Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Okada M et al. | The chronic administration of docosahexaenoic acid reduces the spatial cognitive deficit following transient forebrain ischemia in rats. | 1996 | Neuroscience | pmid:8834389 |
Frøyland L et al. | Chronic administration of eicosapentaenoic acid and docosahexaenoic acid as ethyl esters reduced plasma cholesterol and changed the fatty acid composition in rat blood and organs. | 1996 | Lipids | pmid:8835405 |
Brossard N et al. | Retroconversion and metabolism of [13C]22:6n-3 in humans and rats after intake of a single dose of [13C]22:6n-3-triacylglycerols. | 1996 | Am. J. Clin. Nutr. | pmid:8839503 |
Leaf A et al. | Long chain polyunsaturated fatty acids and visual function in preterm infants. | 1996 | Early Hum. Dev. | pmid:8842638 |
Organisciak DT et al. | Retinal light damage in rats with altered levels of rod outer segment docosahexaenoate. | 1996 | Invest. Ophthalmol. Vis. Sci. | pmid:8843911 |
Karmali RA | Historical perspective and potential use of n-3 fatty acids in therapy of cancer cachexia. | 1996 | Nutrition | pmid:8850210 |
Reithmann C et al. | Exposure to the n-3 polyunsaturated fatty acid docosahexaenoic acid impairs alpha 1-adrenoceptor-mediated contractile responses and inositol phosphate formation in rat cardiomyocytes. | 1996 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:8857587 |
Baskaya MK et al. | Enhanced accumulation of free fatty acids in experimental focal cerebral ischemia. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8860103 |
Saito M et al. | An assessment of docosahexaenoic acid (DHA) intake with special reference to lipid metabolism in rats. | 1996 | J. Nutr. Sci. Vitaminol. | pmid:8866256 |
Hamano H et al. | Docosahexaenoic acid reduces GABA response in substantia nigra neuron of rat. | 1996 | J. Neurophysiol. | pmid:8867135 |
Liu W et al. | Docosahexaenoic acid ethyl ester and its ultraviolet degradation products showed DNA-breaking activity in vitro and cytotoxic effects on the HSC-4 cell line. | 1995 | Kobe J Med Sci | pmid:8869009 |
Stillwell W et al. | Cholesterol versus alpha-tocopherol: effects on properties of bilayers made from heteroacid phosphatidylcholines. | 1996 | Biochemistry | pmid:8873602 |
Oski FA | Making the public and pediatric community aware of the importance of fatty acids in infant nutrition. | 1996 | Nutrition | pmid:8875527 |
Berkenboom G et al. | Effect of dietary supplementation with fish oil on cyclosporine A-induced vascular toxicity. | 1996 | Cardiovasc Drugs Ther | pmid:8877082 |
Schjøtt J et al. | Effects of eicosapentaenoic acid and docosahexaenoic acid diet supplement on tolerance to the cardiotoxicity of epirubicin and to ischaemia reperfusion in the isolated rat heart. | 1996 | Pharmacol. Toxicol. | pmid:8878248 |
Hughes DA and Pinder AC | Influence of n-3 polyunsaturated fatty acids (PUFA) on the antigen-presenting function of human monocytes. | 1996 | Biochem. Soc. Trans. | pmid:8878933 |
Alessandri JM et al. | Polyunsaturated fatty acids status in blood, heart, liver, intestine, retina and brain of newborn piglets fed either sow milk or a milk replacer diet. | 1996 | Reprod. Nutr. Dev. | pmid:8881596 |
Lambert MS et al. | Modification of the fatty acid composition of dietary oils and fats on incorporation into chylomicrons and chylomicron remnants. | 1996 | Br. J. Nutr. | pmid:8881715 |
Dahlan W et al. | Fish meal lecithin as alternative precursor of docosahexaenoate and choline. | 1996 | Biomed. Environ. Sci. | pmid:8886341 |
