Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Marcheselli VL et al. | Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression. | 2003 | J. Biol. Chem. | pmid:12923200 |
Gu X et al. | Carboxyethylpyrrole protein adducts and autoantibodies, biomarkers for age-related macular degeneration. | 2003 | J. Biol. Chem. | pmid:12923198 |
Dallongeville J et al. | Fish consumption is associated with lower heart rates. | 2003 | Circulation | pmid:12912821 |
Meyer A et al. | Biosynthesis of docosahexaenoic acid in Euglena gracilis: biochemical and molecular evidence for the involvement of a Delta4-fatty acyl group desaturase. | 2003 | Biochemistry | pmid:12911321 |
Trebble T et al. | Inhibition of tumour necrosis factor-alpha and interleukin 6 production by mononuclear cells following dietary fish-oil supplementation in healthy men and response to antioxidant co-supplementation. | 2003 | Br. J. Nutr. | pmid:12908901 |
Sekine S et al. | Dietary docosahexaenoic acid-induced production of tissue lipid peroxides is not suppressed by higher intake of ascorbic acid in genetically scorbutic Osteogenic Disorder Shionogi/Shi-od/od rats. | 2003 | Br. J. Nutr. | pmid:12908899 |
Burdge GC et al. | Effect of altered dietary n-3 fatty acid intake upon plasma lipid fatty acid composition, conversion of [13C]alpha-linolenic acid to longer-chain fatty acids and partitioning towards beta-oxidation in older men. | 2003 | Br. J. Nutr. | pmid:12908891 |
Tiangson CL et al. | Docosahexaenoic acid level of the breast milk of some Filipino women. | 2003 | Int J Food Sci Nutr | pmid:12907409 |
Otto SJ et al. | Increased risk of postpartum depressive symptoms is associated with slower normalization after pregnancy of the functional docosahexaenoic acid status. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12907133 |
Mashek DG and Grummer RR | Effects of long chain fatty acids on lipid and glucose metabolism in monolayer cultures of bovine hepatocytes. | 2003 | J. Dairy Sci. | pmid:12906057 |
Agostoni C and Verduci E | DHA in pregnancy benefits child development. | 2003 | Pediatr. Res. | pmid:12904586 |
Mickleborough TD et al. | Fish oil supplementation reduces severity of exercise-induced bronchoconstriction in elite athletes. | 2003 | Am. J. Respir. Crit. Care Med. | pmid:12904324 |
Ruiz-Meana M and GarcÃa-Dorado D | Direct myocardial effects of fish oil on ischemia-reperfusion injury. Beyond lipid membrane composition? | 2003 | Cardiovasc. Res. | pmid:12903630 |
Miyazawa D et al. | Dietary alpha-linolenic acid suppresses the formation of lysophosphatidic acid, a lipid mediator, in rat platelets compared with linoleic acid. | 2003 | Life Sci. | pmid:12899931 |
Ferdinandusse S et al. | Studies on the metabolic fate of n-3 polyunsaturated fatty acids. | 2003 | J. Lipid Res. | pmid:12897190 |
Hu SX and Yang JN | [Biological effects of docosahexaenoic acid on the retina]. | 2003 | Zhonghua Yan Ke Za Zhi | pmid:12894762 |
Ajuyah AO et al. | Maternal diet with diverse omega-6/omega-3 ratio affects the brain docosahexaenoic acid content of growing chickens. | 2003 | Biol. Neonate | pmid:12890936 |
Bellamy CM et al. | Can supplementation of diet with omega-3 polyunsaturated fatty acids reduce coronary angioplasty restenosis rate? | 1992 | Eur. Heart J. | pmid:1289091 |
Malcolm CA et al. | Scotopic electroretinogram in term infants born of mothers supplemented with docosahexaenoic acid during pregnancy. | 2003 | Invest. Ophthalmol. Vis. Sci. | pmid:12882824 |
