Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Liao Z et al. | Resolvin D1 attenuates inflammation in lipopolysaccharide-induced acute lung injury through a process involving the PPARγ/NF-κB pathway. | 2012 | Respir. Res. | pmid:23199346 |
Lecchi C et al. | Effects of EPA and DHA on lipid droplet accumulation and mRNA abundance of PAT proteins in caprine monocytes. | 2013 | Res. Vet. Sci. | pmid:23102647 |
Hirafuji M et al. | Effect of docosahexaenoic acid on intracellular calcium dynamics in vascular smooth muscle cells from normotensive and genetically hypertensive rats. | 1998 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:9920344 |
Kimura S et al. | Docosahexaenoic acid inhibits blood viscosity in stroke-prone spontaneously hypertensive rats. | 1998 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:9730013 |
Kimura S et al. | Ameliorative effects of docosahexaenoic acid on serum lipid changes in stroke-prone spontaneously hypertensive rats. | 1998 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:9644719 |
Portillo-Reyes V et al. | Clinical significance of neuropsychological improvement after supplementation with omega-3 in 8-12 years old malnourished Mexican children: a randomized, double-blind, placebo and treatment clinical trial. | 2014 | Res Dev Disabil | pmid:24508294 |
Sundrani D et al. | Matrix metalloproteinases-2, -3 and tissue inhibitors of metalloproteinases-1, -2 in placentas from preterm pregnancies and their association with one-carbon metabolites. | 2013 | Reproduction | pmid:23412981 |
Moallem U et al. | Dietary α-linolenic acid from flaxseed oil improved folliculogenesis and IVF performance in dairy cows, similar to eicosapentaenoic and docosahexaenoic acids from fish oil. | 2013 | Reproduction | pmid:24062566 |
Stark MJ et al. | Differential effects of docosahexaenoic acid on preterm and term placental pro-oxidant/antioxidant balance. | 2013 | Reproduction | pmid:23813449 |
Bender K et al. | Metabolite concentrations in follicular fluid may explain differences in fertility between heifers and lactating cows. | 2010 | Reproduction | pmid:20385782 |
Waterhouse KE et al. | Within and between breed differences in freezing tolerance and plasma membrane fatty acid composition of boar sperm. | 2006 | Reproduction | pmid:16672353 |
Alessandri JM et al. | Polyunsaturated fatty acids in the central nervous system: evolution of concepts and nutritional implications throughout life. | 2004 Nov-Dec | Reprod. Nutr. Dev. | pmid:15762297 |
Alessandri JM et al. | Polyunsaturated fatty acids status in blood, heart, liver, intestine, retina and brain of newborn piglets fed either sow milk or a milk replacer diet. | 1996 | Reprod. Nutr. Dev. | pmid:8881596 |
Lauritzen L et al. | Maternal fish oil supplementation in lactation: effect on developmental outcome in breast-fed infants. | 2005 Sep-Oct | Reprod. Nutr. Dev. | pmid:16188206 |
Young GS et al. | Effect of randomized supplementation with high dose olive, flax or fish oil on serum phospholipid fatty acid levels in adults with attention deficit hyperactivity disorder. | 2005 Sep-Oct | Reprod. Nutr. Dev. | pmid:16188207 |
Stillwell W et al. | Docosahexaenoic acid affects cell signaling by altering lipid rafts. | 2005 Sep-Oct | Reprod. Nutr. Dev. | pmid:16188208 |
Sergeeva M et al. | Regulation of intracellular calcium levels by polyunsaturated fatty acids, arachidonic acid and docosahexaenoic acid, in astrocytes: possible involvement of phospholipase A2. | 2005 Sep-Oct | Reprod. Nutr. Dev. | pmid:16188212 |
Burdge GC and Calder PC | Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults. | 2005 Sep-Oct | Reprod. Nutr. Dev. | pmid:16188209 |
Burdge GC et al. | Docosahexaenoic acid is selectively enriched in plasma phospholipids during pregnancy in Trinidadian women--results of a pilot study. | 2006 Jan-Feb | Reprod. Nutr. Dev. | pmid:16438916 |
Meher AP et al. | Preconceptional omega-3 fatty acid supplementation on a micronutrient-deficient diet improves the reproductive cycle in Wistar rats. | 2013 | Reprod. Fertil. Dev. | pmid:23137932 |
Kiernan M et al. | The effect of the in vitro supplementation of exogenous long-chain fatty acids on bovine sperm cell function. | 2013 | Reprod. Fertil. Dev. | pmid:23036717 |
Kaeoket K et al. | Effect of docosahexaenoic acid on quality of cryopreserved boar semen in different breeds. | 2010 | Reprod. Domest. Anim. | pmid:19090818 |
Alexopoulos E et al. | Treatment of severe IgA nephropathy with omega-3 fatty acids: the effect of a "very low dose" regimen. | 2004 | Ren Fail | pmid:15462115 |
