Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Alexander JW | Influence of EPA and DHA intravenous fat emulsions on nitrogen retention and protein kinetics in burned rats. | 1999 | Nutrition | pmid:9990585 |
Sasaki T et al. | Effects of dietary docosahexaenoic acid on surface molecules involved in T cell proliferation. | 1999 | Biochim. Biophys. Acta | pmid:9989281 |
Krugman S and Law P | Breastfeeding and IQ. | 1999 | Pediatrics | pmid:9988628 |
Matorras R et al. | Biochemical markers of n-3 long chain polyunsaturated fatty acid intake during pregnancy. | 1998 | Clin Exp Obstet Gynecol | pmid:9987571 |
Cellini M et al. | Fatty acid use in glaucomatous optic neuropathy treatment. | 1998 | Acta Ophthalmol Scand Suppl | pmid:9972342 |
Azavache V et al. | [The liver as a source of essential long chain polyunsaturated fatty acids for postnatal brain development in the rat]. | 1998 | Arch Latinoam Nutr | pmid:9951533 |
Araya Araya J et al. | [Differences in percent composition of long chain polyunsaturated fatty acids in maternal-fetal erythrocytes in term and preterm infants]. | 1998 | Arch Latinoam Nutr | pmid:9951532 |
Weisinger HS et al. | Effects of dietary n-3 fatty acid deficiency and repletion in the guinea pig retina. | 1999 | Invest. Ophthalmol. Vis. Sci. | pmid:9950590 |
Nourooz-Zadeh J et al. | F4-isoprostanes as specific marker of docosahexaenoic acid peroxidation in Alzheimer's disease. | 1999 | J. Neurochem. | pmid:9930747 |
Hirafuji M et al. | Effect of docosahexaenoic acid on intracellular calcium dynamics in vascular smooth muscle cells from normotensive and genetically hypertensive rats. | 1998 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:9920344 |
Terano T et al. | Eicosapentaenoic acid and docosahexaenoic acid inhibit vascular smooth muscle cell proliferation by inhibiting phosphorylation of Cdk2-cyclinE complex. | 1999 | Biochem. Biophys. Res. Commun. | pmid:9918868 |
Hashimoto M et al. | The hypotensive effect of docosahexaenoic acid is associated with the enhanced release of ATP from the caudal artery of aged rats. | 1999 | J. Nutr. | pmid:9915878 |
Baur LA et al. | Relationships between maternal risk of insulin resistance and the child's muscle membrane fatty acid composition. | 1999 | Diabetes | pmid:9892230 |
Lin Q et al. | Ligand selectivity of the peroxisome proliferator-activated receptor alpha. | 1999 | Biochemistry | pmid:9890897 |
Su HM et al. | Bioequivalence of dietary alpha-linolenic and docosahexaenoic acids as sources of docosahexaenoate accretion in brain and associated organs of neonatal baboons. | 1999 | Pediatr. Res. | pmid:9890614 |
Perin N et al. | Dietary lipid composition modifies intestinal morphology and nutrient transport in young rats. | 1999 | J. Pediatr. Gastroenterol. Nutr. | pmid:9890468 |
Kollman KA et al. | Dietary lipids influence intestinal adaptation after massive bowel resection. | 1999 | J. Pediatr. Gastroenterol. Nutr. | pmid:9890467 |
Marzo I et al. | Loss of delta6-desaturase activity leads to impaired docosahexaenoic acid synthesis in Y-79 retinoblastoma cells. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9888202 |
Mani I et al. | Evidence of nuclear PKC/MAP-kinase cascade in guinea pig model of epidermal hyperproliferation. | 1999 | J. Invest. Dermatol. | pmid:9886262 |
Bernoud N et al. | Preferential transfer of 2-docosahexaenoyl-1-lysophosphatidylcholine through an in vitro blood-brain barrier over unesterified docosahexaenoic acid. | 1999 | J. Neurochem. | pmid:9886086 |