Yuri T et al. | Dietary docosahexaenoic acid suppresses N-methyl-N-nitrosourea-induced mammary carcinogenesis in rats more effectively than eicosapentaenoic acid. | 2003 | Nutr Cancer | pmid:12881016 |
Heard CM et al. | The in vitro delivery of NSAIDs across skin was in proportion to the delivery of essential fatty acids in the vehicle--evidence that solutes permeate skin associated with their solvation cages? | 2003 | Int J Pharm | pmid:12878406 |
Ponder DL et al. | Docosahexaenoic acid status of term infants fed breast milk or infant formula containing soy oil or corn oil. | 1992 | Pediatr. Res. | pmid:1287559 |
Rodemer C et al. | Inactivation of ether lipid biosynthesis causes male infertility, defects in eye development and optic nerve hypoplasia in mice. | 2003 | Hum. Mol. Genet. | pmid:12874108 |
Morris MC et al. | Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. | 2003 | Arch. Neurol. | pmid:12873849 |
Moriguchi K et al. | Dietary docosahexaenoic acid protects against N-methyl-N-nitrosourea-induced retinal degeneration in rats. | 2003 | Exp. Eye Res. | pmid:12873446 |
Véricel E et al. | Pro- and antioxidant activities of docosahexaenoic acid on human blood platelets. | 2003 | J. Thromb. Haemost. | pmid:12871467 |
Lee JY et al. | Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids. | 2003 | J. Biol. Chem. | pmid:12865424 |
Lagarde M et al. | Pathophysiologic role of redox status in blood platelet activation. Influence of docosahexaenoic acid. | 2003 | Lipids | pmid:12848295 |
Gawrisch K et al. | The structure of DHA in phospholipid membranes. | 2003 | Lipids | pmid:12848292 |
Mitchell DC et al. | Enhancement of G protein-coupled signaling by DHA phospholipids. | 2003 | Lipids | pmid:12848291 |
Cleland LG et al. | A biomarker of n-3 compliance in patients taking fish oil for rheumatoid arthritis. | 2003 | Lipids | pmid:12848288 |
Visioli F et al. | Dietary intake of fish vs. formulations leads to higher plasma concentrations of n-3 fatty acids. | 2003 | Lipids | pmid:12848287 |
Smuts CM et al. | High-DHA eggs: feasibility as a means to enhance circulating DHA in mother and infant. | 2003 | Lipids | pmid:12848286 |
Dewailly E et al. | Fish consumption and blood lipids in three ethnic groups of Québec (Canada). | 2003 | Lipids | pmid:12848280 |
Crawford MA et al. | The potential role for arachidonic and docosahexaenoic acids in protection against some central nervous system injuries in preterm infants. | 2003 | Lipids | pmid:12848275 |
Fan YY et al. | Chemopreventive n-3 fatty acids activate RXRalpha in colonocytes. | 2003 | Carcinogenesis | pmid:12844485 |
Montgomery C et al. | Maternal docosahexaenoic acid supplementation and fetal accretion. | 2003 | Br. J. Nutr. | pmid:12844385 |
Strokin M et al. | Docosahexaenoic acid and arachidonic acid release in rat brain astrocytes is mediated by two separate isoforms of phospholipase A2 and is differently regulated by cyclic AMP and Ca2+. | 2003 | Br. J. Pharmacol. | pmid:12839876 |
Hoffman DR et al. | Visual function in breast-fed term infants weaned to formula with or without long-chain polyunsaturates at 4 to 6 months: a randomized clinical trial. | 2003 | J. Pediatr. | pmid:12838196 |
Högyes E et al. | Neuroprotective effect of developmental docosahexaenoic acid supplement against excitotoxic brain damage in infant rats. | 2003 | Neuroscience | pmid:12831859 |
Speake BK et al. | Distribution of lipids from the yolk to the tissues during development of the water python (Liasis fuscus). | 2003 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:12827419 |