Horrobin DF | Schizophrenia as a membrane lipid disorder which is expressed throughout the body. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888116 |
Glen AI et al. | Membrane fatty acids, niacin flushing and clinical parameters. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888117 |
Peet M et al. | Essential fatty acid deficiency in erythrocyte membranes from chronic schizophrenic patients, and the clinical effects of dietary supplementation. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888126 |
Abbate R et al. | n-3 PUFA supplementation, monocyte PCA expression and interleukin-6 production. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888356 |
Luukkainen P et al. | Impact of solid food on plasma arachidonic and docosahexaenoic acid status of term infants at 8 months of age. | 1996 | J. Pediatr. Gastroenterol. Nutr. | pmid:8890071 |
Farkas K et al. | Developmental changes in the levels of molecular species of triacylglycerol that contain docosahexaenoic acid in adipose tissue of the chick embryo. | 1996 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:8896327 |
Ohno T et al. | Fatty acid profiles of phospholipids in brown adipose tissue from rats during cold acclimation and repetitive intermittent immobilization: with special reference to docosahexaenoic acid. | 1996 | Jpn. J. Physiol. | pmid:8899494 |
Farkas K et al. | Changes in the size and docosahexaenoic acid content of adipocytes during chick embryo development. | 1996 | Lipids | pmid:8900461 |
Vreugdenhil M et al. | Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8901621 |
Yamada K et al. | Effects of fatty acids on accumulation and secretion of histamine in RBL-2H3 cells and leukotriene release from peritoneal exudate cells isolated from Wistar rats. | 1996 | J. Nutr. Sci. Vitaminol. | pmid:8906631 |
Chambon M et al. | Influence of orthotopic liver transplantation on docosehexaenoic acid deficiency in cholestatic children. | 1996 | Transplant. Proc. | pmid:8908096 |
Retterstøl K et al. | The metabolism of 22:5(-6) and of docosahexaenoic acid [22:6(-3)] compared in rat hepatocytes. | 1996 | Biochim. Biophys. Acta | pmid:8908151 |
Crosby AJ et al. | Modulation of glutathione peroxidase activity in human vascular endothelial cells by fatty acids and the cytokine interleukin-1 beta. | 1996 | Biochim. Biophys. Acta | pmid:8908152 |
Woods J et al. | Is docosahexaenoic acid necessary in infant formula? Evaluation of high linolenate diets in the neonatal rat. | 1996 | Pediatr. Res. | pmid:8910933 |
Marignani PA and Sebaldt RJ | The formation of diradylglycerol molecular species in murine peritoneal macrophages varies dose-dependently with dietary purified eicosapentaenoic and docosahexaenoic ethyl esters. | 1996 | J. Nutr. | pmid:8914943 |
Hamazaki T et al. | Docosahexaenoic acid-rich fish oil does not affect serum lipid concentrations of normolipidemic young adults. | 1996 | J. Nutr. | pmid:8914949 |
Raederstorff D et al. | Anti-inflammatory properties of docosahexaenoic and eicosapentaenoic acids in phorbol-ester-induced mouse ear inflammation. | 1996 | Int. Arch. Allergy Immunol. | pmid:8917124 |
Zerouga M et al. | Phospholipid class as a determinant in docosahexaenoic acid's effect on tumor cell viability. | 1996 Sep-Oct | Anticancer Res. | pmid:8917399 |
Carballeira NM et al. | Phospholipid fatty acid composition of gorgonians of the genus Pseudopterogorgia: identification of tetracosapolyenoic acids. | 1996 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:8925444 |
Santos FF et al. | Alterations in rabbit retina lipid metabolism induced by detachment. Decreased incorporation of [3H]DHA into phospholipids. | 1995-1996 | Int Ophthalmol | pmid:8926126 |
