Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Shikano M et al. | Complete discrimination of docosahexaenoate from arachidonate by 85 kDa cytosolic phospholipase A2 during the hydrolysis of diacyl- and alkenylacylglycerophosphoethanolamine. | 1994 | Biochim. Biophys. Acta | pmid:8180247 |
Bouziane M et al. | Dietary protein deficiency affects n-3 and n-6 polyunsaturated fatty acids hepatic storage and very low density lipoprotein transport in rats on different diets. | 1994 | Lipids | pmid:8177019 |
Andersson L et al. | Hydrolysis of phosphatidylethanolamine by human pancreatic phospholipase A2. Effect of bile salts. | 1994 | Scand. J. Gastroenterol. | pmid:8171289 |
Ter-Karapetian VA | [The use of marine products in the prevention and treatment of vascular diseases of the heart and brain]. | 1994 | Voen Med Zh | pmid:8165800 |
Demoz A et al. | Modulation of plasma and hepatic oxidative status and changes in plasma lipid profile by n-3 (EPA and DHA), n-6 (corn oil) and a 3-thia fatty acid in rats. | 1994 | Biochim. Biophys. Acta | pmid:8161562 |
Anderson RE et al. | Plasma lipid changes in PRCD-affected and normal miniature poodles given oral supplements of linseed oil. Indications for the involvement of n-3 fatty acids in inherited retinal degenerations. | 1994 | Exp. Eye Res. | pmid:8157107 |
Rodriguez de Turco EB et al. | Docosahexaenoic acid is taken up by the inner segment of frog photoreceptors leading to an active synthesis of docosahexaenoyl-inositol lipids: similarities in metabolism in vivo and in vitro. | 1994 | Curr. Eye Res. | pmid:8156822 |
Zhu BQ et al. | Is the reduction of myocardial infarct size by dietary fish oil the result of altered platelet function? | 1994 | Am. Heart J. | pmid:8154411 |
Leung FW | Prostaglandins mediate fish oil protection against ethanol-induced gastric mucosal injury in rats. | 1994 | Dig. Dis. Sci. | pmid:8149856 |
Shiina T et al. | Eicosapentaenoic acid and docosahexaenoic acid suppress the proliferation of vascular smooth muscle cells. | 1993 | Atherosclerosis | pmid:8141854 |
Bénistant C et al. | Platelet inhibitory functions of aortic endothelial cells. Effects of eicosapentaenoic and docosahexaenoic acids. | 1993 | Atherosclerosis | pmid:8141848 |
Schjøtt J et al. | Infusion of EPA and DHA lipid emulsions: effects on heart lipids and tolerance to ischaemia-reperfusion in the isolated rat heart. | 1993 | Scand. J. Clin. Lab. Invest. | pmid:8140399 |
Hardy SJ et al. | In vitro activation of rat brain protein kinase C by polyenoic very-long-chain fatty acids. | 1994 | J. Neurochem. | pmid:8133282 |
Piatti G et al. | Delaying effects of dietary eicosapentaenoic-docosahexaenoic acids on development of "fatty streaks" in hypercholesterolaemic rabbits. A morphological study by scanning electron microscopy. | 1993 | Drugs Exp Clin Res | pmid:8131713 |
Honoré E et al. | External blockade of the major cardiac delayed-rectifier K+ channel (Kv1.5) by polyunsaturated fatty acids. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8127910 |
Henderson WR et al. | Oral absorption of omega-3 fatty acids in patients with cystic fibrosis who have pancreatic insufficiency and in healthy control subjects. | 1994 | J. Pediatr. | pmid:8120709 |
Somers SD and Erickson KL | Alteration of tumor necrosis factor-alpha production by macrophages from mice fed diets high in eicosapentaenoic and docosahexaenoic fatty acids. | 1994 | Cell. Immunol. | pmid:8118867 |
Wakabayashi S et al. | In vivo cerebral incorporation of radiolabeled fatty acids after acute unilateral orbital enucleation in adult hooded Long-Evans rats. | 1994 | J. Cereb. Blood Flow Metab. | pmid:8113326 |
