Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Reardon HT et al. | Dietary long-chain polyunsaturated fatty acids upregulate expression of FADS3 transcripts. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22398025 |
Offman E et al. | Steady-state bioavailability of prescription omega-3 on a low-fat diet is significantly improved with a free fatty acid formulation compared with an ethyl ester formulation: the ECLIPSE II study. | 2013 | Vasc Health Risk Manag | pmid:24124374 |
Mirza M et al. | Progressive retinal degeneration and glial activation in the CLN6 (nclf) mouse model of neuronal ceroid lipofuscinosis: a beneficial effect of DHA and curcumin supplementation. | 2013 | PLoS ONE | pmid:24124525 |
Daak AA et al. | Docosahexaenoic and eicosapentaenoic acid supplementation does not exacerbate oxidative stress or intravascular haemolysis in homozygous sickle cell patients. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24095588 |
Hegarty B and Parker G | Fish oil as a management component for mood disorders - an evolving signal. | 2013 | Curr Opin Psychiatry | pmid:23108232 |
Ren LJ et al. | Impact of phosphate concentration on docosahexaenoic acid production and related enzyme activities in fermentation of Schizochytrium sp. | 2013 | Bioprocess Biosyst Eng | pmid:23108442 |
MacLean E et al. | n-3 Fatty acids inhibit transcription of human IL-13: implications for development of T helper type 2 immune responses. | 2013 | Br. J. Nutr. | pmid:22849952 |
Hajjaji N and Bougnoux P | Selective sensitization of tumors to chemotherapy by marine-derived lipids: a review. | 2013 | Cancer Treat. Rev. | pmid:22850619 |
Tang Y et al. | Proresolution therapy for the treatment of delayed healing of diabetic wounds. | 2013 | Diabetes | pmid:23043160 |
Gillingham LG et al. | Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition. | 2013 | Am. J. Clin. Nutr. | pmid:23221573 |
Maskrey BH et al. | Emerging importance of omega-3 fatty acids in the innate immune response: molecular mechanisms and lipidomic strategies for their analysis. | 2013 | Mol Nutr Food Res | pmid:23417926 |
Lapillonne A et al. | Lipid needs of preterm infants: updated recommendations. | 2013 | J. Pediatr. | pmid:23445847 |
West AA et al. | Choline intake influences phosphatidylcholine DHA enrichment in nonpregnant women but not in pregnant women in the third trimester. | 2013 | Am. J. Clin. Nutr. | pmid:23446897 |
Snodgrass RG et al. | Inflammasome-mediated secretion of IL-1β in human monocytes through TLR2 activation; modulation by dietary fatty acids. | 2013 | J. Immunol. | pmid:24043885 |
Correia M et al. | Crosstalk between Helicobacter pylori and gastric epithelial cells is impaired by docosahexaenoic acid. | 2013 | PLoS ONE | pmid:23577140 |
Weise C et al. | Dietary polyunsaturated fatty acids and non-digestible oligosaccharides reduce dermatitis in mice. | 2013 | Pediatr Allergy Immunol | pmid:23577592 |
De Genaro P et al. | Retinoic acid promotes apoptosis and differentiation in photoreceptors by activating the P38 MAP kinase pathway. | 2013 | Invest. Ophthalmol. Vis. Sci. | pmid:23580485 |
Hudson AG et al. | Erythrocyte omega-6 and omega-3 fatty acids and mammographic breast density. | 2013 | Nutr Cancer | pmid:23530640 |
Russell KL et al. | Low brain DHA content worsens sensorimotor outcomes after TBI and decreases TBI-induced Timp1 expression in juvenile rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23796971 |
Xue Z et al. | Production of omega-3 eicosapentaenoic acid by metabolic engineering of Yarrowia lipolytica. | 2013 | Nat. Biotechnol. | pmid:23873085 |
