Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Lee SM et al. | Characterization of lecithin isolated from anchovy (Engraulis japonica) residues deoiled by supercritical carbon dioxide and organic solvent extraction. | 2012 | J. Food Sci. | pmid:22757698 |
Siriwardhana N et al. | Health benefits of n-3 polyunsaturated fatty acids: eicosapentaenoic acid and docosahexaenoic acid. | 2012 | Adv. Food Nutr. Res. | pmid:22361189 |
Keim SA et al. | Breastfeeding and long-chain polyunsaturated fatty acid intake in the first 4 post-natal months and infant cognitive development: an observational study. | 2012 | Matern Child Nutr | pmid:21615865 |
Ayas D et al. | The effects of season and sex on fat, fatty acids and protein contents of Sepia officinalis in the northeastern Mediterranean Sea. | 2012 | Int J Food Sci Nutr | pmid:22106841 |
Türkez H et al. | Ameliorative effect of docosahexaenoic acid on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced histological changes, oxidative stress, and DNA damage in rat liver. | 2012 | Toxicol Ind Health | pmid:21996711 |
Kelley DS et al. | Docosahexaenoic acid supplementation improved lipocentric but not glucocentric markers of insulin sensitivity in hypertriglyceridemic men. | 2012 | Metab Syndr Relat Disord | pmid:21999398 |
Murphy RA et al. | n-3 polyunsaturated fatty acids: the potential role for supplementation in cancer. | 2012 | Curr Opin Clin Nutr Metab Care | pmid:22366922 |
Larsen BM et al. | Pre-treatment with an intravenous lipid emulsion containing fish oil (eicosapentaenoic and docosahexaenoic acid) decreases inflammatory markers after open-heart surgery in infants: a randomized, controlled trial. | 2012 | Clin Nutr | pmid:22136963 |
Itoyama A et al. | Docosahexaenoic acid mediates peroxisomal elongation, a prerequisite for peroxisome division. | 2012 | J. Cell. Sci. | pmid:22389399 |
Phang M et al. | Acute supplementation with eicosapentaenoic acid reduces platelet microparticle activity in healthy subjects. | 2012 | J. Nutr. Biochem. | pmid:22137256 |
Ortiz-Alvarado O et al. | Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid in the management of hypercalciuric stone formers. | 2012 | Urology | pmid:22000931 |
Zhang MJ and Spite M | Resolvins: anti-inflammatory and proresolving mediators derived from omega-3 polyunsaturated fatty acids. | 2012 | Annu. Rev. Nutr. | pmid:22404117 |
Oliver E et al. | Docosahexaenoic acid attenuates macrophage-induced inflammation and improves insulin sensitivity in adipocytes-specific differential effects between LC n-3 PUFA. | 2012 | J. Nutr. Biochem. | pmid:22137266 |
Hall JC et al. | Docosahexaenoic acid, but not eicosapentaenoic acid, reduces the early inflammatory response following compression spinal cord injury in the rat. | 2012 | J. Neurochem. | pmid:22404382 |
Nakamoto K et al. | Involvement of the long-chain fatty acid receptor GPR40 as a novel pain regulatory system. | 2012 | Brain Res. | pmid:22137657 |
Ji A et al. | n-3 polyunsaturated fatty acids inhibit lipopolysaccharide-induced microglial activation and dopaminergic injury in rats. | 2012 | Neurotoxicology | pmid:22406923 |
Betancor MB et al. | Selenium inclusion decreases oxidative stress indicators and muscle injuries in sea bass larvae fed high-DHA microdiets. | 2012 | Br. J. Nutr. | pmid:22409905 |
Kim HW et al. | Effects of chronic clozapine administration on markers of arachidonic acid cascade and synaptic integrity in rat brain. | 2012 | Psychopharmacology (Berl.) | pmid:22414961 |
Eady TN et al. | Docosahexaenoic acid signaling modulates cell survival in experimental ischemic stroke penumbra and initiates long-term repair in young and aged rats. | 2012 | PLoS ONE | pmid:23118851 |
