DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hypothyroidism D007037 32 associated lipids
Vision Disorders D014786 10 associated lipids
Melanoma D008545 69 associated lipids
Pain, Postoperative D010149 13 associated lipids
Asthma D001249 52 associated lipids
Kidney Diseases D007674 29 associated lipids
Weight Gain D015430 101 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Bone Diseases, Metabolic D001851 9 associated lipids
Obesity D009765 29 associated lipids
Thrombosis D013927 49 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Peritonitis D010538 38 associated lipids
Proteinuria D011507 30 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Refsum Disease D012035 19 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Carlo T and Levy BD Molecular circuits of resolution in airway inflammation. 2010 ScientificWorldJournal pmid:20623098
de Urquiza AM et al. Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain. 2000 Science pmid:11118147
Fernández-González R et al. Decontamination solutions for polychlorinated biphenyls (PCBs) in raw fish oils from environmentally contaminated sea fishes. 2014 Sci. Total Environ. pmid:24095964
Glomset JA Role of docosahexaenoic acid in neuronal plasma membranes. 2006 Sci. STKE pmid:16467193
Gough NR Focus issue: signaling lipids. 2006 Sci. STKE pmid:16467192
Li Q et al. Effect of docosahexaenoic acid on interleukin-2 receptor signaling pathway in lipid rafts. 2006 Sci. China, C, Life Sci. pmid:16544577
Sapieha P et al. 5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of ω-3 polyunsaturated fatty acids. 2011 Sci Transl Med pmid:21307302
Chen CT et al. Plasma non-esterified docosahexaenoic acid is the major pool supplying the brain. 2015 Sci Rep pmid:26511533
Dalli J et al. Novel n-3 immunoresolvents: structures and actions. 2013 Sci Rep pmid:23736886
Sharma S et al. High-fat diet transition reduces brain DHA levels associated with altered brain plasticity and behaviour. 2012 Sci Rep pmid:22666534
Wang CS et al. ALX/FPR2 Modulates Anti-Inflammatory Responses in Mouse Submandibular Gland. 2016 Sci Rep pmid:27064029
Schmitt Y and Schneider H [Effect of the administration of highly-unsaturated fatty acids on the parameters of lipoprotein metabolism and rheology of patients under chronic hemodialysis treatment]. 1991 Schweiz Med Wochenschr pmid:1836897
McNamara RK et al. Abnormalities in the fatty acid composition of the postmortem orbitofrontal cortex of schizophrenic patients: gender differences and partial normalization with antipsychotic medications. 2007 Schizophr. Res. pmid:17236749
Kale A et al. Opposite changes in predominantly docosahexaenoic acid (DHA) in cerebrospinal fluid and red blood cells from never-medicated first-episode psychotic patients. 2008 Schizophr. Res. pmid:17997280
Peet M et al. Two double-blind placebo-controlled pilot studies of eicosapentaenoic acid in the treatment of schizophrenia. 2001 Schizophr. Res. pmid:11356585
Ward PE et al. Niacin skin flush in schizophrenia: a preliminary report. 1998 Schizophr. Res. pmid:9516668
McNamara RK Omega-3 fatty acid deficiency: a preventable risk factor for schizophrenia? 2011 Schizophr. Res. pmid:21276713
Harper KN et al. Maternal serum docosahexaenoic acid and schizophrenia spectrum disorders in adult offspring. 2011 Schizophr. Res. pmid:21324652
McNamara RK et al. Chronic risperidone treatment preferentially increases rat erythrocyte and prefrontal cortex omega-3 fatty acid composition: evidence for augmented biosynthesis. 2009 Schizophr. Res. pmid:18993032
Medema S et al. Levels of Red Blood Cell Fatty Acids in Patients With Psychosis, Their Unaffected Siblings, and Healthy Controls. 2016 Schizophr Bull pmid:26385764
Westberg G and Tarkowski A Effect of MaxEPA in patients with SLE. A double-blind, crossover study. 1990 Scand. J. Rheumatol. pmid:2186476
Thusgaard M et al. Effect of fish oil (n-3 polyunsaturated fatty acids) on plasma lipids, lipoproteins and inflammatory markers in HIV-infected patients treated with antiretroviral therapy: a randomized, double-blind, placebo-controlled study. 2009 Scand. J. Infect. Dis. pmid:19685375
Khalfoun B et al. Docosahexaenoic and eicosapentaenoic acids inhibit human lymphoproliferative responses in vitro but not the expression of T cell surface activation markers. 1996 Scand. J. Immunol. pmid:8602457