Alvarez RA et al. | Docosapentaenoic acid is converted to docosahexaenoic acid in the retinas of normal and prcd-affected miniature poodle dogs. | 1994 | Invest. Ophthalmol. Vis. Sci. | pmid:8112987 |
Ikai K et al. | Leukotriene A4 hydrolase in human skin. | 1994 | J. Invest. Dermatol. | pmid:8106755 |
Spady DK | Regulatory effects of individual n-6 and n-3 polyunsaturated fatty acids on LDL transport in the rat. | 1993 | J. Lipid Res. | pmid:8105015 |
Bourre JM et al. | Dietary alpha-linolenic acid at 1.3 g/kg maintains maximal docosahexaenoic acid concentration in brain, heart and liver of adult rats. | 1993 | J. Nutr. | pmid:8100576 |
Orii T et al. | [Peroxisomal disorders--DNA analysis]. | 1993 | Nippon Rinsho | pmid:8096253 |
Crawford MA | Aspirin in pregnancy. | 1993 | Lancet | pmid:8095644 |
Hanai T et al. | Comparison of prostanoids and their precursor fatty acids in human hepatocellular carcinoma and noncancerous reference tissues. | 1993 | J. Surg. Res. | pmid:8094103 |
Fonlupt P et al. | Incorporation of arachidonic and docosahexaenoic acids into phospholipids of rat brain membranes. | 1994 | Neurosci. Lett. | pmid:8084475 |
Alberghina M et al. | Differential transport of docosahexaenoate and palmitate through the blood-retina and blood-brain barrier of the rat. | 1994 | Neurosci. Lett. | pmid:8084474 |
Pyzh MV et al. | [Food supplement containing ω-3 polyunsaturated fatty acids prevents experimental thrombotic occlusion of coronary arteries in dogs]. | 1993 | Kardiologiia | pmid:8084128 |
Jump DB et al. | Coordinate regulation of glycolytic and lipogenic gene expression by polyunsaturated fatty acids. | 1994 | J. Lipid Res. | pmid:8077846 |
McVeigh GE et al. | Fish oil improves arterial compliance in non-insulin-dependent diabetes mellitus. | 1994 | Arterioscler. Thromb. | pmid:8068603 |
Sukenik A et al. | Dietary lipids from marine unicellular algae enhance the amount of liver and blood omega-3 fatty acids in rats. | 1994 | Ann. Nutr. Metab. | pmid:8067689 |
Karanian JW et al. | Lipoxygenase stimulating effects of hydroxylated docosahexaenoates produced by human platelets. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8066103 |
Takahashi M et al. | Effect of docosahexaenoic acid on azoxymethane-induced colon carcinogenesis in rats. | 1994 | Cancer Lett. | pmid:8062213 |
Reddy S et al. | The influence of maternal vegetarian diet on essential fatty acid status of the newborn. | 1994 | Eur J Clin Nutr | pmid:8055852 |
Brand MD et al. | Liposomes from mammalian liver mitochondria are more polyunsaturated and leakier to protons than those from reptiles. | 1994 | Comp. Biochem. Physiol. Biochem. Mol. Biol. | pmid:8055185 |
North JA et al. | Cell fatty acid composition affects free radical formation during lipid peroxidation. | 1994 | Am. J. Physiol. | pmid:8048478 |
Felouati BE et al. | Oestradiol-induced changes in the composition of phospholipid classes of quail oviduct: specific replacement of arachidonic acid by docosahexaenoic acid in alkenylacyl-glycerophosphoethanolamine. | 1994 | Biochem. J. | pmid:8042978 |
Wang H et al. | The effects of n-3 fatty acids on the secretion of carboxyl-terminally truncated forms of human apoprotein B. | 1994 | J. Biol. Chem. | pmid:8034600 |
Haglund O et al. | Effects of fish oil on some parameters of fibrinolysis and lipoprotein(a) in healthy subjects. | 1994 | Am. J. Cardiol. | pmid:8023790 |
Sacks FM et al. | Short report: the effect of fish oil on blood pressure and high-density lipoprotein-cholesterol levels in phase I of the Trials of Hypertension Prevention. | 1994 | J. Hypertens. | pmid:8021472 |