Jørgensen MH et al. | Long-chain PUFA in granulocytes, mononuclear cells, and RBC in patients with cystic fibrosis: relation to liver disease. | 2012 | J. Pediatr. Gastroenterol. Nutr. | pmid:22241510 |
Galli C et al. | Bioequivalence of two omega-3 fatty acid ethyl ester formulations: a case of clinical pharmacology of dietary supplements. | 2012 | Br J Clin Pharmacol | pmid:22242645 |
Fedor DM et al. | Docosahexaenoic acid prevents trans-10, cis-12-conjugated linoleic acid-induced nonalcoholic fatty liver disease in mice by altering expression of hepatic genes regulating fatty acid synthesis and oxidation. | 2012 | Metab Syndr Relat Disord | pmid:22242926 |
Gutiérrez-Mata AP et al. | [Neurological, neuropsychological, and ophthalmological evolution after one year of docosahexaenoic acid supplementation in phenylketonuric patients]. | 2012 | Rev Neurol | pmid:22829083 |
Lockyer S et al. | SATgenε dietary model to implement diets of differing fat composition in prospectively genotyped groups (apoE) using commercially available foods. | 2012 | Br. J. Nutr. | pmid:22243632 |
Peyronnet R et al. | Mechanoprotection by polycystins against apoptosis is mediated through the opening of stretch-activated K(2P) channels. | 2012 | Cell Rep | pmid:22832196 |
Stanley WC et al. | Update on lipids and mitochondrial function: impact of dietary n-3 polyunsaturated fatty acids. | 2012 | Curr Opin Clin Nutr Metab Care | pmid:22248591 |
Damiano F et al. | Citrate carrier promoter is target of peroxisome proliferator-activated receptor alpha and gamma in hepatocytes and adipocytes. | 2012 | Int. J. Biochem. Cell Biol. | pmid:22249025 |
Will BrainStrong boost your brain? | 2012 | Consum Rep | pmid:22891387 | |
Shabrani NC et al. | Polyunsaturated fatty acids confer cryoresistance on megakaryocytes generated from cord blood and also enhance megakaryocyte production from cryopreserved cord blood cells. | 2012 | Cytotherapy | pmid:22250991 |
Shearer GC et al. | Effects of prescription niacin and omega-3 fatty acids on lipids and vascular function in metabolic syndrome: a randomized controlled trial. | 2012 | J. Lipid Res. | pmid:22892157 |
Lauritzen L et al. | Fish intake, erythrocyte n-3 fatty acid status and metabolic health in Danish adolescent girls and boys. | 2012 | Br. J. Nutr. | pmid:21736784 |
Isobe Y et al. | Identification and structure determination of novel anti-inflammatory mediator resolvin E3, 17,18-dihydroxyeicosapentaenoic acid. | 2012 | J. Biol. Chem. | pmid:22275352 |
Yetimler B et al. | Differential effect of age on the brain fatty acid levels and their correlation with animal cognitive status in mice. | 2012 | Pharmacol. Biochem. Behav. | pmid:22878041 |
Macášek J et al. | Plasma fatty acid composition in patients with pancreatic cancer: correlations to clinical parameters. | 2012 | Nutr Cancer | pmid:23061902 |
Betancor MB et al. | Vitamin C enhances vitamin E status and reduces oxidative stress indicators in sea bass larvae fed high DHA microdiets. | 2012 | Lipids | pmid:23086553 |
Hou L et al. | Reduction of n-3 PUFAs, specifically DHA and EPA, and enhancement of peroxisomal beta-oxidation in type 2 diabetic rat heart. | 2012 | Cardiovasc Diabetol | pmid:23057715 |
Pineda-Peña EA et al. | Docosahexaenoic acid, an omega-3 polyunsaturated acid protects against indomethacin-induced gastric injury. | 2012 | Eur. J. Pharmacol. | pmid:23063544 |
Giudetti AM and Cagnazzo R | Beneficial effects of n-3 PUFA on chronic airway inflammatory diseases. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:23064030 |
