci | pmid:23470441 |
Dobson EP et al. | Controlled formation of mono- and dihydroxy-resolvins from EPA and DHA using soybean 15-lipoxygenase. | 2013 | J. Lipid Res. | pmid:23471029 |
McNamara RK | Deciphering the role of docosahexaenoic acid in brain maturation and pathology with magnetic resonance imaging. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22521863 |
Raatz SK et al. | Dose-dependent consumption of farmed Atlantic salmon (Salmo salar) increases plasma phospholipid n-3 fatty acids differentially. | 2013 | J Acad Nutr Diet | pmid:23351633 |
Lohner S et al. | Gender differences in the long-chain polyunsaturated fatty acid status: systematic review of 51 publications. | 2013 | Ann. Nutr. Metab. | pmid:23327902 |
MacIntosh BA et al. | Low-n-6 and low-n-6 plus high-n-3 diets for use in clinical research. | 2013 | Br. J. Nutr. | pmid:23328113 |
Goustard-Langelier B et al. | Rat neural stem cell proliferation and differentiation are durably altered by the in utero polyunsaturated fatty acid supply. | 2013 | J. Nutr. Biochem. | pmid:23036607 |
Usami M et al. | Analysis of fecal microbiota, organic acids and plasma lipids in hepatic cancer patients with or without liver cirrhosis. | 2013 | Clin Nutr | pmid:23068014 |
Kimura AK and Kim HY | Phosphatidylserine synthase 2: high efficiency for synthesizing phosphatidylserine containing docosahexaenoic acid. | 2013 | J. Lipid Res. | pmid:23071296 |
Harris WS et al. | Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: observations from 160,000 patients. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23375840 |
Dalli J et al. | The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype. | 2013 | FASEB J. | pmid:23504711 |
Arem H et al. | Omega-3 and omega-6 fatty acid intakes and endometrial cancer risk in a population-based case-control study. | 2013 | Eur J Nutr | pmid:22915050 |
Mickleborough TD | Omega-3 polyunsaturated fatty acids in physical performance optimization. | 2013 | Int J Sport Nutr Exerc Metab | pmid:23400626 |
Kim HY and Spector AA | Synaptamide, endocannabinoid-like derivative of docosahexaenoic acid with cannabinoid-independent function. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22959887 |
Minihane AM | Fish oil omega-3 fatty acids and cardio-metabolic health, alone or with statins. | 2013 | Eur J Clin Nutr | pmid:23403872 |
Miyahara T et al. | D-series resolvin attenuates vascular smooth muscle cell activation and neointimal hyperplasia following vascular injury. | 2013 | FASEB J. | pmid:23407709 |
Huang LL et al. | Suppression of acute ethanol-induced hepatic steatosis by docosahexaenoic acid is associated with downregulation of stearoyl-CoA desaturase 1 and inflammatory cytokines. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23474173 |
Morita M et al. | The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza. | 2013 | Cell | pmid:23477864 |
Wijendran V et al. | Dietary arachidonic acid and docosahexaenoic acid regulate liver fatty acid desaturase (FADS) alternative transcript expression in suckling piglets. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24075244 |
Liu X et al. | Oxidized fatty acid analysis by charge-switch derivatization, selected reaction monitoring, and accurate mass quantitation. | 2013 | Anal. Biochem. | pmid:23850559 |
Miller E et al. | A short-term n-3 DPA supplementation study in humans. | 2013 | Eur J Nutr | pmid:22729967 |
Khaled M et al. | Effects of resolvin D1 on cell survival and cytokine expression of human gingival fibroblasts. | 2013 | J. Periodontol. | pmid:23398023 |
Friedman AN et al. | Fatty acids and other risk factors for sudden cardiac death in patients starting hemodialysis. | 2013 | Am. J. Nephrol. | pmid:23816975 |
Arnold C et al. | Macular xanthophylls and ω-3 long-chain polyunsaturated fatty acids in age-related macular degeneration: a randomized trial. | 2013 | JAMA Ophthalmol | pmid:23519529 |
Xu MX et al. | Resolvin D1, an endogenous lipid mediator for inactivation of inflammation-related signaling pathways in microglial cells, prevents lipopolysaccharide-induced inflammatory responses. | 2013 | CNS Neurosci Ther | pmid:23521911 |
Zulyniak MA et al. | Fish oil supplementation alters circulating eicosanoid concentrations in young healthy men. | 2013 | Metab. Clin. Exp. | pmid:23522836 |
Qadhi R et al. | Differential responses to docosahexaenoic acid in primary and immortalized cardiac cells. | 2013 | Toxicol. Lett. | pmid:23523905 |
Gódor-Kacsándi A et al. | Developmental docosahexaenoic and arachidonic acid supplementation improves adult learning and increases resistance against excitotoxicity in the brain. | 2013 | Acta Physiol Hung | pmid:23524180 |