Mariee AD and Abd-Ellah MF | Protective effect of docosahexaenoic acid against cyclosporine A-induced nephrotoxicity in rats: a possible mechanism of action. | 2011 | Ren Fail | pmid:21219208 |
Hammond BG et al. | Safety assessment of DHA-rich microalgae from Schizochytrium sp. | 2002 | Regul. Toxicol. Pharmacol. | pmid:12052009 |
Abril R et al. | Safety assessment of DHA-rich microalgae from Schizochytrium sp. Part V: target animal safety/toxicity study in growing swine. | 2003 | Regul. Toxicol. Pharmacol. | pmid:12662911 |
Hammond BG et al. | Safety assessment of DHA-rich microalgae from Schizochytrium sp. | 2001 | Regul. Toxicol. Pharmacol. | pmid:11350202 |
Hammond BG et al. | Safety assessment of DHA-rich microalgae from Schizochytrium sp. | 2001 | Regul. Toxicol. Pharmacol. | pmid:11350203 |
Blum R et al. | Genotoxicity and subchronic toxicity studies of DHA-rich oil in rats. | 2007 | Regul. Toxicol. Pharmacol. | pmid:17933446 |
Blum R et al. | One-generation reproductive toxicity study of DHA-rich oil in rats. | 2007 | Regul. Toxicol. Pharmacol. | pmid:17976878 |
Balestrieri GP et al. | Fish oil supplementation in patients with heterozygous familial hypercholesterolemia. | 1996 | Recenti Prog Med | pmid:8650428 |
Chen S and Chen R | Docosahexaenoic acid-containing phospholipids and triglycerides based nutritional supplements. | 2010 | Recent Pat Food Nutr Agric | pmid:20863272 |
Chen S | Highly pure phospholipids based brain docosahexaenoic acid transporters. | 2010 | Recent Pat CNS Drug Discov | pmid:19832689 |
Alves SP et al. | Acetonitrile covalent adduct chemical ionization tandem mass spectrometry of non-methylene-interrupted pentaene fatty acid methyl esters. | 2011 | Rapid Commun. Mass Spectrom. | pmid:21698676 |
Pacetti D et al. | High-performance liquid chromatography/electrospray ionization ion-trap tandem mass spectrometric analysis and quantification of phosphatidylcholine molecular species in the serum of cystic fibrosis subjects supplemented with docosahexaenoic acid. | 2004 | Rapid Commun. Mass Spectrom. | pmid:15386630 |
Wang B et al. | Resolvin D1 protects mice from LPS-induced acute lung injury. | 2011 | Pulm Pharmacol Ther | pmid:21501693 |
Lucas M et al. | Plasma n-3 fatty acids and psychological distress in aboriginal Cree Indians (Canada). | 2009 | Public Health Nutr | pmid:19243672 |
Abu-Saad K et al. | Rapid assessment tools for ranking pregnant minority women into multi-nutrient exposure groups. | 2011 | Public Health Nutr | pmid:20519048 |
Maqbool A et al. | The skinny on tuna fat: health implications. | 2011 | Public Health Nutr | pmid:21324226 |
Lucas M et al. | n-3 Fatty acid intake from marine food products among Quebecers: comparison to worldwide recommendations. | 2010 | Public Health Nutr | pmid:19433004 |
Mendez MA et al. | Maternal fish and other seafood intakes during pregnancy and child neurodevelopment at age 4 years. | 2009 | Public Health Nutr | pmid:19026093 |
Lucas M et al. | Validation of an FFQ for evaluation of EPA and DHA intake. | 2009 | Public Health Nutr | pmid:19102810 |
Conklin SM et al. | High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism. | 2007 | Psychosom Med | pmid:17991818 |
Amin AA et al. | Acute coronary syndrome patients with depression have low blood cell membrane omega-3 fatty acid levels. | 2008 | Psychosom Med | pmid:18842751 |
Kim HW et al. | Effects of chronic clozapine administration on markers of arachidonic acid cascade and synaptic integrity in rat brain. | 2012 | Psychopharmacology (Berl.) | pmid:22414961 |
Bazinet RP et al. | Valproic acid selectively inhibits conversion of arachidonic acid to arachidonoyl-CoA by brain microsomal long-chain fatty acyl-CoA synthetases: relevance to bipolar disorder. | 2006 | Psychopharmacology (Berl.) | pmid:16344985 |
Lee LK et al. | Docosahexaenoic acid-concentrated fish oil supplementation in subjects with mild cognitive impairment (MCI): a 12-month randomised, double-blind, placebo-controlled trial. | 2013 | Psychopharmacology (Berl.) | pmid:22932777 |
Bazinet RP et al. | Chronic valproate does not alter the kinetics of docosahexaenoic acid within brain phospholipids of the unanesthetized rat. | 2005 | Psychopharmacology (Berl.) | pmid:15986187 |
Mocking RJ et al. | Relationship between the hypothalamic-pituitary-adrenal-axis and fatty acid metabolism in recurrent depression. | 2013 | Psychoneuroendocrinology | pmid:23465556 |
McNamara RK et al. | Gender differences in rat erythrocyte and brain docosahexaenoic acid composition: role of ovarian hormones and dietary omega-3 fatty acid composition. | 2009 | Psychoneuroendocrinology | pmid:19046819 |