Agren JJ et al. | Fish diet, fish oil and docosahexaenoic acid rich oil lower fasting and postprandial plasma lipid levels. | 1996 | Eur J Clin Nutr | pmid:8933125 |
Santos GA and Silversides FG | Utilization of the sex-linked gene for imperfect albinism (S*ALS). 1. Effect of early weight loss on chick metabolism. | 1996 | Poult. Sci. | pmid:8933584 |
De Craemer D et al. | Dietary docosahexaenoic acid has little effect on peroxisomes in healthy mice. | 1996 | Lipids | pmid:8934448 |
Krämer HJ et al. | Fish oil fatty acids and human platelets: dose-dependent decrease in dienoic and increase in trienoic thromboxane generation. | 1996 | Biochem. Pharmacol. | pmid:8937428 |
Poling JS et al. | Docosahexaenoic acid block of neuronal voltage-gated K+ channels: subunit selective antagonism by zinc. | 1996 | Neuropharmacology | pmid:8938727 |
Suzuki Y et al. | Trial of docosahexaenoic acid supplementation on a Japanese patient with a peroxisome biogenesis defect. | 1996 | Acta Paediatr Jpn | pmid:8942014 |
Katoku Y et al. | Effect of the cholesterol content of a formula on the lipid compositions of plasma lipoproteins and red blood cell membranes in early infancy. | 1996 | Am. J. Clin. Nutr. | pmid:8942411 |
Reinboth JJ et al. | Light elicits the release of docosahexaenoic acid from membrane phospholipids in the rat retina in vitro. | 1996 | Exp. Eye Res. | pmid:8943700 |
Awad AB et al. | The effect of unsaturated fatty acids on membrane composition and signal transduction in HT-29 human colon cancer cells. | 1996 | Cancer Lett. | pmid:8950205 |
Ohira T et al. | Improvement by eicosanoids in cancer cachexia induced by LLC-IL6 transplantation. | 1996 | J. Cancer Res. Clin. Oncol. | pmid:8954167 |
Garratt JC et al. | Blockade of two voltage-dependent potassium channels, mKv1.1 and mKv1.2, by docosahexaenoic acid. | 1996 | Eur. J. Pharmacol. | pmid:8957264 |
Foreman-van Drongelen MM et al. | Influence of feeding artificial-formula milks containing docosahexaenoic and arachidonic acids on the postnatal long-chain polyunsaturated fatty acid status of healthy preterm infants. | 1996 | Br. J. Nutr. | pmid:8958000 |
Futamura Y | Toxicity of amiodarone on mouse pulmonary endothelial cells cultured with or without alveolar macrophages. | 1996 | J Toxicol Sci | pmid:8959650 |
Brossard N et al. | Metabolic fate of an oral tracer dose of [13C]docosahexaenoic acid triglycerides in the rat. | 1996 | Am. J. Physiol. | pmid:8967415 |
Khalfoun B et al. | Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human lymphocyte-endothelial cell adhesion. | 1996 | Transplantation | pmid:8970622 |
Martin DD et al. | The fatty acid composition of human gliomas differs from that found in nonmalignant brain tissue. | 1996 | Lipids | pmid:8972462 |
Fritsche KL and Cassity NA | Metabolism of [3H]arachidonic acid by n-3 polyunsaturated fatty acid-enriched piglet alveolar macrophages. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8981628 |
Pregnolato P et al. | Effect of diets containing different amounts of precursor and derivative fatty acids on serum TXB2. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8981629 |
Taugbøl O et al. | An experimental study on transcutaneous absorption of ethylesters of eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3) in pigs. | 1996 | Acta Vet. Scand. | pmid:8996873 |
Liutova LV et al. | [Effect of docanol on the status of hemostasis and fibrinolysis systems, as well as lipid spectrum in patients with ischemic heart disease depending on the initial level of fibrinolytic activity]. | 1996 Jan-Mar | Vopr. Med. Khim. | pmid:8999661 |
