Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Barceló-Coblijn G and Murphy EJ | Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: benefits for human health and a role in maintaining tissue n-3 fatty acid levels. | 2009 | Prog. Lipid Res. | pmid:19619583 |
Frisardi V et al. | Glycerophospholipids and glycerophospholipid-derived lipid mediators: a complex meshwork in Alzheimer's disease pathology. | 2011 | Prog. Lipid Res. | pmid:21703303 |
Cunnane SC et al. | Fish, docosahexaenoic acid and Alzheimer's disease. | 2009 | Prog. Lipid Res. | pmid:19362576 |
Bougnoux P et al. | Fatty acids and breast cancer: sensitization to treatments and prevention of metastatic re-growth. | 2010 | Prog. Lipid Res. | pmid:19715726 |
Valentine RC and Valentine DL | Omega-3 fatty acids in cellular membranes: a unified concept. | 2004 | Prog. Lipid Res. | pmid:15458813 |
Giusto NM et al. | Lipid metabolism in vertebrate retinal rod outer segments. | 2000 | Prog. Lipid Res. | pmid:10856601 |
Elsherbiny ME et al. | Interaction of brain fatty acid-binding protein with the polyunsaturated fatty acid environment as a potential determinant of poor prognosis in malignant glioma. | 2013 | Prog. Lipid Res. | pmid:23981365 |
Poudyal H et al. | Omega-3 fatty acids and metabolic syndrome: effects and emerging mechanisms of action. | 2011 | Prog. Lipid Res. | pmid:21762726 |
Lauritzen L et al. | The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina. | 2001 Jan-Mar | Prog. Lipid Res. | pmid:11137568 |
Venegas-Calerón M et al. | An alternative to fish oils: Metabolic engineering of oil-seed crops to produce omega-3 long chain polyunsaturated fatty acids. | 2010 | Prog. Lipid Res. | pmid:19857520 |
Domenichiello AF et al. | Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain? | 2015 | Prog. Lipid Res. | pmid:25920364 |
Wetzel MG et al. | Fatty acid metabolism in normal miniature poodles and those affected with progressive rod-cone degeneration (prcd). | 1989 | Prog. Clin. Biol. Res. | pmid:2532748 |
Karanian JW et al. | Cardiovascular properties of hydroxylated docosahexaenoates. | 1989 | Prog. Clin. Biol. Res. | pmid:2529554 |
Bazan NG | The metabolism of omega-3 polyunsaturated fatty acids in the eye: the possible role of docosahexaenoic acid and docosanoids in retinal physiology and ocular pathology. | 1989 | Prog. Clin. Biol. Res. | pmid:2529559 |
Martinez M | Treatment with docosahexaenoic acid favorably modifies the fatty acid composition of erythrocytes in peroxisomal patients. | 1992 | Prog. Clin. Biol. Res. | pmid:1438383 |
Huang WH et al. | Control of the sodium pump by liponucleotides and unsaturated fatty acids: side-dependent effects in red cells. | 1988 | Prog. Clin. Biol. Res. | pmid:2851818 |
Organisciak DT et al. | Aspects of the ascorbate protective mechanism in retinal light damage of rats with normal and reduced ROS docosahexaenoic acid. | 1987 | Prog. Clin. Biol. Res. | pmid:2960984 |
Judé S et al. | Dietary long-chain omega-3 fatty acids of marine origin: a comparison of their protective effects on coronary heart disease and breast cancers. | 2006 Jan-Apr | Prog. Biophys. Mol. Biol. | pmid:16005051 |
Uauy-Dagach R and Valenzuela A | Marine oils as a source of omega-3 fatty acids in the diet: how to optimize the health benefits. | 1992 | Prog Food Nutr Sci | pmid:1438808 |
Nishio K et al. | Novel water-soluble derivatives of docosahexaenoic acid increase diacylglycerol production mediated by phosphatidylcholine-specific phospholipase C. | 1993 | Proc. Soc. Exp. Biol. Med. | pmid:8389049 |
Engler MM et al. | Docosahexaenoic acid is an antihypertensive nutrient that affects aldosterone production in SHR. | 1999 | Proc. Soc. Exp. Biol. Med. | pmid:10320629 |
Jenski LJ et al. | Omega-3 fatty acid-containing liposomes in cancer therapy. | 1995 | Proc. Soc. Exp. Biol. Med. | pmid:8539260 |
Xiao YF et al. | Single point mutations affect fatty acid block of human myocardial sodium channel alpha subunit Na+ channels. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11248125 |
Vreugdenhil M et al. | Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8901621 |