Shahar E et al. | Dietary n-3 polyunsaturated fatty acids and smoking-related chronic obstructive pulmonary disease. Atherosclerosis Risk in Communities Study Investigators. | 1994 | N. Engl. J. Med. | pmid:8015569 |
Carlson SE et al. | Long-chain fatty acids and early visual and cognitive development of preterm infants. | 1994 | Eur J Clin Nutr | pmid:7995262 |
Belluzzi A et al. | Effects of new fish oil derivative on fatty acid phospholipid-membrane pattern in a group of Crohn's disease patients. | 1994 | Dig. Dis. Sci. | pmid:7995183 |
Bright JM et al. | The effects of n-3 fatty acid supplementation on bleeding time, plasma fatty acid composition, and in vitro platelet aggregation in cats. | 1994 Jul-Aug | J. Vet. Intern. Med. | pmid:7983618 |
Brossard N et al. | Stable isotope tracer and gas-chromatography combustion isotope ratio mass spectrometry to study the in vivo compartmental metabolism of docosahexaenoic acid. | 1994 | Anal. Biochem. | pmid:7978245 |
Thies F et al. | Preferential incorporation of sn-2 lysoPC DHA over unesterified DHA in the young rat brain. | 1994 | Am. J. Physiol. | pmid:7977854 |
Imre SG et al. | Increased proportion of docosahexanoic acid and high lipid peroxidation capacity in erythrocytes of stroke patients. | 1994 | Stroke | pmid:7974583 |
Yano Y et al. | Production of docosahexaenoic acid by marine bacteria isolated from deep sea fish. | 1994 | Lipids | pmid:7968276 |
Hardy SC and Kleinman RE | Fat and cholesterol in the diet of infants and young children: implications for growth, development, and long-term health. | 1994 | J. Pediatr. | pmid:7965456 |
Gibson RA et al. | Ratios of linoleic acid to alpha-linolenic acid in formulas for term infants. | 1994 | J. Pediatr. | pmid:7965453 |
Carlson SE | Lessons learned from randomizing infants to marine oil-supplemented formulas in nutrition trials. | 1994 | J. Pediatr. | pmid:7965451 |
Saito M and Nakatsugawa K | Increased susceptibility of liver to lipid peroxidation after ingestion of a high fish oil diet. | 1994 | Int J Vitam Nutr Res | pmid:7960494 |
Anti M et al. | Effects of different doses of fish oil on rectal cell proliferation in patients with sporadic colonic adenomas. | 1994 | Gastroenterology | pmid:7958682 |
Eritsland J et al. | Long-term effects of n-3 fatty acids on serum lipids and glycaemic control. | 1994 | Scand. J. Clin. Lab. Invest. | pmid:7939369 |
Kang JX and Leaf A | Effects of long-chain polyunsaturated fatty acids on the contraction of neonatal rat cardiac myocytes. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7937911 |
Karanian JW et al. | Inhibitory effects of n-6 and n-3 hydroxy fatty acids on thromboxane (U46619)-induced smooth muscle contraction. | 1994 | J. Pharmacol. Exp. Ther. | pmid:7932158 |
Ikeda I et al. | alpha-Linolenic, eicosapentaenoic and docosahexaenoic acids affect lipid metabolism differently in rats. | 1994 | J. Nutr. | pmid:7931698 |
Arm JP et al. | Leukotrienes, fish-oil, and asthma. | 1994 May-Jun | Allergy Proc | pmid:7926711 |
del Carmen Boyano-Adánez M et al. | Protein kinase C-mediated phospholipase D activity is increased by linolenic acid supplementation in NG 108-15 cells. | 1994 | Biochim. Biophys. Acta | pmid:7918608 |
Tremoli E et al. | n-3 fatty acid ethyl ester administration to healthy subjects and to hypertriglyceridemic patients reduces tissue factor activity in adherent monocytes. | 1994 | Arterioscler. Thromb. | pmid:7918310 |
Winters BL et al. | Linolenic acid provides a source of docosahexaenoic acid for artificially reared rat pups. | 1994 | J. Nutr. | pmid:7916377 |