Vedtofte MS et al. | The role of essential fatty acids in the control of coronary heart disease. | 2012 | Curr Opin Clin Nutr Metab Care | pmid:23037902 |
Molloy C et al. | Docosahexaenoic acid and visual functioning in preterm infants: a review. | 2012 | Neuropsychol Rev | pmid:23065239 |
Burillo E et al. | Omega-3 fatty acids and HDL. How do they work in the prevention of cardiovascular disease? | 2012 | Curr Vasc Pharmacol | pmid:22339302 |
Serhan CN et al. | Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain. | 2012 | FASEB J. | pmid:22253477 |
Sundrani DP et al. | Matrix metalloproteinase-1 and -9 in human placenta during spontaneous vaginal delivery and caesarean sectioning in preterm pregnancy. | 2012 | PLoS ONE | pmid:22253805 |
Bragt MC and Mensink RP | Comparison of the effects of n-3 long chain polyunsaturated fatty acids and fenofibrate on markers of inflammation and vascular function, and on the serum lipoprotein profile in overweight and obese subjects. | 2012 | Nutr Metab Cardiovasc Dis | pmid:21429719 |
Tian H et al. | 14S,21R-dihydroxy-docosahexaenoic acid treatment enhances mesenchymal stem cell amelioration of renal ischemia/reperfusion injury. | 2012 | Stem Cells Dev. | pmid:21846180 |
Ruan D and So SP | Screening and identification of dietary oils and unsaturated fatty acids in inhibiting inflammatory prostaglandin E2 signaling in fat stromal cells. | 2012 | BMC Complement Altern Med | pmid:22938033 |
Contreras GA et al. | Enhanced n-3 phospholipid content reduces inflammatory responses in bovine endothelial cells. | 2012 | J. Dairy Sci. | pmid:23040031 |
Park Y et al. | N-3 polyunsaturated fatty acid consumption produces neurobiological effects associated with prevention of depression in rats after the forced swimming test. | 2012 | J. Nutr. Biochem. | pmid:21852084 |
Finlin BS et al. | DHA reduces the atrophy-associated Fn14 protein in differentiated myotubes during coculture with macrophages. | 2012 | J. Nutr. Biochem. | pmid:21852085 |
Skender B et al. | Docosahexaenoic fatty acid (DHA) in the regulation of colon cell growth and cell death: a review. | 2012 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub | pmid:23069883 |
Xue B et al. | Omega-3 polyunsaturated fatty acids antagonize macrophage inflammation via activation of AMPK/SIRT1 pathway. | 2012 | PLoS ONE | pmid:23071533 |
Kisos H et al. | Increased neuronal α-synuclein pathology associates with its accumulation in oligodendrocytes in mice modeling α-synucleinopathies. | 2012 | PLoS ONE | pmid:23077527 |
Martin N et al. | Primary human airway epithelial cell-dependent inhibition of human lung mast cell degranulation. | 2012 | PLoS ONE | pmid:22970103 |
Richardson AJ et al. | Docosahexaenoic acid for reading, cognition and behavior in children aged 7-9 years: a randomized, controlled trial (the DOLAB Study). | 2012 | PLoS ONE | pmid:22970149 |
Rasti B et al. | Comparative study of the oxidative and physical stability of liposomal and nanoliposomal polyunsaturated fatty acids prepared with conventional and Mozafari methods. | 2012 | Food Chem | pmid:22980870 |
Sauerwald UC et al. | Effect of different levels of docosahexaenoic acid supply on fatty acid status and linoleic and α-linolenic acid conversion in preterm infants. | 2012 | J. Pediatr. Gastroenterol. Nutr. | pmid:22008957 |
Moore RL et al. | Oxidative stability of an extended shelf-life dairy-based beverage system designed to contribute to heart health. | 2012 | J. Dairy Sci. | pmid:22981572 |
Adolph S et al. | Unsaturated fatty acids promote the phagocytosis of P. aeruginosa and R. equi by RAW264.7 macrophages. | 2012 | Curr. Microbiol. | pmid:22903555 |