Salem N et al. | Arachidonic and docosahexaenoic acids are biosynthesized from their 18-carbon precursors in human infants. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8552667 |
Freedman SD et al. | A membrane lipid imbalance plays a role in the phenotypic expression of cystic fibrosis in cftr(-/-) mice. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10570187 |
Farkas T et al. | Docosahexaenoic acid-containing phospholipid molecular species in brains of vertebrates. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10823917 |
He C et al. | Improved spatial learning performance of fat-1 mice is associated with enhanced neurogenesis and neuritogenesis by docosahexaenoic acid. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19549874 |
Hoshi T et al. | Omega-3 fatty acids lower blood pressure by directly activating large-conductance Ca²âº-dependent K⺠channels. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23487785 |
Hoshi T et al. | Mechanism of the modulation of BK potassium channel complexes with different auxiliary subunit compositions by the omega-3 fatty acid DHA. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23487786 |
Abdulnour RE et al. | Maresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25369934 |
Mukherjee PK et al. | Photoreceptor outer segment phagocytosis attenuates oxidative stress-induced apoptosis with concomitant neuroprotectin D1 synthesis. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17670935 |
Mukherjee PK et al. | Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17670936 |
Pepe S et al. | Omega 3 polyunsaturated fatty acid modulates dihydropyridine effects on L-type Ca2+ channels, cytosolic Ca2+, and contraction in adult rat cardiac myocytes. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7522322 |
Scott BL and Bazan NG | Membrane docosahexaenoate is supplied to the developing brain and retina by the liver. | 1989 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2523075 |
Barceló-Coblijn G et al. | Modification by docosahexaenoic acid of age-induced alterations in gene expression and molecular composition of rat brain phospholipids. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:13679584 |
Norris PC and Dennis EA | Omega-3 fatty acids cause dramatic changes in TLR4 and purinergic eicosanoid signaling. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22586114 |
Zhang G et al. | Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23553837 |
Kang JX and Leaf A | Effects of long-chain polyunsaturated fatty acids on the contraction of neonatal rat cardiac myocytes. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7937911 |
Massaro M et al. | The omega-3 fatty acid docosahexaenoate attenuates endothelial cyclooxygenase-2 induction through both NADP(H) oxidase and PKC epsilon inhibition. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17018645 |
Krishnamoorthy S et al. | Resolvin D1 binds human phagocytes with evidence for proresolving receptors. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20080636 |
Mukherjee PK et al. | Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15152078 |
Berger A et al. | Anandamide and diet: inclusion of dietary arachidonate and docosahexaenoate leads to increased brain levels of the corresponding N-acylethanolamines in piglets. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11353819 |
Jones CN et al. | Microfluidic chambers for monitoring leukocyte trafficking and humanized nano-proresolving medicines interactions. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23185003 |
Corey EJ et al. | Docosahexaenoic acid is a strong inhibitor of prostaglandin but not leukotriene biosynthesis. | 1983 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6304720 |
Fredman G et al. | Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25246560 |
Harris WS et al. | Docosahexaenoic acid ethyl esters ineffective? | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23671065 |
Kang JX et al. | Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7732020 |
Akbar M et al. | Docosahexaenoic acid: a positive modulator of Akt signaling in neuronal survival. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16040805 |