Makrides M et al. | Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. | 1994 | Am. J. Clin. Nutr. | pmid:7913291 |
Anderson GJ and Connor WE | Accretion of n-3 fatty acids in the brain and retina of chicks fed a low-linolenic acid diet supplemented with docosahexaenoic acid. | 1994 | Am. J. Clin. Nutr. | pmid:7911000 |
Green P and Yavin E | Elongation, desaturation, and esterification of essential fatty acids by fetal rat brain in vivo. | 1993 | J. Lipid Res. | pmid:7905509 |
Ghebremeskel K et al. | Fatty acid composition of plasma and red cell phospholipids of preterm babies fed on breast milk and formulae. | 1995 | Eur. J. Pediatr. | pmid:7895755 |
Karikó K et al. | Stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor-1 mRNA in cultured human endothelial cells. | 1995 | FEBS Lett. | pmid:7890029 |
Gibney MJ and Daly E | The incorporation of n-3 polyunsaturated fatty acids into plasma lipid and lipoprotein fractions in the postprandial phase in healthy volunteers. | 1994 | Eur J Clin Nutr | pmid:7889895 |
Purasiri P et al. | Modulation of cytokine production in vivo by dietary essential fatty acids in patients with colorectal cancer. | 1994 | Clin. Sci. | pmid:7874864 |
Santos MJ et al. | Influence of dietary supplementation with fish on plasma fatty acid composition in coronary heart disease patients. | 1995 | Ann. Nutr. Metab. | pmid:7872656 |
Martinez M | Polyunsaturated fatty acids in the developing human brain, red cells and plasma: influence of nutrition and peroxisomal disease. | 1994 | World Rev Nutr Diet | pmid:7871835 |
von Houwelingen AC and Hornstra G | Trans fatty acids in early human development. | 1994 | World Rev Nutr Diet | pmid:7871822 |
Anderson RE et al. | The accretion of docosahexaenoic acid in the retina. | 1994 | World Rev Nutr Diet | pmid:7871813 |
Bazan NG et al. | Docosahexaenoic acid supply to the retina and its conservation in photoreceptor cells by active retinal pigment epithelium-mediated recycling. | 1994 | World Rev Nutr Diet | pmid:7871812 |
Chen LY et al. | Reduction in human neutrophil superoxide anion generation by n-3 polyunsaturated fatty acids: role of cyclooxygenase products and endothelium-derived relaxing factor. | 1994 | Thromb. Res. | pmid:7871491 |
Poling JS et al. | Time- and voltage-dependent block of delayed rectifier potassium channels by docosahexaenoic acid. | 1995 | Mol. Pharmacol. | pmid:7870048 |
Tessier C et al. | Docosahexaenoic acid is a potent inhibitor of rat uterine stromal cell proliferation. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7864887 |
Al MD et al. | The relationship between the essential fatty acid status of mother and child and the occurrence of pregnancy-induced hypertension. Intermediate results of a prospective longitudinal study. | 1994 | World Rev Nutr Diet | pmid:7856218 |
Alexander-North LS et al. | Polyunsaturated fatty acids increase lipid radical formation induced by oxidant stress in endothelial cells. | 1994 | J. Lipid Res. | pmid:7852854 |
Lokesh BR and Kinsella JE | Effects of n-3 polyunsaturated fatty acids on the reacylation of arachidonic acid in peritoneal macrophages. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846090 |
Vaidyanathan VV et al. | Regulation of diacylglycerol kinase in rat brain membranes by docosahexaenoic acid. | 1994 | Neurosci. Lett. | pmid:7845615 |
Yamashiro Y et al. | Docosahexaenoic acid status of patients with extrahepatic biliary atresia. | 1994 | J. Pediatr. Surg. | pmid:7844720 |
Terasawa F et al. | Effects of dietary casein and soy-protein on metabolic conversion of eicosapentaenoic acid to docosahexaenoic acid in the liver of rat. | 1994 | J. Nutr. Sci. Vitaminol. | pmid:7844642 |