Solakivi T et al. Serum fatty acid profile in subjects with irritable bowel syndrome. 2011 Scand. J. Gastroenterol. pmid:21073373
Andersson L et al. Hydrolysis of phosphatidylethanolamine by human pancreatic phospholipase A2. Effect of bile salts. 1994 Scand. J. Gastroenterol. pmid:8171289
Hexeberg S et al. Docosahexaenoic acid induces lipid accumulation in myocardial cells of rats. 1994 Scand. J. Clin. Lab. Invest. pmid:7709170
Hagve TA et al. Membrane fluidity and fatty acid metabolism in kidney cells from rats fed purified eicosapentaenoic acid or purified docosahexaenoic acid. 1998 Scand. J. Clin. Lab. Invest. pmid:9670342
Eritsland J et al. Long-term effects of n-3 fatty acids on serum lipids and glycaemic control. 1994 Scand. J. Clin. Lab. Invest. pmid:7939369
Foulon T et al. Effects of fish oil fatty acids on plasma lipids and lipoproteins and oxidant-antioxidant imbalance in healthy subjects. 1999 Scand. J. Clin. Lab. Invest. pmid:10463462
Schjøtt J et al. Infusion of EPA and DHA lipid emulsions: effects on heart lipids and tolerance to ischaemia-reperfusion in the isolated rat heart. 1993 Scand. J. Clin. Lab. Invest. pmid:8140399
Hagve TA et al. The decrease in osmotic fragility of erythrocytes during supplementation with n-3 fatty acids is a transient phenomenon. 1991 Scand. J. Clin. Lab. Invest. pmid:1835122
Carvajal O and Angulo O Effect of n-3 polyunsaturated fatty acids on the lipidic profile of healthy Mexican volunteers. 1997 May-Jun Salud Publica Mex pmid:9304226
Chetty N et al. Fatty acid composition of some South African fresh-water fish. 1989 S. Afr. Med. J. pmid:2552593
Buznikov GA et al. [Cholinergic regulation of the sea urchin embryonic and larval development]. 2001 Ross Fiziol Zh Im I M Sechenova pmid:11822358
Cardoso C et al. Methylmercury risks and EPA + DHA benefits associated with seafood consumption in Europe. 2010 Risk Anal. pmid:20604879
Yazawa K [Importance of "health foods", EPA and DHA, for preventive medicine]. 2004 Rinsho Byori pmid:15137325
Torres AG and Trugo NM Evidence of inadequate docosahexaenoic acid status in Brazilian pregnant and lactating women. 2009 Rev Saude Publica pmid:19287877
Wright AK et al. Slowly progressive dopamine cell loss--a model on which to test neuroprotective strategies for Parkinson's disease? 2009 Rev Neurosci pmid:19774787
Gutiérrez-Mata AP et al. [Neurological, neuropsychological, and ophthalmological evolution after one year of docosahexaenoic acid supplementation in phenylketonuric patients]. 2012 Rev Neurol pmid:22829083
Martínez M et al. [Treatment of generalized peroxisomal disorders with docosahexaenoic acid ethyl ether]. 1999 Rev Neurol pmid:10778491
Carratalá-Marco F et al. [The influence of docosahexaenoic acid and moderate perinatal hypoxia on the performance of one-month-old Wistar rats in a T-maze test]. 2010 Rev Neurol pmid:20669126
Maillard MH [Resolvins: new derivates of fatty acids, polyunsaturated (omega-3) with therapeutic potential in inflammatory intestinal diseases]. 2006 Rev Med Suisse pmid:17343155
López-Alarcón M et al. [The effect of docosahexaenoic acid on the loss of appetite in pediatric patients with pneumonia]. 2006 Jan-Feb Rev Med Inst Mex Seguro Soc pmid:16497254
Leon MM et al. [Resolution of inflammation--pharmacological aspects]. 2011 Apr-Jun Rev Med Chir Soc Med Nat Iasi pmid:21870743
Valenzuela A and Nieto MS [Docosahexaenoic acid (DHA) in fetal development and in infant nutrition]. 2001 Rev Med Chil pmid:11775350
Birch DG A randomized placebo-controlled clinical trial of docosahexaenoic acid (DHA) supplementation for X-linked retinitis pigmentosa. 2005 Retina (Philadelphia, Pa.) pmid:16374336
Spaide RF et al. Characterization of peroxidized lipids in Bruch's membrane. 1999 Retina (Philadelphia, Pa.) pmid:10213241
Gustavsson C et al. Inflammatory markers in nondiabetic and diabetic rat retinas exposed to ischemia followed by reperfusion. 2008 Retina (Philadelphia, Pa.) pmid:18398369
Aarsetøy H et al. Low levels of cellular omega-3 increase the risk of ventricular fibrillation during the acute ischaemic phase of a myocardial infarction. 2008 Resuscitation pmid:18556107
Liao Z et al. Resolvin D1 attenuates inflammation in lipopolysaccharide-induced acute lung injury through a process involving the PPARγ/NF-κB pathway. 2012 Respir. Res. pmid:23199346