Qian SY et al. | Identification of spin trapped carbon-centered radicals in soybean lipoxygenase-dependent peroxidations of omega-3 polyunsaturated fatty acids by LC/ESR, LC/MS, and tandem MS. | 2003 | Free Radic. Biol. Med. | pmid:12826254 |
Rojas CV et al. | Gene expression analysis in human fetal retinal explants treated with docosahexaenoic acid. | 2003 | Invest. Ophthalmol. Vis. Sci. | pmid:12824268 |
Chen H et al. | EPA and DHA attenuate ox-LDL-induced expression of adhesion molecules in human coronary artery endothelial cells via protein kinase B pathway. | 2003 | J. Mol. Cell. Cardiol. | pmid:12818567 |
Erkkilä AT et al. | n-3 Fatty acids and 5-y risks of death and cardiovascular disease events in patients with coronary artery disease. | 2003 | Am. J. Clin. Nutr. | pmid:12816772 |
Judé S et al. | Peroxidation of docosahexaenoic acid is responsible for its effects on I TO and I SS in rat ventricular myocytes. | 2003 | Br. J. Pharmacol. | pmid:12813005 |
Wang Z | Role of redox state in modulation of ion channel function by fatty acids and phospholipids. | 2003 | Br. J. Pharmacol. | pmid:12812990 |
Ng R | Fish oil therapy in recurrent IgA nephropathy. | 2003 | Ann. Intern. Med. | pmid:12809474 |
Hulbert AJ | Life, death and membrane bilayers. | 2003 | J. Exp. Biol. | pmid:12796449 |
Clements KM et al. | Spontaneously hypertensive and Wistar Kyoto rats differ in delayed matching-to-place performance and response to dietary long-chain polyunsaturated fatty acids. | 2003 | Dev Psychobiol | pmid:12794779 |
pmid:12794672 | ||||
Rodriguez A et al. | Preterm infant formula supplementation with alpha linolenic acid and docosahexaenoic acid. | 2003 | Eur J Clin Nutr | pmid:12792656 |
Del Castillo IC et al. | Docosahexaenoic acid selectively augments muscarinic stimulation of epithelial Cl- secretion. | 2003 | J. Surg. Res. | pmid:12788663 |
Youssef JA et al. | Age-independent, gray matter-localized, brain-enhanced oxidative stress in male fischer 344 rats: brain levels of F(2)-isoprostanes and F(4)-neuroprostanes. | 2003 | Free Radic. Biol. Med. | pmid:12788483 |
Eldho NV et al. | Polyunsaturated docosahexaenoic vs docosapentaenoic acid-differences in lipid matrix properties from the loss of one double bond. | 2003 | J. Am. Chem. Soc. | pmid:12785780 |
Torres CF et al. | Lipase-catalyzed ethanolysis of fish oils: multi-response kinetics. | 2003 | Biotechnol. Bioeng. | pmid:12783483 |
Beck S et al. | Potentiation of tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation. | 2003 | J. Biol. Chem. | pmid:12782627 |
Barceló-Coblijn G et al. | Gene expression and molecular composition of phospholipids in rat brain in relation to dietary n-6 to n-3 fatty acid ratio. | 2003 | Biochim. Biophys. Acta | pmid:12782153 |
Harel M and Place AR | Tissue essential fatty acid composition and competitive response to dietary manipulations in white bass (Morone chrysops), striped bass (M. saxatilis) and hybrid striped bass (M. chrysopsxM. saxatilis). | 2003 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:12781976 |
de Swaaf ME et al. | Analysis of docosahexaenoic acid biosynthesis in Crypthecodinium cohnii by 13C labelling and desaturase inhibitor experiments. | 2003 | J. Biotechnol. | pmid:12770501 |
Yusufi AN et al. | Differential effects of low-dose docosahexaenoic acid and eicosapentaenoic acid on the regulation of mitogenic signaling pathways in mesangial cells. | 2003 | J. Lab. Clin. Med. | pmid:12761475 |
Sano Y et al. | A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord. | 2003 | J. Biol. Chem. | pmid:12754259 |