Dalli J and Serhan CN | Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators. | 2012 | Blood | pmid:22904297 |
Dong PS et al. | [Effects of docosahexaenoic acid on ion channels of rat coronary artery smooth muscle cells]. | 2012 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:22883096 |
Kuang YL et al. | Regulation of the expression of key genes involved in HDL metabolism by unsaturated fatty acids. | 2012 | Br. J. Nutr. | pmid:22221450 |
Yakunin E et al. | Α-synuclein neuropathology is controlled by nuclear hormone receptors and enhanced by docosahexaenoic acid in a mouse model for Parkinson's disease. | 2012 | Brain Pathol. | pmid:21929559 |
Thomas T et al. | The effect of a 1-year multiple micronutrient or n-3 fatty acid fortified food intervention on morbidity in Indian school children. | 2012 | Eur J Clin Nutr | pmid:22009072 |
Stough C et al. | The effects of 90-day supplementation with the omega-3 essential fatty acid docosahexaenoic acid (DHA) on cognitive function and visual acuity in a healthy aging population. | 2012 | Neurobiol. Aging | pmid:21531481 |
Connor S et al. | DHA supplementation enhances high-frequency, stimulation-induced synaptic transmission in mouse hippocampus. | 2012 | Appl Physiol Nutr Metab | pmid:22716290 |
Angulo J et al. | Effects of polyunsaturated fatty acids from plant oils and algae on milk fat yield and composition are associated with mammary lipogenic and SREBF1 gene expression. | 2012 | Animal | pmid:22717104 |
Basak S and Duttaroy AK | Leptin induces tube formation in first-trimester extravillous trophoblast cells. | 2012 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:22717511 |
Motter AL and Ahern GP | TRPA1 is a polyunsaturated fatty acid sensor in mammals. | 2012 | PLoS ONE | pmid:22723860 |
Sirot V et al. | A restricted cubic spline approach to assess the association between high fat fish intake and red blood cell EPA + DHA content. | 2012 | Nutr Metab Cardiovasc Dis | pmid:20875947 |
Dornstauder B et al. | Dietary docosahexaenoic acid supplementation prevents age-related functional losses and A2E accumulation in the retina. | 2012 | Invest. Ophthalmol. Vis. Sci. | pmid:22427551 |
de Goede J et al. | Gender-specific associations of marine n-3 fatty acids and fish consumption with 10-year incidence of stroke. | 2012 | PLoS ONE | pmid:22496770 |
Huang LT et al. | Fatty acid composition of 12 fish species from the Black Sea. | 2012 | J. Food Sci. | pmid:22497457 |
Turan D et al. | Production of human milk fat analogue containing docosahexaenoic and arachidonic acids. | 2012 | J. Agric. Food Chem. | pmid:22497589 |
Donohue MC and Aisen PS | Mixed model of repeated measures versus slope models in Alzheimer's disease clinical trials. | 2012 | J Nutr Health Aging | pmid:22499459 |
Rosa DD et al. | Fish oil improves the lipid profile and reduces inflammatory cytokines in Wistar rats with precancerous colon lesions. | 2012 | Nutr Cancer | pmid:22483364 |
Norling LV et al. | Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions. | 2012 | Arterioscler. Thromb. Vasc. Biol. | pmid:22499990 |
Zhang G et al. | Erythrocyte n-3 fatty acids and metabolic syndrome in middle-aged and older Chinese. | 2012 | J. Clin. Endocrinol. Metab. | pmid:22456621 |
Cunningham E | Are krill oil supplements a better source of n-3 fatty acids than fish oil supplements? | 2012 | J Acad Nutr Diet | pmid:22459227 |
da Silva Acosta D et al. | Fullerene and omega-3 and omega-6 fatty acids on fish brain antioxidant status. | 2012 | Fish Physiol. Biochem. | pmid:22451341 |
Du Q et al. | Dairy fat blends high in α-linolenic acid are superior to n-3 fatty-acid-enriched palm oil blends for increasing DHA levels in the brains of young rats. | 2012 | J. Nutr. Biochem. | pmid:22445803 |
