Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Reardon HT et al. | Dietary long-chain polyunsaturated fatty acids upregulate expression of FADS3 transcripts. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22398025 |
Zhang J et al. | Characteristics of fatty acid distribution is associated with colorectal cancer prognosis. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23465412 |
Hegarty B and Parker G | Fish oil as a management component for mood disorders - an evolving signal. | 2013 | Curr Opin Psychiatry | pmid:23108232 |
Ren LJ et al. | Impact of phosphate concentration on docosahexaenoic acid production and related enzyme activities in fermentation of Schizochytrium sp. | 2013 | Bioprocess Biosyst Eng | pmid:23108442 |
Jansen D et al. | Effects of specific multi-nutrient enriched diets on cerebral metabolism, cognition and neuropathology in AβPPswe-PS1dE9 mice. | 2013 | PLoS ONE | pmid:24086523 |
Abdelmoaty S et al. | Spinal actions of lipoxin A4 and 17(R)-resolvin D1 attenuate inflammation-induced mechanical hypersensitivity and spinal TNF release. | 2013 | PLoS ONE | pmid:24086560 |
Stamey Lanier J et al. | Mammary uptake of fatty acids supplied by intravenous triacylglycerol infusion to lactating dairy cows. | 2013 | Lipids | pmid:23504269 |
Bazan NG et al. | Docosahexaenoic acid and its derivative neuroprotectin D1 display neuroprotective properties in the retina, brain and central nervous system. | 2013 | Nestle Nutr Inst Workshop Ser | pmid:24107502 |
Lindberg M et al. | Long-term tracking of plasma phospholipid fatty acid concentrations and their correlation with the dietary intake of marine foods in newly diagnosed diabetic patients: results from a follow-up of the HUNT Study, Norway. | 2013 | Br. J. Nutr. | pmid:22846205 |
MacLean E et al. | n-3 Fatty acids inhibit transcription of human IL-13: implications for development of T helper type 2 immune responses. | 2013 | Br. J. Nutr. | pmid:22849952 |
Hajjaji N and Bougnoux P | Selective sensitization of tumors to chemotherapy by marine-derived lipids: a review. | 2013 | Cancer Treat. Rev. | pmid:22850619 |
Paz-Raymundo B et al. | Effect of DHA on the expression of the delta6-desaturase during larval development of yellow snapper, Lutjanus argentiventris. | 2013 | Commun. Agric. Appl. Biol. Sci. | pmid:25141709 |
Lapillonne A et al. | Lipid needs of preterm infants: updated recommendations. | 2013 | J. Pediatr. | pmid:23445847 |
West AA et al. | Choline intake influences phosphatidylcholine DHA enrichment in nonpregnant women but not in pregnant women in the third trimester. | 2013 | Am. J. Clin. Nutr. | pmid:23446897 |
Miyata J et al. | Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma. | 2013 | J. Allergy Clin. Immunol. | pmid:23006546 |
Randall KM et al. | Effects of dietary supplementation of coriander oil, in canola oil diets, on the metabolism of [1-(14)C] 18:3n-3 and [1-(14)C] 18:2n-6 in rainbow trout hepatocytes. | 2013 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:23867781 |
Ammann EM et al. | ω-3 fatty acids and domain-specific cognitive aging: secondary analyses of data from WHISCA. | 2013 | Neurology | pmid:24068783 |
Araújo JR et al. | Gestational diabetes mellitus decreases placental uptake of long-chain polyunsaturated fatty acids: involvement of long-chain acyl-CoA synthetase. | 2013 | J. Nutr. Biochem. | pmid:23790250 |
Russell KL et al. | Low brain DHA content worsens sensorimotor outcomes after TBI and decreases TBI-induced Timp1 expression in juvenile rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23796971 |
Xue Z et al. | Production of omega-3 eicosapentaenoic acid by metabolic engineering of Yarrowia lipolytica. | 2013 | Nat. Biotechnol. | pmid:23873085 |
Pase MP and Stough C | Describing a taxonomy of cognitive processes for clinical trials assessing cognition. | 2013 | Am. J. Clin. Nutr. | pmid:23873682 |
Aarak KE et al. | Release of EPA and DHA from salmon oil - a comparison of in vitro digestion with human and porcine gastrointestinal enzymes. | 2013 | Br. J. Nutr. | pmid:23510480 |
Stonehouse W et al. | DHA supplementation improved both memory and reaction time in healthy young adults: a randomized controlled trial. | 2013 | Am. J. Clin. Nutr. | pmid:23515006 |
Fagan P and Wijesundera C | Rapid isolation of omega-3 long-chain polyunsaturated fatty acids using monolithic high performance liquid chromatography columns. | 2013 | J Sep Sci | pmid:23559561 |
Jans JJ et al. | Supplementation with a powdered blend of PUFAs normalizes DHA and AA levels in patients with PKU. | 2013 | Mol. Genet. Metab. | pmid:23562298 |
