DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
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What lipids are associated with DHA?
Related references are published most in these journals:
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What genes are associated with DHA?
Related references are published most in these journals:
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mustafa M et al. | Resolvin D1 protects periodontal ligament. | 2013 | Am. J. Physiol., Cell Physiol. | pmid:23864609 |
| Gelsomino G et al. | Omega 3 fatty acids chemosensitize multidrug resistant colon cancer cells by down-regulating cholesterol synthesis and altering detergent resistant membranes composition. | 2013 | Mol. Cancer | pmid:24225025 |
| Amminger GP et al. | Omega-3 fatty acid supplementation in adolescents with borderline personality disorder and ultra-high risk criteria for psychosis: a post hoc subgroup analysis of a double-blind, randomized controlled trial. | 2013 | Can J Psychiatry | pmid:23870722 |
| Milic I et al. | Simultaneous detection of low and high molecular weight carbonylated compounds derived from lipid peroxidation by electrospray ionization-tandem mass spectrometry. | 2013 | Anal. Chem. | pmid:23186270 |
| Mizwicki MT et al. | 1α,25-dihydroxyvitamin D3 and resolvin D1 retune the balance between amyloid-β phagocytosis and inflammation in Alzheimer's disease patients. | 2013 | J. Alzheimers Dis. | pmid:23186989 |
| Fiol-deRoque MA et al. | Cognitive recovery and restoration of cell proliferation in the dentate gyrus in the 5XFAD transgenic mice model of Alzheimer's disease following 2-hydroxy-DHA treatment. | 2013 | Biogerontology | pmid:24114505 |
| Olson MV et al. | Docosahexaenoic acid reduces inflammation and joint destruction in mice with collagen-induced arthritis. | 2013 | Inflamm. Res. | pmid:24008816 |
| Marze S et al. | In vitro digestion of fish oils rich in n-3 polyunsaturated fatty acids studied in emulsion and at the oil-water interface. | 2013 | Food Funct | pmid:23086175 |
| Isosapent ethyl (Vascepa) for severe hypertriglyceridemia. | 2013 | Med Lett Drugs Ther | pmid:23836343 | |
| Carlson SE et al. | DHA supplementation and pregnancy outcomes. | 2013 | Am. J. Clin. Nutr. | pmid:23426033 |
| Cartiff SE et al. | Eicosapentaenoic and docosahexaenoic acids increase insulin sensitivity in growing steers. | 2013 | J. Anim. Sci. | pmid:23463554 |
| McNamara RK | Deciphering the role of docosahexaenoic acid in brain maturation and pathology with magnetic resonance imaging. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22521863 |
| Raatz SK et al. | Dose-dependent consumption of farmed Atlantic salmon (Salmo salar) increases plasma phospholipid n-3 fatty acids differentially. | 2013 | J Acad Nutr Diet | pmid:23351633 |
| Goustard-Langelier B et al. | Rat neural stem cell proliferation and differentiation are durably altered by the in utero polyunsaturated fatty acid supply. | 2013 | J. Nutr. Biochem. | pmid:23036607 |
| Harris WS et al. | Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: observations from 160,000 patients. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23375840 |
| Arem H et al. | Omega-3 and omega-6 fatty acid intakes and endometrial cancer risk in a population-based case-control study. | 2013 | Eur J Nutr | pmid:22915050 |
| Mickleborough TD | Omega-3 polyunsaturated fatty acids in physical performance optimization. | 2013 | Int J Sport Nutr Exerc Metab | pmid:23400626 |
| Kim HY and Spector AA | Synaptamide, endocannabinoid-like derivative of docosahexaenoic acid with cannabinoid-independent function. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22959887 |
| Minihane AM | Fish oil omega-3 fatty acids and cardio-metabolic health, alone or with statins. | 2013 | Eur J Clin Nutr | pmid:23403872 |
| Wijendran V et al. | Dietary arachidonic acid and docosahexaenoic acid regulate liver fatty acid desaturase (FADS) alternative transcript expression in suckling piglets. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24075244 |
| Liu X et al. | Oxidized fatty acid analysis by charge-switch derivatization, selected reaction monitoring, and accurate mass quantitation. | 2013 | Anal. Biochem. | pmid:23850559 |
| Xu MX et al. | Resolvin D1, an endogenous lipid mediator for inactivation of inflammation-related signaling pathways in microglial cells, prevents lipopolysaccharide-induced inflammatory responses. | 2013 | CNS Neurosci Ther | pmid:23521911 |
| Zulyniak MA et al. | Fish oil supplementation alters circulating eicosanoid concentrations in young healthy men. | 2013 | Metab. Clin. Exp. | pmid:23522836 |
| Watson AM et al. | Taurine supplementation of plant derived protein and n-3 fatty acids are critical for optimal growth and development of cobia, Rachycentron canadum. | 2013 | Lipids | pmid:23884630 |
| Mocellin MC et al. | Fish oil decreases C-reactive protein/albumin ratio improving nutritional prognosis and plasma fatty acid profile in colorectal cancer patients. | 2013 | Lipids | pmid:23888317 |