Popp-Snijders C and Blonk MC | Omega-3 fatty acids in adipose tissue of obese patients with non-insulin-dependent diabetes mellitus reflect long-term dietary intake of eicosapentaenoic and docosahexaenoic acid. | 1995 | Am. J. Clin. Nutr. | pmid:7840075 |
Kurlandsky LE et al. | The absorption and effect of dietary supplementation with omega-3 fatty acids on serum leukotriene B4 in patients with cystic fibrosis. | 1994 | Pediatr. Pulmonol. | pmid:7838619 |
Bazan NG and Rodriguez de Turco EB | Review: pharmacological manipulation of docosahexaenoic-phospholipid biosynthesis in photoreceptor cells: implications in retinal degeneration. | 1994 | J Ocul Pharmacol | pmid:7836869 |
Gazzah N et al. | Decrease of brain phospholipid synthesis in free-moving n-3 fatty acid deficient rats. | 1995 | J. Neurochem. | pmid:7830085 |
Delton I et al. | Distribution and metabolism of arachidonic and docosahexaenoic acids in rat pineal cells. Effect of norepinephrine. | 1995 | Biochim. Biophys. Acta | pmid:7827119 |
Christensen MS et al. | Intestinal absorption and lymphatic transport of eicosapentaenoic (EPA), docosahexaenoic (DHA), and decanoic acids: dependence on intramolecular triacylglycerol structure. | 1995 | Am. J. Clin. Nutr. | pmid:7825539 |
Das UN | Beneficial effect of eicosapentaenoic and docosahexaenoic acids in the management of systemic lupus erythematosus and its relationship to the cytokine network. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7824535 |
Gazzah N et al. | Evidence for brain docosahexaenoate recycling in the free-moving adult rat: implications for measurement of phospholipid synthesis. | 1994 | Neurosci. Lett. | pmid:7824158 |
Petroni A et al. | Inhibition by n-3 fatty acids of arachidonic acid metabolism in a primary culture of astroglial cells. | 1994 | Neurochem. Res. | pmid:7824073 |
Khair-el-Din TA et al. | Docosahexaenoic acid, a major constituent of fetal serum and fish oil diets, inhibits IFN gamma-induced Ia-expression by murine macrophages in vitro. | 1995 | J. Immunol. | pmid:7822798 |
Roche H and Gibney MJ | The effect of consumption of fish oil-enriched spreadable fats on platelet phospholipid fatty acid composition in human volunteers. | 1994 | Int J Vitam Nutr Res | pmid:7814240 |
Kim HY et al. | Liquid chromatography/mass spectrometry of phospholipids using electrospray ionization. | 1994 | Anal. Chem. | pmid:7810900 |
Mallampalli RK et al. | Regulation of CTP:choline-phosphate cytidylyltransferase by polyunsaturated n-3 fatty acids. | 1994 | Am. J. Physiol. | pmid:7810669 |
Kinoshita K et al. | Inhibitory effects of purified eicosapentaenoic acid and docosahexaenoic acid on growth and metastasis of murine transplantable mammary tumor. | 1994 May-Jun | In Vivo | pmid:7803721 |
Zerouga M et al. | Comparison of phosphatidylcholines containing one or two docosahexaenoic acyl chains on properties of phospholipid monolayers and bilayers. | 1995 | Biochim. Biophys. Acta | pmid:7794965 |
Jenski LJ et al. | Docosahexaenoic acid-induced alteration of Thy-1 and CD8 expression on murine splenocytes. | 1995 | Biochim. Biophys. Acta | pmid:7794954 |
Burdge GC and Postle AD | Effect of maternal ethanol consumption during pregnancy on the phospholipid molecular species composition of fetal guinea-pig brain, liver and plasma. | 1995 | Biochim. Biophys. Acta | pmid:7786898 |
Shimizu S et al. | omega-Hydroxylation of docosahexaenoic acid or arachidonic acid in human colonic well differentiated adenocarcinoma homogenate. | 1995 | Biochim. Biophys. Acta | pmid:7786890 |