Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Moate PJ et al. | Effects of feeding algal meal high in docosahexaenoic acid on feed intake, milk production, and methane emissions in dairy cows. | 2013 | J. Dairy Sci. | pmid:23498011 |
Calder PC | Editorial: Fat chance to enhance B cell function. | 2013 | J. Leukoc. Biol. | pmid:23547174 |
Zhang X et al. | Resolvin D1 reverts lipopolysaccharide-induced TJ proteins disruption and the increase of cellular permeability by regulating IκBα signaling in human vascular endothelial cells. | 2013 | Oxid Med Cell Longev | pmid:24381712 |
Takayama M et al. | Association of marine-origin n-3 polyunsaturated fatty acids consumption and functional mobility in the community-dwelling oldest old. | 2013 | J Nutr Health Aging | pmid:23299385 |
Nagai T et al. | Actual ratios of triacylglycerol positional isomers and enantiomers comprising saturated fatty acids and highly unsaturated fatty acids in fishes and marine mammals. | 2013 | J Oleo Sci | pmid:24292353 |
Dalal JJ et al. | Role of omega-3 ethyl ester concentrate in reducing sudden cardiac death following myocardial infarction and in management of hypertriglyceridemia: an Indian consensus statement. | 2012 Sep-Oct | Indian Heart J | pmid:23102390 |
Baum SJ | EPA and DHA: distinct yet essential n-3 fatty acids. | 2012 Sep-Oct | J Clin Lipidol | pmid:23009786 |
Castro González MI et al. | [Renal patient's diet: Can fish be included?]. | 2012 Sep-Oct | Nutr Hosp | pmid:23478696 |
Block RC et al. | The combination of EPA+DHA and low-dose aspirin ingestion reduces platelet function acutely whereas each alone may not in healthy humans. | 2012 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23017325 |
Kartikasari LR et al. | Dietary alpha-linolenic acid enhances omega-3 long chain polyunsaturated fatty acid levels in chicken tissues. | 2012 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22925778 |
Ma L et al. | Arginyl-glutamine dipeptide or docosahexaenoic acid attenuate hyperoxia-induced lung injury in neonatal mice. | 2012 Nov-Dec | Nutrition | pmid:23044165 |
Sanz ParÃs A et al. | [Proposed profile of omega 3 fatty acids in enteral nutrition]. | 2012 Nov-Dec | Nutr Hosp | pmid:23588426 |
Brown WV | From the editor. | 2012 Nov-Dec | J Clin Lipidol | pmid:23312044 |
Derosa G et al. | Effects of n-3 PUFAs on postprandial variation of metalloproteinases, and inflammatory and insulin resistance parameters in dyslipidemic patients: evaluation with euglycemic clamp and oral fat load. | 2012 Nov-Dec | J Clin Lipidol | pmid:23312051 |
Davidson MH et al. | A novel omega-3 free fatty acid formulation has dramatically improved bioavailability during a low-fat diet compared with omega-3-acid ethyl esters: the ECLIPSE (Epanova(®) compared to Lovaza(®) in a pharmacokinetic single-dose evaluation) study. | 2012 Nov-Dec | J Clin Lipidol | pmid:23312053 |
Abad S and Turon X | Valorization of biodiesel derived glycerol as a carbon source to obtain added-value metabolites: Focus on polyunsaturated fatty acids. | 2012 May-Jun | Biotechnol. Adv. | pmid:22261015 |
An WS et al. | Effect of omega-3 fatty acids on the modification of erythrocyte membrane fatty acid content including oleic acid in peritoneal dialysis patients. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22071008 |
Jacobson TA et al. | Effects of eicosapentaenoic acid and docosahexaenoic acid on low-density lipoprotein cholesterol and other lipids: a review. | 2012 Jan-Feb | J Clin Lipidol | pmid:22264569 |
Widgerow AD | Cellular resolution of inflammation--catabasis. | 2012 Jan-Feb | Wound Repair Regen | pmid:22276585 |
Kuipers RS et al. | Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22115845 |
Brenna T | Tissue-specific LCPUFA accretion in fetal humans. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22078006 |
Helmersson-Karlqvist J et al. | Enhanced prostaglandin F2α formation in human pregnancy and the effect of increased oily fish intake: results from the Salmon in Pregnancy Study. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22047909 |
Kuipers RS et al. | Gestational age dependent content, composition and intrauterine accretion rates of fatty acids in fetal white adipose tissue. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22093549 |
Liang W and Chikritzhs T | Does light alcohol consumption during pregnancy improve offspring's cognitive development? | 2012 | Med. Hypotheses | pmid:21985759 |