Simões T et al. | Seasonal variation in proximate composition and fatty acid profile of grey triggerfish (Balistes capriscus) captured along the coast of Portugal. | 2013 | J. Food Sci. | pmid:23551246 |
Watson AM et al. | Taurine supplementation of plant derived protein and n-3 fatty acids are critical for optimal growth and development of cobia, Rachycentron canadum. | 2013 | Lipids | pmid:23884630 |
Mocellin MC et al. | Fish oil decreases C-reactive protein/albumin ratio improving nutritional prognosis and plasma fatty acid profile in colorectal cancer patients. | 2013 | Lipids | pmid:23888317 |
Zhang J et al. | Different intakes of n-3 fatty acids among pregnant women in 3 regions of China with contrasting dietary patterns are reflected in maternal but not in umbilical erythrocyte phosphatidylcholine fatty acid composition. | 2013 | Nutr Res | pmid:23890350 |
Yao C et al. | Neuroprotectin D1 attenuates brain damage induced by transient middle cerebral artery occlusion in rats through TRPC6/CREB pathways. | 2013 | Mol Med Rep | pmid:23799606 |
Davidson MH | Omega-3 fatty acids: new insights into the pharmacology and biology of docosahexaenoic acid, docosapentaenoic acid, and eicosapentaenoic acid. | 2013 | Curr. Opin. Lipidol. | pmid:24184945 |
Al-Farsi YM et al. | Impact of nutrition on serum levels of docosahexaenoic acid among Omani children with autism. | 2013 | Nutrition | pmid:23800562 |
Aslan M et al. | LC-MS/MS analysis of plasma polyunsaturated fatty acids in type 2 diabetic patients after insulin analog initiation therapy. | 2013 | Lipids Health Dis | pmid:24195588 |
Leino O et al. | Effects of docosahexaenoic acid and methylmercury on child's brain development due to consumption of fish by Finnish mother during pregnancy: a probabilistic modeling approach. | 2013 | Food Chem. Toxicol. | pmid:21723361 |
Mizia-Stec K et al. | N-3 polyunsaturated fatty acids do not influence the efficacy of dual antiplatelet therapy in stable angina pectoris patients after percutaneous coronary intervention. | 2013 | Cardiol J | pmid:24469870 |
Liu Y et al. | Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge. | 2013 | J. Nutr. | pmid:23739309 |
Parletta N et al. | Effects of fish oil supplementation on learning and behaviour of children from Australian Indigenous remote community schools: a randomised controlled trial. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23756346 |
Juman S et al. | Effects of long-term oral administration of arachidonic acid and docosahexaenoic acid on the immune functions of young rats. | 2013 | Nutrients | pmid:23760060 |
Merendino N et al. | Dietary ω -3 polyunsaturated fatty acid DHA: a potential adjuvant in the treatment of cancer. | 2013 | Biomed Res Int | pmid:23762838 |
Hunina LM et al. | [Effectiveness of use of omega-3 polyunsaturated fatty acids at physical loads]. | 2013 | Fiziol Zh | pmid:23713352 |
Dangour AD et al. | N-3 fatty acids and retinal function. | 2013 | Ophthalmology | pmid:23714605 |
Shida T et al. | Colonic delivery of docosahexaenoic acid improves impaired glucose tolerance via GLP-1 secretion and suppresses pancreatic islet hyperplasia in diabetic KK-A(y) mice. | 2013 | Int J Pharm | pmid:23618969 |
Berger H et al. | SOCS3 transactivation by PPARγ prevents IL-17-driven cancer growth. | 2013 | Cancer Res. | pmid:23619236 |
Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. | 2013 | JAMA | pmid:23644932 | |
Veszelka S et al. | Docosahexaenoic acid reduces amyloid-β induced toxicity in cells of the neurovascular unit. | 2013 | J. Alzheimers Dis. | pmid:23645098 |
Stephenson JA et al. | Unsaturated fatty acids differ between hepatic colorectal metastases and liver tissue without tumour in humans: results from a randomised controlled trial of intravenous eicosapentaenoic and docosahexaenoic acids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23647811 |
Nishinaka T et al. | [Elucidation of mechanisms underlying docosahexaenoic acid-induced antinociception]. | 2013 | Yakugaku Zasshi | pmid:23649389 |
Ravacci GR et al. | Lipid raft disruption by docosahexaenoic acid induces apoptosis in transformed human mammary luminal epithelial cells harboring HER-2 overexpression. | 2013 | J. Nutr. Biochem. | pmid:22749134 |
Adler EM | Of fish oil, rafts, and scrambling things up. | 2013 | J. Gen. Physiol. | pmid:24277599 |
Ramprasath VR et al. | Enhanced increase of omega-3 index in healthy individuals with response to 4-week n-3 fatty acid supplementation from krill oil versus fish oil. | 2013 | Lipids Health Dis | pmid:24304605 |
Fecchio C et al. | α-Synuclein oligomers induced by docosahexaenoic acid affect membrane integrity. | 2013 | PLoS ONE | pmid:24312431 |