Tanigai T et al. | Docosahexaenoic acid exerts anti-inflammatory action on human eosinophils through peroxisome proliferator-activated receptor-independent mechanisms. | 2012 | Int. Arch. Allergy Immunol. | pmid:22487606 |
Smink W et al. | Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs. | 2012 | Animal | pmid:22436184 |
Jiang LH et al. | Pure docosahexaenoic acid can improve depression behaviors and affect HPA axis in mice. | 2012 | Eur Rev Med Pharmacol Sci | pmid:23208960 |
Sigal LH | Basic science for the clinician 59: polymorphonuclear cells: mechanisms in human defense and in the pathogenesis of autoimmune disease. | 2012 | J Clin Rheumatol | pmid:23211587 |
Duda MK | [Polyunsaturated fatty acids omega-3 as modulators of intracellular signaling pathways]. | 2012 | Postepy Biochem. | pmid:23214138 |
Zheng JS et al. | Low docosahexaenoic acid content in plasma phospholipids is associated with increased non-alcoholic fatty liver disease in China. | 2012 | Lipids | pmid:22527845 |
Jin F et al. | Supplementation of milled chia seeds increases plasma ALA and EPA in postmenopausal women. | 2012 | Plant Foods Hum Nutr | pmid:22538527 |
Patterson AC et al. | Biomarker and dietary validation of a Canadian food frequency questionnaire to measure eicosapentaenoic and docosahexaenoic acid intakes from whole food, functional food, and nutraceutical sources. | 2012 | J Acad Nutr Diet | pmid:22583924 |
Sahin N et al. | A novel nutritional supplement containing chromium picolinate, phosphatidylserine, docosahexaenoic acid, and boron activates the antioxidant pathway Nrf2/HO-1 and protects the brain against oxidative stress in high-fat-fed rats. | 2012 | Nutr Neurosci | pmid:23232054 |
Balakumar P and Taneja G | Fish oil and vascular endothelial protection: bench to bedside. | 2012 | Free Radic. Biol. Med. | pmid:22584102 |
Mandal CC et al. | miR-21 is targeted by omega-3 polyunsaturated fatty acid to regulate breast tumor CSF-1 expression. | 2012 | Carcinogenesis | pmid:22678116 |
Harris WS et al. | Changes in erythrocyte membrane trans and marine fatty acids between 1999 and 2006 in older Americans. | 2012 | J. Nutr. | pmid:22623386 |
GarcÃa-RodrÃguez CE et al. | Plasma inflammatory and vascular homeostasis biomarkers increase during human pregnancy but are not affected by oily fish intake. | 2012 | J. Nutr. | pmid:22623389 |
Rossmeisl M et al. | Metabolic effects of n-3 PUFA as phospholipids are superior to triglycerides in mice fed a high-fat diet: possible role of endocannabinoids. | 2012 | PLoS ONE | pmid:22701720 |
Xiong A et al. | Distinct roles of different forms of vitamin E in DHA-induced apoptosis in triple-negative breast cancer cells. | 2012 | Mol Nutr Food Res | pmid:22707267 |
Carter JR et al. | Fish oil and neurovascular control in humans. | 2012 | Am. J. Physiol. Heart Circ. Physiol. | pmid:22707560 |
Milte CM et al. | Eicosapentaenoic and docosahexaenoic acids, cognition, and behavior in children with attention-deficit/hyperactivity disorder: a randomized controlled trial. | 2012 | Nutrition | pmid:22541055 |
Sharma S et al. | High-fat diet transition reduces brain DHA levels associated with altered brain plasticity and behaviour. | 2012 | Sci Rep | pmid:22666534 |
Tang X et al. | Short term effects of different omega-3 fatty acid formulation on lipid metabolism in mice fed high or low fat diet. | 2012 | Lipids Health Dis | pmid:22676394 |
Settimio R et al. | Resolvin D1 reduces the immunoinflammatory response of the rat eye following uveitis. | 2012 | Mediators Inflamm. | pmid:23304060 |