Nasiri AH et al. | Combined effect of DHA and α-tocopherol supplementation during bull semen cryopreservation on sperm characteristics and fatty acid composition. | 2012 | Andrologia | pmid:21951061 |
Luxwolda MF et al. | A maternal erythrocyte DHA content of approximately 6Â g% is the DHA status at which intrauterine DHA biomagnifications turns into bioattenuation and postnatal infant DHA equilibrium is reached. | 2012 | Eur J Nutr | pmid:21952690 |
Martinez-Micaelo N et al. | Omega-3 docosahexaenoic acid and procyanidins inhibit cyclo-oxygenase activity and attenuate NF-κB activation through a p105/p50 regulatory mechanism in macrophage inflammation. | 2012 | Biochem. J. | pmid:21954853 |
Chew EY et al. | The Age-Related Eye Disease Study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1). | 2012 | Ophthalmology | pmid:22840421 |
Hong WK et al. | Growth of the oleaginous microalga Aurantiochytrium sp. KRS101 on cellulosic biomass and the production of lipids containing high levels of docosahexaenoic acid. | 2012 | Bioprocess Biosyst Eng | pmid:21959581 |
Vanlint SJ and Ried K | Efficacy and tolerability of calcium, vitamin D and a plant-based omega-3 oil for osteopenia: a pilot RCT. | 2012 | Maturitas | pmid:22078660 |
Clà ria J et al. | Resolvin D1 and resolvin D2 govern local inflammatory tone in obese fat. | 2012 | J. Immunol. | pmid:22844113 |
Lin DC et al. | Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor. | 2012 | Mol. Pharmacol. | pmid:22859723 |
Martin CR et al. | The safety and efficacy of oral docosahexaenoic acid supplementation for the treatment of primary sclerosing cholangitis - a pilot study. | 2012 | Aliment. Pharmacol. Ther. | pmid:22129201 |
Tsushima T et al. | Docosahexaenoic- and eicosapentaenoic acid-bound lysophospholipids are more effective in suppressing angiogenesis than conjugated docosahexaenoic acid. | 2012 | J Oleo Sci | pmid:22864513 |
Begum G et al. | DHA inhibits ER Ca2+ release and ER stress in astrocytes following in vitro ischemia. | 2012 | J. Neurochem. | pmid:22129278 |
López-Alarcón M et al. | Oral administration of docosahexaenoic acid attenuates interleukin-1β response and clinical course of septic neonates. | 2012 | Nutrition | pmid:22079797 |
Skulas-Ray AC et al. | Effects of marine-derived omega-3 fatty acids on systemic hemodynamics at rest and during stress: a dose-response study. | 2012 | Ann Behav Med | pmid:22865498 |
Towhidi A and Parks JE | Effect of n-3 fatty acids and α-tocopherol on post-thaw parameters and fatty acid composition of bovine sperm. | 2012 | J. Assist. Reprod. Genet. | pmid:22869241 |
Chen J et al. | DPA n-3, DPA n-6 and DHA improve lipoprotein profiles and aortic function in hamsters fed a high cholesterol diet. | 2012 | Atherosclerosis | pmid:22284366 |
Whelan J et al. | Effects of dietary stearidonic acid on biomarkers of lipid metabolism. | 2012 | J. Nutr. | pmid:22279143 |
Wu JH et al. | Association of plasma phospholipid long-chain ω-3 fatty acids with incident atrial fibrillation in older adults: the cardiovascular health study. | 2012 | Circulation | pmid:22282329 |
Weylandt KH et al. | Omega-3 fatty acids and their lipid mediators: towards an understanding of resolvin and protectin formation. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:22326554 |
Harlioglu AG et al. | Fatty acid, cholesterol and fat-soluble vitamin composition of wild and captive freshwater crayfish (Astacus leptodactylus). | 2012 | Food Sci Technol Int | pmid:22328124 |
Dawson K et al. | Modulation of blood cell gene expression by DHA supplementation in hypertriglyceridemic men. | 2012 | J. Nutr. Biochem. | pmid:21775114 |
Swanson D et al. | Omega-3 fatty acids EPA and DHA: health benefits throughout life. | 2012 | Adv Nutr | pmid:22332096 |
Vedtofte MS et al. | The role of essential fatty acids in the control of coronary heart disease. | 2012 | Curr Opin Clin Nutr Metab Care | pmid:23037902 |
Hofmanová J et al. | Lipid alterations in human colon epithelial cells induced to differentiation and/or apoptosis by butyrate and polyunsaturated fatty acids. | 2012 | J. Nutr. Biochem. | pmid:21775115 |
Berson EL et al. | ω-3 intake and visual acuity in patients with retinitis pigmentosa receiving vitamin A. | 2012 | Arch. Ophthalmol. | pmid:22332205 |