Pase MP and Stough C | Describing a taxonomy of cognitive processes for clinical trials assessing cognition. | 2013 | Am. J. Clin. Nutr. | pmid:23873682 |
Safarinejad MR et al. | Effects of EPA, γ-linolenic acid or coenzyme Q10 on serum prostate-specific antigen levels: a randomised, double-blind trial. | 2013 | Br. J. Nutr. | pmid:23199523 |
Haller MJ et al. | Autologous umbilical cord blood infusion followed by oral docosahexaenoic acid and vitamin D supplementation for C-peptide preservation in children with Type 1 diabetes. | 2013 | Biol. Blood Marrow Transplant. | pmid:23611977 |
Chen J et al. | Docosahexaenoic acid (DHA) ameliorates paraquat-induced pulmonary fibrosis in rats possibly through up-regulation of Smad 7 and SnoN. | 2013 | Food Chem. Toxicol. | pmid:23590892 |
Damsgaard CT et al. | n-3 PUFA status in school children is associated with beneficial lipid profile, reduced physical activity and increased blood pressure in boys. | 2013 | Br. J. Nutr. | pmid:23591057 |
Dalli J et al. | Novel n-3 immunoresolvents: structures and actions. | 2013 | Sci Rep | pmid:23736886 |
Shiraishi M et al. | Estimation of eicosapentaenoic acid and docosahexaenoic acid intakes in pregnant Japanese women without nausea by using a self-administered diet history questionnaire. | 2013 | Nutr Res | pmid:23746563 |
Azordegan N et al. | Carcinogenesis alters fatty acid profile in breast tissue. | 2013 | Mol. Cell. Biochem. | pmid:23180247 |
Vaezi R et al. | Identification and functional characterization of genes encoding omega-3 polyunsaturated fatty acid biosynthetic activities from unicellular microalgae. | 2013 | Mar Drugs | pmid:24351909 |
Thomas J et al. | Dietary supplementation with resveratrol and/or docosahexaenoic acid alters hippocampal gene expression in adult C57Bl/6 mice. | 2013 | J. Nutr. Biochem. | pmid:23746933 |
Chang G et al. | Improvement of docosahexaenoic acid production on glycerol by Schizochytrium sp. S31 with constantly high oxygen transfer coefficient. | 2013 | Bioresour. Technol. | pmid:23747449 |
Lundström SL et al. | Lipid mediator serum profiles in asthmatics significantly shift following dietary supplementation with omega-3 fatty acids. | 2013 | Mol Nutr Food Res | pmid:23824870 |
Lohner S et al. | Lower n-3 long-chain polyunsaturated fatty acid values in patients with phenylketonuria: a systematic review and meta-analysis. | 2013 | Nutr Res | pmid:23827125 |
Kelly OJ et al. | Long-chain polyunsaturated fatty acids may mutually benefit both obesity and osteoporosis. | 2013 | Nutr Res | pmid:23827126 |
Collins MA et al. | Docosahexaenoic acid (DHA) prevents binge ethanol-dependent aquaporin-4 elevations while inhibiting neurodegeneration: experiments in rat adult-age entorhino-hippocampal slice cultures. | 2013 | Neurotox Res | pmid:23184649 |
Nobre ME et al. | Eicosapentaenoic acid and docosahexaenoic acid exert anti-inflammatory and antinociceptive effects in rodents at low doses. | 2013 | Nutr Res | pmid:23684444 |
Xu ZZ et al. | Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma. | 2013 | Ann. Neurol. | pmid:23686636 |
Flock MR et al. | Immunometabolic role of long-chain omega-3 fatty acids in obesity-induced inflammation. | 2013 | Diabetes Metab. Res. Rev. | pmid:23592441 |
Nagachinta S and Akoh CC | Synthesis of structured lipid enriched with omega fatty acids and sn-2 palmitic acid by enzymatic esterification and its incorporation in powdered infant formula. | 2013 | J. Agric. Food Chem. | pmid:23597247 |
Reinders I et al. | Associations of serum n-3 and n-6 polyunsaturated fatty acids with echocardiographic measures among older adults: the Hoorn Study. | 2013 | Eur J Clin Nutr | pmid:24084512 |
