DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Polycystic Kidney Diseases D007690 12 associated lipids
Learning Disorders D007859 11 associated lipids
Leiomyoma D007889 8 associated lipids
Leukemia D007938 74 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Listeriosis D008088 12 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Long QT Syndrome D008133 10 associated lipids
Lordosis D008141 1 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lupus Nephritis D008181 8 associated lipids
Macular Degeneration D008268 5 associated lipids
Magnesium Deficiency D008275 9 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Medulloblastoma D008527 22 associated lipids
Melanoma D008545 69 associated lipids
Memory Disorders D008569 33 associated lipids
Myocarditis D009205 3 associated lipids
Myoglobinuria D009212 3 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Nerve Degeneration D009410 53 associated lipids
Neuralgia D009437 28 associated lipids
Neuroblastoma D009447 66 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Nutrition Disorders D009748 6 associated lipids
Obesity D009765 29 associated lipids
Optic Nerve Diseases D009901 6 associated lipids
Pain D010146 64 associated lipids
Pain, Postoperative D010149 13 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Paracoccidioidomycosis D010229 2 associated lipids
Parkinson Disease D010300 53 associated lipids
Parkinson Disease, Secondary D010302 17 associated lipids
Periodontitis D010518 22 associated lipids
Peritoneal Neoplasms D010534 16 associated lipids
Peritonitis D010538 38 associated lipids
Pneumonia D011014 10 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Precancerous Conditions D011230 48 associated lipids
Pregnancy Complications D011248 19 associated lipids
Pregnancy Complications, Cardiovascular D011249 11 associated lipids
Pregnancy Complications, Hematologic D011250 11 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Proteinuria D011507 30 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

Download all related citations
Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Abril R and Barclay W Production of docosahexaenoic acid-enriched poultry eggs and meat using an algae-based feed ingredient. 1998 World Rev Nutr Diet pmid:9648506
Kyle DJ and Arterburn LM Single cell oil sources of docosahexaenoic acid: clinical studies. 1998 World Rev Nutr Diet pmid:9648509
Wright T et al. Docosahexaenoic acid-enriched milk. 1998 World Rev Nutr Diet pmid:9648512
Bazan NG et al. Docosahexaenoic acid supply to the retina and its conservation in photoreceptor cells by active retinal pigment epithelium-mediated recycling. 1994 World Rev Nutr Diet pmid:7871812
Anderson RE et al. The accretion of docosahexaenoic acid in the retina. 1994 World Rev Nutr Diet pmid:7871813
von Houwelingen AC and Hornstra G Trans fatty acids in early human development. 1994 World Rev Nutr Diet pmid:7871822
Martinez M Developmental profiles of polyunsaturated fatty acids in the brain of normal infants and patients with peroxisomal diseases: severe deficiency of docosahexaenoic acid in Zellweger's and pseudo-Zellweger's syndromes. 1991 World Rev Nutr Diet pmid:1828923
Niemoller TD et al. Omega-3 fatty acid docosahexaenoic acid is the precursor of neuroprotectin D1 in the nervous system. 2009 World Rev Nutr Diet pmid:19136838
Lukiw WJ Docosahexaenoic acid and amyloid-beta peptide signaling in Alzheimer's disease. 2009 World Rev Nutr Diet pmid:19136839
Wurtman RJ et al. Administration of docosahexaenoic acid, uridine and choline increases levels of synaptic membranes and dendritic spines in rodent brain. 2009 World Rev Nutr Diet pmid:19136840
Hadley KB et al. An assessment of dietary docosahexaenoic acid requirements for brain accretion and turnover during early childhood. 2009 World Rev Nutr Diet pmid:19136841