Llorente AM et al. | Effect of maternal docosahexaenoic acid supplementation on postpartum depression and information processing. | 2003 | Am. J. Obstet. Gynecol. | pmid:12748510 |
Armstrong VT et al. | Rapid flip-flop in polyunsaturated (docosahexaenoate) phospholipid membranes. | 2003 | Arch. Biochem. Biophys. | pmid:12745257 |
Almansa E et al. | Temperature-activity relationship for the intestinal Na+-K+-ATPase of Sparus aurata. A role for the phospholipid microenvironment? | 2003 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:12743726 |
Mashek DG and Grummer RR | Short communication: Net uptake of nonesterified long chain fatty acids by the perfused caudate lobe of the caprine liver. | 2003 | J. Dairy Sci. | pmid:12741546 |
Merritt RJ et al. | Safety evaluation of sources of docosahexaenoic acid and arachidonic acid for use in infant formulas in newborn piglets. | 2003 | Food Chem. Toxicol. | pmid:12738195 |
Gu X et al. | Oxidatively truncated docosahexaenoate phospholipids: total synthesis, generation, and Peptide adduction chemistry. | 2003 | J. Org. Chem. | pmid:12737551 |
Sarkadi-Nagy E et al. | The influence of prematurity and long chain polyunsaturate supplementation in 4-week adjusted age baboon neonate brain and related tissues. | 2003 | Pediatr. Res. | pmid:12736388 |
Cha MC et al. | Dietary docosahexaenoic acid levels influence the outcome of arabinosylcytosine chemotherapy in L1210 leukemic mice. | 2002 | Nutr Cancer | pmid:12734065 |
Sumino H et al. | Effects of hormone replacement therapy on circulating docosahexaenoic acid and eicosapentaenoic acid levels in postmenopausal women. | 2003 | Endocr. J. | pmid:12733709 |
Thorpe M | Infant formula supplemented with DHA: are there benefits? | 2003 | J Am Diet Assoc | pmid:12733531 |
Berry CB and McBean GJ | An investigation into the role of calcium in the modulation of rat synaptosomal D-[3H]aspartate transport by docosahexaenoic acid. | 2003 | Brain Res. | pmid:12729959 |
Inagaki K et al. | Evidence of isozymes for delta6 fatty acid desaturase in rat hepatocytes. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12729021 |
Marangell LB et al. | A double-blind, placebo-controlled study of the omega-3 fatty acid docosahexaenoic acid in the treatment of major depression. | 2003 | Am J Psychiatry | pmid:12727707 |
Li H et al. | [Effect of fish oil supplementation on fatty acid composition and neurotransmitters of growing rats]. | 2000 | Wei Sheng Yan Jiu | pmid:12725043 |
Mattos R et al. | Polyunsaturated fatty acids and bovine interferon-tau modify phorbol ester-induced secretion of prostaglandin F2 alpha and expression of prostaglandin endoperoxide synthase-2 and phospholipase-A2 in bovine endometrial cells. | 2003 | Biol. Reprod. | pmid:12724278 |
Wallace FA et al. | Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects. | 2003 | Br. J. Nutr. | pmid:12720588 |
Kew S et al. | Lack of effect of foods enriched with plant- or marine-derived n-3 fatty acids on human immune function. | 2003 | Am. J. Clin. Nutr. | pmid:12716684 |
James MJ et al. | Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids. | 2003 | Am. J. Clin. Nutr. | pmid:12716664 |
Rotstein NP et al. | Protective effect of docosahexaenoic acid on oxidative stress-induced apoptosis of retina photoreceptors. | 2003 | Invest. Ophthalmol. Vis. Sci. | pmid:12714668 |
Insua MF et al. | Cell cycle regulation in retinal progenitors by glia-derived neurotrophic factor and docosahexaenoic acid. | 2003 | Invest. Ophthalmol. Vis. Sci. | pmid:12714666 |