| Zhang J et al. | Different intakes of n-3 fatty acids among pregnant women in 3 regions of China with contrasting dietary patterns are reflected in maternal but not in umbilical erythrocyte phosphatidylcholine fatty acid composition. | 2013 | Nutr Res | pmid:23890350 |
| Aslan M et al. | LC-MS/MS analysis of plasma polyunsaturated fatty acids in type 2 diabetic patients after insulin analog initiation therapy. | 2013 | Lipids Health Dis | pmid:24195588 |
| Liu Y et al. | Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge. | 2013 | J. Nutr. | pmid:23739309 |
| Parletta N et al. | Effects of fish oil supplementation on learning and behaviour of children from Australian Indigenous remote community schools: a randomised controlled trial. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23756346 |
| Juman S et al. | Effects of long-term oral administration of arachidonic acid and docosahexaenoic acid on the immune functions of young rats. | 2013 | Nutrients | pmid:23760060 |
| Shida T et al. | Colonic delivery of docosahexaenoic acid improves impaired glucose tolerance via GLP-1 secretion and suppresses pancreatic islet hyperplasia in diabetic KK-A(y) mice. | 2013 | Int J Pharm | pmid:23618969 |
| Berger H et al. | SOCS3 transactivation by PPARγ prevents IL-17-driven cancer growth. | 2013 | Cancer Res. | pmid:23619236 |
| Ravacci GR et al. | Lipid raft disruption by docosahexaenoic acid induces apoptosis in transformed human mammary luminal epithelial cells harboring HER-2 overexpression. | 2013 | J. Nutr. Biochem. | pmid:22749134 |
| Adler EM | Of fish oil, rafts, and scrambling things up. | 2013 | J. Gen. Physiol. | pmid:24277599 |
| Hashimoto M et al. | Prescription n-3 fatty acids, but not eicosapentaenoic acid alone, improve reference memory-related learning ability by increasing brain-derived neurotrophic factor levels in SHR.Cg-Lepr(cp)/NDmcr rats, a metabolic syndrome model. | 2013 | Neurochem. Res. | pmid:23963508 |
| Tabbaa M et al. | Docosahexaenoic acid, inflammation, and bacterial dysbiosis in relation to periodontal disease, inflammatory bowel disease, and the metabolic syndrome. | 2013 | Nutrients | pmid:23966110 |
| O'Sullivan BP et al. | Evolution of pancreatic function during the first year in infants with cystic fibrosis. | 2013 | J. Pediatr. | pmid:23245194 |
| Rincón Cervera Mà et al. | Acyl migration evaluation in monoacylglycerols from Echium plantagineum seed oil and Marinol. | 2013 | J. Biosci. Bioeng. | pmid:23287502 |
| Chen HW et al. | Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells. | 2013 | Arch. Toxicol. | pmid:23288142 |
| LluÃs L et al. | Protective effect of the omega-3 polyunsaturated fatty acids: Eicosapentaenoic acid/Docosahexaenoic acid 1:1 ratio on cardiovascular disease risk markers in rats. | 2013 | Lipids Health Dis | pmid:24083393 |
| Nikolakopoulou Z et al. | Omega-3 polyunsaturated fatty acids selectively inhibit growth in neoplastic oral keratinocytes by differentially activating ERK1/2. | 2013 | Carcinogenesis | pmid:23892603 |
| D'Souza V et al. | Counteracting oxidative stress in pregnancy through modulation of maternal micronutrients and omega-3 fatty acids. | 2013 | Curr. Med. Chem. | pmid:24274816 |
| Wu D et al. | Novel biphasic role of resolvin D1 on expression of cyclooxygenase-2 in lipopolysaccharide-stimulated lung fibroblasts is partly through PI3K/AKT and ERK2 pathways. | 2013 | Mediators Inflamm. | pmid:24174713 |
| Otsuka R et al. | Higher serum EPA or DHA, and lower ARA compositions with age independent fatty acid intake in Japanese aged 40 to 79. | 2013 | Lipids | pmid:23389403 |
| Barbadoro P et al. | Fish oil supplementation reduces cortisol basal levels and perceived stress: a randomized, placebo-controlled trial in abstinent alcoholics. | 2013 | Mol Nutr Food Res | pmid:23390041 |
| Phang M et al. | Eicosapentaenoic and docosahexaenoic acid supplementations reduce platelet aggregation and hemostatic markers differentially in men and women. | 2013 | J. Nutr. | pmid:23390192 |
| Kenchegowda S et al. | Involvement of pigment epithelium-derived factor, docosahexaenoic acid and neuroprotectin D1 in corneal inflammation and nerve integrity after refractive surgery. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22579364 |
| Delplanque B et al. | A dairy fat matrix providing alpha-linolenic acid (ALA) is better than a vegetable fat mixture to increase brain DHA accretion in young rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22884780 |
| Satkunendrarajah K and Fehlings MG | Do omega-3 polyunsaturated fatty acids ameliorate spinal cord injury?: Commentary on: Lim et al., Improved outcome after spinal cord compression injury in mice treated with docosahexaeonic acid. Exp. Neurol. Jan; 239:13-27. | 2013 | Exp. Neurol. | pmid:23994716 |
| Li Y et al. | Plasticity of leukocytic exudates in resolving acute inflammation is regulated by MicroRNA and proresolving mediators. | 2013 | Immunity | pmid:24238341 |