Hoshi T et al. | Reply to Harris et al.: Differential impacts of omega-3 fatty acids and their derivatives on blood pressure. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23940844 |
Kitajka K et al. | The role of n-3 polyunsaturated fatty acids in brain: modulation of rat brain gene expression by dietary n-3 fatty acids. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11880617 |
Fontes-Villalba M et al. | African hominin stable isotopic data do not necessarily indicate grass consumption. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24062471 |
Ruyle M et al. | Placental transfer of essential fatty acids in humans: venous-arterial difference for docosahexaenoic acid in fetal umbilical erythrocytes. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2146677 |
Honoré E et al. | External blockade of the major cardiac delayed-rectifier K+ channel (Kv1.5) by polyunsaturated fatty acids. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8127910 |
Bruno MJ et al. | Docosahexaenoic acid alters bilayer elastic properties. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17535898 |
Billman GE et al. | Prevention of ischemia-induced ventricular fibrillation by omega 3 fatty acids. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8183925 |
Mori TA | Dietary n-3 PUFA and CVD: a review of the evidence. | 2014 | Proc Nutr Soc | pmid:24119287 |
von Schacky C | n-3 PUFA in CVD: influence of cytokine polymorphism. | 2007 | Proc Nutr Soc | pmid:17466099 |
Sijben JW and Calder PC | Differential immunomodulation with long-chain n-3 PUFA in health and chronic disease. | 2007 | Proc Nutr Soc | pmid:17466105 |
Hennebelle M et al. | Ageing and apoE change DHA homeostasis: relevance to age-related cognitive decline. | 2014 | Proc Nutr Soc | pmid:24103099 |
Anil E | The impact of EPA and DHA on blood lipids and lipoprotein metabolism: influence of apoE genotype. | 2007 | Proc Nutr Soc | pmid:17343773 |
Morris MC | Nutritional determinants of cognitive aging and dementia. | 2012 | Proc Nutr Soc | pmid:22067138 |
Ian Givens D and Gibbs RA | Current intakes of EPA and DHA in European populations and the potential of animal-derived foods to increase them. | 2008 | Proc Nutr Soc | pmid:18498671 |
Childs CE et al. | Gender differences in the n-3 fatty acid content of tissues. | 2008 | Proc Nutr Soc | pmid:18234128 |
Calder PC | Dietary modification of inflammation with lipids. | 2002 | Proc Nutr Soc | pmid:12296294 |
Yaqoob P | Fatty acids and the immune system: from basic science to clinical applications. | 2004 | Proc Nutr Soc | pmid:15070442 |
Wainwright PE | Dietary essential fatty acids and brain function: a developmental perspective on mechanisms. | 2002 | Proc Nutr Soc | pmid:12002796 |
Spite M | Deciphering the role of n-3 polyunsaturated fatty acid-derived lipid mediators in health and disease. | 2013 | Proc Nutr Soc | pmid:23991833 |
Cottin SC et al. | The differential effects of EPA and DHA on cardiovascular risk factors. | 2011 | Proc Nutr Soc | pmid:21349231 |
Williams CM and Burdge G | Long-chain n-3 PUFA: plant v. marine sources. | 2006 | Proc Nutr Soc | pmid:16441943 |
Gibbs RA et al. | Postgraduate Symposium: Long-chain n-3 PUFA: intakes in the UK and the potential of a chicken meat prototype to increase them. | 2010 | Proc Nutr Soc | pmid:19954567 |
Calder PC | Long-chain fatty acids and inflammation. | 2012 | Proc Nutr Soc | pmid:22369781 |
Kelley DS and Adkins Y | Similarities and differences between the effects of EPA and DHA on markers of atherosclerosis in human subjects. | 2012 | Proc Nutr Soc | pmid:22369859 |
Muramatsu T et al. | Higher dietary intake of alpha-linolenic acid is associated with lower insulin resistance in middle-aged Japanese. | 2010 May-Jun | Prev Med | pmid:20211645 |
Gomez-Pinilla F | The combined effects of exercise and foods in preventing neurological and cognitive disorders. | 2011 | Prev Med | pmid:21281667 |
Mourek J | Metabolic syndrome (does it have a common denominator?). | 2008 | Prague Med Rep | pmid:19548590 |
Houston L | Dietary change in arthritis. | 1994 | Practitioner | pmid:8208662 |