Pass the fish (oil capsules), please. Following the latest recommendations from the American Heart Association may mean reaching for fish oil supplements. | 2003 | Harv Heart Lett | pmid:12711572 | |
Horrobin D et al. | The effects on plasma, red cell and platelet fatty acids of taking 12 g/day of ethyl-eicosapentaenoate for 16 months: dihomogammalinolenic, arachidonic and docosahexaenoic acids and relevance to Inuit metabolism. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12711245 |
Mansour MP et al. | The effect of growth phase on the lipid class, fatty acid and sterol composition in the marine dinoflagellate, Gymnodinium sp. in batch culture. | 2003 | Phytochemistry | pmid:12711135 |
Wright TC et al. | Effect of combinations of fish meal and feather meal on milk fatty acid content and nitrogen utilization in dairy cows. | 2003 | J. Dairy Sci. | pmid:12703623 |
[Additional omega-3-fatty acids. Infarct mortality gets reduced]. | 2003 | MMW Fortschr Med | pmid:12688033 | |
Komatsu W et al. | Docosahexaenoic acid suppresses nitric oxide production and inducible nitric oxide synthase expression in interferon-gamma plus lipopolysaccharide-stimulated murine macrophages by inhibiting the oxidative stress. | 2003 | Free Radic. Biol. Med. | pmid:12684085 |
Wu FC et al. | Dietary docosahexaenoic acid is more optimal than eicosapentaenoic acid affecting the level of cellular defence responses of the juvenile grouper Epinephelus malabaricus. | 2003 | Fish Shellfish Immunol. | pmid:12681278 |
Koo WW | Efficacy and safety of docosahexaenoic acid and arachidonic acid addition to infant formulas: can one buy better vision and intelligence? | 2003 | J Am Coll Nutr | pmid:12672705 |
Meireles LA et al. | Lipid class composition of the microalga Pavlova lutheri: eicosapentaenoic and docosahexaenoic acids. | 2003 | J. Agric. Food Chem. | pmid:12670163 |
Youssef J et al. | Pantothenic acid: an organ-specific pro-oxidant vitamin. Brain and liver neuroprostane levels in rats fed a pantothenic acid-deficient diet. | 2002 | Adv. Exp. Med. Biol. | pmid:12664639 |
Reich EE et al. | Formation of novel D-ring and E-ring isoprostane-like compounds (D4/E4-neuroprostanes) in vivo from docosahexaenoic acid. | 2002 | Adv. Exp. Med. Biol. | pmid:12664634 |
Djoussé L et al. | Dietary linolenic acid and carotid atherosclerosis: the National Heart, Lung, and Blood Institute Family Heart Study. | 2003 | Am. J. Clin. Nutr. | pmid:12663278 |
Finnegan YE et al. | Plant- and marine-derived n-3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects. | 2003 | Am. J. Clin. Nutr. | pmid:12663273 |
Abril R et al. | Safety assessment of DHA-rich microalgae from Schizochytrium sp. Part V: target animal safety/toxicity study in growing swine. | 2003 | Regul. Toxicol. Pharmacol. | pmid:12662911 |
Nesbitt GH et al. | Effect of n-3 fatty acid ratio and dose on clinical manifestations, plasma fatty acids and inflammatory mediators in dogs with pruritus. | 2003 | Vet. Dermatol. | pmid:12662263 |
de Swaaf ME et al. | Fed-batch cultivation of the docosahexaenoic-acid-producing marine alga Crypthecodinium cohnii on ethanol. | 2003 | Appl. Microbiol. Biotechnol. | pmid:12658513 |
Okada M et al. | How does prolonged caloric restriction ameliorate age-related impairment of long-term potentiation in the hippocampus? | 2003 | Brain Res. Mol. Brain Res. | pmid:12654517 |
Tully AM et al. | Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case-control study. | 2003 | Br. J. Nutr. | pmid:12654166 |