Herber SM and Van Elswyk ME | Dietary marine algae promotes efficient deposition of n-3 fatty acids for the production of enriched shell eggs. | 1996 | Poult. Sci. | pmid:9000275 |
Conquer JA and Holub BJ | Supplementation with an algae source of docosahexaenoic acid increases (n-3) fatty acid status and alters selected risk factors for heart disease in vegetarian subjects. | 1996 | J. Nutr. | pmid:9001371 |
Tamura M and Suzuki H | Effects of docosahexaenoic acid and sardine oil diets on the ultrastructure of jejunal absorptive cells in adult mice. | 1996 | Ann. Nutr. Metab. | pmid:9001686 |
Sheaff Greiner RC et al. | Linoleate, alpha-linolenate, and docosahexaenoate recycling into saturated and monounsaturated fatty acids is a major pathway in pregnant or lactating adults and fetal or infant rhesus monkeys. | 1996 | J. Lipid Res. | pmid:9017518 |
Noguchi M et al. | Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA. | 1997 | Br. J. Cancer | pmid:9020478 |
Badalamenti S et al. | Lack of renal effects of fish oil administration in patients with advanced cirrhosis and impaired glomerular filtration. | 1997 | Hepatology | pmid:9021940 |
Sauerwald TU et al. | Intermediates in endogenous synthesis of C22:6 omega 3 and C20:4 omega 6 by term and preterm infants. | 1997 | Pediatr. Res. | pmid:9029636 |
Delton-Vandenbroucke I et al. | Polyunsaturated fatty acid metabolism in retinal and cerebral microvascular endothelial cells. | 1997 | J. Lipid Res. | pmid:9034209 |
Kresiun VI et al. | [The membrane-protective action of a new preparation of n-3 polyenic acids in the adrenaline-damaged myocardium]. | 1996 Mar-Apr | Lik. Sprava | pmid:9035880 |
Wainwright PE et al. | Arachidonic acid offsets the effects on mouse brain and behavior of a diet with a low (n-6):(n-3) ratio and very high levels of docosahexaenoic acid. | 1997 | J. Nutr. | pmid:9040564 |
Iigo M et al. | Inhibitory effects of docosahexaenoic acid on colon carcinoma 26 metastasis to the lung. | 1997 | Br. J. Cancer | pmid:9043019 |
Dacremont G and Vincent G | Assay of plasmalogens and polyunsaturated fatty acids (PUFA) in erythrocytes and fibroblasts. | 1995 | J. Inherit. Metab. Dis. | pmid:9053558 |
Orth M and Luley C | Diagnostic pitfalls during therapy for extreme hypertriglyceridaemia. | 1997 | Eur J Clin Chem Clin Biochem | pmid:9056751 |
Infante JP and Huszagh VA | On the molecular etiology of decreased arachidonic (20:4n-6), docosapentaenoic (22:5n-6) and docosahexaenoic (22:6n-3) acids in Zellweger syndrome and other peroxisomal disorders. | 1997 | Mol. Cell. Biochem. | pmid:9062899 |
Yamane M and Abe A | Properties of the omega-hydroxylation system of docosahexaenoic or arachidonic acid in brain or liver homogenate of rat. | 1995 | Neurosci. Lett. | pmid:9064612 |
Kelso KA et al. | Lipid and antioxidant changes in spermatozoa and seminal plasma throughout the reproductive period of bulls. | 1997 | J. Reprod. Fertil. | pmid:9068407 |
Horimoto N et al. | Arachidonic acid activation of potassium channels in rat visual cortex neurons. | 1997 | Neuroscience | pmid:9070743 |
Kimura S et al. | Dietary docosahexaenoic acid (22: 6n-3) prevents the development of hypertension in SHRSP. | 1995 | Clin Exp Pharmacol Physiol Suppl | pmid:9072405 |
Atkinson TG et al. | Incorporation of long-chain n-3 fatty acids in tissues and enhanced bone marrow cellularity with docosahexaenoic acid feeding in post-weanling Fischer 344 rats. | 1997 | Lipids | pmid:9076666 |