Du M et al. | Effects of dietary conjugated linoleic acid and linoleic:linolenic acid ratio on polyunsaturated fatty acid status in laying hens. | 2000 | Poult. Sci. | pmid:11194037 |
Pappas AC et al. | Maternal organo-selenium compounds and polyunsaturated fatty acids affect progeny performance and levels of selenium and docosahexaenoic acid in the chick tissues. | 2006 | Poult. Sci. | pmid:16977847 |
Meluzzi A et al. | Effects of dietary vitamin E on the quality of table eggs enriched with n-3 long-chain fatty acids. | 2000 | Poult. Sci. | pmid:10780651 |
Carrillo-DomÃnguez S et al. | Cholesterol and n-3 and n-6 fatty acid content in eggs from laying hens fed with red crab meal (Pleuroncodes planipes). | 2005 | Poult. Sci. | pmid:15685957 |
Ko YH et al. | Cloning and expression of Tsaiya duck liver fatty acid binding protein. | 2004 | Poult. Sci. | pmid:15554058 |
Grobas S et al. | Influence of source and percentage of fat added to diet on performance and fatty acid composition of egg yolks of two strains of laying hens. | 2001 | Poult. Sci. | pmid:11495470 |
Cherian G and Sim J | Preferential accumulation of n-3 fatty acids in the brain of chicks from eggs enriched with n-3 fatty acids. | 1992 | Poult. Sci. | pmid:1454683 |
Ding ST and Lilburn MS | Changes in fatty acid profiles in different lipid classes during late development of turkey embryos from two genetic lines. | 1997 | Poult. Sci. | pmid:9181615 |
Santos GA and Silversides FG | Utilization of the sex-linked gene for imperfect albinism (S*ALS). 1. Effect of early weight loss on chick metabolism. | 1996 | Poult. Sci. | pmid:8933584 |
Herber SM and Van Elswyk ME | Dietary marine algae promotes efficient deposition of n-3 fatty acids for the production of enriched shell eggs. | 1996 | Poult. Sci. | pmid:9000275 |
Surai PF and Sparks NH | Tissue-specific fatty acid and alpha-tocopherol profiles in male chickens depending on dietary tuna oil and vitamin E provision. | 2000 | Poult. Sci. | pmid:10947182 |
Koppenol A et al. | Effect of the ratio of dietary n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid on broiler breeder performance, egg quality, and yolk fatty acid composition at different breeder ages. | 2014 | Poult. Sci. | pmid:24604849 |
Bou R et al. | Effect of dietary fat sources and zinc and selenium supplements on the composition and consumer acceptability of chicken meat. | 2005 | Poult. Sci. | pmid:16050130 |
López-Ferrer S et al. | n-3 enrichment of chicken meat. 1. Use of very long-chain fatty acids in chicken diets and their influence on meat quality: fish oil. | 2001 | Poult. Sci. | pmid:11441841 |
Wang YW et al. | Maternal dietary N-3 fatty acids alter the spleen fatty acid composition and bovine serum albumin-induced wing web swelling in broilers. | 2002 | Poult. Sci. | pmid:12455601 |
Cherian G et al. | Dietary conjugated linoleic acid with fish oil alters yolk n-3 and trans fatty acid content and volatile compounds in raw, cooked, and irradiated eggs. | 2002 | Poult. Sci. | pmid:12412926 |
Allen PC and Danforth HD | Effects of dietary supplementation with n-3 fatty acid ethyl esters on coccidiosis in chickens. | 1998 | Poult. Sci. | pmid:9835336 |
Gao YC and Charter EA | Nutritionally important fatty acids in hen egg yolks from different sources. | 2000 | Poult. Sci. | pmid:10875777 |
Szabó A et al. | Differential utilization of hepatic and myocardial fatty acids during forced molt of laying hens. | 2005 | Poult. Sci. | pmid:15685949 |
Crandell JR et al. | Lipid effects of switching from prescription EPA+DHA (omega-3-acid ethyl esters) to prescription EPA only (icosapent ethyl) in dyslipidemic patients. | 2016 | Postgrad Med | pmid:27684412 |
Leaf DA | Omega-3 fatty acids and coronary artery disease. More than a fish tale. | 1989 | Postgrad Med | pmid:2542914 |
Sadovsky R and Kris-Etherton P | Prescription omega-3-acid ethyl esters for the treatment of very high triglycerides. | 2009 | Postgrad Med | pmid:19641280 |
Harris WS et al. | Omega-3 fatty acids and cardiovascular disease: new developments and applications. | 2013 | Postgrad Med | pmid:24200766 |