Lee AL and Park Y | The association between n-3 polyunsaturated fatty acid levels in erythrocytes and the risk of rheumatoid arthritis in Korean women. | 2013 | Ann. Nutr. Metab. | pmid:23949659 |
Metherel AH et al. | EPA and DHA levels in whole blood decrease more rapidly when stored at -20 °C as compared with room temperature, 4 and -75 °C. | 2013 | Lipids | pmid:23949919 |
Ishikado A et al. | 4-Hydroxy hexenal derived from docosahexaenoic acid protects endothelial cells via Nrf2 activation. | 2013 | PLoS ONE | pmid:23936010 |
Hoshi T et al. | Reply to Harris et al.: Differential impacts of omega-3 fatty acids and their derivatives on blood pressure. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23940844 |
Betancor MB et al. | Physiological pathways involved in nutritional muscle dystrophy and healing in European sea bass (Dicentrarchus labrax) larvae. | 2013 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:23202658 |
de Oliveira Otto MC et al. | Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of Atherosclerosis. | 2013 | J Am Heart Assoc | pmid:24351702 |
Wu BT et al. | Low fish intake is associated with low blood concentrations of vitamin D, choline and n-3 DHA in pregnant women. | 2013 | Br. J. Nutr. | pmid:22691303 |
Tam VC | Lipidomic profiling of bioactive lipids by mass spectrometry during microbial infections. | 2013 | Semin. Immunol. | pmid:24084369 |
Fontes-Villalba M et al. | African hominin stable isotopic data do not necessarily indicate grass consumption. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24062471 |
Yusof HM et al. | Limited impact of 2 g/day omega-3 fatty acid ethyl esters (Omacor®) on plasma lipids and inflammatory markers in patients awaiting carotid endarterectomy. | 2013 | Mar Drugs | pmid:24065166 |
Neuhofer A et al. | Impaired local production of proresolving lipid mediators in obesity and 17-HDHA as a potential treatment for obesity-associated inflammation. | 2013 | Diabetes | pmid:23349501 |
Sofi F et al. | The atherosclerotic risk profile is affected differently by fish flesh with a similar EPA and DHA content but different n-6/n-3 ratio. | 2013 | Asia Pac J Clin Nutr | pmid:23353608 |
McEwen BJ et al. | Effects of omega-3 polyunsaturated fatty acids on platelet function in healthy subjects and subjects with cardiovascular disease. | 2013 | Semin. Thromb. Hemost. | pmid:23329646 |
Sun SN et al. | Docosahexaenoic acid (DHA) induces apoptosis in human hepatocellular carcinoma cells. | 2013 | Int J Clin Exp Pathol | pmid:23330014 |
Bohr S et al. | Resolvin D2 prevents secondary thrombosis and necrosis in a mouse burn wound model. | 2013 Jan-Feb | Wound Repair Regen | pmid:23110665 |
Piñeiro-Corrales G et al. | [Role of omega-3 fatty acids in cardiovascular disease prevention]. | 2013 Jan-Feb | Nutr Hosp | pmid:23808424 |
Zajdel A et al. | Polyunsaturated fatty acids inhibit melanoma cell growth in vitro. | 2013 Mar-Apr | Acta Pol Pharm | pmid:23614295 |
Docosahexaenoic and arachidonic acid levels in ELBW infants with prolonged exposure to intravenous lipids. | 2013 May-Jun | Neonatal Netw | pmid:23807965 | |
Tatsuno I et al. | Efficacy and safety of TAK-085 compared with eicosapentaenoic acid in Japanese subjects with hypertriglyceridemia undergoing lifestyle modification: the omega-3 fatty acids randomized double-blind (ORD) study. | 2013 May-Jun | J Clin Lipidol | pmid:23725919 |
Nishimura RY et al. | Breast milk fatty acid composition of women living far from the coastal area in Brazil. | 2013 May-Jun | J Pediatr (Rio J) | pmid:23669215 |