Chang YL et al. | Docosahexaenoic acid promotes dopaminergic differentiation in induced pluripotent stem cells and inhibits teratoma formation in rats with Parkinson-like pathology. | 2012 | Cell Transplant | pmid:21669041 |
O'Flaherty JT et al. | 15-lipoxygenase metabolites of docosahexaenoic acid inhibit prostate cancer cell proliferation and survival. | 2012 | PLoS ONE | pmid:23029040 |
Cazzola R et al. | Effects of DHA-phospholipids, melatonin and tryptophan supplementation on erythrocyte membrane physico-chemical properties in elderly patients suffering from mild cognitive impairment. | 2012 | Exp. Gerontol. | pmid:23000875 |
Tanaka T et al. | Oral supplementation with dihomo-γ-linolenic acid (DGLA)-enriched oil increases serum DGLA content in healthy adults. | 2012 | Lipids | pmid:22411689 |
Hajjaji N et al. | DHA effect on chemotherapy-induced body weight loss: an exploratory study in a rodent model of mammary tumors. | 2012 | Nutr Cancer | pmid:23035949 |
Contreras GA et al. | Enhanced n-3 phospholipid content reduces inflammatory responses in bovine endothelial cells. | 2012 | J. Dairy Sci. | pmid:23040031 |
D'Vaz N et al. | Postnatal fish oil supplementation in high-risk infants to prevent allergy: randomized controlled trial. | 2012 | Pediatrics | pmid:22945403 |
Francescato G et al. | Early retinol-binding protein levels are associated with growth changes in infants born to diabetic mothers. | 2012 | Pediatr Obes | pmid:22991250 |
Joseph MS et al. | Effects of diet and/or exercise in enhancing spinal cord sensorimotor learning. | 2012 | PLoS ONE | pmid:22911773 |
Mas E et al. | Resolvins D1, D2, and other mediators of self-limited resolution of inflammation in human blood following n-3 fatty acid supplementation. | 2012 | Clin. Chem. | pmid:22912397 |
Mitchell DC et al. | Quantifying the differential effects of DHA and DPA on the early events in visual signal transduction. | 2012 | Chem. Phys. Lipids | pmid:22405878 |
Bonatto SJ et al. | Fish oil supplementation improves neutrophil function during cancer chemotherapy. | 2012 | Lipids | pmid:22160495 |
Yan J et al. | Improving stability and activity of cross-linked enzyme aggregates based on polyethylenimine in hydrolysis of fish oil for enrichment of polyunsaturated fatty acids. | 2012 | Appl. Biochem. Biotechnol. | pmid:22167690 |
Mil-Homens D et al. | The antibacterial properties of docosahexaenoic omega-3 fatty acid against the cystic fibrosis multiresistant pathogen Burkholderia cenocepacia. | 2012 | FEMS Microbiol. Lett. | pmid:22150831 |
Rupp H et al. | Mechanisms involved in the differential reduction of omega-3 and omega-6 highly unsaturated fatty acids by structural heart disease resulting in "HUFA deficiency". | 2012 | Can. J. Physiol. Pharmacol. | pmid:22188440 |
Bang S et al. | 17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception. | 2012 | Br. J. Pharmacol. | pmid:21718307 |
Landmark K and Alm CS | [Fish and omega-3 fatty acids and heart failure]. | 2012 | Tidsskr. Nor. Laegeforen. | pmid:23736195 |
de Batlle J et al. | Association between Ω3 and Ω6 fatty acid intakes and serum inflammatory markers in COPD. | 2012 | J. Nutr. Biochem. | pmid:21889886 |
Stough C et al. | The effects of 90-day supplementation with the omega-3 essential fatty acid docosahexaenoic acid (DHA) on cognitive function and visual acuity in a healthy aging population. | 2012 | Neurobiol. Aging | pmid:21531481 |
Hughes BH et al. | Oxidative stability and consumer acceptance of fish oil fortified nutrition bars. | 2012 | J. Food Sci. | pmid:22957916 |
Park Y et al. | Erythrocyte n-3 polyunsaturated fatty acid and seafood intake decrease the risk of depression: case-control study in Korea. | 2012 | Ann. Nutr. Metab. | pmid:22776859 |
Rogerio AP et al. | Resolvin D1 and aspirin-triggered resolvin D1 promote resolution of allergic airways responses. | 2012 | J. Immunol. | pmid:22802419 |
Quiroga AD et al. | Deficiency of carboxylesterase 1/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia. | 2012 | Hepatology | pmid:22806626 |
Gruber JF et al. | Associations between toenail arsenic concentration and dietary factors in a New Hampshire population. | 2012 | Nutr J | pmid:22747713 |
Kitson AP et al. | Enzymes in brain phospholipid docosahexaenoic acid accretion: a PL-ethora of potential PL-ayers. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22749739 |
Sirot V et al. | A restricted cubic spline approach to assess the association between high fat fish intake and red blood cell EPA + DHA content. | 2012 | Nutr Metab Cardiovasc Dis | pmid:20875947 |