Hashimoto M et al. | Prescription n-3 fatty acids, but not eicosapentaenoic acid alone, improve reference memory-related learning ability by increasing brain-derived neurotrophic factor levels in SHR.Cg-Lepr(cp)/NDmcr rats, a metabolic syndrome model. | 2013 | Neurochem. Res. | pmid:23963508 |
Tabbaa M et al. | Docosahexaenoic acid, inflammation, and bacterial dysbiosis in relation to periodontal disease, inflammatory bowel disease, and the metabolic syndrome. | 2013 | Nutrients | pmid:23966110 |
Szklenar M et al. | Eicosanoids and docosanoids in plasma and aorta of healthy and atherosclerotic rabbits. | 2013 | J. Vasc. Res. | pmid:23969947 |
Dabkowski ER et al. | Docosahexaenoic acid supplementation alters key properties of cardiac mitochondria and modestly attenuates development of left ventricular dysfunction in pressure overload-induced heart failure. | 2013 | Cardiovasc Drugs Ther | pmid:24013804 |
Porta A et al. | Biology and chemistry of neuroprostanes. First total synthesis of 17-A4-NeuroP: validation of a convergent strategy to a number of cyclopentenone neuroprostanes. | 2013 | Chem. Phys. Lipids | pmid:23895793 |
Costa S et al. | The emerging farmed fish species meagre (Argyrosomus regius): how culinary treatment affects nutrients and contaminants concentration and associated benefit-risk balance. | 2013 | Food Chem. Toxicol. | pmid:23900006 |
O'Sullivan BP et al. | Evolution of pancreatic function during the first year in infants with cystic fibrosis. | 2013 | J. Pediatr. | pmid:23245194 |
Rincón Cervera Mà et al. | Acyl migration evaluation in monoacylglycerols from Echium plantagineum seed oil and Marinol. | 2013 | J. Biosci. Bioeng. | pmid:23287502 |
Chen HW et al. | Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells. | 2013 | Arch. Toxicol. | pmid:23288142 |
Matsuoka Y et al. | Tachikawa project for prevention of posttraumatic stress disorder with polyunsaturated fatty acid (TPOP): study protocol for a randomized controlled trial. | 2013 | BMC Psychiatry | pmid:23289548 |
LluÃs L et al. | Protective effect of the omega-3 polyunsaturated fatty acids: Eicosapentaenoic acid/Docosahexaenoic acid 1:1 ratio on cardiovascular disease risk markers in rats. | 2013 | Lipids Health Dis | pmid:24083393 |
Nikolakopoulou Z et al. | Omega-3 polyunsaturated fatty acids selectively inhibit growth in neoplastic oral keratinocytes by differentially activating ERK1/2. | 2013 | Carcinogenesis | pmid:23892603 |
Takkunen M et al. | Dietary fat in relation to erythrocyte fatty acid composition in men. | 2013 | Lipids | pmid:23975575 |
Qu L et al. | Biomass composition, lipid characterization, and metabolic profile analysis of the fed-batch fermentation process of two different docosahexanoic acid producing Schizochytrium sp. strains. | 2013 | Appl. Biochem. Biotechnol. | pmid:24061873 |
D'Souza V et al. | Counteracting oxidative stress in pregnancy through modulation of maternal micronutrients and omega-3 fatty acids. | 2013 | Curr. Med. Chem. | pmid:24274816 |
Wu D et al. | Novel biphasic role of resolvin D1 on expression of cyclooxygenase-2 in lipopolysaccharide-stimulated lung fibroblasts is partly through PI3K/AKT and ERK2 pathways. | 2013 | Mediators Inflamm. | pmid:24174713 |
Barbadoro P et al. | Fish oil supplementation reduces cortisol basal levels and perceived stress: a randomized, placebo-controlled trial in abstinent alcoholics. | 2013 | Mol Nutr Food Res | pmid:23390041 |
Phang M et al. | Eicosapentaenoic and docosahexaenoic acid supplementations reduce platelet aggregation and hemostatic markers differentially in men and women. | 2013 | J. Nutr. | pmid:23390192 |
Nikolakopoulou Z et al. | The induction of apoptosis in pre-malignant keratinocytes by omega-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) is inhibited by albumin. | 2013 | Toxicol. Lett. | pmid:23391486 |
Souied EH et al. | Oral docosahexaenoic acid in the prevention of exudative age-related macular degeneration: the Nutritional AMD Treatment 2 study. | 2013 | Ophthalmology | pmid:23395546 |
Kenchegowda S et al. | Involvement of pigment epithelium-derived factor, docosahexaenoic acid and neuroprotectin D1 in corneal inflammation and nerve integrity after refractive surgery. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22579364 |
Delplanque B et al. | A dairy fat matrix providing alpha-linolenic acid (ALA) is better than a vegetable fat mixture to increase brain DHA accretion in young rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22884780 |
Li Y et al. | Plasticity of leukocytic exudates in resolving acute inflammation is regulated by MicroRNA and proresolving mediators. | 2013 | Immunity | pmid:24238341 |