SanGiovanni JP et al. Variation in lipid-associated genes as they relate to risk of advanced age-related macular degeneration. 2009 World Rev Nutr Diet pmid:19136842
Bohr S et al. Resolvin D2 prevents secondary thrombosis and necrosis in a mouse burn wound model. 2013 Jan-Feb Wound Repair Regen pmid:23110665
Widgerow AD Cellular resolution of inflammation--catabasis. 2012 Jan-Feb Wound Repair Regen pmid:22276585
McDaniel JC et al. Omega-3 fatty acids effect on wound healing. 2008 May-Jun Wound Repair Regen pmid:18471252
McDaniel JC et al. Fish oil supplementation alters levels of lipid mediators of inflammation in microenvironment of acute human wounds. 2011 Mar-Apr Wound Repair Regen pmid:21362086
Kimura S [Antihypertensive effect of docosahexaenoic acid in stroke-prone spontaneously hypertensive rats]. 2000 Yakugaku Zasshi pmid:10920715
Nishinaka T et al. [Elucidation of mechanisms underlying docosahexaenoic acid-induced antinociception]. 2013 Yakugaku Zasshi pmid:23649389
Okuyama H [Need to change the direction of cholesterol-related medication--a problem of great urgency]. 2005 Yakugaku Zasshi pmid:16272805
Ishiguro J et al. [Effects of ethyl eicosapentaenoate (EPA-E) and its metabolite on the drug and fatty acid metabolizing enzyme systems in rat liver]. 1988 Yakugaku Zasshi pmid:2841446
Li QC et al. [Determination of docosahexenoic acid in human serum by capillary gas chromatography]. 1997 Yao Xue Xue Bao pmid:11596318
Qi AD et al. [Effects of arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid on tension of rabbit aortic strips]. 1992 Yao Xue Xue Bao pmid:1442036
Schmitt Y and Schneider H [The effect of highly unsaturated fatty acids on the parameters of lipoprotein metabolism and rheology during their administration to patients undergoing chronic hemodialysis treatment]. 1993 Z Ernahrungswiss pmid:8237080
Wechsler JG et al. [Effect of omega-3-fatty acids on biliary lipids and lithogenicity]. 1989 Z Gastroenterol pmid:2756729
Gohlke H [Prevention of coronary disease and sudden death by nutrition]. 2004 Z Kardiol pmid:15021992
Obukhova GP et al. [A neuromorphological analysis of the motor area of the cerebral cortex in rat pups subjected to prenatal exposure to normal and pathological blood serum]. 1992 Jul-Aug Zh. Evol. Biokhim. Fiziol. pmid:1455957
Wu Q et al. [Effect of combination of docosahexaenoic acid and fluorouracil on human gastric carcinoma cell strain MGC803]. 2010 Zhongguo Yi Xue Ke Xue Yuan Xue Bao pmid:20236591
Chen R et al. [Effects of docosahexaenoic acid on hypoxia-induced pulmonary arterial hypertension]. 2014 Zhonghua Jie He He Hu Xi Za Zhi pmid:24796591
Wang RX et al. [Mechanism related to docosahexaenoic acid induced large conductance calcium-activated potassium channel currents increase in coronary smooth muscle cells]. 2011 Zhonghua Xin Xue Guan Bing Za Zhi pmid:21624312
Lai LH et al. [Effects of docosahexaenoic acid on sodium channel current and transient outward potassium channel current in rat ventricular myocytes]. 2011 Zhonghua Xin Xue Guan Bing Za Zhi pmid:21781602
Dong PS et al. [Effects of docosahexaenoic acid on ion channels of rat coronary artery smooth muscle cells]. 2012 Zhonghua Xin Xue Guan Bing Za Zhi pmid:22883096
Wang RX et al. [Effects of docosahexaenoic acid on action potential and transient outward potassium current on ventricular myocytes of Sprague-Dawley rat]. 2009 Zhonghua Xin Xue Guan Bing Za Zhi pmid:19719983
Lu G [The role of n-3 polyunsaturated fatty acid on coronary heart disease]. 1990 Zhonghua Xin Xue Guan Bing Za Zhi pmid:2150806
Hu SX and Yang JN [Biological effects of docosahexaenoic acid on the retina]. 2003 Zhonghua Yan Ke Za Zhi pmid:12894762
Yu XJ et al. [Effect of omega-3 long-chain polyunsaturated fatty acids on the cultured oligodendrocyte precursor cells]. 2009 Zhonghua Yi Xue Za Zhi pmid:19563717
Feng XG et al. [Antitumor effect of DHA compound in vitro and in vivo and its mechanism]. 2010 Zhonghua Zhong Liu Za Zhi pmid:20819480