Tatsuno I et al. | Long-term safety and efficacy of TAK-085 in Japanese subjects with hypertriglyceridemia undergoing lifestyle modification: the omega-3 fatty acids randomized long-term (ORL) study. | 2013 Nov-Dec | J Clin Lipidol | pmid:24314359 |
Igarashi M et al. | Kinetics of eicosapentaenoic acid in brain, heart and liver of conscious rats fed a high n-3 PUFA containing diet. | 2013 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24209500 |
Fenton JI et al. | Immunomodulation by dietary long chain omega-3 fatty acids and the potential for adverse health outcomes. | 2013 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24183073 |
Hernández E et al. | Prenatal determinants of cord blood total immunoglobulin E levels in Mexican newborns. | 2013 Sep-Oct | Allergy Asthma Proc | pmid:23998234 |
Harris WS et al. | Comparative effects of an acute dose of fish oil on omega-3 fatty acid levels in red blood cells versus plasma: implications for clinical utility. | 2013 Sep-Oct | J Clin Lipidol | pmid:24079284 |
Fernández-González R et al. | Decontamination solutions for polychlorinated biphenyls (PCBs) in raw fish oils from environmentally contaminated sea fishes. | 2014 | Sci. Total Environ. | pmid:24095964 |
Ponnampalam EN et al. | Health beneficial long chain omega-3 fatty acid levels in Australian lamb managed under extensive finishing systems. | 2014 | Meat Sci. | pmid:23643471 |
Hennebelle M et al. | Ageing and apoE change DHA homeostasis: relevance to age-related cognitive decline. | 2014 | Proc Nutr Soc | pmid:24103099 |
Jilkova ZM et al. | Adipose tissue-related proteins locally associated with resolution of inflammation in obese mice. | 2014 | Int J Obes (Lond) | pmid:23756677 |
Wang S et al. | Lipid content in hepatic and gonadal adipose tissue parallel aortic cholesterol accumulation in mice fed diets with different omega-6 PUFA to EPA plus DHA ratios. | 2014 | Clin Nutr | pmid:23672804 |
De Mel D and Suphioglu C | Fishy business: effect of omega-3 fatty acids on zinc transporters and free zinc availability in human neuronal cells. | 2014 | Nutrients | pmid:25195602 |
Tungen JE et al. | Synthesis and anti-inflammatory and pro-resolving activities of 22-OH-PD1, a monohydroxylated metabolite of protectin D1. | 2014 | J. Nat. Prod. | pmid:25247845 |
McCauley LK et al. | Cutting edge: Parathyroid hormone facilitates macrophage efferocytosis in bone marrow via proresolving mediators resolvin D1 and resolvin D2. | 2014 | J. Immunol. | pmid:24890726 |
Serhan CN | Pro-resolving lipid mediators are leads for resolution physiology. | 2014 | Nature | pmid:24899309 |
[Recommendations of the Polish Gynecological Society concerning docosahexaenoic acid supplementation in the prevention of preterm birth]. | 2014 | Ginekol. Pol. | pmid:24834713 | |
Abdulnour RE et al. | Maresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25369934 |
Aursnes M et al. | Stereoselective synthesis of protectin D1: a potent anti-inflammatory and proresolving lipid mediator. | 2014 | Org. Biomol. Chem. | pmid:24253202 |
White PJ et al. | Protectin DX alleviates insulin resistance by activating a myokine-liver glucoregulatory axis. | 2014 | Nat. Med. | pmid:24813250 |
Evans SJ et al. | Dietary intake and plasma metabolomic analysis of polyunsaturated fatty acids in bipolar subjects reveal dysregulation of linoleic acid metabolism. | 2014 | J Psychiatr Res | pmid:24953860 |
Santos S et al. | Fatty acids derived from a food frequency questionnaire and measured in the erythrocyte membrane in relation to adiponectin and leptin concentrations. | 2014 | Eur J Clin Nutr | pmid:24642786 |
Liu X et al. | Amide-type adduct of dopamine - plausible cause of Parkinson diseases. | 2014 | Subcell. Biochem. | pmid:24374917 |