Kuipers RS et al. | Gestational age dependent changes of the fetal brain, liver and adipose tissue fatty acid compositions in a population with high fish intakes. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22425685 |
Jeckel KM et al. | Docosahexaenoic acid supplementation does not improve Western diet-induced cardiomyopathy in rats. | 2012 | PLoS ONE | pmid:23300587 |
Candelario J et al. | PTH1 receptor is involved in mediating cellular response to long-chain polyunsaturated fatty acids. | 2012 | PLoS ONE | pmid:23300710 |
Gladyshev MI et al. | Comparison of polyunsaturated fatty acids content in filets of anadromous and landlocked sockeye salmon Oncorhynchus nerka. | 2012 | J. Food Sci. | pmid:23240970 |
Chen YJ et al. | Docosahexaenoic acid suppresses the expression of FoxO and its target genes. | 2012 | J. Nutr. Biochem. | pmid:22444500 |
Krishnamoorthy S et al. | Resolvin D1 receptor stereoselectivity and regulation of inflammation and proresolving microRNAs. | 2012 | Am. J. Pathol. | pmid:22449948 |
Gil-Sánchez A et al. | Current understanding of placental fatty acid transport. | 2012 | Curr Opin Clin Nutr Metab Care | pmid:22450774 |
Moon HJ et al. | Positive correlation between erythrocyte levels of n-3 polyunsaturated fatty acids and bone mass in postmenopausal Korean women with osteoporosis. | 2012 | Ann. Nutr. Metab. | pmid:22507833 |
Calandria JM et al. | Ataxin-1 poly(Q)-induced proteotoxic stress and apoptosis are attenuated in neural cells by docosahexaenoic acid-derived neuroprotectin D1. | 2012 | J. Biol. Chem. | pmid:22511762 |
Smink W et al. | Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs. | 2012 | Animal | pmid:22436184 |
Lifschitz C | New actions for old nutrients. | 2012 | Acta Sci Pol Technol Aliment | pmid:22493160 |
Kwak SM et al. | Efficacy of omega-3 fatty acid supplements (eicosapentaenoic acid and docosahexaenoic acid) in the secondary prevention of cardiovascular disease: a meta-analysis of randomized, double-blind, placebo-controlled trials. | 2012 | Arch. Intern. Med. | pmid:22493407 |
Crawford MA and Broadhurst CL | The role of docosahexaenoic and the marine food web as determinants of evolution and hominid brain development: the challenge for human sustainability. | 2012 | Nutr Health | pmid:22544773 |
Vedin I et al. | Effects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study. | 2012 | PLoS ONE | pmid:22545106 |
Gronroos NN et al. | Fish, fish-derived n-3 fatty acids, and risk of incident atrial fibrillation in the Atherosclerosis Risk in Communities (ARIC) study. | 2012 | PLoS ONE | pmid:22570739 |
Novak EM et al. | Low linoleic acid may facilitate Δ6 desaturase activity and docosahexaenoic acid accretion in human fetal development. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22365109 |
Meldrum SJ et al. | Determinants of DHA levels in early infancy: differential effects of breast milk and direct fish oil supplementation. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22572105 |
Chiang N et al. | Infection regulates pro-resolving mediators that lower antibiotic requirements. | 2012 | Nature | pmid:22538616 |
Gil-Campos M and Sanjurjo Crespo P | Omega 3 fatty acids and inborn errors of metabolism. | 2012 | Br. J. Nutr. | pmid:22591887 |
Glover KE et al. | Effect of feeding fresh forage and marine algae on the fatty acid composition and oxidation of milk and butter. | 2012 | J. Dairy Sci. | pmid:22612917 |
Lopez-Huertas E | The effect of EPA and DHA on metabolic syndrome patients: a systematic review of randomised controlled trials. | 2012 | Br. J. Nutr. | pmid:22591892 |
Delgado-Lista J et al. | Long chain omega-3 fatty acids and cardiovascular disease: a systematic review. | 2012 | Br. J. Nutr. | pmid:22591894 |
Corsetto PA et al. | Chemical-physical changes in cell membrane microdomains of breast cancer cells after omega-3 PUFA incorporation. | 2012 | Cell Biochem. Biophys. | pmid:22622660 |
Serra-Majem L et al. | Dietary methods and biomarkers of omega 3 fatty acids: a systematic review. | 2012 | Br. J. Nutr. | pmid:22591904 |
Larqué E et al. | Omega 3 fatty acids, gestation and pregnancy outcomes. | 2012 | Br. J. Nutr. | pmid:22591905 |
Campoy C et al. | Omega 3 fatty acids on child growth, visual acuity and neurodevelopment. | 2012 | Br. J. Nutr. | pmid:22591907 |