Decsi T and Boehm G | trans Isomeric fatty acids are inversely related to the availability of long-chain PUFAs in the perinatal period. | 2013 | Am. J. Clin. Nutr. | pmid:23824720 |
Lundström SL et al. | Lipid mediator serum profiles in asthmatics significantly shift following dietary supplementation with omega-3 fatty acids. | 2013 | Mol Nutr Food Res | pmid:23824870 |
Lohner S et al. | Lower n-3 long-chain polyunsaturated fatty acid values in patients with phenylketonuria: a systematic review and meta-analysis. | 2013 | Nutr Res | pmid:23827125 |
Kelly OJ et al. | Long-chain polyunsaturated fatty acids may mutually benefit both obesity and osteoporosis. | 2013 | Nutr Res | pmid:23827126 |
Meyer BJ et al. | Improvement of major depression is associated with increased erythrocyte DHA. | 2013 | Lipids | pmid:23733443 |
Zawadzki M et al. | Perna canaliculus lipid complex PCSO-524â„¢ demonstrated pain relief for osteoarthritis patients benchmarked against fish oil, a randomized trial, without placebo control. | 2013 | Mar Drugs | pmid:23739042 |
Xu ZZ et al. | Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma. | 2013 | Ann. Neurol. | pmid:23686636 |
Flock MR et al. | Immunometabolic role of long-chain omega-3 fatty acids in obesity-induced inflammation. | 2013 | Diabetes Metab. Res. Rev. | pmid:23592441 |
Nagachinta S and Akoh CC | Synthesis of structured lipid enriched with omega fatty acids and sn-2 palmitic acid by enzymatic esterification and its incorporation in powdered infant formula. | 2013 | J. Agric. Food Chem. | pmid:23597247 |
Gordon WC and Bazan NG | Mediator lipidomics in ophthalmology: targets for modulation in inflammation, neuroprotection and nerve regeneration. | 2013 | Curr. Eye Res. | pmid:23981028 |
Elsherbiny ME et al. | Interaction of brain fatty acid-binding protein with the polyunsaturated fatty acid environment as a potential determinant of poor prognosis in malignant glioma. | 2013 | Prog. Lipid Res. | pmid:23981365 |
Wang Y et al. | DHA inhibits protein degradation more efficiently than EPA by regulating the PPARγ/NFκB pathway in C2C12 myotubes. | 2013 | Biomed Res Int | pmid:23984342 |
Chien KL et al. | Comparison of predictive performance of various fatty acids for the risk of cardiovascular disease events and all-cause deaths in a community-based cohort. | 2013 | Atherosclerosis | pmid:23958266 |
van der Merwe LF et al. | Long-chain PUFA supplementation in rural African infants: a randomized controlled trial of effects on gut integrity, growth, and cognitive development. | 2013 | Am. J. Clin. Nutr. | pmid:23221579 |
Betancor MB et al. | Physiological pathways involved in nutritional muscle dystrophy and healing in European sea bass (Dicentrarchus labrax) larvae. | 2013 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:23202658 |
Das UN | Autism as a disorder of deficiency of brain-derived neurotrophic factor and altered metabolism of polyunsaturated fatty acids. | 2013 | Nutrition | pmid:23911220 |
Wu BT et al. | Low fish intake is associated with low blood concentrations of vitamin D, choline and n-3 DHA in pregnant women. | 2013 | Br. J. Nutr. | pmid:22691303 |
Flock MR et al. | Determinants of erythrocyte omega-3 fatty acid content in response to fish oil supplementation: a dose-response randomized controlled trial. | 2013 | J Am Heart Assoc | pmid:24252845 |
Sofi F et al. | The atherosclerotic risk profile is affected differently by fish flesh with a similar EPA and DHA content but different n-6/n-3 ratio. | 2013 | Asia Pac J Clin Nutr | pmid:23353608 |
McEwen BJ et al. | Effects of omega-3 polyunsaturated fatty acids on platelet function in healthy subjects and subjects with cardiovascular disease. | 2013 | Semin. Thromb. Hemost. | pmid:23329646 |
Turk HF et al. | Inhibitory effects of omega-3 fatty acids on injury-induced epidermal growth factor receptor transactivation contribute to delayed wound healing. | 2013 | Am. J. Physiol., Cell Physiol. | pmid:23426968 |
Sun SN et al. | Docosahexaenoic acid (DHA) induces apoptosis in human hepatocellular carcinoma cells. | 2013 | Int J Clin Exp Pathol | pmid:23330014 |
Uhl O et al. | Changes of molecular glycerophospholipid species in plasma and red blood cells during docosahexaenoic acid supplementation. | 2013 | Lipids | pmid:24043586 |
Aliche-Djoudi F et al. | A role for lipid rafts in the protection afforded by docosahexaenoic acid against ethanol toxicity in primary rat hepatocytes. | 2013 | Food Chem. Toxicol. | pmid:23907024 |
Thom VT et al. | Regulation of ecto-5´-nucleotidase by docosahexaenoic acid in human endothelial cells. | 2013 | Cell. Physiol. Biochem. | pmid:23988425 |