Wang Q et al. | Resolvin D1 stimulates alveolar fluid clearance through alveolar epithelial sodium channel, Na,K-ATPase via ALX/cAMP/PI3K pathway in lipopolysaccharide-induced acute lung injury. | 2014 | J. Immunol. | pmid:24646745 |
Pottala JV et al. | Higher RBC EPA + DHA corresponds with larger total brain and hippocampal volumes: WHIMS-MRI study. | 2014 | Neurology | pmid:24453077 |
Zhao JP et al. | Circulating docosahexaenoic acid levels are associated with fetal insulin sensitivity. | 2014 | PLoS ONE | pmid:24454790 |
O'Callaghan N et al. | Telomere shortening in elderly individuals with mild cognitive impairment may be attenuated with ω-3 fatty acid supplementation: a randomized controlled pilot study. | 2014 | Nutrition | pmid:24342530 |
Martorell M et al. | Effect of DHA on plasma fatty acid availability and oxidative stress during training season and football exercise. | 2014 | Food Funct | pmid:24955731 |
Fredman G et al. | Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25246560 |
Kitessa SM et al. | DHA-containing oilseed: a timely solution for the sustainability issues surrounding fish oil sources of the health-benefitting long-chain omega-3 oils. | 2014 | Nutrients | pmid:24858407 |
Nelson JW et al. | ALX/FPR2 receptor for RvD1 is expressed and functional in salivary glands. | 2014 | Am. J. Physiol., Cell Physiol. | pmid:24259417 |
O'Sullivan A et al. | Habitual diets rich in dark-green vegetables are associated with an increased response to ω-3 fatty acid supplementation in Americans of African ancestry. | 2014 | J. Nutr. | pmid:24259553 |
Cipollina C et al. | Dual anti-oxidant and anti-inflammatory actions of the electrophilic cyclooxygenase-2-derived 17-oxo-DHA in lipopolysaccharide- and cigarette smoke-induced inflammation. | 2014 | Biochim. Biophys. Acta | pmid:24594225 |
Siddiqui RA et al. | Characterization of lovastatin-docosahexaenoate anticancer properties against breast cancer cells. | 2014 | Bioorg. Med. Chem. | pmid:24556504 |
Hashimoto M et al. | Possibility of polyunsaturated fatty acids for the prevention and treatment of neuropsychiatric illnesses. | 2014 | J. Pharmacol. Sci. | pmid:24561447 |
Bauer I et al. | Does omega-3 fatty acid supplementation enhance neural efficiency? A review of the literature. | 2014 | Hum Psychopharmacol | pmid:24285504 |
Sublimi Saponetti M et al. | Aggregation of Aß(25-35) on DOPC and DOPC/DHA bilayers: an atomic force microscopy study. | 2014 | PLoS ONE | pmid:25551704 |
Cho Y et al. | Colon cancer cell apoptosis is induced by combined exposure to the n-3 fatty acid docosahexaenoic acid and butyrate through promoter methylation. | 2014 | Exp. Biol. Med. (Maywood) | pmid:24495951 |
Park J et al. | Reciprocal modulation of surface expression of annexin A2 in a human umbilical vein endothelial cell-derived cell line by eicosapentaenoic acid and docosahexaenoic acid. | 2014 | PLoS ONE | pmid:24465474 |
Tang H et al. | Protective actions of aspirin-triggered (17R) resolvin D1 and its analogue, 17R-hydroxy-19-para-fluorophenoxy-resolvin D1 methyl ester, in C5a-dependent IgG immune complex-induced inflammation and lung injury. | 2014 | J. Immunol. | pmid:25172497 |
Montgomery P et al. | Fatty acids and sleep in UK children: subjective and pilot objective sleep results from the DOLAB study--a randomized controlled trial. | 2014 | J Sleep Res | pmid:24605819 |
Zheng MG et al. | Cloning, expression and stress-respondent transcription of long-chain acyl-coenzyme A synthetase cDNA gene of Nannochloropsis gaditana and its involvement in the biosynthesis of eicosapentaenoic and decosahexaenoic acids. | 2014 | Biotechnol. Lett. | pmid:24068506 |