Conquer JA and Holub BJ | Dietary docosahexaenoic acid as a source of eicosapentaenoic acid in vegetarians and omnivores. | 1997 | Lipids | pmid:9076673 |
Bouglé D et al. | Relationships between red blood cell vitamin E and polyunsaturated fatty acid in the premature infant. | 1996 | Ann. Nutr. Metab. | pmid:9087310 |
Mohan IK and Das UN | Oxidant stress, anti-oxidants and essential fatty acids in systemic lupus erythematosus. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9089797 |
Rodriguez de Turco EB et al. | Post-Golgi vesicles cotransport docosahexaenoyl-phospholipids and rhodopsin during frog photoreceptor membrane biogenesis. | 1997 | J. Biol. Chem. | pmid:9099692 |
McKeone BJ et al. | Alterations in serum phosphatidylcholine fatty acyl species by eicosapentaenoic and docosahexaenoic ethyl esters in patients with severe hypertriglyceridemia. | 1997 | J. Lipid Res. | pmid:9101424 |
Mandell IB et al. | Effects of fish meal in beef cattle diets on growth performance, carcass characteristics, and fatty acid composition of longissimus muscle. | 1997 | J. Anim. Sci. | pmid:9110201 |
Ndiaye J and Hayashi S | Effect of docosahexaenoic acid on lipoprotein synthesis and secretion by cultured eel hepatocytes. | 1996 | Cell Struct. Funct. | pmid:9118236 |
Kikugawa K et al. | beta-Carotene effectively scavenges toxic nitrogen oxides: nitrogen dioxide and peroxynitrous acid. | 1997 | FEBS Lett. | pmid:9119059 |
Khalfoun B et al. | In vitro effects of docosahexaenoic and eicosapentaenoic acids in association with cyclosporine A on human lymphocyte proliferation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123309 |
Heird WC et al. | Docosahexaenoic acid and the development and function of the infant retina. | 1997 | Curr. Opin. Lipidol. | pmid:9127705 |
Tamura M and Suzuki H | Effect of docosahexaenoic acid and linoleic acid diets on the ultrastructure of liver cells in adult mice. | 1997 | Int J Vitam Nutr Res | pmid:9129257 |
Harris WS | n-3 fatty acids and serum lipoproteins: human studies. | 1997 | Am. J. Clin. Nutr. | pmid:9129504 |
Oski FA | What we eat may determine who we can be. | 1997 | Nutrition | pmid:9131682 |
Gordon N | Nutrition and cognitive function. | 1997 | Brain Dev. | pmid:9134186 |
Andreassen AK et al. | Hypertension prophylaxis with omega-3 fatty acids in heart transplant recipients. | 1997 | J. Am. Coll. Cardiol. | pmid:9137231 |
Buzzi M et al. | Biosynthesis of docosahexaenoic acid in trout hepatocytes proceeds via 24-carbon intermediates. | 1997 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:9159889 |
Green P et al. | Replenishment of docosahexaenoic acid in n-3 fatty acid-deficient fetal rats by intraamniotic ethyl-docosahexaenoate administration. | 1997 | J. Neurosci. Res. | pmid:9160249 |
Benassayag C et al. | High polyunsaturated fatty acid, thromboxane A2, and alpha-fetoprotein concentrations at the human feto-maternal interface. | 1997 | J. Lipid Res. | pmid:9162747 |
Jumpsen J et al. | Small changes of dietary (n-6) and (n-3)/fatty acid content ration alter phosphatidylethanolamine and phosphatidylcholine fatty acid composition during development of neuronal and glial cells in rats. | 1997 | J. Nutr. | pmid:9164993 |
Stillwell W et al. | Effect of docosahexaenoic acid on mouse mitochondrial membrane properties. | 1997 | Lipids | pmid:9168456 |
Bell JG et al. | The effect of dietary lipid on polyunsaturated fatty acid metabolism in Atlantic salmon (Salmo salar) undergoing parr-smolt transformation. | 1997 | Lipids | pmid:9168458 |
Allard JP et al. | Lipid peroxidation during n-3 fatty acid and vitamin E supplementation in humans. | 1997 | Lipids | pmid:9168460 |